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1.
Int. braz. j. urol ; 41(4): 808-812, July-Aug. 2015. graf
Artigo em Inglês | LILACS (Américas) | ID: lil-763050

RESUMO

ABSTRACTKidney disease presenting with cutaneous fistula is a rare condition. We present a case of a 90-year-old woman with dementia who had no prior urological problems and had a cutaneous fistula in the left lumbar region. A fistulogram and computer tomography examination revealed a large staghorn calculus with signs of xanthogranulomatous pyelonephritis in the left kidney and renal fistulisation to the psoas muscle, skin and bronchi. To our knowledge this is the first report in the literature of coexisting renal fistulisation to the psoas major muscle, skin and bronchi. This report illustrates how computed tomography in combination with fistulography can resolve the diagnostic dilemma that pertains to the complex spread of the disease in cases involving nephrocutaneous fistula. Furthermore, the report shows how a renal calculus, even asymptomatic, can cause a serious medical condition, and highlights the importance of early medical intervention.


Assuntos
Idoso de 80 Anos ou mais , Feminino , Humanos , Broncopatias/etiologia , Fístula Cutânea/etiologia , Cálculos Renais/complicações , Transtornos de Início Tardio/etiologia , Doenças Musculares/etiologia , Músculos Psoas , Fístula Urinária/etiologia , Pielonefrite Xantogranulomatosa , Tomografia Computadorizada por Raios X
2.
Rev. peru. med. exp. salud publica ; 30(1): 129-132, ene.-mar. 2013. ilus, graf, mapas, tab
Artigo em Espanhol | LILACS (Américas) | ID: lil-671705

RESUMO

La tiroiditis de Hashimoto constituye la causa más frecuente de hipotiroidismo en las regiones sin deficiencia de yodo, es más frecuente en mujeres y muchas veces tiene asociación familiar. Los síntomas y signos del hipotiroidismo son sistémicos y dependen de la duración e intensidad de la deficiencia de la hormona tiroidea. Las manifestaciones neuromusculares, son excepcionalmente los únicos signos clínicos. Se presenta el caso de un paciente joven con una miopatía severa con rabdomiolisis como la única manifestación de hipotiroidismo severo debido a tiroiditis de Hashimoto.


Hashimoto’s thyroiditis is the most frequent cause of hypothyroidism. In the regions with no iodine deficiency, it is more frequent in women and oftentimes has a familial association. The symptoms and signs of hypothyroidism are systemic and depend on the duration and intensity of the thyroid hormone deficiency. Neuromuscular manifestations are seldom the only symptoms and signs present. We present the case of a young patient with severe myopathy, where rhabdomyolysis was the sole manifestation of severe hypothyroidism secondary to Hashimoto’s thyroiditis.


Assuntos
Feminino , Humanos , Adulto Jovem , Doença de Hashimoto/complicações , Hipotireoidismo/diagnóstico , Hipotireoidismo/etiologia , Doenças Musculares/etiologia , Rabdomiólise/etiologia , Hipotireoidismo/complicações , Índice de Gravidade de Doença
3.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-176452

RESUMO

Telbivudine is an L-nucleoside analogue with potent antiviral activity against hepatitis B virus (HBV). Clinical trials have shown that telbivudine has a more potent and sustained antiviral activity with a lower frequency of viral resistance than lamivudine. Although there are several reports concerning the safety profile of telbivudine, most adverse events are described as mild and transient in nature. Here we report two cases of telbivudine-induced myopathy in patients with chronic hepatitis B who were siblings.


