Fire needling stripping after local anesthesia for verruca vulgaris: a multi-center randomized controlled trial / 中国针灸

OBJECTIVE@#To compare the clinical therapeutic effect of fire needling stripping after local anesthesia, simple fire needling and liquid nitrogen cryotherapy on verruca vulgaris.@*METHODS@#A total of 900 patients with verruca vulgaris were randomized into a fire needling stripping group (300 cases, 2 cases dropped off), a fire needling group (300 cases, 4 cases dropped off) and a liquid nitrogen cryotherapy group (300 cases, 5 cases dropped off). After local anesthesia of compound lidocaine cream, fire needling therapy was adopted, and the necrotic tissue of verruca was stripped in the fire needling stripping group. Simple fire needling therapy was adopted in the fire needling group, without local anesthesia and stripping. Liquid nitrogen cryotherapy was adopted in the liquid nitrogen cryotherapy group. The treatment was given once a week, and totally 3 weeks were required in the 3 groups. The skin lesion scores of number, area, thickness, color, pruritus, isomorphism and the level of T lymphocyte (CD@*RESULTS@#Compared before treatment, the skin lesion scores were decreased (@*CONCLUSION@#Fire needling stripping after local anesthesia can effectively treat the verruca vulgaris, improve the skin lesion and immunity, its therapeutic effect is superior to simple fire needling and liquid nitrogen cryotherapy.

Tratamiento Homeopático de la Verruga Plantar. Caso Clínico Tratado en una Farmacia Comunitaria / Homeopathic Wart Treatment Plant. Clinical Case Treated in a Community Pharmacy

Las verrugas plantares son un tipo de infección causadas por el virus del papiloma humano (VPH). En muchos de los casos son muy dolorosas y difíciles de tratar; aunque generalmente desaparecen con tratamiento en unos meses, en otros casos persisten durante años. Se presenta el caso de un varón de 13 años que acudió a la oficina de farmacia tras el fracaso de un prolongado tratamiento convencional para una verruga plantar en el talón. Existen antecedentes documentados y experiencias favorables en el tratamiento homeopático de las verrugas plantares y de su utilización en farmacia. Se le pautaron Thuja occidentalis 15CH (10 gránulos semanalmente), Dulcamara 9CH (5-0-5), Antimonium crudum 15CH (5-0-5) y Nitricum acidum 15CH (5-0-5) durante 1 mes. Se observó una mejoría clínica importante al cabo de sólo 1 mes exclusivamente con tratamiento homeopático, que puede suponer una posibilidad de tratamiento eficaz para las verrugas plantares, incluso tras el fracaso de otras intervenciones convencionales.(AU)

Plantar warts are a type of infection caused by the human papillomavirus. In many cases they are very painful and difficult to treat, they usually disappear in a few months with the treatment but in several cases they will persist for years. The case of a 13 years old male is presented, who came to the pharmacy after a long and unsuccessful conventional treatment of a plantar wart on the heel of the left foot. The plantar warts have been successfully treated by homeopathic medicines in the bibliography and according to our own experience. The chosen medicines were Thuja occidentalis 15CH (10 granules weekly), Dulcamara 9CH 5 (5-0-5), Antimonium crudum 15CH (5-0-5) and Nitricum acidum 15CH (5-0-5). An important improvement was observed after 1 month of treatment. The homeopathic treatment can be an effective treatment option for plantar warts, including those where other conventional interventions have not succeeded. (AU)

Safety and effectiveness of autoinoculation therapy in cutaneous warts: A double - blind, randomized, placebo - controlled study.

Background: In spite of the availability of multiple treatment options, viral warts are known for their persistence and recurrence, causing frustration to patients and treating physicians. Aims: To study the effectiveness and safety of autoinoculation as a treatment modality in cutaneous warts. Methods: A double‑blind, placebo‑controlled study was carried out. In the treatment group, full‑thickness warty tissue was excised, minced and implanted in a small dermal pocket. In the control group, warty tissue was only excised and not implanted, though a dermal pocket was made. Patients were evaluated every four weeks with lesion counts. The procedure was repeated at 4 and 8 weeks. Response was assessed at each visit and at 12 weeks. Results: Forty‑eight patients with cutaneous warts (male: female = 32:16) were randomized into autoinoculation and control groups. The number of warts at baseline was comparable in both groups (P = 0.293). Reduction in the number of warts was significantly more in the autoinoculation group (8.50 ± 13.88) than in the control group (10.04 ± 5.80) from 8 weeks onwards (P = 0.010). Complete resolution occurred only in the autoinoculation group, in 62.5% of cases. Adverse effects were seen in 11 patients, including infection of the donor site (5 cases), keloid formation (3) and hypopigmentation (3). Conclusion: Autoinoculation may be an effective therapeutic modality for cutaneous warts and two sessions may be required for optimum results.

