Does height catch-up in schoolchildren have an effect on bone mass in adolescents? Analysis in a Brazilian birth cohort / Catch-up de estatura em escolares tem efeito sobre massa óssea em adolescentes? Análise em uma coorte brasileira de nascimento

Abstract Objective: To analyze the effect of height catch-up at school age on the bone mass of adolescents of a Brazilian birth cohort. Methods: A cohort study using data obtained from the three moments (birth, 7/9 years and 18/19 years of age) of the Cohorts-RPS study. Height catch-up was defined based on the difference between the schoolchild's z-score and birth z-score. The adolescents' bone mineral mass was analyzed using the z-score index for the lumbar spine measured by dual emission X-ray absorptiometry. A theoretical model was developed for the proposed analysis using directed acyclic graphs paired through the nearest-neighbor matching propensity score using the STATA software, version 14.0. The level of significance was set at 5%. Results: Of the 297 studied children, 24.5% achieved height catch-up. The bone mass below the expected for age was observed in 5.39% of the subjects. The mean lumbar spine z-score was −0.34 (±1.01). After the adjustment, no effect was observed between height catch-up at school age and bone mass in adolescents (Coeff = 0.598; 95% CI −0.117 to 1.313; p = 0.101). Conclusion: Even using the directed acyclic graphs and the causal inference method by adjusting the propensity score, the height catch-up did not seem to affect bone mass in adolescents, a result perhaps related to the sample size.

Resumo: Objetivo: Analisar o efeito do catch-up de estatura na idade escolar na massa óssea em adolescentes em uma coorte brasileira de nascimento. Métodos: Estudo de coorte, utilizando dados dos três momentos (nascimento, aos 7/9 anos e 18/19 anos) da pesquisa Coortes-RPS. Catch-up de estatura foi definida a partir da diferença entre o Z-score do escolar e Z-score do nascimento. Para a análise da massa óssea em adolescentes foi utilizado o índice Z-score da coluna lombar medido pela densitometria por dupla emissão de raio X. Para análise proposta, foi construído modelo teórico usando os gráficos acíclicos direcionados e pareado por escore de propensão do tipo vizinho mais próximo utilizando o software STATA versão 14.0. O nível de significância adotado foi de 5%. Resultados: Das 297 crianças, 24,58% realizaram o catch-up estatural. Massa óssea abaixo do esperado para a idade foi de 5,39%. O Z-score médio da coluna lombar foi −0,34 (± 1,01). Após ajuste, não foi observado efeito entre catch-up de estatura na idade escolar e massa óssea no adolescente (Coef = 0,598; IC 95% −0,117-1,313; p = 0,101). Conclusão: Mesmo com os gráficos acíclicos direcionados e o método de inferência causal por ajuste do escore de propensão, o catch-up de estatura parece não afetar a massa óssea em adolescentes, resultado talvez relacionado ao tamanho da amostra.

Lean mass as a determinant of bone mineral density of proximal femur in postmenopausal women

ABSTRACT Objective: To verify which component of body composition (BC) has greater influence on postmenopausal women bone mineral density (BMD). Subjects and methods: Four hundred and thirty women undergoing treatment for osteoporosis and 513 untreated women, except for calcium and vitamin D. Multiple linear regression analysis was performed in order to correlated BMD at lumbar spine (LS), total femur (FT), femoral neck (FN) with body mass (BM), total lean mass (LM) and total fat mass (FM), all determined by DXA. Results: BM significantly correlated with all bone sites in untreated and treated women (r = 0.420 vs 0.277 at LS; r = 0.490 vs 0.418 at FN, r = 0.496 vs 0.414 at FT, respectively). In untreated women, the LM correlated better than FM with all sites, explaining 179% of LS; 32.3% of FN and 30.2% of FT; whereas FM explained 13.2% of LS; 277% of FN, 23.4% of FT In treated women, correlations with BC were less relevant, with the LM explaining 6.7% of BMD at LS; 15.2% of FN, 16% of FT, whereas the FM explained 8.1% of LS; 179% of FN and 176% of FT. Conclusion: LM in untreated women was better predictor of BMD than FM, especialy for distal femur, where it explained more than 30% of the BMD, suggesting that maintaining a healthy muscle mass may contribute to decrease osteoporosis risk. Treatment with anti-osteoporotic drugs seems to mask these relationships. Arch Endocrinol Metab. 2018;62(4):431-7

Is there correlation between alveolar and systemic bone density?

