RESUMO
La deficiencia de vitamina D y el raquitismo son problemas de salud importantes en los países en desarrollo. El raquitismo congénito es una forma infrecuente de raquitismo. La deficiencia materna de vitamina D es el factor de riesgo más importante para la deficiencia de vitamina D y el raquitismo en los recién nacidos y lactantes. Presentamos el caso de un niño de 2 meses de edad, con convulsiones durante su hospitalización por neumonía. Se diagnosticó raquitismo congénito asociado a deficiencia materna de vitamina D.
Vitamin D deficiency and rickets are major health problems in developing countries. Congenital rickets is a rare form of rickets. Maternal vitamin D deficiency is the most important risk factor for vitamin D deficiency and rickets in newborns and early infancy. In this report, we presented a two-monthold infant with seizures while hospitalized for pulmonary infection. Finally, congenital rickets due to maternal vitamin D deficiency was diagnosed.
Assuntos
Humanos , Lactente , Masculino , Hipocalcemia/etiologia , Raquitismo/complicações , Raquitismo/congênito , Convulsões/etiologia , Países em Desenvolvimento , Deficiência de Vitamina DRESUMO
Congenital rickets in 3 newborns of mothers with advanced nutritional osteomalacia, healed with maternal breast milk feeding when mothers alone were given calcium supplements and 7.5 mg of intravenous D2 and the mother baby pair protected from sunlight. Maternal plasma biochemistry indicated more severe vitamin D deficiency compared to their newborns (intrauterine foetal priority). The first dose of 7.5 mg of vitamin D3 and calcium supplements to mother healed osteomalacia but did not appear to heal the rickets of their breast fed infants (extrauterine maternal priority for vitamin D). A second dose given at 3 months interval healed the rickets in their infants and the biochemistry of the mother and baby returned towards normal. Congenital rickets developed when maternal bone mineral and vitamin D stores had been completely exhausted. Raised IPTH levels in the newborn suggested that foetal parathyroids were responsive to hypocalcaemic stimulus.