Antioxidant and cardio protective effect of palm oil leaves extract [standardized ethanolic fraction] in rats' model of saturated fats induced metabolic disorders

Recently, it is suggested to use POLE [palm oil leaf extract] as a nutraceutical health product in food industry due to its newly discovered content of polyphenols and antioxidant vitamins. In the experiment, the antioxidant and anti-lipid-peroxidation activities of the extract were confirmed using; DPPH [1-diphenyl-2-picryl-hydrazil] radical scavenging activity, ferric ion induced lipid peroxidation inhibition, reducing power and hydrogen peroxide scavenging activity assays. The cardio-protective activity was studied in vivo using a model of metabolic syndrome induced by high fat diet. Lipid profile, obesity indices, renal tubular handling of water and electrolytes, blood pressure and arterial stiffness were measured at the end of the treatment period. Sprague Dawley rats weighing 150-200 g were divided into six groups, viz; group C; was treated as a negative control and fed with standard rodents chow, group H; was treated as a positive control and fed with an experimental diet enriched with saturated free fatty acids for 8 weeks, groups HP0.5, HP1 and HP2 which were fed with 0.5,1 and 2 g/kg [body weight] /day of POLE orally during the last 24 days of the high fat diet feeding period and group P; fed with highest dose of POLE. Results revealed that POLE possesses a cardio-protective effect which is ascribed to its content of polyphenols.

Renal function in children with congenital neurogenic bladder

AIMS: Preservation of renal function in children with congenital neurogenic bladder is an important goal of treatment for the disease. This study analyzed the evolution of renal function in patients with congenital neurogenic bladder. METHODS: We reviewed the records of 58 pediatric patients with respect to the following attributes: gender, age, etiology of neurogenic bladder, reason for referral, medical/surgical management, episodes of treated urinary tract infections, urodynamics, DMSA scintigraphy, weight, height, blood pressure, glomerular filtration rate, microalbuminuria and metabolic acidosis. Statistical analysis was performed, adopting the 5 percent significance level. RESULTS: The mean age at presentation was 4.2 ± 3.5 years. Myelomeningocele was the most frequent etiology (71.4 percent). Recurrent urinary tract infection was the reason for referral in 82.8 percent of the patients. Recurrent urinary tract infections were diagnosed in 84.5 percent of the patients initially; 83.7 percent of those patients experienced improvement during follow-up. The initial mean glomerular filtration rate was 146.7 ± 70.1 mL/1.73 m²/min, and the final mean was 193.6 ± 93.6 mL/1.73 m²/min, p = 0.0004. Microalbuminuria was diagnosed in 54.1 percent of the patients initially and in 69 percent in the final evaluation. Metabolic acidosis was present in 19 percent of the patients initially and in 32.8 percent in the final assessment. CONCLUSIONS: Patient referral to a pediatric nephrologist was late. A reduction in the number of urinary tract infections was observed with adequate treatment, but microalbuminuria and metabolic acidosis occurred frequently despite adequate management.

Low-Intensity physical activity beneficially alters the ultrastructural renal morphology of spontaneously hypertensive rats

INTRODUCTION AND OBJECTIVE: Kidney disorders can cause essential hypertension, which can subsequently cause renal disease. High blood pressure is also common among those with chronic kidney disease; moreover, it is a well-known risk factor for a more rapid progression to kidney failure. Because hypertension and kidney function are closely linked, the present study aimed to observe the beneficial effects of low-intensity physical activity on structural and ultrastructural renal morphology and blood pressure in normotensive and spontaneously hypertensive rats. METHOD: Male Wistar-Kyoto rats and spontaneously hypertensive rats were randomly allocated into four groups: sedentary or exercised Wistar-Kyoto and sedentary or exercised spontaneously hypertensive rats. The exercise lasted 20 weeks and consisted of treadmill training for 1 hour/day, 5 days/week. RESULTS: The exercised, spontaneously hypertensive rats showed a significant blood pressure reduction of 26 percent. The body masses of the Wistar-Kyoto and spontaneously hypertensive strains were significantly different. There were improvements in some of the renal structures of the animals treated with physical activity: (i) the interdigitations of the proximal and distal convoluted tubules; (ii) the basal membrane of the proximal and distal convoluted tubules; and (iii) in the basal membrane, slit diaphragm and pedicels of the glomerular filtration barrier. The spontaneously hypertensive rats also showed a decreased expression of connexin-43. CONCLUSION: Physical exercise could be a therapeutic tool for improving kidney ultrastructure and, consequently, renal function in hypertensive individuals.

