VIPoma pancreático: Caso clínico / Pancreatic VIPoma: Report of one case

Neuroendocrine tumors are uncommon, including VIPoma that produces vasoactive intestinal polypeptide. We report a 45-year-old female presenting with a history of diarrhea lasting three months. An abdominal CAT scan showed a solid tumor in the body of the pancreas. A fine needle aspiration biopsy of the tumor was compatible with a neuroendocrine tumor. The patient was subjected to a partial pancreatectomy, excising a 4 cm diameter tumor. The pathological study was compatible with a neuroendocrine carcinoma. There was no regional lymph node involvement. During the postoperative period the results of serum vasoactive intestinal polypeptide were received. These were 815.9 pg/ml before surgery and normalized after the operation.

Age related changes of intestinal motility in rats

The pattern of intestinal motility in different segments of the small and large intestine as well as plasma VIP level were studied in young, adult, old and senescent male albino rats. Results obtained in this study showed that aging has a suppressive effect on the different intestinal motility parameters and this intestinal motility dysfunction was more manifest in the senescent rats than in the old ones. The frequency of contractions of the duodenum and descending colon was significantly reduced with marked prolongation in the average duration of contractions in old and senescent rats compared to the young rats. Regarding the motility index in the duodenum, ileum and descending colon, it was reduced in old and senescent rats compared to the adults. This decrease was more pronounced and statistically significant in the senescent group. There was. Insignificant decrease in the plasma VIP levels with the advance of age and it was not related to the dysmotility of aging. Intramuscular injection of vitamin E for two successive months significantly increased the average force of contraction and motility index of both the small and large intestinal regions especially the caecum and descending colon. This improvement was more evident in senescent than old rats