RESUMO
Abstracts We report the case of a patient presenting with multiple severe electrolyte disturbances who was subsequently found to have small cell lung cancer. Upon further evaluation, she demonstrated three distinct paraneoplastic processes, including the syndrome of inappropriate antidiuretic hormone, Fanconi syndrome, and an inappropriate elevation in fibroblast growth factor-23 (FGF23). The patient underwent one round of chemotherapy, but she was found to have progressive disease. After 36 days of hospitalization, the patient made the decision to enter hospice care and later she expired.
Resumen Se reporta el caso de una paciente que ingresó al hospital para evaluación de múltiples trastornos electrolíticos y, posteriormente, se le hizo el diagnóstico de cáncer de pulmón de células pequeñas. Tras la evaluación médica, se detectaron tres síndromes paraneoplásicos: síndrome de secreción inadecuada de hormona antidiurética, síndrome de Fanconi y elevación inapropiada del factor 23 de crecimiento de fibroblastos. Se le administró quimioterapia sin éxito, por lo cual se decidió darle tratamiento paliativo y, un tiempo después, falleció.
Assuntos
Humanos , Síndromes Paraneoplásicas/etiologia , Precursores de Proteínas/fisiologia , Neurofisinas/fisiologia , Vasopressinas/fisiologia , Carcinoma de Pequenas Células do Pulmão/complicações , Neoplasias Pulmonares/etiologia , Precursores de Proteínas/genética , Precursores de Proteínas/química , Neurofisinas/genética , Neurofisinas/química , Vasopressinas/genética , Vasopressinas/química , Carcinoma de Pequenas Células do Pulmão/patologia , Fator de Crescimento de Fibroblastos 23 , Neoplasias Pulmonares/patologiaRESUMO
The cDNA for pre-pro-Concanavalin A (pre-pro-ConA) was cloned into the cytoplasmic expression vector pKK233-2 to give rise to pCONEXP2 which was used to express the lectin precursor. Pre-pro-ConA is stable and is not transposed and ligated to form the mature protein. No signal peptide removal is observed. The solubility of pre-pro-ConA could not be increased by guanidine hydrochloride denaturation/dilution treatment.