Assuntos
Adulto , Antivirais/efeitos adversos , Creatina Quinase/sangue , Eletromiografia , Hepatite B Crônica/tratamento farmacológico , Humanos , Masculino , Músculo Esquelético/patologia , Doenças Musculares/etiologia , Irmãos , Timidina/efeitos adversos
4.
Rev. bras. reumatol ; 52(2): 252-259, mar.-abr. 2012. ilus, tab
Artigo em Português | LILACS (Américas) | ID: lil-618379

RESUMO

Cerca de 66 por cento dos pacientes com artrite reumatoide (AR) apresentam significativa perda de massa celular, denominada caquexia reumatoide, predominantemente de músculo esquelético (sarcopenia reumatoide). A sarcopenia é caracterizada por perda de massa muscular associada a prejuízos de função. Pacientes com AR apresentam uma redução significativa na força muscular, causada pela perda de proteínas musculares, alterando sua funcionalidade. As diversas condições que levam à perda de massa muscular envolvem distintas cascatas de sinalização intracelular, que podem levar: (i) à morte celular programada (apoptose); (ii) ao aumento da degradação proteica, por meio de autofagia, de proteases dependentes de cálcio (calpaínas e caspases) e do sistema proteossomo; e (iii) à diminuição da ativação das células-satélite responsáveis pela regeneração muscular. Este artigo tem como objetivo revisar esses mecanismos gerais de sarcopenia e seu envolvimento na AR. O melhor conhecimento desses mecanismos pode levar ao desenvolvimento de terapias inovadoras para essa debilitante complicação.


Approximately 66 percent of the patients with rheumatoid arthritis (RA) have significant loss of cell mass (rheumatoid cachexia), mainly of skeletal muscle (rheumatoid sarcopenia). Sarcopenia is defined as muscle wasting associated with functional impairment. Patients with RA possess significant reduction in muscle strength, caused by muscle protein wasting, and loss of functionality. Various conditions leading to muscle wasting involve different pathways of intracellular signaling that trigger: (i) programmed cell death (apoptosis); (ii) increased protein degradation through autophagy, calcium-dependent proteases (calpains and caspases), and proteasome system; (iii) decreased satellite cell activation, responsible for muscle regeneration. This article aimed at reviewing these general mechanisms of sarcopenia and their involvement in RA. Greater knowledge of these mechanisms may lead to the development of innovative therapies to this important comorbidity.


Assuntos
Humanos , Artrite Reumatoide/complicações , Doenças Musculares/etiologia , Sarcopenia/complicações , Síndrome de Emaciação/etiologia , Autofagia , Complexo de Endopeptidases do Proteassoma
5.
Rev. bras. reumatol ; 51(6): 651-654, dez. 2011. ilus
Artigo em Português | LILACS (Américas) | ID: lil-624866

RESUMO

Amiloidose é uma designação genérica para se referir à deposição de fibrilas amiloides nos tecidos corporais. Ela apresenta-se, frequentemente, após os 40 anos de idade, com envolvimento localizado ou sistêmico, associada a mieloma múltiplo ou a doenças inflamatórias crônicas, podendo mimetizar diferentes síndromes reumatológicas. Relata-se o caso de uma paciente com amiloidose associada a mieloma múltiplo cuja apresentação inicial simulava miopatia.


Amyloidosis is a generic term that refers to the deposition of amyloid fibrils in bodily tissues. Its onset is usually after 40 years of age, with localized or systemic involvement associated with multiple myeloma or chronic inflammatory diseases, and can mimic various rheumatic syndromes. We report the case of a patient with amyloidosis associated with multiple myeloma, showing clinical characteristics of pseudomyopathy.


Assuntos
Adulto , Feminino , Humanos , Amiloidose/complicações , Mieloma Múltiplo/complicações , Doenças Musculares/etiologia
6.
Rev. bras. reumatol ; 51(4): 311-313, jul.-ago. 2011. tab
Artigo em Português | LILACS (Américas) | ID: lil-593317

RESUMO

Pacientes com Esclerose Sistêmica (ES) podem apresentar envolvimento muscular na forma de miosite ou miopatianão inflamatória. É verificada também associação entre acometimento muscular e disfunção ventricular esquerda (DVE) em pacientes com ES, o que lhes confere pior prognóstico. Avaliamos 87 pacientes do Hospital de Clínicas da Universidade Federal do Paraná, com diagnóstico de ES, quanto à presença de manifestações da musculatura esquelética e a relação destas com DVE. Verificamos uma prevalência de 42,5 por cento de acometimento muscular nos pacientes avaliados, observando uma correlação positiva com a forma difusa da doença. Afastadas outras causas de DVE, três dos quatro pacientes com fração de ejeção abaixo do valor de normalidade apresentaram alteração de força muscular, atrofia e/ou elevação de enzima creatinofosfoquinase sérica (CPK).


Patients with systemic sclerosis (SSc) can have muscle involvement in the form of myositis or non-infl ammatory myopathy. The muscle involvement can be associated with left ventricular dysfunction (LVD) in patients with SSc, resulting in worse prognosis. Eighty-seven patients of the Hospital de Clínicas of the Universidade Federal do Paraná, diagnosed with SSc, were assessed regarding the presence of skeletal muscle manifestations and their relation with LVD. A 42.5 percent prevalence of muscle involvement was observed in the patients studied, as well as a positive correlation with the diffuse form of the disease. Excluding other causes of LVD, three of the four patients with ejection fraction below the normal reference value had alteration of the muscle strength, atrophy and/or serum creatine phosphokinase (CPK) elevation.


Assuntos
Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Músculo Esquelético , Miocárdio , Doenças Musculares/etiologia , Escleroderma Sistêmico/complicações , Disfunção Ventricular Esquerda/etiologia
7.
Indian J Med Sci ; 2011 July; 65(7) 311-315
Artigo em Inglês | IMSEAR (Sudeste Asiático), GHL | ID: sea-145622

RESUMO

Spontaneous aseptic diabetic muscle infarction (DMI) is one of the rare complications of diabetes. We report a case of type 2 diabetes mellitus with advanced microvascular complications presenting with severe muscular pain. She was diagnosed as DMI on the basis of clinical presentation, radiological and histopathological investigations. She was managed conservatively. During 18 months of follow up, she had good improvement but subsequently other muscle groups were involved suggesting recurrent DMI.


Assuntos
Adulto , Diabetes Mellitus Tipo 2/complicações , Neuropatias Diabéticas/complicações , Neuropatias Diabéticas/diagnóstico , Neuropatias Diabéticas/etiologia , Neuropatias Diabéticas/terapia , Feminino , Humanos , Infarto/diagnóstico , Infarto/etiologia , Infarto/terapia , Doenças Musculares/diagnóstico , Doenças Musculares/etiologia , Doenças Musculares/terapia , Recidiva
8.
Rev. chil. endocrinol. diabetes ; 4(3): 198-200, jul. 2011. tab
Artigo em Espanhol | LILACS (Américas) | ID: lil-640639

RESUMO

Diffuse muscular involvement is common in hypothyroidism and ranges from asymptomatic elevation of creatine kinase levels to severe muscle weakness and rhabdomyolysis. We report a 74 years old male that developed a progressive muscle weakness without muscle pain, during the course of an hypothyroidism secondary to a silent thyroiditis. Laboratory showed a TSH of 149 uUI/ml, a thyroxin of 1.5 ug/dl a free thyroxin of less than 0.15 ng/dl and a creatine kinase of 4345 U/l. Treatment with levothyroxine rapidly reverted the muscular alterations.


Assuntos
Humanos , Masculino , Idoso , Doenças Musculares/etiologia , Hipotireoidismo/complicações , Doença Aguda , Hipotireoidismo/tratamento farmacológico , Tempo de Internação , Rabdomiólise/etiologia , Resultado do Tratamento , Tiroxina/uso terapêutico
9.
Rev. chil. enferm. respir ; 27(2): 80-93, jun. 2011. ilus, tab
Artigo em Espanhol | LILACS (Américas) | ID: lil-597551

RESUMO

Dyspnea and decreased exercise capacity are the main factors that limit the daily living activities in patients with chronic respiratory diseases. The cardinal symptoms limiting exercise capacity in most patients with chronic obstructive pulmonary disease (COPD) are dyspnea and fatigue, which could be caused by alveolar ventilation and gas exchange disturbances, skeletal muscle dysfunction and/or cardiovascular failure. Anxiety, lack of motivation and depression were also associated with reduced exercise capacity, probably affecting the perception of symptoms. The relationship between psychological status and mood disorders in patients with COPD and exercise tolerance is complex and not yet fully understood. The origin of the exercise capacity limitation in COPD patients is multifactorial, so the separation of the variables involved for academic purposes is not always feasible. The pathogenic mechanisms may interact in complex ways, as an example, muscle deconditioning and hypoxemia can increase alveolar ventilation causing exercise limitation. Therefore, physical training and supplemental oxygen can reduce ventilatory limitation during exercise without changing lung function and maximum ventilatory capacity. The analysis of these factors could potentially identify reversible conditions that can improve the exercise performance and quality of life ofpatients with COPD, such as hypoxemia, bronchospasm, heart failure, arrhythmias, musculoskeletal dysfunction and myocardial ischemia. This review examines the principal mechanisms contributing to physical activity limitation in patients with COPD: alveolar ventilation and gas exchange abnormalities, cardiovascular and musculoskeletal system dysfunction, and respiratory muscles dysfunction.


La disnea y la disminución de la capacidad de realizar ejercicio son los principales factores que limitan las actividades de la vida diaria en pacientes con enfermedades respiratorias crónicas. Los síntomas cardinales que limitan la capacidad de ejercicio en la mayoría de los pacientes con enfermedad pulmonar obstructiva crónica (EPOC) son la disnea y/o fatigabilidad, los cuales pueden ser ocasionados por trastornos de la ventilación alveolar e intercambio gaseoso, disfunción de los músculos esqueléticos y/o falla cardiovascular. La ansiedad, falta de motivación y depresión también han sido asociadas a una menor capacidad de realizar ejercicio, probablemente afectando la percepción de los síntomas. La relación entre el estado psicológico y los trastornos del ánimo en pacientes con EPOC y la tolerancia al ejercicio es compleja y aún no ha sido completamente dilucidada. El origen de la limitación de la capacidad de ejercicio en pacientes con EPOC es multifactorial, por lo cual la separación de las variables involucradas con fines académicos no siempre es factible realizarlo en los pacientes. Los mecanismos patogénicos pueden relacionarse en forma compleja, a modo de ejemplo, el desacondicionamiento físico y la hipoxemia pueden contribuir a aumentar la ventilación alveolar ocasionando limitación del ejercicio de causa ventilatoria. Por lo tanto, el entrenamiento físico y el suplemento de oxígeno pueden reducir la limitación ventilatoria durante el ejercicio sin modificar la función pulmonar o la capacidad ventilatoria máxima. El análisis de los factores limitantes de la capacidad de ejercicio permite identificar trastornos potencialmente reversibles que pueden mejorar la calidad de vida de los enfermos, tales como la hipoxemia, broncoespasmo, insuficiencia cardiaca, arritmias, disfunción musculoesquelética y/o isquemia miocárdica. En esta revisión se examinan los principales mecanismos que contribuyen a la limitación de la actividad física en pacientes con EPOC:...


