RESUMO
Abstract The authors have successfully treated and monitored a case of paraneoplastic pemphigus in association with follicular dendritic cell sarcoma aggravated by hyaline-vascular Castleman's disease. The patient was a 56-year-old female who presented with recalcitrant erosive lichen planus of the oral cavity, tongue, and genital mucosa, along with polymorphous eruptions throughout her body. Histological examination of the cutaneous lesions, indirect immunofluorescence on rat bladder epithelium, and western blot of human keratinocyte proteins identified anti-epidermal antibodies in the patient's serum. Positron emission tomography and computed tomography scans found a mass in her retroperitoneal region. Pathology and immunohistochemistry investigation further corroborated the diagnosis of follicular dendritic cell sarcoma originated from hyaline-vascular Castleman's disease. Complete remission was achieved and the patient has been monitored for four years.
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Hiperplasia do Linfonodo Gigante/complicações , Hiperplasia do Linfonodo Gigante/patologia , Pênfigo/etiologia , Pênfigo/patologia , Sarcoma de Células Dendríticas Foliculares/etiologia , Sarcoma de Células Dendríticas Foliculares/patologia , Biópsia , Tomografia Computadorizada por Raios X , Western Blotting , Resultado do Tratamento , Técnica Indireta de Fluorescência para Anticorpo , Tomografia por Emissão de Pósitrons , Sarcoma de Células Dendríticas Foliculares/cirurgia , HialinaRESUMO
Castleman's disease is a condition which usually occurs in the mediasternum. Very few cases have been reported to present as a neck swelling. Castleman's disease is rarely associated with follicular dendritic sarcoma. We report a case of 65 years old male with painless and slowly progressive right neck swelling who was initially suspected to be schwannoma but proved to be a Castleman's disease with associated follicular dendritic sarcoma