1.
Indian J Exp Biol
;
2000 Jan; 38(1): 31-5
Artigo
em Inglês
| IMSEAR
| ID: sea-58617
RESUMO
Carbohydrates are the integral parts of glyco-conjugates and play an important role in cellular functions. 2-Deoxy-D-glucose (2-dGlc) is a sugar analogue of glucose and mannose and is reported to inhibit the lipid-linked saccharide formation involved in N-linked glycosylation of proteins. Administration of 2-dGlc (1 mg/100 g body weight) produced a decrease in the tissue total glycosaminoglycans level. We found that the activity of the enzymes involved in the biosynthesis of precursors of glycosaminoglycans (GAG) decreased, but that of the degrading enzymes increased. Thus, the decreased levels of GAG in tissues in 2-dGlc-administered rats occurs via enhanced degradation as well as decreased synthesis.
Assuntos
Animais , Arteriosclerose/etiologia , Arilsulfatases/metabolismo , Catepsina D/metabolismo , Desoxiglucose/farmacologia , Dieta Aterogênica , Glucuronidase/metabolismo , Glutamina-Frutose-6-Fosfato Transaminase (Isomerizante)/metabolismo , Glicosaminoglicanos/metabolismo , Glicosilação/efeitos dos fármacos , Hialuronoglucosaminidase/metabolismo , Hipercolesterolemia/complicações , Masculino , Especificidade de Órgãos , Precursores de Proteínas/metabolismo , Processamento de Proteína Pós-Traducional/efeitos dos fármacos , Ratos , Ratos Sprague-Dawley , Uridina Difosfato Glucose Desidrogenase/metabolismo , beta-N-Acetil-Hexosaminidases/metabolismo
2.
Indian J Biochem Biophys
;
1980 Oct; 17(5): 385-7
Artigo
em Inglês
| IMSEAR
| ID: sea-27855