RESUMO
Objectives To compare the effect of the consumption of buriti oil and soybean oil on the metabolism of rats under stress induced by iron overload.Materials and methods A total of 28 rats were randomized into control groups who consumed diet added of soybean (CS) or buriti oil (CB) and gavage with saline and two experimental groups who consumed diet added of soybean (ES) or buriti oil (EB) and daily gavage with iron II sulfate as stress inducer. The fatty acid profile of diets was analyzed. Body weight and diet consumption were evaluated every two days. The lipid profile and liver weight of animals were evaluated at the end of the experiment.Results Diet added of soybean oil showed higher percentage of polyunsaturated fatty acids (45.6%) and diet with buriti oil was rich in monounsaturated fatty acids (66.9%). There were no differences in food intake, total cholesterol, HDL-cholesterol and LDL-cholesterol among groups (p > 0.05). However, animals fed with diet supplemented with buriti oil showed intermediate triglyceride levels (CB: 65 mg/dL; EB: 68.7 mg/dL) compared to ES group (102.5 mg/dL). The liver of rats from the CS group had higher weight (2.06 ± 0.2 g) compared to the CB group (1.56 ± 0.1 g).Conclusion Buriti oil consumption was able to minimize some changes related to iron overload.
Assuntos
Animais , Masculino , Carotenoides/farmacologia , Sobrecarga de Ferro/metabolismo , Estresse Oxidativo/efeitos dos fármacos , Óleos de Plantas/farmacologia , Óleo de Soja/farmacologia , Peso Corporal/efeitos dos fármacos , Gorduras na Dieta/administração & dosagem , Gorduras na Dieta/análise , Ácidos Graxos Insaturados/análise , Ácidos Graxos/análise , Sobrecarga de Ferro/induzido quimicamente , Fígado/metabolismo , Modelos Animais , Distribuição Aleatória , Ratos Wistar , Triglicerídeos/sangue , Aumento de PesoRESUMO
To assess the knowledge and practice of thalassemic patients about desferal administration and complications of iron overload. The present study composed of [50] thalssemic patient who are registered in center and was performed in Ibn AI-Atheer center for congenital anemia for the period from 15/12/2006 to 1/4/2007. The result of the study showed highly significant difference at [P<0.05] for knowledge of thalassemic patients and also appear highly significant difference at [P<0.05] for practice of thalassemic patients. The study recommends that there is necessity to increase the knowledge and practice of thalassemic patient about desferal administration to minimize the complications of iron overload