OBJECTIVE: The present study assessed the correlation between maxillomandibular alveolar bone density and systemic bone mineral density (BMD). METHODS: Dual-energy X-ray absorptiometry of the anterior and posterior maxillomandibular alveolar bone, of the standard sites for the measurement of BMD (lumbar spine and femur) and the third cervical vertebra was performed on 23 middle-aged women. Periapical radiographs were also obtained, with an aluminum step-wedge as reference for the digital reading of apical bone density of the upper incisors. RESULTS: Spearman's correlations coefficients revealed that density in the apical region was correlated with that of the femoral neck (r = 0.433; p < 0.05); BMDs of the posterior regions of the mandible and maxilla were significantly correlated with that of the cervical vertebra (r = 0.554, p < 0.01 and r = 0.423, p < 0.05, respectively); and the anterior maxilla was correlated with the posterior mandible (r = 0.488, p < 0.05). CONCLUSION: Bone density of the maxillary alveolar bone was significantly correlated with that of the femoral neck. Among the bone densities of the alveolar regions, only the anterior maxilla and the posterior mandible were significantly correlated. The findings suggested that bone densitometry might be individually and locally evaluated.

OBJETIVO: avaliar a correlação entre a densidade óssea alveolar maxilomandibular e a densidade mineral óssea sistêmica. MÉTODOS: a absorciometria duoenergética por raios X do osso alveolar maxilomandibular (região anterior e posterior), dos sítios sistêmicos padrões (coluna lombar e fêmur) e da terceira vértebra cervical foi realizada em 23 mulheres de meia idade. Radiografias periapicais dos incisivos superiores também foram obtidas com uma escala de alumínio como referência para a leitura digital da densidade óssea da região apical. RESULTADOS: o teste de correlação de Spearman revelou que a densidade da região apical foi correlacionada com a do colo femoral (r = 0,433; p < 0,05), a densidade óssea da região posterior mandibular e maxilar foram significativamente correlacionadas com a DMO da vértebra cervical (r = 0,554, p < 0,01; e r = 0,423, p < 0,05) e a da região maxilar anterior foi correlacionada com a mandibular posterior (r = 0,488, p < 0,05). CONCLUSÃO: a densidade óssea alveolar maxilar foi significativamente correlacionada com a do colo femoral. Entre as densidades ósseas das regiões alveolares, somente a anterior maxilar (AMx) e posterior mandibular (PMd) foram significativamente correlacionadas. Esse achado sugere que a densitometria óssea deveria ser individual e localmente avaliada.

Evolución de la morfología del raquis e inclinación pélvica en ciclistas de diferentes edades: un estudio transversal / Evolution of spinal morphology and pelvic tilt in cyclists of different ages. A cross sectional study

El objetivo principal del estudio fue determinar la morfología del raquis e inclinación pélvica en bipedestación en tres grupos de ciclistas de distintas edades, con un volumen de entrenamiento y experiencia similares. Un total de 65 ciclistas fueron divididos en tres grupos de edad: grupo 1 ( 30 años; n = 20); grupo 2 (entre 31 y 40 años; n = 25); y grupo 3 ( 41 años; n = 20). Posteriormente se les evaluó la morfología sagital del raquis torácico, lumbar e inclinación pélvica en bipedestación, mediante el sistema Spinal Mouse. Los valores angulares medios para el raquis torácico, lumbar e inclinación pélvica para el grupo 1 fueron: 46,60 +/- 10,09; - 26,40 +/- 7,17; 13,20 +/- 4,94; para el grupo 2: 47,64 +/- 8,58; -26,92 +/- 6,34; 12,24 +/- 4,45; y para el grupo 3: 50,75 +/- 12,77; -20,70 +/- 10,10 y 8,15 +/- 8,21. Se encontraron diferencias significativas en el raquis lumbar e inclinación pélvica en los grupos 1 y 2, con respecto al 3. En conclusión, la edad es un factor que condiciona la morfología del raquis e inclinación pélvica en ciclistas que presentan los mismos años de práctica y volumen de entrenamiento en ciclismo.