Assuntos
Humanos , Tolerância ao Exercício , Doença Pulmonar Obstrutiva Crônica/fisiopatologia , Doença Pulmonar Obstrutiva Crônica/reabilitação , Consenso , Dispneia/fisiopatologia , Exercício Físico , Doenças Musculares/etiologia , Músculos Respiratórios/fisiopatologia , Apoio Nutricional , Oxigenoterapia , Troca Gasosa Pulmonar , Ventilação Pulmonar , Qualidade de Vida , Sistema Cardiovascular/fisiopatologia
10.
Indian J Med Sci ; 2011 May; 65(5) 186-192
Artigo em Inglês | IMSEAR (Sudeste Asiático), GHL | ID: sea-145609

RESUMO

Background: The complications associated with type 2 Diabetes Mellitus (DM) may cause functional impairment in older people. Recently it has been proved that motor dysfunction in the form of skeletal muscle dysfunction does occur in type II DM. However very few studies have assessed the upper limb skeletal muscle dysfunction. Objectives: The study was aimed to assess the hand grip strength, endurance in type 2 DM patients and compare the same with age matched healthy controls. We also correlated glycosylated Hb and duration of illness with the hand grip strength and endurance in the patients. Materials and Methods: Hand grip dynamometer was used to measure the hand grip strength and endurance in sixty diagnosed patients of type II DM. Similar tests were performed in age matched healthy controls. Blood samples were collected for blood glucose fasting, postprandial levels and Hb1AC in both the groups. Comparisons between patients and controls, and correlations were done by applying suitable tests. Results: The hand grip muscle strength and endurance in type II DM patients were significantly lower as compared to the normal controls (P < 0.05, P < 0.001). There was no correlation between the hand grip muscle strength and endurance with HbA1c and the duration of the disease in the patients of type II DM (P > 0.05). Conclusions: The present study shows that type II DM patients suffer from skeletal muscle dysfunction in the form of reduced hand grip strength and endurance. Hence the treating Physician should not be ignorant about these disabilities. In addition to the strict measures to control the blood glucose levels, interventions to improve the muscle mass and strength in these patients should be undertaken.


Assuntos
Adulto , Idoso , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/epidemiologia , Força da Mão/fisiologia , Hemoglobina A Glicada/análise , Humanos , Índia/epidemiologia , Masculino , Doenças Musculares/diagnóstico , Doenças Musculares/etiologia , Força Muscular/fisiologia , Resistência Física/fisiologia
12.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-173901

RESUMO

Hypothyroidism can cause a variety of signs and symptoms of the neuromuscular system. However, ptosis in a patient with hypothyroidism is very rare. We report here on a case of central hypothyroidism that was due to Sheehan's syndrome and it manifested as bilateral ptosis in a 51-yr-old woman. She complained of exertional dyspnea and weakness. About 25-yr ago, she had a history of severe postpartum vaginal bleeding. The laboratory studies demonstrated hypopituitarism with secondary hypothyroidism. The ptosis was improved by replacement of thyroid hormone. Hypothyroidism should be considered in the differential diagnosis of patients who manifest with ptosis and that prompt replacement of hormone can lead to a complete recovery.


Assuntos
Blefaroptose/complicações , Eletromiografia , Feminino , Glucocorticoides/uso terapêutico , Humanos , Hipopituitarismo/complicações , Hipotireoidismo/complicações , Imagem por Ressonância Magnética , Pessoa de Meia-Idade , Doenças Musculares/etiologia , Junção Neuromuscular/fisiopatologia , Prednisolona/uso terapêutico , Tiroxina/uso terapêutico
13.
Saudi Medical Journal. 2010; 31 (8): 931-934
em Inglês | IMEMR (Mediterrâneo Oriental) | ID: emr-145030

RESUMO

Carnitine-acylcarnitine translocase [CACT] deficiency [McKusick 212138] is a rare life threatening disorder characterized by hypoketotic hypoglycemia, hyperammonemia, encephalopathy, cardiomyopathy hepatopathy, and myopathy. Here, we present a detailed clinical course of 3 Saudi siblings with a severe phenotype. The third patient was described in more detail. Early medical intervention in the form of 25% dextrose intravenous infusion and carnitine supplement followed by a gradual introduction of a high carbohydrate low fat special formula resulted in a good clinical and biochemical response to the treatment in our patient. However, early nephrocalcinosis, severe hypotonia, and subsequently intravascular cerebral accident could not be prevented. He died at 18 months of age as a result of metabolic decompensation. This suggests that CACT deficiency is still a lethal disorder even with an early and aggressive medical intervention


