Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Adicionar filtros








Intervalo de ano
1.
Journal of Korean Medical Science ; : 1103-1107, 2006.
Artigo em Inglês | WPRIM | ID: wpr-174093

RESUMO

The purpose of this study is to investigate the mechanism of alternative responses to low dose irradiation for neuronal cell proliferation in the dentate gyrus of rats. To determine the effect of a single exposure to radiation, rats were irradiated with a single dose of 0.1, 1, 10 or 20 Gy. To determine the effect of the cumulative dose, the animals were irradiated daily with 0.01 Gy or 0.1 Gy from 1 to 4 days. The neuronal cell proliferation was evaluated using immunohistochemistry for 5-bromo-2'-deoxyuridine (BrdU), Ki-67 and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) staining. Four consecutive daily irradiations with a 0.01 Gy/fraction increased the number of BrdU-positive and Ki-67-positive cells in a dose dependent manner, but this did not affect the number of TUNEL-positive cells. However, there was not a dose dependent relationship for the 0.1 Gy/fraction irradiation with the number of BrdU, Ki-67 and TUNEL positive cells. Our data support the explanation that the adaptive response, induced by low-dose radiation, in the hippocampus of rats is more likely a reflection of the perturbations of cell cycle progression.


Assuntos
Ratos , Masculino , Animais , Ratos Sprague-Dawley , Doses de Radiação , Neurônios/citologia , Plasticidade Neuronal/efeitos da radiação , Relação Dose-Resposta à Radiação , Giro Denteado/citologia , Sobrevivência Celular/efeitos da radiação , Proliferação de Células/efeitos dos fármacos , Adaptação Fisiológica/efeitos da radiação
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA