1.
Indian J Exp Biol
;
1989 Aug; 27(8): 735-8
Artigo
em Inglês
| IMSEAR
| ID: sea-58465
RESUMO
Effects of methyl [5[[4-(2-pyridinyl)-1-piperazinyl] carbonyl] 1H-benzimidazol-2-yl] carbamate (CDRI Comp. 81-470) and mebendazole on the energy metabolism of A. ceylanicum and N. brasiliensis were compared. At 10 and 50 microM concentration both compounds inhibited glucose uptake and its conversion into metabolic endproducts. The shift towards the increased production of lactic acid appeared to be the result of inhibition of PEP carboxykinase and increase in LDH activity. The compounds also caused significant inhibition of ATP production in mitochondria.
Assuntos
Ancylostoma/metabolismo , Animais , Anti-Helmínticos/farmacologia , Benzimidazóis/farmacologia , Carbamatos/farmacologia , Metabolismo Energético/efeitos dos fármacos , Mebendazol/farmacologia , Nippostrongylus/metabolismo
2.
Indian J Exp Biol
;
1988 Sep; 26(9): 724-7
Artigo
em Inglês
| IMSEAR
| ID: sea-60410