The aim of this study was to evaluate the sagittal spinal morphology and pelvic tilt in standing in three different age-group cyclists who had the same cycling experience and training volume. A total of 65 cyclists were divided in three age-groups: group 1: ( 30 years old; n = 20); group 2 (between 31 y 40 years old; n = 25); and group 3 ( 41 years old; n = 20). The Spinal Mouse was used to measure sagittal thoracic and lumbar spine and pelvic tilt in standing on the floor. The mean values for thoracic and lumbar spine and pelvic tilt were: group 1, 46.60 +/- 10.09; - 26.40 +/- 7.17; 13.20 +/- 4.94; group 2, 47.64 +/- 8.58; -26.92 +/- 6.34; 12.24 +/- 4.45; and group 3, 50.75 +/- 12.77; -20.70 +/- 10.10 y 8.15 +/- 8.21, respectively. Significant differences were found for the lumbar spine and pelvic tilt in the groups 1 and 2 with respect to group 3. In conclusion, aging is a conditional factor to the sagittal spinal morphology and pelvic tilt in cyclists who present the same years of experience and training volume in cycling.

A Decline in Renal Function is Associated With Loss of Bone Mass in Korean Postmenopausal Women With Mild Renal Dysfunction

This study was conducted to assess the relationship between estimated glomerular filtration rate (eGFR) and bone mineral density (BMD) in Korean postmenopausal women with mild renal dysfunction. A total of 328 postmenopausal women who underwent BMD measurement during health check-up was investigated. BMD was measured in lumbar spine (L1-L4), femoral neck, total proximal femur and femoral trochanteric areas by dual energy radiography absorptiometry and renal function was estimated by eGFR using Cockcroft-Gault equation. Of the 328 subjects, 317 (96.6%) had an eGFR > or =60 mL/min/1.73 m2. By using simple linear regression analysis, age, height, weight and eGFR were significantly associated with BMD for the 4 aforementioned anatomic sites, while serum levels of creatinine and blood urea nitrogen did not influence BMD. When multiple regression analyses were applied, age and body weight still had significant associations with BMD at 4 different anatomic sites (P < 0.001). A significant association of eGFR with BMD remained in the lumbar spine, femoral neck and proximal total femur (P < 0.05) but not in the trochanteric area (P = 0.300). Our study suggests that a decline of renal function is associated with lower BMD in the lumbar spine, femoral neck and total proximal femur areas in Korean menopausal women with mild renal dysfunction.

Effects of pilates training on lumbo-pelvic stability on flexibility

This study was performed to assess and compare the effects of Pilates exercise on flexibility and lumbo-pelvic movement control between the Pilates training and control groups. A randomized single-blinded controlled design was utilized in the study. Forty healthy male and female volunteers [mean age 31.65 +/- 6.21 years] were randomly divided into Pilates-based training [20 subjects] and the control groups [20 subjects]. The Pilates group attended 45-minutes training sessions, 2 times per week, for a period of 8 weeks. Flexibility and lumbo-pelvic stability tests were determined as outcome measures using a standard "sit and reach test" and "pressure biofeedback" respectively at 0,4 and 8 weeks of the study. The results showed that the Pilates training group improved flexibility significantly [P<0.001] during time intervals. This effect was also significantly greater than the control group for both 4 weeks and 8 weeks of the training period [P<0.001]. There were 65% and 85% of the subjects from Pilates group passing the lumbo-pelvic stability test at 4 and 8 weeks of training periods respectively. No subjects from the control group passed the test at any stages. Pilates can be used as an adjunctive exercise program to improve flexibility, enhance control-mobility of trunk and pelvic segments. It may also prevent and attenuate the predisposition to axial musculoskeletal injury

