RESUMO
A new second generation anticoagulant rodenticide, difethialone (0.0025%), was evaluated in the rice fields at three different cropping stages, viz. Milky, Panicle formation and Panicle maturation, during Kuruvai and Thaladi seasons. The difethailone (0.0025%) yielded satisfactory control success suggesting a great potential as a rodenticide especially in the early stages of rice.
Assuntos
4-Hidroxicumarinas/farmacologia , Anticoagulantes/farmacologia , Produtos Agrícolas , Oryza , Rodenticidas/farmacologiaRESUMO
Three sulphur containing compounds, carbon disulphide, dimethyl disulphide and dimethyl sulphide were bioassayed for preference after admixing them in cereal base as ready bait block for use against commensal rat, R. rattus (wild type) in four way choice chamber system. Rat preference for different baits was also studied with automatic recording animal activity meter. Rats exhibited attractancy to the baits at 0.005% concentration of all the three compounds while at 0.01% concentration they have showed repellency. Dimethyl sulphide at 0.005% concentration showed better attractancy towards both sexes of rat.
Assuntos
Animais , Dissulfeto de Carbono/farmacologia , Grão Comestível , Dissulfetos/farmacologia , Feminino , Masculino , Movimento , Odorantes , Ratos , Controle de Roedores , Rodenticidas/farmacologia , Sulfetos/farmacologiaRESUMO
Con el propósito de determinar, analizar y comparar el efecto rodenticidad de cuatro drogas anticoagulantes, se sometió a grupos de Rattus norvegicus línea Sprague Dawley no resistentes a drogas anticosagulantes, en tres períodos (2, 3 y 5 días respectivamente), con warfarina, clorafacinona, coumatetralyl y brodifacoum. Para este efecto se trabajó con 110 ratas cepa blanca. Luego, se analizaron y compararon los consumos de cebos para las 4 drogas, determinándose las mortalidades por ingestión de éstas. Se observaron las principales alteraciones anatomopatológicas. Los resultados del experimento muestran disminución significativa (p< 0,05) del consumo de cebo para tratamiento con coumatetralyl en período de 3 y 5 días de cebado, warfarina en el período de 5 dias de cebado y brodifacoum en dos días de cebado. Esta dosificación resultó ser la más eficiente con una mortalidad de 100 por ciento. Coumatetralyl también resultó ser eficiente, provocando 100 por ciento de mortalidad a partir de tres días de cebado, clorafacinona, fue menos eficiente, ya que se logró un 100 por ciento de mortalidad sólo a partir del 5º día de cebado. Se observó alteraciones anatomopatológicas tales como: congestión pulmonar, cardíaca y hepática, esplenomegalia y hepatomegalia. La sangre se observó de color rojo oscuro y sin coagular
Assuntos
Animais , Ratos , Anticoagulantes/farmacologia , Controle de Roedores , Rodenticidas/farmacologia , Anticoagulantes , /estatística & dados numéricos , Formas de Dosagem , Rodenticidas , Rodenticidas/classificação , Varfarina/farmacologiaRESUMO
Single dose (1 mg/rat) administration of VACOR (N-3-pyridyl methyl-N'-nitrophenyl urea) produced significant paralytic symptoms in rats. Such rats which lived for one week were sacrificed and serum AChE was extracted and purified by Sephadex column chromatography. The serum enzyme from the normal rats showed the existence of two isozymes on polyacrylamide gels which could be resolved through column chromatography. Both the isozymes showed non-competitive inhibition with VACOR in vitro; but to a varied degree. The ACh concentration increased by 70-75% in serum and 95-100% in erythrocytes of the poisoned rats. VACOR thus affects ACh hydrolysis thereby causing an accumulation of ACh in the serum of poisoned rats.