RESUMO
To study role of orexin-A in obesity, type 2 diabetes as well as combined obesity and type2 diabetes in male patients and its correlation with leptin hormone. The study was conducted on 30 male patients and 10 healthy age and sex matched control subjects. The patients were divided into 3 groups each of ten as follow: obese normoglycemic, nonobese type 2 diabetic and obese type 2 diabetic patients. All patients and controls were subjected to full history taking and complete clinical examination with determination of BMI. The following parameters were measured: fasting serum levels of glucose, insulin, triglycerides and glycosylated hemoglobin. Serum orexin-A and leptin concentrations were determined. The results of the study revealed that, serum orexin-A was significantly low in all the studied patient groups as compared to control subjects. Significant high serum leptin levels were detected in all patient groups compared to normal ones. An inverse correlation was found between serum orexin-A and BMJ, leptin, glucose and insulin levels. On the other hand, serum leptin was positively correlated with BMI and insulin levels. Orexin-A is implicated in the pathogenesis of both obesity and type 2 diabetes. Leptin may be an important negative regulator of orexin-A