Synthesis of novel pyrazol, pyrazolylthiadiazole and pyrazolylth iadiazolin derivatives as potential anti-inflammatory agents

Variety of 3-p-cholrophenyl-5-[3-p-chlorophenyl-1-phenyl-1H-pyrazol-4-yl]-1-phenyl and p-substituted phenyl-1H-pyrazoles [IIIa-d], 5-amino and substituted amino-2-[3-p-chlorophenyl-1-phenyl-1h-pyrazol-4-yl]-1, 3, 4-thiadiazoles [Va-d] and 3-acetyl-5-acetamido and N-substituted acetamido-2-[3-p-chlorophenyl-1-phenyl-1H-pyrazol-4-yl]-2, 3-dihydro-1, 3, 4-thiadiazoles [VIa-d] were synthesized as examples of bi-heterocyclic systems having the pyrazole, thiadiazole or thiadiazoline rings surmounted on a pyrazole moiety at the 4-posiition. The IR and PMR spectra of the products are discussed. The local anti-inflammatory activity of some selected new bi-hetereocyclic compounds was evaluated