Reference values for areal bone mineral density among a healthy Mexican population / Valores de referencia para la densidad mineral ósea expresada en área para una población mexicana sana

OBJECTIVE: Compare the influence of ethnicity in the prevalence of osteopenia and osteoporosis in various Mexican populations using two normal dual X-ray absorptiometry (DXA) reference databases: manufacturer's incorporating US Hispanic population and a normal mestizo Mexican population. MATERIAL AND METHODS: MMP included 9 946 subjects participating in an ongoing long-term cohort study focusing on lifestyle and chronic diseases, of which 6 487 MMP males and females aged 7 to 80 years were the normal subjects used to determine bone density T- and Z-scores, following WHO criteria, and peak bone mass values. Abnormal bone mass density values estimated by the manufacturer's and peak bone mass reference values were compared. RESULTS AND CONCLUSIONS: Our results show that by using the manufacturer's T-score values in the mestizo Mexican population we are underestimating the number of abnormal bone mass BMD populations.

OBJETIVO: Comparar la influencia de la etnicidad en la prevalencia de osteopenia y osteoporosis en varias poblaciones mexicanas utilizando dos bases de referencia normal de densitometría de rayos X (DXA): referencia del fabricante que incorpora hispanos en Estados Unidos y datos de una población mestiza mexicana. MATERIAL Y MÉTODOS: Un total de 9 946 sujetos de población mestiza mexicana participantes en una cohorte de largo plazo dirigida al estudio de estilos de vida y ocurrencia de enfermedades crónicas; de los cuales 6 487 sujetos sanos de ambos sexos, con edad entre los 7 y los 80 años, fueron utilizados para determinar los valores T, Z, de acuerdo a los criterios de la OMS, así como a los valores de masa ósea pico. Se compararon los casos de densidad mineral ósea anormal de acuerdo a los valores de referencia del fabricante y los valores de masa ósea pico de la población mestiza. RESULTADOS Y CONCLUSIÓN: Las bases de referencia del fabricante subestima significativamente el número de casos con densidad mineral ósea anormal en la población mestiza mexicana.

Peak bone mass and bone mineral density correlates for 9 to 24 year-old Mexican women, using corrected BMD / Pico mineral óseo y factores asociados a la densidad mineral ósea en mujeres mexicanas de 9 a 24 años de edad usando densidad mineral ósea corregida

OBJECTIVE: To determine the age of peak bone mass (PBM) in Mexican women and factors associated with both BMDa and corrected BMD (BMDcorr) at the femoral neck and the spine (L2-L4). MATERIAL AND METHODS: Data on 461 women between 9 and 24 years old was used. An interview was performed and height and weight were measured. BMDa was measured by a densitometer and BMDcorr by the method proposed by Krõger et al. (1992). RESULTS: PBM at the spine (L2-L4) was observed later than at the femoral neck. Both BMDa and BMDcorr at the lumbar spine correlate with age, socio-economic status, body fat percentage and height. BMDa at the femoral neck correlates with overweight and obesity, body fat percentage, height and moderate physical activity; the same variables were associated with BMDcorr except for height. CONCLUSIONS: The method proposed by Krõger et al. was more precise at the femoral neck than at the spine.

OBJETIVO: Determinar la edad del pico de masa ósea (PMO) y los factores asociados a DMOa y a DMOcorr del cuello femoral y de la columna vertebral (L2-L4) en mujeres mexicanas. MATERIAL Y MÉTODOS: Se utilizaron datos de 461 mujeres de 9 a 24 años de edad. La DMO se midió mediante un densitómetro y la DMOcorr mediante el método propuesto por Krõger et al. (1992). RESULTADOS: El PMO en la columna vertebral (L2-L4) se observó más tarde que en el cuello femoral. A la DMOa y DMOcorr de la columna se asociaron: edad, estado socio económico, porcentaje de grasa corporal y la talla. A DMOa del cuello femoral se asociaron: sobrepeso y obesidad, porcentaje de grasa corporal, talla y actividad física moderada; las mismas variables se asociaron con la DMOcorr excepto talla. CONCLUSIONES: El método propuesto por Krõger et al. fue más preciso para el cuello femoral que para la columna.

