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1.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-811217

RESUMO

OBJECTIVE: To evaluate the effectiveness and safety of the combination of pegylated liposomal doxorubicin with carboplatin (CD) compared with those of carboplatin and paclitaxel (CP) for platinum-sensitive recurrent ovarian, fallopian, or primary peritoneal cancer in a real-world setting in Korea.METHODS: We enrolled relevant patients from 9 institutions. All patients received CD or CP as the second- or third-line chemotherapy in routine clinical practice during 2013–2018. The primary endpoints were progression-free survival (PFS) and toxicity. The secondary endpoint included the objective response rate (ORR).RESULTS: Overall, 432 patients (224 and 208 in the CD and CP groups, respectively) were included. With a median follow-up of 18.9 months, the median PFS was not different between the groups (12.7 vs. 13.6 months; hazard ratio, 1.161; 95% confidence interval, 0.923–1.460; p=0.202). The ORR was 74.6% and 80.1% in the CD and CP group, respectively (p=0.556). Age and surgery at relapse were independent prognostic factors. More patients in the CD group significantly experienced a grade 3 to 4 hematologic toxicity and hand-foot syndrome (13.8% vs. 6.3%), whereas grade 2 or more alopecia (6.2% vs. 36.1%), peripheral neuropathy (4.4% vs. 11.4%), and allergic/hypersensitivity reaction (0.4% vs. 8.5%) developed more often in the CP group.CONCLUSIONS: The safety and effectiveness of chemotherapy with CD in a real-world setting were consistent with the results from a randomized controlled study. The different toxicity profiles between the 2 chemotherapy (CD and CP) regimens should be considered in the clinical practice.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03562533


Assuntos
Alopecia , Carboplatina , Estudos de Coortes , Intervalo Livre de Doença , Doxorrubicina , Tratamento Farmacológico , Seguimentos , Síndrome Mão-Pé , Humanos , Coreia (Geográfico) , Neoplasias Ovarianas , Paclitaxel , Doenças do Sistema Nervoso Periférico , Platina , Prognóstico , Recidiva , Estudos Retrospectivos
2.
Annals of Dermatology ; : 141-145, 2020.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-811084

RESUMO

BACKGROUND: Telogen effluvium (TE) is characterized by massive hair shedding and results from an abrupt conversion of anagen to telogen. Differentiation of TE with other hair disorders showing massive hair shedding is difficult.OBJECTIVE: To evaluate the morphologic characteristics of pulled out hair of TE.METHODS: We analyzed microscopic examination of pulled out hairs by hair pull test in TE patients, and compared these hairs with pulled out hairs in diffuse alopecia areata (AA) patients and healthy volunteers.RESULTS: Hair microscopic examination in 44 TE patients (370 hairs) and 30 healthy volunteers (295 hairs) were as follows: typical club hair, 32.7%, 62.7%; club hair with tail, 23.5%, 23.7%; club hair with remnant sheath, 23.0%, 6.8%; club hair with both tail and remnant sheath, 18.9%, 5.4%; and unclassified hair, 1.9%, 1.4%. The examination in 7 diffuse AA patients (63 hairs) was as follows: typical club hair, 23.9%; atypical club hair, 47.7%; and distinctive AA hair, 28.4%. There was statistical difference between TE patients and healthy volunteers group (p=0.000).CONCLUSION: Increased atypical club hair in microscopic hair examination might be characteristics of TE.


Assuntos
Alopecia , Alopecia em Áreas , Cabelo , Voluntários Saudáveis , Humanos , Cauda
3.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-782153

RESUMO

PURPOSE: Probiotic supplementation demonstrates beneficial effects on serum lipid profiles. We hypothesized that probiotics could benefit patients presenting with alopecia, secondary to improved blood flow to the scalp.MATERIALS AND METHODS: Our study included men with stage II to V patterns of hair loss based on the Hamilton–Norwood classification and women with stage I to III patterns of hair loss based on the Ludwig classification. All patients were administered 80 mL of Mogut® (a kimchi and cheonggukjang probiotic product) twice a day. Hair growth and numbers were measured using the Triple Scope System® (KC Technology, Korea) at baseline and after 1 and 4 months of administration of a kimchi and cheonggukjang probiotic product.RESULTS: At baseline, the mean hair count was 85.98±20.54 hairs/cm2 and the mean thickness was 0.062±0.011 mm in all patients (n=46). Hair count and thickness had significantly increased at 1 month (90.28±16.13 hairs/cm2 and 0.068±0.008 mm, respectively) and at 4 months (91.54±16.29 hairs/cm2 and 0.066±0.009 mm, respectively). In this study, we found that a kimchi and cheonggukjang probiotic product could promote hair growth and reverse hair loss without associated adverse effects such as diarrhea.CONCLUSIONS: We suggest that the observed improvements in hair count and thickness resulted from initiation of the anagen phase in hair follicles in response to probiotics.


Assuntos
Alopecia , Classificação , Diarreia , Feminino , Alimento Funcional , Cabelo , Folículo Piloso , Humanos , Leuconostoc , Masculino , Projetos Piloto , Probióticos , Couro Cabeludo , Soja
4.
ABCS health sci ; 44(3): 209-212, 20 dez 2019. ilus
Artigo em Inglês, Português | LILACS (Américas) | ID: biblio-1047756

RESUMO

INTRODUÇÃO: O tratamento do câncer vem evoluindo a cada dia. Entretanto, efeitos adversos como alterações dermatológicas apresentam um grande impacto psicossocial ao paciente oncológico. Uma dessas alterações dermatológicas é a alopecia, caracterizada pela perda dos fios da sobrancelha e do couro cabeludo. RELATO DE CASO: Foram referidos dois casos de pacientes em tratamento quimioterápico com alopecia parcial e total. Ambas receberam tratamento por meio do Minoxidil, de uso tópico, havendo repilação completa após três meses. Não foram observados efeitos adversos. CONCLUSÃO: A loção tópica de Minoxidil mostrou-se um método efetivo e seguro para tratar a alopecia parcial e total em pacientes que ainda estão em tratamento oncológico.


INTRODUCTION: The treatment of cancer has been evolving every day. However, adverse effects such as dermatological changes have a great psychosocial impact on cancer patients. One dermatological change is alopecia, characterized by loss of eyebrow and scalp strands. CASE REPORT: Two cases of patients undergoing chemotherapy with partial and total alopecia were reported. Both were treated with Minoxidil, which was topically used, with complete repilation after three months. No adverse effects observed. CONCLUSION: Minoxidil topical lotion has proven to be an effective and safe method to treat partial and total alopecia in patients still undergoing cancer treatment.


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Idoso , Relatos de Casos , Dermatologia , Alopecia/tratamento farmacológico , Oncologia Integrativa , Minoxidil/uso terapêutico , Tratamento Farmacológico
6.
An. bras. dermatol ; 94(4): 416-421, July-Aug. 2019. tab, graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-1038289

RESUMO

Abstract: Background: Frontal fibrosing alopecia is a condition of unknown origin, histologically similar to classic lichen planopilaris and generally observed in postmenopausal women with alopecia of the frontal-temporal hairline. Objectives: To describe the clinical, dermatoscopic, and histopathological characteristics and the treatment used in patients who have frontal fibrosing alopecia at the Alopecia Outpatient Clinic in a university hospital. Methods: Retrospective descriptive study performed by reviewing medical charts and biopsies of the scalp. Results: Sixteen patients were analyzed, all of them female, 93.75% of them postmenopausal, and 56.25% brown-skinned. All had frontal alopecia (100%), followed by temporal alopecia (87.5%) and madarosis (87.5%). On dermatoscopy, perifollicular erythema and tubular scales were found as a sign of disease activity. Of the patients, 68.75% had associated autoimmune diseases, including lupus, thyroid disease and vitiligo. Of the 13 biopsies from 8 patients, 10 showed microscopic aspects compatible with frontal fibrosing alopecia. Laboratory tests did not show major abnormalities and minoxidil was the most used treatment. Study limitation: Data collection limited by the study's retrospective design associated to flaws while filling in the medical charts and absence in standards to the collection and processing of the pathology and histopathological examination. Conclusions: A demographical, clinical, and histopathological description of 16 patients diagnosed with frontal fibrosing alopecia, which remains a challenging disease, of unknown origin, and frequently associated with autoimmune diseases. This study reinforces literary findings. However, more research is needed to establish the pathogenesis and effective treatments.


Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Alopecia/patologia , Couro Cabeludo/patologia , Biópsia , Fibrose , Estudos Retrospectivos , Folículo Piloso/patologia , Dermoscopia/métodos , Alopecia/tratamento farmacológico , Hospitais Universitários
8.
An. bras. dermatol ; 94(4): 479-481, July-Aug. 2019. graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-1038315

RESUMO

Abstract: A 63-year-old black female patient with blisters and exulcerations on the face, neck, upper limbs, and subsequent evolution with hypochromic sclerotic areas and alopecia, is reported. Chronic hepatitis C and presence of high levels of porphyrins in urine were demonstrated. There was complete remission with the use of hydroxychloroquine, photoprotection, and treatment of hepatitis. Significant sclerodermoid involvement of the skin as a manifestation of porphyria cutanea tarda secondary to hepatitis C emphasizes the importance of diagnostic suspicion regarding skin manifestation in order to indicate the appropriate therapy, and to minimize the hepatic morbidity.


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Esclerodermia Localizada/etiologia , Porfiria Cutânea Tardia/etiologia , Porfiria Cutânea Tardia/patologia , Hepatite C Crônica/complicações , Hepatite C Crônica/patologia , Esclerodermia Localizada/patologia , Esclerodermia Localizada/terapia , Resultado do Tratamento , Porfiria Cutânea Tardia/terapia , Hepatite C Crônica/terapia , Alopecia/etiologia
9.
Arch. med ; 19(2): 374-386, 2019/07/30.
Artigo em Espanhol | LILACS (Américas) | ID: biblio-1023151

RESUMO

Objetivo: el ambiente universitario sumado a las exigencias de tipo mental, físico y demás, representaría un factor de riesgo para el desarrollo de patologías capilares, que impliquen la pérdida de cabello, dentro de la población de estudiantes universitarios. El objetivo de la presente investigación es identificar la frecuencia del fenómeno de la caída de cabello en estudiantes regulares de la Universidad de Manizales, Manizales (Colombia), 2016. Materiales y métodos: estudio poblacional de corte transversal analítico, en una muestra de 330 estudiantes de la Universidad de Manizales. Se aplicó un instrumento que medía variables demográficas, variables de cuidado capilar y las escalas de alopecia androgénica Hamilton-Norwood y Ludwig. Resultados: edad promedio 21,8 años. Según las escalas empleadas el 55,7% de los estudiantes presentan caída de cabello. Se encontró enfermedad autoinmune en 7,6% de la muestra, siendo la más común el hipotiroidismo autoinmune en un 44%. El antecedente de alopecia se encontró en el 42,7% de los participantes. El nivel de estrés encontrado fue moderado en un 76,7% según cuestionario de estrés de examen de Cisco. Hubo relación significativa (p=0,000) entre el fenómeno de caída de cabello detectado y el programa académico cursado por el estudiante, siendo los más afectados contaduría 85%, derecho 75% y medicina 72%. Psicología reportó la menor cifra con 27,5%. El 84% de los estudiantes con enfermedad autoinmune presentan caída de cabello, el porcentaje de caída de cabello en quienes refirieron estrés de examen moderdo fue de 59,4%. Conclusiones: en la población del presente estudio se encuentra una proporción alta de caída de cabello, lo que hace urgente una intervención..(AU)