Assuntos
Humanos , Masculino , Fenótipo , Hipoglicemia/etiologia , Hiperamonemia/etiologia , Encefalopatias Metabólicas/etiologia , Cardiomiopatias/etiologia , Doenças Musculares/etiologia
15.
Kinesiologia ; 27(2): 18-26, jun. 2008. ilus, graf
Artigo em Espanhol | LILACS (Américas) | ID: lil-503400

RESUMO

El daño muscular inducido por sobrecarga es frecuente. Los estudios de estructura y función han configurado dos vertientes que intentan aclarar sus mecanismos. La primera se entiende con la generación de excesivas tensiones en elongación por estrés mecánico, reconocidas como las responsables del daño estructural del músculo, involucrando a proteínas tales como Titina, Desmina y Distrofina. La segunda provocada a partir de la alteración en la regulación intracelular del calcio por estrés metabólico, activando proteasas como Calpaína 3, fosfolipasas y especies reactivas de oxígeno. Una vez gatillados estos procesos, se inician una serie de eventos que inducen la reparación con la activación de factores de transcripción, miogénicos y de respuesta al estrés, mientras que la regeneración se caracteriza por la síntesis y la remodelación tisular.


Muscle damage by overload is frequent. Structural and functional studies oriented to clarify the mechanisms involved in this process have raised two possible and complementary explanations. The first one refers to the generation of a large tension by mechanical stress, wich could be responsible of the structural damage of the muscle and involve proteins such as Titina, Desmina and Dystrophin. The second one is originated by changes in the regulation of intracellular calcium concentration as a consequence of the metabolic stress of the fibre and subsequent activation of proteases like Calpain 3, phospholipases and reactive oxygen species. Once triggered these processes, are initiated a series of events that induce the repair with activation transcription, miogenic and stress factors, while regeneration is characterized the synthesis an tissue remodelation.


Assuntos
Humanos , Exercício Físico , Doenças Musculares/fisiopatologia , Músculo Esquelético/fisiopatologia , Estresse Mecânico , Fenômenos Biomecânicos , Cálcio/metabolismo , Doenças Musculares/etiologia , Contração Isométrica , Músculo Esquelético/fisiologia , Proteínas Musculares/metabolismo , Recuperação de Função Fisiológica , Regeneração
16.
Rev. chil. pediatr ; 79(2): 146-151, abr. 2008. tab
Artigo em Espanhol | LILACS (Américas) | ID: lil-496228

RESUMO

Background: The Newborn Hypotonic Syndrome (NHS) is a clinical entity that presents up to 28 days after birth. The main symptom is a significant decrease in muscular tone, but its severity is determined by the lack of muscular strength. NHS is a relatively frequent entity, so it becomes an important diagnosis problem. There is few information in literature regarding its incidence. Method: Retrospective study performed between May 2000 - April 2006, including patients with diagnosis of NHS in a Neonatal Intesive Care Unit. Results: 2 158 newborns, of which 113 (5.2 percent) had NHS. 83 percent of cases were attributed to central causes, such as hipoxic-isquemic encephalopathy (49 percent) and genetic disorders (15 percent). 17 percent of cases corresponded to peripheral causes, including hypermagnesemia (68 percent) and myopathic diseases (21 percent). Conclusions: 1) NHS is a relatively frequent clinical entity; 2) Central causes are the most prevalent; 3) It is possible to study the etiology of NHS with a systematic approach.