Contribution of the xenograft bone plate-screw system in lumbar transpedicular stabilization of dogs: an in-vitro study

We performed biomechanical comparison of a xenograft bone plate-screw (XBPS) system for achieving cadaveric lumbar transpedicular stabilization (TS) in dogs. Twenty dogs' cadaveric L2-4 lumbar specimens were harvested and their muscles were removed, but the discs and ligaments were left intact. These specimens were separated to four groups: the L2-4 intact group as control (group I, n = 5), the L3 laminectomy and bilateral facetectomy group (LBF) (group II, n = 5), the LBF plus TS with metal plate-screw group (group III, n = 5) and the LBF plus TS with XBPS group (group IV, n = 5). Five kinds of biomechanical tests were applied to the specimens: flexion, extension, left-right bending and rotation. The averages of the 16 stiffness values were calculated and then these were statistically analyzed. The statistical results show that the XBPS system contributes spinal stability and this system can be a good choice for achieving TS.

Analysis on body impairment assessment upon 447 thoracolumbar, spinal injury cases in traffic accidents / 法医学杂志

OBJECTIVE@#To discuss the relation between degree of body impairment and that of thoracolumbar spinal injuries resulting from road traffic accidents, and sum up the experiences in body impairment assessment and its regularity.@*METHODS@#For comprehensive body impairment assessment, 477 cases of thoracolumbar spinal injuries in road accidents have been sorted out, reassessed and rediagnosed. In addition, analyses have been undertaken about their treatment, the assessment of the degree of their thoracolumbar dysfunction,nerve dysfunction and the relations between injuries and sequelaes.@*RESULTS@#The analyses show that the degree of thoracolumbar dysfunction and that of the post-injury nerve dysfunction don't necessarily depend on the quantity and degree of spinal injuries. However, the position suffering from the thoracolumbar spinal injuries has an immense impact on the thoracolumbar dysfunction, and the nerve impairment result mainly from the T1-1L spinal injuries. The research also shows that there has been a high misdiagnosis rate in hospital about the spinal injuries.@*CONCLUSION@#In body impairment assessment, the cause and effect relations between the injury and degree of injury extent should be analyzed, the injury extent should be employed as principal evidence, and the degree of spinal dysfunction should be taken into greater consideration.

Desintrometría ósea en mujeres chilenas normales en edad fértil: correlación con valores referenciales y variables antropométricas / Dual X-ray absorptiometry [DEXA] in normal Chilean women: correlation between reference values and anthropometric variables

Background: Bone mineral density results are expressed as the number of standard deviations from reference values in similar populations. However, these reference values have not been obtained locally and there may be discrepancies between Chilean and other Hispanic populations. Aim: To evaluate the results of DEXA in healthy Chilean women and to correlate them with reference values and anthropometric parameters. Material and Method: We studied prospectively 166 normal women aged between 15 and 55 years, using a Hologic QDR 1000 equipment, yielding bone mineral density (BMD), bone mineral content (BMC) and bone area (A) in the lumbar spine (LS) and femoral neck (FN). These bone densitometric variables were correlated with weight, height and age of women and compared against the reference values of the Hologic equipment. Relation between BMC and A was evaluated using a regression analysis. Results: BMD and BMC were lower to reference values in most age groups, especially for LS. There was a significant correlation of BMD with A in LS (r: 0.278, p <0.001), weight in both LS (r: 0.382, p <0.0001) and FN (r: 0.266, p <0.001), height in LS (r: 0.258, p <0.001) and age in FN (r: -0.231, p <0.01). Only in LS, regression analysis between A and BMC did not show direct proportionality. Conclusions: BMD of healthy Chilean women was lower than the reference values of the Hologic equipment for most age groups. Bone densitometric variables are non uniformly influenced by weight, height and size of bone structures (A) in normal women, especially in LS. Correct interpretation of DEXA requires the validation of reference values and to assess the value of bone area measurements (Rev Méd Chile 2004; 132: 681-90).

