Neuroglobina: nuevo miembro de la familia de las globinas / Neuroglobin: a novel member of the globin family

Durante mucho tiempo se asumió que la hemoglobina y la mioglobina eran las únicas globinas de los vertebrados. En el año 2000 se descubrió un tercer tipo de globina, que sobre la base de su ubicación preferencial en el sistema nervioso fue denominada neuroglobina. Aunque aún se desconoce su función específica, se han planteado varias hipótesis entre las que se destaca la que sugiere que puede destoxificar las especies reactivas del oxígeno y el nitrógeno. Otros estudios proponen que es parte de una cadena de transducción de señales que transmite el estado redox de la célula o que inhibe la apoptosis. Aunque algunas funciones son más probables que otras, aún no se ha establecido definitivamente cuál es la función fisiológica de la neuroglobina en los vertebrados. No obstante, no hay dudas de que esta globina tiene una función esencial, conservada y que es beneficiosa para las neuronas

For a long time, it was taken for granted that hemoglobin and mioglobin were the only vertebrate globins. In 2000, a third type of globins was discovered on the basis of its preferential location in the nervous system and it was called neuroglobin. Although its specific function is still unknown, a number of hypotheses has been put forward, mainly the one suggesting that it may detoxify the reactive oxygen species and the nitrogen. On the other hand, other studies state that neuroglobin is part of a signal transduction chain that transmits the redox state of the cell or inhibits apoptosis. Though some functions are more probable than others, the real physiological function of neuroglobin in vertebrae has not been finally established. Nevertheless, this globin has undoubtedly an essential preserved function that is useful for neurons

Effect of ingestion of glucose on fibrinolytic activity and prothrombin time in diabetic and non-diabetic persons.

Effect of ingestion of 50 g of glucose on euglobulin clot lysis time and prothrombin time was studied in 14 diabetic and 12 non-diabetic persons. There was no significant change in euglobulin clot lysis time and prothrombin time after ingestion of glucose in the non-diabetic group. In the diabetic group, ingestion of glucose resulted in significant increase in euglobulin clot lysis time at the end of one hr which returned to initial level at the end of two hours even though blood glucose level at two hrs was still higher than fasting level. Increase in clot lysis time has no correlation to the blood glucose level. There was no significant change in prothrombin time after glucose ingestion.