Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome

The objective of this study was to elucidate the cause of the spermatogenic defect in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome. Genomic DNAs from 9 cases of Korean idiopathic azoospermia and 6 of Korean non-mosaic type of Klinefelter syndrome were used for the detection of Y chromosome microdeletions by polymerase chain reaction using 60 primers. Microdeletions of the Y chromosome were found in 1 of 9 (11.1%) patients with idiopathic azoospermia, whereas none was deleted in non-mosaic type of Klinefelter syndrome. This result suggests that Y chromosome microdeletions could be one of the etiologic factors in idiopathic azoospermia.

Sperm motility and morphology as changing parameters linked to sperm count variations.

Variations in semen analyses of 177 males over a 1 year period were assessed. The average means of total counts, motility, morphology, total motile count and non-motile % were determined for 5 classes of patients ranging from azoospermic to normospermic. Positive relationships between a falling sperm count, a decrease in motility and total motile counts were seen. Also, increasingly, abnormal forms were found with lower sperm counts.

Factores etiológicos más frecuentes en varones subfértiles / Most frequent etiological factors in subfertile males

Se estudiaron 85 pacientes subfértiles en la clínica de Andrología del Hospital General del Centro Médico Nacional. La azoospermia fue la alteración más frecuente en grupo, y los factores etiológicos que propiciaron con mayor frecuencia esterilidad fueron infecciones, varicoceles y disgenesias gonadles. El estudio integral de estos pacientes desde los puntos de vista clínico, de laboratorio y de gabinete permitió hacer un diagnóstico más preciso y tener un pronóstico definitivo en cuanto a fertilidad