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1.
Southeast Asian J Trop Med Public Health ; 1997 ; 28 Suppl 3(): 64-8
Artigo em Inglês | IMSEAR | ID: sea-33814

RESUMO

In Thailand, the most common cause of chronic hemolytic anemia is thalassemia hemoglobinopathy. We report here a 10-year-old girl with pyruvate kinase (PK) deficiency who was initially diagnosed to have Hb H disease, like her sister. The patient had a history of neonatal jaundice which required blood exchange transfusion twice and phototherapy. She became anemic and regular blood transfusion was required since the age of 2 1/2 months. She was very anemic compared to her sister and was transfusion dependent. Besides, she never had red cell inclusion bodies, thus re-evaluation was performed. The diagnosis of red cell pyruvate kinase deficiency and the exclusion of Hb H disease was achieved after cessation of blood transfusion for 3 months. The family study also confirmed the diagnosis. The patient is now on high transfusion and iron chelation. She is doing well with mild splenomegaly.


Assuntos
Criança , Eritrócitos/enzimologia , Família , Feminino , Humanos , Piruvato Quinase/efeitos dos fármacos , Tailândia/epidemiologia , Talassemia alfa/epidemiologia
2.
Indian J Exp Biol ; 1992 Jan; 30(1): 8-11
Artigo em Inglês | IMSEAR | ID: sea-57505

RESUMO

Effects of prolactin (PRL), bromocriptine (Br), testosterone propionate (TP), dihydrotestosterone (DHT) and the combinations of these androgens with PRL/Br on the specific activities of caudal and cranial prostatic cellular enzymes involved in carbohydrate metabolism in castrated mature bonnet monkeys have been studied. Castration decreased all the enzymes studied such as hexokinase (HK), 6-phosphofructokinase (6-PFK), glyceraldehyde-3-phosphate dehydrogenase (G-3-PD), pyruvate kinase (PK), glucose-6-phosphate dehydrogenase (G-6-PD) and 6-phosphogluconate dehydrogenase (6-PGD) in the cranial and caudal prostates. PRL elevated the activities of all the enzymes above normal except G-3-PD of cranial lobe. In the caudal lobe, PRL brought back the activities of HK, PFK, PK, G-6-PD to normal and 6-PGD above normal except G-3-PD. TP/DHT treatment increased all the enzymes in both the lobes. PRL given along with TP/DHT further enhanced the androgen action with regard to HK, PK, G-6-PD and 6-PGD of cranial and PFK, G-3-PD, PK, G-6-PD and 6-PGD of caudal lobe. Br treatment did not produce any alteration of these enzymes in both the lobes. In the cranial lobe, during Br+TP/DHT treatment, the stimulating effects of androgen were unaffected on all the enzymes except PK. On the other hand in the caudal, the stimulatory effects of androgens were affected and the activities of HK, PFK, PK and 6-PGD were significantly decreased. The present results suggest that PRL has a direct as well as a synergistic action with androgens on enzymes of EMP and HMP shunt in the prostates of monkeys.


Assuntos
Androgênios/farmacologia , Animais , Metabolismo dos Carboidratos , Castração , Glucosefosfato Desidrogenase/efeitos dos fármacos , Gliceraldeído-3-Fosfato Desidrogenases/efeitos dos fármacos , Hexoquinase/efeitos dos fármacos , Macaca radiata , Masculino , Fosfofrutoquinase-1/efeitos dos fármacos , Fosfogluconato Desidrogenase/efeitos dos fármacos , Prolactina/farmacologia , Próstata/efeitos dos fármacos , Piruvato Quinase/efeitos dos fármacos
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