Introducción: El síndrome hipotónico del recién nacido (SHRN) es un cuadro clínico que se presenta hasta los 28 días de vida extrauterina. Su síntoma definitorio es la disminución significativa en tono muscular, pero su gravedad se relaciona a asociación a falta de fuerzas. Es un cuadro aparentemente poco frecuente en este grupo etáreo, pero que plantea un problema diagnóstico importante. Existe escasa información en la literatura respecto a su frecuencia real. Objetivo: Evaluar la incidencia de SHRN, su etiología y aprobación diagnóstica. Método: Estudio retrospectivo con revisión de fichas clínicas, desde mayo 2000 a abril 2006, incluyendo pacientes ingresados con diagnóstico de SHRN a unidad de intermedio-intensivo de servicio de recién-nacidos de un hospital universitario (SRNU). Resultados: El número total de RN ingresados a SRNU fue 2158, en 5,2 por ciento (113) el motivo de ingreso, principal o secundario, correspondió a SHRN. Del total de SHRN, 83 por ciento correspondió a causas centrales, destacando encefalopatía hipóxico-isquemica (ehi) (49 por ciento) y genetopatía (15 por ciento). Las causas periféricas correspondieron a 17 por ciento, destacando hipermagnesemia (68 por ciento) y miopatías (21 por ciento). Conclusiones: Con los datos obtenidos, es posible concluir para este estudio: 1) El SHRN es una entidad clínica relativamente frecuente; 2) Las causas centrales son las más frecuentes; 3) Es posible estudio escalonado orientado a encontrar etiología específica del SHRN.


Assuntos
Humanos , Recém-Nascido , Doenças Musculares/epidemiologia , Doenças Musculares/etiologia , Doenças do Recém-Nascido/epidemiologia , Doenças do Recém-Nascido/etiologia , Chile/epidemiologia , Doenças Musculares/patologia , Hipotonia Muscular/etiologia , Incidência , Estudos Retrospectivos , Síndrome
17.
Qatar Medical Journal. 2008; 17 (1): 71-75
em Inglês | IMEMR (Mediterrâneo Oriental) | ID: emr-89949

RESUMO

Inflammatory myopathies are heterogeneous groups of immune mediated myopathies that present as pure form or in association with other auto-immune diseases or malignancy. There are three major subsets: dermatomyositis, polymyositis and sporadic inclusion body myositis. This review highlights our understanding of these disorders, their clinical aspects, diagnosis, pathogenesis and treatment. The idiopathic inflammatory myopathies occurring alone or in association with auto-immune disease and / or cancer have an overlapping clinical presentation with an overall incidence of 3.0 to 7.8 per million and a prevalence from 10 to 60 per million. Because of the variability in epidemiological studies, the interpretation of these results cannot be conclusive. Recent evidence indicates that polymyositis is over diagnosed and many reported cases are likely to be some other disorders. Decreasing the incidence of true polymyositis is due to reliance not only on clinical criteria but also on immunopathological changes in muscle biopsies. Polymyositis and inclusion body myositis occur primarily in adults, whereas dermatomyositis occurs in adults and children between five and fifteen years of age. Sporadic inclusion body myositis affects almost exclusively men over the age of 50 years


Assuntos
Humanos , Doenças Musculares/patologia , Doenças Musculares/etiologia , Inflamação , Dermatomiosite , Polimiosite , Miosite de Corpos de Inclusão
18.
Indian Pediatr ; 2007 Jul; 44(7): 522-5
Artigo em Inglês | IMSEAR (Sudeste Asiático), GHL | ID: sea-8590

RESUMO

We investigated cases of the annual seasonal outbreaks of acute hepato-myo-encephalopathy in young children in western Uttar Pradesh for causal association with Cassia occidentalis poisoning, by a prospective survey in 2006. During September-October homes of 10 consecutive cases were visited and history of eating Cassia beans was obtained in all. Nine children died within 4-5 days. There appears to be an etiological association between consumption of Cassia occidentalis beans and acute hepato-myo-encephalopathy.


