RESUMO
Ethanol produces alterations in muscular contraction and neuromuscular function both in vitro and in vivo in mammalian and amphibian tissues in dose dependent manner. It is not very well known whether gallamine, a commonly used muscle relaxant produces any interaction with ethanol. Hence in the present study, interactions of ethanol with gallamine are undertaken using rabbit head drop method. The latency time to produce head drop by gallamine in the absence and presence of ethanol (dose which produce ataxia) was insignificantly different (P > 0.05). It may be due to fact that ataxic dose may not be affecting neuromuscular transmission a significant manner. It, therefore, does not warrant to adjust the dose of gallamine in alcoholic persons.
Assuntos
Animais , Interações Medicamentosas , Etanol/farmacologia , Feminino , Trietiodeto de Galamina/farmacologia , Masculino , Fármacos Neuromusculares não Despolarizantes/farmacologia , CoelhosRESUMO
O autor faz uma revisäo das açöes farmacológicas dos relaxantes neuromusculares sobre o sistema cardiovascular. Os mecanismos básicos pelos quais os relaxantes neuromusculares induzem efeitos cardiovasculares säo sumarizados. Entre estes incluem a liberaçäo de histamina, bloqueio ganglionar, bloqueio dos receptores muscarínicos no sistema cardiovascular e a recaptaçäo das catecolaminas a nível neural. Consideraçöes sobre os mais recentes agentes, atracúrio e vecurônio, säo feitas, especialmente quanto aos seus efeitos hemodinâmicos
Assuntos
Atracúrio/farmacologia , Sistema Cardiovascular/efeitos dos fármacos , Bloqueadores Neuromusculares/farmacologia , Brometo de Vecurônio/farmacologia , Aminopiridinas/farmacologia , Edrofônio/farmacologia , Trietiodeto de Galamina/farmacologia , Neostigmina/farmacologia , Pancurônio/farmacologia , Brometo de Piridostigmina/farmacologia , Succinilcolina/farmacologia , Tubocurarina/farmacologiaRESUMO
Forty-five adult patients underwent a noninhalational anaesthetic method for investigation of awareness during surgery and recall of events associated with surgery in postoperative period. All the patients were divided into two groups. The first group of patients were male and had upper abdominal operations. The second group were female and had lower abdominal operations. No significant difference was found between these two groups either in requirements of depth of anaesthesia or in the evidence of per-operative awakefulness. Eighty percent patients of both the groups showed various signs of peroperative awakefulness but did not recall any events associated with surgery in the postoperative period. There was no report of dream either.
Assuntos
Adulto , Anestesia Intravenosa/métodos , Anestésicos/farmacologia , Conscientização/efeitos dos fármacos , Cognição/efeitos dos fármacos , Feminino , Trietiodeto de Galamina/farmacologia , Humanos , Masculino , Rememoração Mental/efeitos dos fármacos , Meperidina/farmacologiaRESUMO
Gallamine triethiodide pancuronium bromide or d-tubocurarine was infused intravenously at different rates in urethane anaesthetized rats. When given in neuromuscular blocking doses gallamine triethiodide produced significant hypotension if the rate of infusion exceeded 2 mg/min whereas neither pancuronium bromide nor d-tubocurarine produced a marked change in blood pressure in neuromuscular blocking doses.