Bone mineral parameters in healthy young Indian adults with optimal vitamin D availability.

BACKGROUND: Several recent studies indicate a marked prevalence of vitamin D deficiency in asymptomatic, apparently healthy urban subjects from different socioeconomic groups in north India. METHODS: To further examine this trend, we studied 40 men and 50 women, 20-30 years of age, from the Indian paramilitary forces. These individuals consume a nutritious, high-protein diet, have optimal exposure to sunlight and undertake strenuous outdoor physical exercise. RESULTS: The mean serum calcium, phosphorus and alkaline phosphatase levels were normal in both men and women. The mean (SD) serum intact parathyroid hormone and 25-hydroxyvitamin D3 levels were 19.3 (8.2) pg/ml and 18.4 (5.3) ng/ml in men, and 11.9 (6.6) pg/ml and 25.3 (7.4) ng/ml in women. Bone mineral density estimated in 20 men and 22 women revealed that in comparison with white Caucasians, 35%-50% of men and 14%-32% of women were osteopenic at different sites, while an additional 10% of men had osteoporosis of the lumbar spine. CONCLUSION: We found that with optimal nutrition, good sunlight exposure and regular physical exercise, healthy young individuals have normal bone and mineral biochemical values. The reasons for the abnormalities detected in bone mineral density in them needs further study. The impact of childhood nutrition on accumulation of peak bone mass may contribute to our findings. There is a need for establishing normative bone mineral density data for Indians.

Unión disco-vertebral: ¿que es lo patológico? / Intervertebral disk: what it's the pathologic?

Se revisan los conceptos de normalidad, variaciones anatómicas y cambios patológicos de la unión discovertebral, actualmente aceptados en la literatura internacional. La utilización de esta nomenciatura permitirá un mejor correlato clínico radiológico, entregando información útil para los clínicos y cirujanos.

Bone mineral density of lumbar spines and proximal femur in the normal northeastern Thai women.

OBJECTIVE: To determine reference data for age-matched bone mineral density (BMD) of normal northeastern Thai women. MATERIAL AND METHOD: 350 northeastern Thai women aged 20-70 years were prospectively studied. After interview, the subjects were examined for BMD of lumbar spines and proximal femur. Mean BMD of each group was determined for each skeletal site. Standard deviation (SD) of BMD in the peak group was calculated to determine BMD cutoff level for diagnosing osteoporosis. RESULT: Peak average BMD of lumbar spines was at 40-45 years, whereas peak BMD of proximal femur was at 35-40 years. Mean value of peak BMD of lumbar spines and proximal femur was 1.226 and 1.035 g/cm2, respectively. According to T-score less than -2.5 SD criteria, osteoporosis of lumbar spines and proximal femur was considered when measured BMD was below 0.889 and 0.785 g/cm2, respectively. CONCLUSION: Our study provided the BMD reference data for northeastern Thai women.

Effect of sacral buttress technique in Ramathibodi spinal system fixation on L5-S1 motion.