Verrugas vulgares: tratamiento con interferón alfa 2b intralesional / Common warts: treatment with intralesional interferon alpha 2b

Los interferones son una gran familia de proteínas y glicoproteínas, de origen natural o producidas artificialmente por biotecnología recombinante, cuyas propiedades antiproliferativas, antivirales e inmunomoduladoras resultan útiles para múltiples terapéuticas. En la actualidad, los diferentes tipos de interferones son ampliamente usados en la práctica clínica para el tratamiento de diversas patologías, como hepatitis C y B, leucemias, linfoma cutáneo de células T, melanoma y mieloma múltiple, entre otras. Sin embargo, existe poca información en la literatura médica dermatológica sobre el uso del interferón alfa 2 b para el tratamiento de verrugas vulgares de difícil acceso o con escasa respuesta a los tratamientos convencionales. En los últimos 23 años hemos aplicado esta terapéutica con resultados ampliamente satisfactorios. Presentamos aquí 3 de nuestros pacientes con el seguimiento iconográfico de las verrugas tratadas...

Interferons constitute a family of naturally occurring proteins and glycoproteins that can be artificially produced by recombinant biotechnology. They have antiproliferative, antiviral and immunomodulatory properties that make them useful for several treatments. At present, these molecules are widely used in clinical practice for the treatment of various diseases as hepatitis C and B, leukemias, T cell cutaneous lymphoma, melanoma, multiple myeloma, etc. However, in dermatology, its use for intralesional treatment of either vulgar inaccessible or with low response to conventional treatments warts, is poorly reported in the literature. Over the past 23 years we have applied interferon therapy with highly promising results. In this article, we present 3 of our patients with the iconographic monitoring of treated warts...

Infecciones virales en piel y mucosas / Cutaneous viral diseases

Diversos virus pueden infectar la piel y las mucosas de los seres humanos, manifestándose en diferentes patologías, de acuerdo a la edad, género y estado inmunológico. Un grupo importante de éstos tiene capacidad de replicar en células epiteliales, originando cuadros clínicos en los cuales se evidencia la destrucción celular o bien la hiperplasia del tejido infectado. Gran parte de estos virus persisten en células infectadas por años y tienen la capacidad de reactivarse y de manifestar nuevamente enfermedades cutáneas o mucosas. En algunos casos, ésta sólo se expresa de manera subclínica en una excreción del virus por secreciones que son fuente de infección. En los últimos años, los avances en técnicas moleculares han permitido contar con metodologías diagnósticas cada vez más sensibles, específicas y rápidas. Así como también el progreso en el área de vacunas y antivirales nos entrega mayores herramientas profilácticas y terapéuticas.

Various viruses can infect the skin and the mucous membranes of human beings, manifesting itself in different diseases, according to age, gender and immune status. An important group has the ability to replicate in epithelial cells, causing clinical manifestations which evidenced the cell destruction either infected tissue hyperplasia. Much of these viruses persist in cells infected by years and have the ability to reactivate and again express cutaneous or mucosal diseases. In some cases, it is only asymptomatically shred in secretions that are a source of infection. In recent years, advances in molecular techniques have allowed to have increasingly sensitive, specific and rapid diagnostic methodologies. As well as, the progress in the area of vaccines and antivirals also gives us greater prophylactic and therapeutic tools.