Assuntos
Encefalopatias/etiologia , Estudos de Casos e Controles , Criança , Pré-Escolar , Coma/etiologia , Surtos de Doenças , Meio Ambiente , Feminino , Humanos , Índia/epidemiologia , Hepatopatias/etiologia , Masculino , Doenças Musculares/etiologia , Estudos Prospectivos , População Rural , Sementes , Senna (Planta)/envenenamento , Síndrome
19.
Bol. Hosp. San Juan de Dios ; 54(1): 59-60, ene.-feb. 2007.
Artigo em Espanhol | LILACS (Américas) | ID: lil-464596

RESUMO

El Síndrome de Sharp es una conectivitis en cuyo cuadro clínico se combinan manifestaciones de varias de las mesenquimopatias más frecuentes. Entre sus principales síntomas destacan el Síndrome de Raynaud; las poliartralgias de manos y las mialgias. El Síndrome de Sharp, generalmente no compromete la piel ni las vísceras y entre ellas especialmente el riñón. En el aspecto inmunológico, es característica la presencia, en el suero, y a título elevados de anticuerpos anti RNP. El pronóstico del Síndrome de Sharp es habitualmente benigno y se describe incluso evoluciones regresivas.


Assuntos
Humanos , Doença Mista do Tecido Conjuntivo/diagnóstico , Artropatias/etiologia , Doença Mista do Tecido Conjuntivo/complicações , Doença de Raynaud/etiologia , Doenças Musculares/etiologia
20.
Journal of the Faculty of Medicine-Baghdad. 2007; 49 (1): 69-72
em Inglês | IMEMR (Mediterrâneo Oriental) | ID: emr-83780

RESUMO

To document electromyographic changes in thyrotoxic patients, and to categorize the type of myopathic process in thyrotoxicosis. This case control study was designed to show the electromyographic changes in thyrotoxic patients and to compare these findings with that of normal aged matched controls to show the significance of these changes in thyrotoxic patients. Student's test was applied on the results and P value was extracted. Subjects in this study were chosen according to certain criteria depending mainly on their blood level of thyroid hormone [T3, and T4] and TSH. All of them are thyrotoxic patients, their ages range between 15 to 45 years. They were 25 patients [15 female and 10 males]. Another 25 subjects were chosen as normal controls they were of the same age and sex, patients with features of myopathy or neuropathy from diseases other than thyrotoxicosis were excluded carefully from studied patients and the normal controls. EMG finding in thyrotoxic patients was as follows: No spontaneous activities in the proximal muscles [deltoid and in rectus femoris muscles]. The amplitude of the motor unit action potentials was ranging between [200-800 microv] with a mean of [488.8 +/- 159.3 microv.] in the deltoid muscle, while the amplitude of the action potential. In rectus femoris muscle in thyrotoxic patients was ranging between [350-900 microv.] in abductor pollicis brevis muscle the action potential amplitude in thyrotoxic patients was ranging between [500-2150 microv.], there was significant difference between thyrotoxic patients and normal controls. The duration of the motor unit potential in thyrotoxic patients was ranging between [7-11.5 msec.] with a mean of [8.51 +/- 1.24 msec] in the deltoid muscle, slightly higher figures in rectus femoris muscle, this indicates significant difference in the duration of action potential between patients and normal controls. The other parameters of EMG study all indicate a myopathic process involving proximal muscles in 76% of thyrotoxic patients and a neuropathic process involving distal muscles in 28% of thyrotoxic patients. 1-thyrotoxicosis involves proximal muscles more than distal muscles. 2-myopathic process in thyrotoxicosis can be observed clearly in EMG study of the proximal muscles. 3-EMG findings in thyrotoxic myopathy includes, short duration polyphasic potentials, with early recruitment full interference pattern. 4-Distal muscles in thyrotoxic patients may show EMG findings of a rather neuropathic process


Assuntos
Humanos , Masculino , Feminino , Eletromiografia , Doenças Musculares/etiologia , Estudos de Casos e Controles , Hormônios Tireóideos/sangue
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