Indicators of renal glomerular and tubular functions in patients with beta-thalassaemia major

There are limited data concerning the assessment of renal function in beta-thalassaemia major, with no study of such involvement in Omani patients. The objective of this study was to establish the pattern of renal glomerular and tubular function using traditional and specific laboratory tests in patients with beta-thalassaemia major. This cross-sectional study, from January-July 2008, included 30 patients of the Thalassaemia Clinic at the Royal Hospital, Oman, with transfusion-dependent homozygous beta-thalassaemia major. They included 15 males and 15 females, aged 16-32 years with mean +/- standard deviation of 21.23 +/- 3.42 years. The medical records were reviewed and renal function states assessed as follows: serum creatinine, estimated glomerular filtration rate [eGFR]; urea; phosphate, fractional excretion of filtered sodium [FENa]; urine albumin: creatinine index; urine beta2-microglobulin:creatinine index; tubular reabsorption of phosphate [TRP], and tubular maximum phosphate reabsorption [TmP]/GFR. All patients had eGFR >90 ml/min/1.73m2; serum creatinine <90 micro mol/L; serum urea <6.0 mmol/L, and urine albumin: creatinine <2.5 mg/mmol. Only 2 [6.7%] patients had FENa >1% and 3 [10.0%] patients had urine s2-microglobulin: creatinine >22 micro g/mmol. All patients had TRP >0.85, of whom seven [23.3%] patients had values within the range of 0.85-0.95 and 23 [76.7%] had values >0.95. Also, all patients had TmP/GFR >1.0 mmol/L, of whom only one [3.3%] patient had TmP/GFR of 1.0-1.5, and 29 [96.7%] patients had TmP/GFR >1.5 mmol/L. Finally, 24 [80%] patients had serum phosphate >1.4 mmol/L. Linear regression revealed a highly significant correlation between serum phosphate and TmP/GFR [r = 0.904, P < 0.001]. Renal function, glomerular and tubular, appears to be well preserved in beta-thalassaemia major. Almost all renal function indicators were within the recommended ranges. Raised TmP/GFR and TRP were noted in the majority of patients, reflecting an up-trend in serum phosphate and therefore increasing renal phosphate reabsorption

Arthrogryposis, renal tubular dysfunction and cholestasis [ARC] syndrome: a case report

Arthrogryposis, renal tubular dysfunctions and chloestasis [ARC] syndrome is a rare multisystem, usually fatal, autosomal recessive disorder. Awareness of this syndrome is growing with more reported cases over the last three decades. Many previously reported cases with similar association are now labeled as ARC syndrome. Although the genetic mutation is recently recognized, the diagnosis still depends on the clinical findings. Our patient is the first case of ARC syndrome to be reported from Kuwait. To the best of our knowledge this is also the first report of an Egyptian family with two siblings of ARC syndrome

Renal tubular and glomerular function in children with iron deficiency anemia

Iron deficiency anemia [IDA] resulting from lack of sufficient iron for synthesis of hemoglobin is most common hematologic disease of infancy and childhood. There is little information about the renal function in iron deficiency anemia. The aim of the present study was to examine the renal function in children with iron deficiency anemia. This case-control study was performed in children with iron deficiency anemia [n=20] and healthy age matched subjects [n=20]. Blood and urine samples were obtained for hematological and biochemical investigation. Statistical analysis was performed by unpaired sample t-test and Pearson's correlation coefficient. Fractional excretion of sodium [FENa+] was significantly higher in children with iron deficiency anemia than control subjects [P=0.006]. There was no significant difference in the level of urine specific gravity, calcium/creatinine ratio, beta 2-microglobulin and creatinine clearance between case and control groups [P>0.05]. There was no correlation between FENa and Hb [r=0.13, P=0.57], FENa+ and Fe+2 [r=0.079, P=0.72], FENa+ and TIBC [r=-0.083, P=0.71], FENa+ and ferritin [r=0.039, P=0.86] as well as Hb and beta 2-microglobulin [r=0.02, P=0.37] in IDA patients. The results showed that FENa+ was higher in children with iron deficiency anemia than in normal subjects. The findings revealed evidence of tubular damage in IDA; this needs confirmation by more investigation

Renal function in late survivors of Iranian children with cancer: single centre experience.

