Impact of aggressive periodontitis and chronic periodontitis on oral health-related quality of life

Abstract The purpose of this cross-sectional study was to investigate the effect of different forms of periodontal diseases on Oral Health-Related Quality of Life (OHRQoL). Fifty-two patients with Aggressive Periodontitis (AP) or Chronic Periodontitis (CP) were included: nine patients with Localized Aggressive Periodontitis (LAP), thirty-three patients with Generalized Aggressive Periodontitis (GAP) and ten patients with Generalized Chronic Periodontitis (GCP). Oral Health Impact Profile questionnaires (OHIP-14) were distributed after a clinical examination that measured the following periodontal parameters: tooth loss, bleeding on probing (BoP), probing depth (PD), gingival recession (REC) and clinical attachment level (CAL). The global OHIP-14 score means were 10.6 for LAP, 16.5 for GAP, and 17.5 for GCP. A statistically significant difference (p < 0.01) was observed between the LAP group and the other two groups. There was significantly less bleeding and recession in the LAP group than in the patients with the generalized forms of periodontitis. LAP, GAP and GCP have an impact on patient quality of life when measured using the OHIP-14. Patients with GAP and GCP had poorer OHRQoL than LAP patients.

Condições periodontais em pacientes com lúpus eritematoso sistêmico juvenil / Periodontal conditions in patients with juvenile systemic lupus erythematosus

Periodontite e lúpus eritematoso sistêmico (LES) apresentam processos de destruição tecidual semelhantes. Pouca evidência é disponível sobre as possíveis relações entre as doenças periodontais e as formas de lúpus que afetam crianças e adolescentes, conhecida como lúpus eritematoso sistêmico juvenil (LESJ). Esta tese é baseada na hipótese de que adolescentes com LESJ podem apresentar condições periodontais diferenciadas devido a mecanismos inflamatórios e destrutivos alterados em comum. Dessa forma, os objetivos foram: (1) avaliar as condições clínicas periodontais de um grupo de adolescentes com LESJ e de um grupo de controles saudáveis sistemicamente; (2) verificar a atividade neutrofílica (elastase) e os níveis de IL-1 β e IL-18 no fluido crevicular gengival (FCG), bem como os níveis séricos de IL-18. A porcentagem média de placa visível, sangramento marginal e sítios com perda de inserção clínica ≥2 foi similar em ambos os grupos. A porcentagem média de sítios com profundidade de sondagem ≥3 mm foi significantemente maior nos controles que nos pacientes com LESJ (30% versus 16,9% - P=0,03). Os pacientes com LESJ ativos apresentaram maiores níveis de placa (P=0,01) e sangramento marginal (P=0,05) quando comparados aos inativos. Não foram encontradas diferenças na profundidade de sondagem e perda de inserção clínica entre os pacientes ativos e inativos. Quando comparados aos controles, os pacientes com LESJ tinham maiores níveis de elastase livre (427 versus 45 - P=0,03), mas níveis menores de Eα2MG (97,5 versus 295 -P=0,001), IL-1 β (13,4 versus 27 - P=0,05) e IL-18 (16,2 versus 41 - P=0,04). Na divisão por atividade só foram encontradas diferenças nos níveis de elastase, maiores no grupo ativo (601 versus 208,5 - P=0, 05). Os pacientes com LESJ apresentaram maiores níveis séricos de IL-18 (369,5 versus 331,19 - P=0,04) e VHS (20 versus 2,2 - P=0,03) quando comparados aos controles...

Periodontitis and systemic lupus erythematosus (SLE) share similar mechanisms of tissue destruction. Little is known about the possible association between periodontal diseases and the the forms of lupus that affect children and adolescents, i.e. juvenile systemic lupus erythematosus (JSLE). This thesis is based on the hypothesis that JSLE adolescents might have a different periodontal condition due to common altered inflammatory and destructive mechanisms. Thus, the aims were: (1) evaluate the periodontal conditions in adolescents with JSLE compared to those of a control group of healthy adolescents; (2) analyse markers of neutrophil activity (elastase), levels of IL-1 β and IL-18 in the gingival crevicular fluid as well as serum levels of IL-18. The mean percentages of visible plaque, marginal bleeding and sites with attachment loss (AL) ≥ 2 were similar in both groups. The mean percentage of sites with pocket depth (PD) ≥ 3 mm was significantIy higher in control than in JSLE patients (30% versus 16,9% - P=0,03). There were significant difference in plaque (P=0,01) and marginal bleeding (P=0,05) levels between JSLE patients with active and inactive disease. There were no significant differences in PD and AL in these subgroups. When compared to controls, JSLE patients showed higher levels of free elastase (427 versus 45 - P=0, 03), but lower levels of Eα2MG (97,5 versus 295 -P=0,001), IL1- β (13,4 versus 27 - P=0,05) and IL-18 (16,2 versus 41 - P=0,04). There were significant differences in the JSLE subgroups in the total amount of elastase, higher in the active subgroup (601 versus 208,5 - P=0,05). The levels of IL β and IL-18 did not differ between the subgroups. In serum, JSLE patients had higher 1evels of IL-18 (369,5 versus 331,19 - P=0,04) and ESR (20 versus 2,2 - P=0,03) when compared to controls...