Clinicopathological prognostic factors of adult granulosa cell tumor of the ovary--a study of 37 cases.

Adult granulosa cell tumor (GCT) of the ovary is the most common malignancy amongst the sex cord stromal tumors. Clinical stage, age, tumor size, residual disease and several histologic factors have been reported to be of prognostic significance. There were 839 ovarian malignancies at our institute during the period from 1998 to 2002. Out of 54 granulosa cell tumors, 40 cases were evaluable which includes 37 cases of adult GCT and 3 cases of juvenile GCT. They were studied retrospectively. Majority of patients presented with abdominal symptoms and FIGO stage I. All patients were treated surgically and 62.1% of adult GCTs were given post-operative chemotherapy. Clinical stage, presence of residual disease and tumor volume were the most important prognostic factors. Age of patient, menstrual status, post-operative chemotherapy, mitosis or histological patterns were of little significance in our study.

Granulosa cell tumor of the ovary.

From January 1984 to December 1994, 36 women with granulosa cell tumors of the ovary were treated at Maharaj Nakorn Chiang Mai Hospital, which accounted for 5.8 per cent of all 620 ovarian malignancies treated at this institute. Twenty patients were in stage I, 2 in stage II, 11 in stage III and the remaining 3 cases were in stage IV. Most patients had unilateral ovarian involvement while 6 (16.7%) had bilateral involvement. The diameter of the tumor ranged from 4 to 30 cm with the median of 14 cm. Treatment consisted of hysterectomy and bilateral salpingo-oophorectomy followed by chemotherapy in most cases. To date 10 patients have no evidence of disease while 9 died of the disease, others were lost to follow-up. The 5-year survival was 94 per cent in the early stages compared to 25 per cent in advanced stages. The overall survival rate was 62.7 per cent for all stages.