CONTEXT: One of the side-effects of chemotherapy is nephrotoxicity, whose incidence rate has reportedly been higher in pediatrics. Early diagnosis of renal dysfunction may decrease the morbidity in those with partial or complete remission by avoiding nephrotoxic agents and promoting regular follow-up. AIMS: We studied the frequency of renal dysfunction in pediatric patients whose therapy was completed regardless of the type of chemotherapy. SETTINGS AND DESIGN: Prospective cross sectional study in Hematoncology department of children's hospital. MATERIALS AND METHODS:0 One hundred and eight pediatric cancer patients (44 females, 64 males), who were at least one year off therapy, enrolled in the study from 2003 to 2005. Demographic data, mean dosages of anticancer drugs, history of other nephrotoxic agents, nephrectomy, radiotherapy and acute renal failure were recorded. Fasting blood and urine samples were collected to calculate fractional excretion of magnesium, calcium, phosphate, urine protein to urine creatinine ratio, creatinine clearance (using Schwartz formula), urine analysis, urine osmolality and blood gas analysis. Statistical analysis used: T-test, Chi square and binary logistic regression were used to compare means, frequency and correlation respectively. P values RESULTS: Renal dysfunction was seen in 25.2% of cases. These abnormalities included hypercalciuria (7.2%), phosphaturia (13.5%), magnesuria (3.6%), glomerular filtration rate less than 90 ml/min (7.5%), metabolic acidosis (3%), metabolic alkalosis (10%), urinary concentration defect (19%), proteinuria (7.2%), glycosuria (2%), microscopic hematuria (4%), sterile pyuria (6%), and hypertension (8%). We found only Procarbazin as an independent variable of nephrotoxicity (P< 0.05). CONCLUSIONS: Mild to moderate tubular dysfunction has been observed in the survivors of cancer disease.

Increased urinary n-acetyl-beta-d-glucosaminidase activity in children with hydronephrosis

OBJECTIVE: Hydronephrosis leads to deterioration of renal function. As urinary N-acetyl-beta-D-glucosaminidase (U-NAG) activity is considered a sensitive marker of renal tubular impairment, our aim was to measure U-NAG in children with hydronephrosis and to look for a relationship among selected clinical parameters. MATERIALS AND METHODS: We studied 31 children (22 boys and 9 girls, mean age 2.3 ± 2.5 years) with hydronephrosis grade 1-4 that had U-NAG/creatinine ratio (U-NAG/Cr) measured. RESULTS: The U-NAG/Cr was significantly higher in patients with hydronephrosis compared to reference data (p = 0.002). There was no difference in U-NAG/Cr between children with unilateral and bilateral hydronephrosis (p = 0.51). There was no significant difference in U-NAG/Cr between children with grades 1-3 (pooled data) and grade 4, respectively (p = 0.89). There was no correlation between U-NAG/Cr and the grade of hydronephrosis (r = 0.01). CONCLUSIONS: U-NAG/Cr is increased in children with hydronephrosis grade 1-4, and there is no relationship with the grade of hydronephrosis. U-NAG is a useful marker of renal tubular dysfunction, however its relationship with the degree of kidney damage in patients with hydronephrosis should be considered as doubtful.

Effect of renal ischemia / reperfusion [I/R] injury on glomerular filtretion rate [GFR] and tubular functions

Renal ischemia reperfusion [I/R] injury is of great clinical interest because of its role in renal failure, renal graft rejection and potential future chronic renal complications. Ten mongrel dogs were the material of the present study. Animals were subjected to renal ischemia by clamping the left renal artery for 30 minutes. After releasing the artery clamp six clearance periods [10 min each] were allowed to determine in each period glomerular filtration rate [GFR] by determining the inulin clearance [C[IN]], urinary flow rate [v], urinary excretion rate [UE] for Na[+], K[+], Cl[-],% Fractional excretion of sodium [%FE[Na]+], for both the ischemic left kidney and contralateral control kidney. The ischemic / control ratio [I/C] was determined for all the above parameters determined. v, UE[K+] decreased during the first collection period after reperfusion [10 min]. v increase markedly after that. GFR [C[IN]] and UE[K+] decreased also during the remaining 5 collection periods [50 min]. UE[Na+], UE[CI-] and FE[Na]% increased dramatically allover the collection periods [60 min]. The mechanisms of these changes were discussed. Gradual renal reperfusion and pre and post administration of antioxidants and anti-inflammatory drugs are recommended to ameliorate the deleterious affects ofl/R on the structure and function of the kidney