This is a retrospective study which reviewed the effects of the sacral buttress technique of Ramathibodi Spinal System (RSS) instrumentation for degenerative conditions of the spine on L5-S1 motion. The inclusion criteria included patients who were treated by wide decompression and fusion of the lumbar spine. Two treatment groups of a different fusion technique were identified; the first group was treated by conventional fixation and the second group was treated by the sacral buttress technique. The objective of this study was to evaluate the effect on L5-S1 motion and translation between the conventional group and sacral buttress group. The material consisted of 66 patients who were operated from 1996 to 1999 for degenerative conditions of the lumbosacral spine. The conventional group included 25 patients in whom instrumentation was stopped at the fifth lumbar spine and the buttress group consisted of 41 patients who underwent the sacral buttress technique with RSS fixation. Dynamic lateral radiographs were measured to determine the motion and translation before and after surgery. In the group with sacral buttress technique, post operation decrease in motion of the lumbosacral joint was statistically significant. Reduced motion was also associated with the level of fusion. The use of the sacral buttress technique with RSS led to significant control in lumbosacral motion without the need for screw fixation to the sacral spine. The usefullness of this technique is a valuable adjunct to spinal fusion in patients who undergo decompressed spinal surgery and may prevent the junctional problem of fusion at this segment and also the upper end of the above fusion level.

Prediction of bone mineral density of lumbar spine, hip, femoral neck and Ward's triangle by forearm bone mineral density.

Bone mineral density (BMD) of dual energy X-ray absorptiometry (DEXA) at both radius and ulna were measured to evaluate the correlation of those and BMD at lumbar (L) spine, hip, femoral neck and Ward's triangle. The 64 simple linear regression analysis was calculated to postulate the predicted equation by using the BMD at supradistal, distal 1/10, distal 1/6 and distal 1/3 of both forearms as independent variables, while the dependent variables were BMD at L1-L4 spine, total hip, femoral neck and Ward's triangle. 115 patients aged between 41-79 years (mean age 55.97+/-8.34 years) from the menopausal clinic, Pramongkutklao Hospital, were scanned at both forearms by Panasonic (DXA-70) DEXA and at non forearm regions by Hologic (QDR 4500) DEXA on the same day. The results showed that the BMD of each of the 4 parts of both radius and ulna had positive correlation to those of L-spine, total hip, femoral neck and Ward's triangle with r = 0.4012 to 0.7032 (P<0.001 for all). The greater distal of the forearm, the better correlation of BMD to the non forearm BMD. The 64 simple linear regression equations were constructed with regression coefficient ranging from 0.6048 to 1.9011 (P<0.001 for all). When considering the non forearm BMD, the mean BMD at Ward's triangle significantly declined more rapidly than that of L-spine, total hip and femoral neck (P<0.05 for all). It indicated that there was an early change of BMD at Ward's triangle. However, this change followed the forearm BMD. Distal forearm BMD was the earliest sign of bone loss. We can predict non forearm BMD by supradistal and distal 1/10 of forearm BMD.

Bone mineral density of the lumbar spine of Brazilian children and adolescents aged 6 to 14 years

The authors performed a study of bone mass in eutrophic Brazilian children and adolescents using dual-energy X-ray absorptiometry (DXA) in order to obtain curves for bone mineral content (BMC) and bone mineral density (BMD) by chronological age and correlate these values with weight and height. Healthy Caucasian children and adolescents, 120 boys and 135 girls, 6 to 14 years of age, residents of São Paulo, Brazil, were selected from the Pediatric Department outpatient clinic of Hospital São Paulo (Universidade Federal de São Paulo). BMC, BMD and the area of the vertebral body of the L2-L4 segment were obtained by DXA. BMC and BMD for the lumbar spine (L2-L4) presented a progressive increase between 6 and 14 years of age in both sexes, with a distribution that fitted an exponential curve. We identified an increase of mineral content in female patients older than 11 years which was maintained until 13 years of age, when a new decrease in the velocity of bone mineralization occurred. Male patients presented a period of accelerated bone mass gain after 11 years of age that was maintained until 14 years of age. At 14 years of age the mean BMD values for boys and girls were 0.984 and 1.017 g/cm², respectively. A stepwise multiple regression analysis of paired variables showed that the "vertebral area-age" pair was the most significant in the determination of BMD values and the introduction of a third variable (weight or height) did not significantly increase the correlation coefficient

Densidade mineral óssea vertebral e femoral de 724 mulheres brancas brasileiras: influência da idade e do peso corporal / Vertebral and femoral bone mineral sessity of 724 caucasian Brazilian woman: influence of age and body weight