Objective: the university environment added to the demands of mental, physical and other types, would represent a risk factor for the development of hair pathologies, involving hair loss, within the population of university students. The objective of the present investigation is to identify the frequency of the phenomenon of hair loss in regular students of the University of Manizales, Manizales (Colombia), 2016. Materials and methods: analytical cross-sectional population study, in a sample of 330 students of the Universidad de Manizales. An instrument that measured demographic variables, capillary care variables and the androgenic alopecia scales Hamilton-Norwood and Ludwig was applied. Results: average age 21.8 years. According to the scales used, 55.7% of students show hair loss. Autoimmune disease was found in 7.6% of the sample, the most common being autoimmune hypothyroidism in 44%. The history of alopecia was found in 42.7% of the participants. The level of stress found was moderate by 76.7% according to the Cisco exam stress test. There was a significant relationship (p = 0.000) between the phenomenon of hair loss detected and the academic program taken by the student, with the most affected being accountancy with 85%, law with 75% law, and medicine 72%. Psychology reported the lowest with 27.5%. 84% of students with autoimmune disease have hair loss, the percentage of hair loss in those who reported moderate levels of stress was 59.4%. Conclusions: in the population of the present study there is a high proportion of hair loss, which makes an intervention urgent..(AU)


Assuntos
Adolescente , Adulto , Estudantes , Alopecia
12.
Artigo em Coreano | WPRIM (Pacífico Ocidental) | ID: wprim-759765

RESUMO

Although hair loss in Cronkhite-Canada syndrome (CCS) developed frequently, its exact mechanism has not been elucidated. Thus, we attempted to investigate the histopathologic features of hair loss with scalp biopsy in one case of CSS. The patient complained of persistent diarrhea and diffuse hair loss of the scalp 1 month prior to the hospital visit. CCS has been already diagnosed through colonoscopy and medical examination. Scalp biopsy was performed to evaluate hair loss of the patient, and pathologic examination showed increased telogen hairs (anagen to telogen is 7:8) without specific dermal inflammation and miniaturization of hair follicles. The patient was treated with topical and systemic steroids, and hair loss has almost completely recovered in 5 months. In this case, we investigated the clinical and pathological features of hair loss through scalp biopsy in one case of CCS and reported them with a review of the literature.


Assuntos
Alopecia , Biópsia , Colonoscopia , Diarreia , Cabelo , Folículo Piloso , Humanos , Inflamação , Polipose Intestinal , Miniaturização , Couro Cabeludo , Esteroides
13.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-759732

RESUMO

BACKGROUND: The development of a safe and convenient agent that can promote hair growth in patients with androgenetic alopecia remains challenging. OBJECTIVE: This study was designed to investigate the efficacy of a newly developed hair tonic containing a human umbilical cord blood mesenchymal stem cell (hUCB-MSC)-derived conditioned medium in promoting hair growth. METHODS: This double-blind, placebo-controlled clinical study investigated the efficacy of a hair tonic containing an hUCB-MSC-derived conditioned medium in 30 patients with patterned hair loss. Treatment efficacy was determined using phototrichograms to evaluate the density, diameter, and hair growth rate at baseline levels and after 4, 8, and 16 weeks of treatment. RESULTS: The hair density in the group treated with the hair tonic significantly increased from 125.2 to 134.6 hairs/cm2 (p<0.05). In this same group, the thickness of hair also increased from 0.083 to 0.110 mm (p<0.05). Additionally, the hair growth rate increased from 0.285 to 0.338 mm/day (p<0.05). No severe adverse reactions were reported. CONCLUSION: A hair tonic containing an hUCB-MSC-derived conditioned medium could be a new effective alternative to treat patients with androgenetic alopecia.


