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Rev. Soc. Bras. Med. Trop ; 50(1): 113-116, Jan.-Feb. 2017. tab
Artigo em Inglês | LILACS | ID: biblio-1041392

RESUMO

Abstract: INTRODUCTION: Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis. METHODS: RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to determine TGFB1, PDGFA, and PDGFB RNA expression. RESULTS: The mRNA expression of PDGFA in platelets was significantly lower in the group with advanced fibrosis than in the group with early-stage fibrosis. TGFB1 was more frequently expressed in platelets than in hepatic tissue, which was different from PDGFB. CONCLUSIONS: A pathway mediated by overexpression of TGFB1 via PDGFA in megakaryocytes could be involved in the development of fibrosis.


Assuntos
Humanos , Masculino , Feminino , Adulto , Fator de Crescimento Derivado de Plaquetas/análise , Hepatite C Crônica/sangue , Proteínas Proto-Oncogênicas c-sis/sangue , Fator de Crescimento Transformador beta1/sangue , Cirrose Hepática/sangue , Índice de Gravidade de Doença , Plaquetas/química , RNA Mensageiro/análise , Reação em Cadeia da Polimerase , Hepatite C Crônica/complicações , Cirrose Hepática/virologia , Pessoa de Meia-Idade
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