Oral Warts among Children Attending a Missionary Dental Clinic in Cameroon

To determine the prevalence of oral warts among children attending missionary dental clinic in Cameroon. This prospective study of children presenting in the Dental Clinic of Cameroon Baptist Convention with oral warts was conducted between January 2006 and August 2010. During the study period; 31 children out of 2912 children had oral warts giving a prevalence rate of 1.1. Out of which; 15 (48.4) of children with oral warts were aged between 7-10 years old; 20 (64.5) were females; 3 (9.7) were HIV positive. Lips were the most predominant oral site among the children. The recurrence rate following treatment with electrocautery was 1 (3.2). The overall prevalence of oral warts among Cameroonian children in a dental clinic setting was low. It was commoner in children aged 7-10 years; females and HIV negative children. Lips were the most predominant oral site in children and recurrence rate following treatment with electrocautery was low

Bacille Calmette-Guerin immunotherapy of viral warts

To assess the effectiveness of the Bacille Calmette-Guerin [BCG] vaccine in the treatment of viral warts. A single blind placebo controlled study conducted at the Department of Dermatology; Baghdad Teaching Hospital, Baghdad, Iraq from March 2005 to June 2006. Two hundred patients with viral warts were enrolled in this study, and were fully assessed before therapy. The patients were divided into 2 equal matched groups. Group 1 was designed as the treatment group and received BCG vaccine in 1-3 doses with a one-month interval, while group 2 was injected with distilled water. The patients were evaluated every 2 weeks for evidence of regression of lesions. The follow up period lasted for 3 months after the last dose. A total of 154 patients completed the study: 81 patients in group I and 73 patients in group II. Thirty [39.7%] patients out of 81 patients in group I showed complete recovery. These results were significantly high [p<0.05] when compared with total response, 10 [13.7%] out of 73 patients in group II. No recurrence has been reported during the follow up period. When cases that failed to respond to placebo were treated with BCG in a similar manner to group I, there was total response in 15 [42.7%] out of 44 patients. No side effects were observed. The BCG vaccine was an effective and safe modality of treatment of viral warts

Diagnóstico y terapia del virus papiloma humano / Diagnosis and treatment of human papilloma virus

Tanto el diagnóstico como el tratamiento de la infección producida por el virus papiloma humano y el cáncer asociado a este virus, nos plantean uno de los mayores desafíos en la última década. Las principales dificultades radican en la identificación del genotipo viral, la ausencia de una terapia antiviral efectiva y las altas tasas de recurrencia y persistencia a pesar de la terapia empleada. Se presenta un resumen de la terapia disponible en la actualidad.

The identification and treatment of human papillomavirus (HPV) infections and HPV-associated neoplasm are complex. Difficulties in diagnosis and treatment of HPV-associated diseases arise from inabilities to detect HPV efficiently, the lack of specific antiviral drugs active against HPV and the high rates of recurrence and persistence of HPV infections after treatment. We present a review of therapies for HPV infections.

Tratamiento de las verrugas vulgares en niños con la hemolinfa del insecto Epicauta sp / Treatment of the viral warts in children with the hemolymph of the insect epicauta sp

La verruga vulgar es una enfermedad viral frecuente en los niños de Huancayo, se observó que desde hace tiempo en forma empírica los habitantes curaban las verrugas con la hemolinfa del insecto Epicauta sp. Se realizó el estudio en niños con verruga en las manos entre 5 y 12 años de edad; 36 fueron varones y 24 mujeres. Los niños en forma aleatoria fueron asignados en dos grupos de tratamiento, uno con nitrógeno líquido (n=30) y el otro con hemolinfa del Epicauta sp (n=30). Se realizó tres aplicaciones, una cada semana y se evaluó los resultados al mes de iniciado el tratamiento. En el grupo tratado con nitrógeno líquido ocho niños abandonaron el tratamiento por dolor. En el grupo tratado con hemolinfa Epicauta. 18 presentaron formación de ampollas, cuatro eritema y sólo dos abandonaron el tratamiento por presentar dermatitis de contacto, Nuestro objetivo fue comparar la efectividad del uso de hemolinfa del insecto Epicauta sp. con el uso de nitrógeno líquido en el tratamiento de las verrugas vulgares en niños. Del total de pacientes que se trató con nitrógeno líquido, 18 pacientes (82 por ciento) fueron curados y cuatro no respondieron; de los tratados con hemolinfa de epicauta sp. 23 pacientes (82 por ciento) fueron curados y cinco no respondieron.

Acroceratose verruciforme de Hopf: relato de caso / Acrokeratosis verruciformis of Hopf: a case report

Acroceratose verruciforme de Hopf é síndrome heredofamilial autossômica dominante caracterizada por pápulas pequenas, verrucosas, planas, presentes predominantemente no dorso de mäos e pés, nos joelhos e cotovelos. Os autores descrevem uma paciente de 38 anos de idade, enfatizando a importância dos aspectos clínicos e histopatológicos