RESUMO
Abstract Purpose: To compare four types of mesh regarding visceral adhesions, inflammatory response and incorporation. Methods: Sixty Wistar rats were divided into four groups, with different meshes implanted intraperitoneally: polytetrafluoroethylene (ePTFE group); polypropylene with polydioxanone and oxidized cellulose (PCD); polypropylene (PM) and polypropylene with silicone (PMS). The variables analyzed were: area covered by adhesions, incorporation of the mesh and inflammatory reaction (evaluated histologically and by COX2 immunochemistry). Results: The PMS group had the lowest adhesion area (63.1%) and grade 1 adhesions. The ePTFE and PM groups presented almost the total area of their surface covered by adherences (99.8% and 97.7% respectively) The group ePTFE had the highest percentage of area without incorporation (42%; p <0.001) with no difference between the other meshes. The PMS group had the best incorporation rate. And the histological analysis revealed that the inflammation scores were significantly different. Conclusions: The PM mesh had higher density of adherences, larger area of adherences, adherences to organs and percentage of incorporation. ePTFE had the higher area of adherences and lower incorporation. The PMS mesh performed best in the inflammation score, had a higher incorporation and lower area of adherences, and it was considered the best type of mesh.
Assuntos
Animais , Masculino , Ratos , Próteses e Implantes/efeitos adversos , Telas Cirúrgicas/normas , Aderências Teciduais/patologia , Hérnia Incisional/cirurgia , Inflamação/patologia , Polipropilenos/efeitos adversos , Politetrafluoretileno/efeitos adversos , Complicações Pós-Operatórias/prevenção & controle , Silicones/efeitos adversos , Telas Cirúrgicas/efeitos adversos , Teste de Materiais , Vísceras/fisiologia , Celulose Oxidada/efeitos adversos , Aderências Teciduais/prevenção & controle , Ratos Wistar , Estatísticas não Paramétricas , Parede AbdominalRESUMO
A teoria do Zang Fu, da medicina tradicional chinesa, considera que os órgaos internos apresentam funçoes inerentes ao órgao anatômico, além de seus aspectos mentais. As consideraçoes propostas neste artigo representam esforço para tentar compreender a complexidade da teoria dos Zang Fu, alicerce da fisiologia, fisiopatologia e do tratamento da medicina tradicional chinesa, de modo a permitir entendimento racional embasado na neuroanatomia e na neurofisiologia, fornecendo dados para que a medicina ocidental passe a reconhecer a validade dos preceitos dos antigos chineses.