Determination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levels

Significant improvements have been noted in heart transplantation with the advent of cyclosporine. However, cyclosporine use is associated with significant side effects, such as chronic renal failure. We were interested in evaluating the incidence of long-term renal dysfunction in heart transplant recipients. Fifty-three heart transplant recipients were enrolled in the study. Forty-three patients completed the entire evaluation and follow-up. Glomerular (serum creatinine, creatinine clearance measured, and creatinine clearance calculated) and tubular functions (urinary retinol-binding protein, uRBP) were re-analyzed after 18 months. At the enrollment time, the prevalence of renal failure ranged from 37.7 to 54 percent according to criteria used to define it (serum creatinine > or = 1.5 mg/dL and creatinine clearance <60 mL/min). Mean serum creatinine was 1.61 ± 1.31 mg/dL (range 0.7 to 9.8 mg/dL) and calculated and measured creatinine clearances were 67.7 ± 25.9 and 61.18 ± 25.04 mL min-1 (1.73 m²)-1, respectively. Sixteen of the 43 patients who completed the follow-up (37.2 percent) had tubular dysfunction detected by increased levels of uRBP (median 1.06, 0.412-6.396 mg/dL). Eleven of the 16 patients (68.7 percent) with elevated uRBP had poorer renal function after 18 months of follow-up, compared with only eight of the 27 patients (29.6 percent) with normal uRBP (RR = 3.47, P = 0.0095). Interestingly, cyclosporine trough levels were not different between patients with or without tubular and glomerular dysfunction. Renal function impairment is common after heart transplantation. Tubular dysfunction, assessed by uRBP, correlates with a worsening of glomerular filtration and can be a useful tool for early detection of renal dysfunction.

Estudio de la función renal en el niño con síndrome de inmunodeficiencia adquirida: Ciudad Hospitalaria "Dr. Enrique Tejera" Universidad de Carabobo: agosto-octubre 2002 Valencia-Venezuela / Study of renal function in children with acquired immunodeficiency syndrome: City Hospital

De los 42 pacientes en tratamiento con VIH/SIDA de la consulta de infectología pediátrica de la Ciudad Hospitalaria "Dr. Enrique Tejera" en octubre 2002; se estudiaron 26 durante el lapso de agosto-octubre (57,7 por ciento del sexo femenino y 42,3 por ciento masculino); comparándose con un grupo control de 24 niños no VIH. 25 de los pacientes en estudio adquirieron la enfermedad de forma vertical y uno por transfusión sanguínea (3,85 por ciento). 80,8 por ciento tenían ocho años o menos de edad. 26,9 por ciento correspondieron al estadio A1 (todos con 8 años o menos de edad), con igual porcentaje en el estadio C3 (42,8 por ciento con nueve años de edad o más). Se realizaron pruebas de funcionalismo tubulo-intersticial renal y de la función glomerular, encontrando en 61,5 por ciento hiperuricosuria e hipercalciuria; mientras que en el 33,3 por ciento del grupo control se diagnóstico hiperuricosuria e hipocloruria. La relación ácido úrico/creatinina y calcio/creatinina urinaria en ausencia de enfermedad renal diagnosticada mediante ecografía, resultaron con un valor medio y superior, con una diferencia significativa (p<0,001), con respecto al grupo control; no así, la excreción de potasio y cloruro urinario. No se detectó deterioro de la función glomerular a través de la fórmula de Schwartz, proteinuria con rango nefrótico, ni alteración en los valores de la creatinina sérica; tampoco, relación entre los indicadores de tubulopatía, estadio clínico-inmunológico, tiempo y esquema de tratamiento antirretroviral recibido (P>0,05). Los pacientes con menor cuenta de linfocitos CD4+ fueron los más propensos a presentar coinfecciones, sin relación significativa (P>0,05) con las tubulopatías. Los niños con infección por el VIH tienen alto riesgo de desarrollar alteración de las pruebas de funcionalismo tubular renal en cualquier momento de la enfermedad, pudiendo tener relación con factores genéricos, ambientales, tratamiento antirretroviral.

Approach to renal tubular disorders.