Objetivo. Estudar a densidade mineral óssea (BMD) vertebral (L2-L4) e femoral (colo do fêmur) de mulheres brancas, normais. Material e Método. Mediu-se o BMD de 724 mulheres (40-79 Kg; 20-69 anos de idade) por dual-energy x-ray absorptiometry e analisaram-se os dados em funçao da idade e peso corporal (PC). Resultados. As mulheres mais leves (40-49 Kg) atingiram o BMD maximo (BMDm) vertebral e femoral aos 30-39 anos de idade, enquanto as mais pesadas (60-79 Kg) apresentaram BMDm aos 20 anos. No fêmur, houve uma correlaçao significativa entre BMDm e PC (r=0,97, p<0,001; slope=0,72 por cento/Kg). Em L2-L4, apenas as mulheres com 40-49Kg apresentaram BMDm menor do que as demais(p<0,001). A diminuiçao do BMD vertebral foi mais intensa (-8,3 vs. -5,7 por cento/década) e iniciou mais cedo (quarta vs. quinta década) nas mulheres pesando 40-59Kg do que nas pesando 60-79Kg. A diminuiçao do BMD femoral iniciou logo após o BMDm ser atingido e, até os 69 anos, as mulheres mais pesadas apresentaram um decréscimo 5,3 por cento menor do que aquelas pesando 40-49Kg. O BMD vertebral das mulheres brasileiras foi praticamente o mesmo de uma populaçao norte-americana previamente descrita. Conclusoes. 1) O BMD vertebral e femoral das brasileiras estudadas comportou-se, em funçao da idade, de forma semelhante a de outras populaçoes brancas; 2) havendo o cuidado de corrigir o PC, o BMD das mulheres brasileiras é comparavel ao de mulheres norte-americanas; e 3) o PC é importante na aquisiçao e diminuiçao da massa óssea, além de influenciar a relaçao BMD-idade.

Correlation of bone mineral density among various measurement sites.

Bone mineral density (BMD) of the lumbar spine and hip was studied in 1,047 women visiting the menopause clinic, to assess the correlation of BMD among various measurement sites. Bone mass measurement was performed utilizing dual energy X-ray absorptiometer (DEXA), Hologic QDR 2000. The results revealed a significantly high correlation of BMD of total hip and spine. (r = 0.7021, P < 0.001) Nevertheless, BMD of the spine was mostly correlated with BMD of trochanteric site (r = 0.7235, P < 0.001) and least correlated with BMD of intertrochanteric region. (r = 0.2426, P < 0.001) In conclusion, BMD of spine and hip is highly correlated. However, there was some heterogeneity of correlation in different specific measurement sites.

Morphometric study of the lumbar vertebral canal in the normal adult Pakistanis

1. To determine the normal values of the midsagittal diameters of the canal and body of lumbar vertebrae in Pakistanis. 2. To find out the relationship between the midsagittal diameters of the vertebral canal and the vertebral body at all lumbar levels. 3. To determine the anteroposterior diameter of inferior vertebral notch and to find out its ratio with the vertebral body. STUDY DESIGN: the anatomic dimensions of the vertebral body and spinal canal of the lumbar vertebral were analysed in Pakistanis. SETTING: Department of Anatomy Nishtar Medical College, Multan. PERIOD: June 1993 to December 1996. MATERIALS AND METHODS :one thousand five hundred measurements were performed on the midsagittal diameters of vertebral bodies, spinal canals and anteroposterior diameters of inferior vertebrae notches using complete sets of 75 lumbar vertebral. The mean midsagittal diameters of the lumber spinal canal in the Pakistani Population was less than that of South African and Nigerian population while the anteroposterior diameter of inferior vertebral notch was slightly greater then that of Nigerians. the midsagittal diameter of the lumbar spinal canal is narrowest in the East Asian population; the radiologic criteria of spinal stenosis should be reconsidered for these people