Anticonvulsant evaluation of 2-pyrazolines carrying naphthyl moiety: An insight into synthesis and molecular docking study

A series of N-substituted-3-(napthalen-2-yl)-5-substituted phenyl-4,5-dihydropyrazole-1-carbothioamide derivatives (4a-n) were synthesized with the view of structural requirements of pharmacophore for potential anticonvulsant agents. The synthesized compounds were assayed intraperitoneally (i.p.) and subcutaneously (s.c.) in mice against seizures induced by MES and scPTZ methods, respectively.Neurologic deficit was evaluated by rotarod method. Among the tested compounds, 4g, 4i, 4j and 4n emerged as the most active molecule in the MES model at a dose of 30 mg/kg at 0.5h comparable to standardscarbamazepine and phenytoin. In the scPTZ test,4e and 4l were found to be most active compounds at the lowest dose of 30 mg/kg at 0.5h, in the management of the convulsive disorder. Molecular docking studies of the titled compounds were also donewith 3D crystal structure of human cytosolic branched chain amino transferase (hBCATc) enzyme and compound 4e was found to have five hydrogen bond interactions with the most important active site residues.In neurotoxicity studies, except compounds 4b, 4c, 4h and 4k, rest of the compounds showed no sign of toxicity.

Synthesis and spectral studies of some new pyrazolines and pyrazoles

A number of 3' -[3-aryl-2-methyl] pyrrol-5-yll-l' - aryl-2 propen-l'-ones 4-13 have been prepared and transformed into the corresponding arylhydrazones 14-28. These hydrazones were cyclized to the pyrazolines 29-43, which were oxidized to the corresponding pyrazoles 49-53. In addition, heating of the pyrazoline 42 with hydrazine hydrate afforded the hydrazide 46 while pyrazolines 41 and 42 gave the acids 47 and 48 upon hydrolysis. Spectral properties of the prepared compounds were discussed

Styryl and dicationic cyanine dyes containing the pyrazole moiety

Three types of cyanine dyes containing the pyrazole moiety have been synthesized and their visible spectra were compared. These include symmetrical dicationic dimethine cyanines, asymmetrical styryl cyanines and asymmetrical dicationic cyanines