polymorphism of angiotensin-receptor gene A1166C in familial hypertension and its distribution in the Han Yellow race of China

To study the polymorphism of angiotensin-type 1 receptor [AT1R] gene A1166C in familial primary hypertension and its distribution in Han Yellow race of China. One hundred and four hypertensive patients with no family history, 178 hypertensive patients with familial history, and 150 healthy adults were randomly selected to participate in a prospective clinical trial, and genetype detection by standard polymerase chain reaction methods and restriction fragment length polymorphism [PCR-RFLP] in trials. The study was carried out between October 2009 and November 2010 at Jinan Center for Cardiovascular Disease, Affiliated Hospital of Taishan Medical College, Jinan, China. Notable statistical significances exist in the frequency of genotype and allele of A1166C in familial hypertension group [x[2]=7.663, p=0.020] compared with the normal control group [x[2]= 8.288, p=0.004]. No significant difference was found in the hypertension group [x[2] = 2.186, p=0.322] compared with the normal control group [x[2]=1.289, p=0.256] in the frequency of genotype and allele of A1166C. No significant differences were found between various ages or genders in each of the 3 groups in genotype and allele of A1166C [p>0.05] distribution. In the Han Yellow race population of China, the frequency of genotype and allele of A1166C of patients with familial hypertension is higher than that of healthy adults. The distribution of AT1R gene polymorphisms of A1166C is not related to age or gender

Angiotensinogen and Angiotensin II Type 1 Receptor Gene Polymorphism in Patients with Autosomal Dominant Polycystic Kidney Disease: Effect on Hypertension and ESRD

Autosomal dominant polycystic kidney disease (ADPKD), a common genetic disease, is characterized by the development of hypertension and end stage renal disease. An increase in the activity of the renin-angiotensin system, due to a renal ischemia caused by cyst expansion, contributes to the development of hypertension and renal failure in ADPKD. Recently, the angiotensinogen (AGT) gene, M235T, and angiotensin II type 1 receptor (ATR) gene, A1166C, polymorphisms have been associated with the susceptibility to develop hypertension and renal disease. We hypothesized that the AGT M235T and ATR A1166C polymorphisms could account for some of the variability in the progression of ADPKD. Genotyping was performed in 108 adult patients with ADPKD, and 105 normotensive healthy controls, using PCR and restriction digestion. We analyzed the effects of the AGT M235T and ATR A1166C polymorphisms on hypertension and age at the end stage renal disease (ESRD). Of the 108 patients with ADPKD, 64 (59%) had hypertension and 24 (22%) reached the ESRD. The prevalence of hypertension were; [MM+MT], [TT] genotypes, 60%, 59% (p=1.00) ; [AA], [AC+CC] genotypes, 60%, 50% respectively (p=0.54). The ages at the onset of ESRD were; [MM+MT], [TT] genotypes, 50 +/- 9 years, 56 +/- 8 years (p=0.07) ; [AA], [AC+CC] genotypes, 54 +/- 8 years, 52 +/- 14 years, respectively (p=0.07). There were no differences in the prevalence of hypertension and the ages at the ESRD in relation to the AGT M235T and ATR A1166C polymorphisms. We suggest that the AGT and ATR gene polymorphisms would not have an effect on hypertension or the ESRD in ADPKD.