Assuntos
Alopecia , Estudo Clínico , Meios de Cultivo Condicionados , Sangue Fetal , Preparações para Cabelo , Cabelo , Humanos , Células-Tronco Mesenquimais , Resultado do Tratamento , Cordão Umbilical
15.
Artigo em Coreano | WPRIM (Pacífico Ocidental) | ID: wprim-759715

RESUMO

BACKGROUND: AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that plays a pivotal role in the balance of cellular energy metabolism. Recent studies have reported that AMPK has numerous roles in physiological conditions, and dysregulation of AMPK induces pathological processes and diseases. However, the role of AMPK and its activators have not yet been studied in the context of hair growth regulation. OBJECTIVE: To investigate the effects of metformin on dermal papilla (DP) and outer root sheath (ORS) cells, as well as the role of the AMPK pathway in hair growth. METHODS: We evaluated whether metformin, a well-known AMPK activator, had any beneficial effects on hair growth. In addition, to evaluate the molecular and cellular mechanisms that were involved, protein levels of AMPK and β-catenin were analyzed. RESULTS: Metformin increased the cellular proliferation of human DP and ORS cells. Ki-67 expression was also significantly increased after metformin treatment in the ex vivo hair follicle organ culture. Furthermore, DP and ORS cells treated with metformin had a significant increase in AMPK phosphorylation, which in turn suppressed β-catenin degradation and enhanced its nuclear accumulation. CONCLUSION: We demonstrated that metformin promoted hair growth via the AMPK/β-catenin signaling pathway in vitro with DP and ORS cells. The hair-promoting effects of AMPK activators may potentially be used for the treatment of alopecia, and further investigation will be needed in the future.


Assuntos
Alopecia , Proteínas Quinases Ativadas por AMP , beta Catenina , Proliferação de Células , Metabolismo Energético , Folículo Piloso , Cabelo , Humanos , Técnicas In Vitro , Metformina , Técnicas de Cultura de Órgãos , Processos Patológicos , Fosforilação , Proteínas Quinases
16.
Artigo em Coreano | WPRIM (Pacífico Ocidental) | ID: wprim-759714

RESUMO

BACKGROUND: Tinea capitis manifests either as a non-inflammatory or inflammatory type including kerion, which may cause permanent alopecia. In addition to antifungals, systemic corticosteroids (prednisolone at 1~2 mg/kg/day) have been used to reduce inflammation in patients with kerion. OBJECTIVE: We studied the clinical and laboratory features, treatments, and prognosis of tinea capitis. METHODS: We performed a retrospective review of 12 cases of kerion and 12 cases of non-inflammatory tinea capitis (median age, 8 years; range, 3 months~80 years) diagnosed using a potassium hydroxide mount at the National Health Insurance Service Ilsan Hospital between November 2011 and April 2018. RESULTS: Fungal cultures showed Microsporum species in 6 cases and Trichophyton species in 1 case. The duration of diseases and extent of lesions were greater in the kerion group than in the non-inflammatory tinea capitis group (p<0.05). Sixteen patients were treated with systemic antifungals. In the kerion group, 10 patients were treated with systemic antifungals (6 with itraconazole [median, 26 days; range, 21~58 days] and 4 with terbinafine [median, 24.5 days; range, 13~31 days]). The median intervals between the onset of treatment and scalp clearing (in 10 cases), the onset of new hair growth (in 9 cases), and complete regrowth of hair (in 7 cases) were 27 (range, 13~77), 33 (range, 19~63), and 89 (range, 42~180) days, respectively, in the kerion group. The median dosage of prednisolone used in patients with kerion was 0.26 mg/kg/day (range, 0.15~0.42) with good clinical response. CONCLUSION: The patients with kerion responded well to antifungal treatments. A lower dose of prednisolone was adequate when systemic corticosteroids were required for the treatment of kerion.


