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1.
Braz. j. med. biol. res ; 48(5): 470-478, 05/2015. tab, graf
Artigo em Inglês | LILACS | ID: lil-744382

RESUMO

Bovine herpesviruses 1 (BoHV-1) and 5 (BoHV-5) share high genetic and antigenic similarities, but exhibit marked differences in tissue tropism and neurovirulence. The amino-terminal region of glycoprotein C (gC), which is markedly different in each of the viruses, is involved in virus binding to cellular receptors and in interactions with the immune system. This study investigated the genetic and antigenic differences of the 5′ region of the gC (5′ gC) gene (amino-terminal) of South American BoHV-1 (n=19) and BoHV-5 (n=25) isolates. Sequence alignments of 374 nucleotides (104 amino acids) revealed mean similarity levels of 97.3 and 94.2% among BoHV-1 gC (gC1), respectively, 96.8 and 95.6% among BoHV-5 gC (gC5), and 62 and 53.3% between gC1 and gC5. Differences included the absence of 40 amino acid residues (27 encompassing predicted linear epitopes) scattered throughout 5′ gC1 compared to 5′ gC5. Virus neutralizing assays testing BoHV-1 and BoHV-5 antisera against each isolate revealed a high degree of cross-neutralization between the viruses, yet some isolates were neutralized at very low titers by heterologous sera, and a few BoHV-5 isolates reacted weakly with either sera. The virus neutralization differences observed within the same viral species, and more pronounced between BoHV-1 and BoHV-5, likely reflect sequence differences in neutralizing epitopes. These results demonstrate that the 5′ gC region is well conserved within each viral species but is divergent between BoHV-1 and BoHV-5, likely contributing to their biological and antigenic differences.


Assuntos
Humanos , Anti-Infecciosos/uso terapêutico , Revisão de Uso de Medicamentos , Política Organizacional , Assistência Ambulatorial/organização & administração , Assistência Ambulatorial/normas , Pesquisa Biomédica , Resistência Microbiana a Medicamentos , Revisão de Uso de Medicamentos/legislação & jurisprudência , Revisão de Uso de Medicamentos/organização & administração , Revisão de Uso de Medicamentos/normas , Avaliação de Programas e Projetos de Saúde , Sociedades Médicas , Estados Unidos
2.
Córdoba; s.n; 2011. 179 p. ilus.
Tese em Espanhol | LILACS | ID: lil-618604

RESUMO

Con el presente trabajo pretendemos desentrañar si, en los supuestos de delitos de tenencia de estupefacientes para consumo personal, la existencia de intereses jurídicamente relevantes, cuyos titulares son personas distintatas al tenedro de la droga - en lo que hace a nuestra investigación nos refierimos a los menores de edad. importa un dato a tener en cuanta que permita justificar la penalización del delito de referencia y en su caso su agravamiento.


With this work we aim to unravel if, in cases of crimes of drug prossession for personal consumption, the existencie of legally relevant interests whose holders are persons other than the holder of the drug-in regard to our investigation we refer to the minor, matter a fact to keep in mind that justifies the punishment of the crime of reference and, if it accurs, its aggravation.


Assuntos
Humanos , Masculino , Feminino , Controle de Medicamentos e Entorpecentes/legislação & jurisprudência , Família , Estratégias de Saúde Nacionais , Revisão de Uso de Medicamentos/legislação & jurisprudência , Argentina
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