The renal tubule plays an important role in fluid and electrolyte homeostasis. Renal tubular disorders may affect multiple ( e.g., Fanconi syndrome) or specific (e.g., nephrogenic diabetes insipidus, renal glucosuria) tubular functions. Most conditions are primary and monogenic but occasionally are secondary to other disorders (focal segmental glomerulosclerosis, cystinosis, Lowe syndrome). Tubular dysfunction should be considered in all children with failure to thrive, polyuria, refractory rickets, hypokalemia and metabolic acidosis. Careful clinical and laboratory evaluation is essential for appropriate diagnosis and specific management of these conditions.

[Kidney in aging: anatomic and functional changes and therapeutic implications]

After the age of 40 years, the kidney undergoes anatomic modifications which are responsible, on one hand in the progressive diminution of glomerular filtration function observed by the decreases in 10% of renal plasma flow by decade, 0,75 ml/mn of glomerular filtration rate by year, and on other hand, by the same parallel reduction of tubular function marked by the decreases in secretary and reabsorption tubular maximum capacity and concentrating and diluting ability of urine. However, some observations have suggested that the decline in renal function with aging are sometimes the result of prerenal, renal, and postrenal pathologies. Nevertheless, these anatomic and functional renal modifications must be involved to adapt the dose and to take precautions in association of eliminated renal medicaments which are used for treatment of various diseases such as arterial hypertension in the aging people

Efecto de diferentes grados de actividad física en la presentación de cambios anatómicos e histológicos relacionados con el envejecimiento renal / Effect of different levels of physical activity upon anatomical and histologic changes related to renal aging

Objetivos: determinar los cambios anatómicos del ejercicio en el envejecimiento renal. Metodología: estudio longitudinal experimental durante 54 semanas. Se tomaron 120 ratones machos cepa Suizo, los cuales según su actividad se dividieron en 3 grupos: sedentarios, normales y activos. El ejercicio se moduló con el espacio habitacional y el acceso al alimento. Se sacrificaron 3 animales por grupo desde la 9ª semana de edad cada 9 semanas. Se consideraron animales jóvenes aquellos menores de 27 semanas y viejos los mayores de 36. Los ratones y sus riñones se pesaron, y se estableción la relación peso riñones/peso ratón. Del riñón izquierdo de cada animal se midió la corteza y se realizó el estudio histológico con las coloraciones clásicas. Los cortes fueron analizados por 2 patólogos que no conocían el propósito del estudio; describieron cambios glomerulares y túbulo intersticiales, los cuales se clasificaron de nulos a severos. Se midieron áreas glomerulares y la relación luz/pared arterial. Resultados: El máximo crecimiento renal se observó a las 18 semanas. En la semana 54, los sedentarios tuvieron menor espesor cortical (2288,65 ± 552,75) que los normales (2502,7 ± 163,81) y los activos (2609,46 ± 273,28), con n=3 para todos los grupos. El área glomerular fue significativamente menor (P= 0,035) en sedentarios (8657,33 ± 1954,38), comparativamente con los activos (10318,64 ± 2425,14), pero entre los normales (9791,52 ± 2211,63) y los otros dos grupos no existieron diferencias significativas: n=18 para cada grupo. La atrofia tubular en animales viejos fue del 55,5 por ciento en los sedentarios, mayor que en normales y activos, en los cuales fue del 44,4 por ciento no significativo. La nefritis intersticial fue menor en normales (55,5 por ciento), en comparación con los sedentarios y activos (77,7 por ciento) no significativo. Conclusión: el grupo sedentario presentó mayor compromiso estructural en el envejecimiento renal. Aunque el ejercicio moderado puede li...

Evaluación de función tubular renal. Valor de estudio simplificado / Evaluation of the renal tubular function. Value of the simplified study

El compromiso túbulointersticial en las nefropatías es uno de los mecanismos responsables de la progresión a la insuficiencia renal extrema. Las pruebas funcionales renales pueden ser un instrumento útil para el diagnóstico y el seguimiento de este compromiso tubulointersticial. Los objetivos de este trabajo son evaluar un conjunto simplificado de pruebas de función tubular en el estudio de nefropatías tubulointersticiales y en glomerulopatías. Se estudiaron 75 pacientes, 38 con diagnóstico probable de nefropatía tubulointeristicial y 37 glomerulopatías. Se evaluó presencia de diskalemia, glucosurina, alteración de equilibrio ácido base y capacidad de concentración urinaria. La disfunción tubular fue frecuente en los pacientes con glomerulopatías (0,65) aún en aquellos pacientes con creatininemia menor 1.4 mg por ciento (0,45). Mediante estas pruebas es posible topografiar el sector nefronal comprometido

Investigation of relationship between idiopathic hypercalciuria and urinary enzyme activities.