Assuntos
Corticosteroides , Alopecia , Cabelo , Humanos , Inflamação , Itraconazol , Microsporum , Programas Nacionais de Saúde , Potássio , Prednisolona , Prognóstico , Estudos Retrospectivos , Couro Cabeludo , Tinha do Couro Cabeludo , Tinha , Trichophyton
18.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-763115

RESUMO

PURPOSE: Dose-dense chemotherapy (DD-CT) is a preferred (neo)adjuvant regimen in early breast cancer (BC). Although the results of reported randomized trials are conflicting, a recent meta-analysis showed improved overall and disease-free survival with DD-CT compared to conventional schedules. However, no DD-CT safety data for Korean BC patients are available. This phase II study was conducted to evaluate the safety and efficacy of pegteograstim in Korean BC patients receiving DD-CT. MATERIALS AND METHODS: Patients with operable (stage I-III), histologically confirmed BC received four cycles of intravenous doxorubicin (60 mg/m2) and cyclophosphamide (600 mg/m2) on day 1 every 2 weeks as neoadjuvant or adjuvant therapy. Pegteograstim (6.0 mg) was administered subcutaneously on day 2 of each cycle. The primary endpoint was the incidence of febrile neutropenia (FN). The secondary endpoints were safety and tolerability. RESULTS: Of 63 patients, one (1.6%) developed FN during all cycles of DD-CT. Dose delay was observed in four patients (6.3%) and dose reduction in two (3.2%) during DD-CT. Frequent adverse events (AEs) were nausea, alopecia, generalized muscle weakness, myalgia, mucositis, anorexia, dyspepsia, and diarrhea; most AEs were related to chemotherapy. Grade 3-4 AEs were reported in five of 63 patients (7.9%), and all grade 3 and 4 AEs were related to chemotherapy. Adverse drug reactions possibly linked to pegteograstim were abdominal pain, bone pain, myalgia, generalized muscle weakness, and headache in five of 63 patients (7.9%). CONCLUSION: Dose-dense AC (doxorubicin/cyclophosphamide) chemotherapywith pegteograstim support is a tolerable and safe regimen in Korean early BC patients.


Assuntos
Dor Abdominal , Alopecia , Anorexia , Agendamento de Consultas , Neoplasias da Mama , Mama , Ciclofosfamida , Diarreia , Intervalo Livre de Doença , Doxorrubicina , Tratamento Farmacológico , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Dispepsia , Neutropenia Febril , Cefaleia , Humanos , Incidência , Mucosite , Debilidade Muscular , Mialgia , Náusea
19.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-762566

RESUMO

BACKGROUND: Many studies have reported the negative effects of long working hours on various health problems. However, whether hair loss is associated with working hours has been rarely investigated so far. The main purpose of this study is to explore the relationship between long working hours and the development of alopecia among Korean male workers. METHODS: A total of 13,391 male workers not to take alopecia medicine in 2013 were followed up to see if they have alopecia medicine after 4 years, and that was used to confirm the alopecia development. Weekly working hours were categorized into three groups: reference working hours (RWH; 52 hours/week). Multiple logistic regression analyses were conducted to investigate the relationship between long working hours and the development of alopecia after adjusting age, marital status, education, monthly household income, smoking, and work schedule within strata of the covariates. RESULTS: Long working hours was significantly related to the development of alopecia. The adjusted odds ratios (ORs) for the development of alopecia were 1.57 (95% confidence interval [CI]: 1.21–2.05) for LWH group and 1.74 (95% CI: 1.23–2.47) for MLWH group relative to RWH group. CONCLUSIONS: Our findings suggest that unintentional development of alopecia is another potential health consequence of long working hours among Korean male workers. Preventive interventions to promote appropriate and reasonable working hours are required in our society.


Assuntos
Alopecia , Agendamento de Consultas , Educação , Características da Família , Seguimentos , Cabelo , Humanos , Modelos Logísticos , Masculino , Estado Civil , Saúde do Trabalhador , Razão de Chances , Fumaça , Fumar
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