In patients with uncomplicated idiopathic hypercalciuria renal function is normal except for increased renal calcium excretion. In this study, the level of fractional urinary enzyme excretion was assessed in relation to calciuria. Fourteen patients with a mean age of 5.8 +/- 0.8 years who had daily urinary calcium excretion more than 4 mg/kg and with otherwise normal renal function tests were included in the study. None of the patients manifested either renal calculus or nephrocalcinosis. Fourteen normal children with a mean age of 5.4 +/- 0.74 were included in the control group. The level of the urinary N-acetyl beta-D glucosaminidase (NAG) to creatinine ratio, fractional aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) excretion were not significantly different compared to the control group (p > 0.05). The patients were subdivided according to the type of hypercalciuria. The levels of NAG/creatinine ratio, fractional ALT, AST, ALP, LDH excretion were not significantly different in the absorptive type of calciuria group compared to the control group (p > 0.05). In conclusion, hypercalciuria during childhood which is 6.46 +/- 1.83 mg/kg/day is not related to the levels of NAG/creatinine ratio, fractional ALT, AST, ALP and LDH excretion in urine.

Renal dysfunction detected by beta-2 microglobulinuria in sick neonates.

OBJECTIVE: To assess renal involvement in sick neonates referred to Neonatal Intensive Care Unit (NICU) using standard renal parameters and urinary beta 2 microglobulin (B2M) excretion. DESIGN: Descriptive study. SETTING: Level II NICU and Nephrology Division of Pediatric Tertiary hospital. SUBJECTS: Forty six term sick neonates transferred for neonatal care and forty healthy term neonates who served as normal controls for urinary B2M excretion. METHODS: Standard tests including estimation of BUN, serum creatinine, blood pH, serum bicarbonate, serum and urinary electrolytes, urine output, and urinalysis. Urinary B2M levels were estimated from urine collected on day 1 (D1) and day 3 (D3) in all and 18 neonates were tested on day 7 (D7) by radio-immunoassay method. RESULTS: Statistically significant elevation of mean values of urinary B2M were noted when sick neonates were compared with normal controls irrespective of primary disease, indicating tubular dysfunction (41/46 = 90%), whilst only 7 of these (17%) had abnormalities indicating renal involvement when judged by standard tests. Very high levels of urinary B2M were noted with birth asphyxia (n = 9), sepsis (n = 8) and renal disease (n = 7). Transient elevation of urinary B2M was noted in meconium aspiration syndrome (n = 4). Ten surgical cases with non renal congenital malformations showed high urinary B2M and 12/18 tested on D7 had persistently high urinary B2M due to multiple factors. CONCLUSIONS: Elevated urinary B2M in 90% sick neonates with apparently normal renal parameters in majority (34/41) indicates subclinical proximal tubular dysfunction especially in neonates with asphyxia, sepsis and congenital malformations. Persistent elevation of urinary B2M appear to be a sensitive diagnostic indicator for defining a group of neonates with subtle renal tubular dysfunction, the clinical relevance of which on long term basis is a subject for future study.

Función renal en el infarto agudo del miocardio / Renal function in acute myocardial infarction

Introducción. El infarto agudo del miocardio frecuentemente se asocia a disfunción renal. Objetivo. Reportar las alteraciones de la función renal en pacientes con infarto agudo del miocardio. Pacientes y métodos. Estudiamos prospectivamente 25 pacientes que ingresaron a una unidad de cuidados coronarios/unidad de cuidados intensivos (UCC/UCI) con infarto agudo del miocardio no complicado. Se hizo seguimiento de la función renal a las 24 y 72 horas de evolución a través de la evaluacion de las fuciones glomerular y tubular. Resultados. La diuresis disminuyó significativamente después de 72 horas; la función glomerular no cambió a las 24 horas pero se deterioró 72 horas más tarde; la función tubular se alteró durante las primeras horas y se normalizó al final del estudio; solo un paciente se complicó con isuficiencia renal aguda. Conclusión. La función renal se alteró transitoriamente durante las primeras 72 horas de evolución del infarto agudo del miocardio. La insuficiencia renal es poco frecuente