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1.
Vaccimonitor (La Habana, Print) ; 29(1)ene.-abr. 2020. tab, graf
Artigo em Espanhol | LILACS (Américas), CUMED | ID: biblio-1094638

RESUMO

La enfermedad meningocócica provoca cada año más de 500.000 casos y 85.000 muertes en el mundo y un 20 por ciento de los sobrevivientes sufre secuelas. En Cuba, en 1980, la incidencia llegó a 14,4 por 100.000 habitantes para todas las edades y fue declarada como el principal problema de salud del país. En niños menores de 1 año se reportaron más de 120 casos por 100.000 habitantes en algunas provincias. En 1989, investigadores en La Habana, Cuba desarrollaron una vacuna contra meningococo B y C; VA-MENGOC-BC®, la primera en el mundo eficaz contra el meningococo del serogrupo B. Su eficacia de 83 por ciento se demostró en un estudio de campo prospectivo a doble ciegas, aleatorizado, contra placebo. En su producción se empleó por primera vez la tecnología vesicular o proteoliposómica. Esta vacuna se usó en una campaña de vacunación masiva y posteriormente fue incluida en el Programa Ampliado de Inmunización en Cuba y tuvo un impacto acumulado sobre la incidencia de la enfermedad meningocócica del serogrupo B superior a 95 por ciento (93 por ciento-98 por ciento). La vacunación masiva y sistemática cambió el espectro de cepas del meningococo en los portadores asintomáticos sanos y la circulación de cepas en las poblaciones hacia fenotipos no virulentos. La enfermedad dejó de ser un problema de salud en el país. VA-MENGOC-BC® es la vacuna contra la enfermedad meningocócica del serogrupo B que se aplicó en el mayor número de susceptibles en el mundo. En América Latina se administraron más de 60 millones de dosis. En varios países donde se ha usado VA-MENGOC-BC®, circulan cepas diferentes a la vacunal y contra todas ellas se demostró un elevado porcentaje de efectividad (55%-98% en menores de 4 años y 73 por ciento-100 por ciento en mayores de 4 años). VA-MENGOC-BC® y su tecnología proteoliposómica han tenido impacto y mantienen su potencialidad, no solo en la enfermedad meningocócica, sino en el desarrollo de otras vacunas y adyuvantes(AU)


Every year, meningococcal infection by Neisseria meningitidis causes over 500,000 cases and 85,000 deaths in the world, with 20 percent of survivors suffering sequelae. In Cuba its incidence in 1980 reached 5.9 cases per 100,000 population; about 80 percent of cases were serogroup B, prompting health authorities to declare meningococcal disease the country's main public health problem. Several provinces reported over 120 cases per 100,000 children aged <1 year, overwhelmingly serogroup B. At that time, no vaccines existed with proven efficacy against N. meningitidis serogroup B, nor was there a vaccine candidate that could be successful in the short term. By 1989, researchers in Havana had developed a Cuban meningococcal B and C vaccine, VA-MENGOC-BC®, the world's first against serogroup B meningococcal disease. Its efficacy of 83% was demonstrated in a prospective, randomized, double-blind, placebo-controlled field study. Vaccine production used vesicle or proteoliposome technology for the first time. The same year, the World Intellectual Property Organization awarded its gold medal to the main authors of the VA-MENGOC-BC® patent. The vaccine was used in a mass vaccination campaign and later included in Cuba's National Immunization Program, with a cumulative impact on incidence of serogroup B meningococcal disease greater than 95 percent (93 percent-98 percent). Mass, systematic vaccination shifted the spectrum of meningococcal strains in healthy asymptomatic carriers and strains circulating among population groups toward nonvirulent phenotypes. The disease ceased to be a public health problem in the country. VA-MENGOC-BC® is the most widely applied vaccine against serogroup B meningococcal disease in the world. Over 60 million doses have been administered in Latin America. In several countries where it has been applied, in which strains other than the vaccine-targeted strains circulate, VA-MENGOC-BC® has demonstrated effectiveness against all (55%-98% in children aged ≥4 years and 73 percent-100 percent in children aged >4 years). The vaccine and its proteoliposome technology have had an impact and continue to have potential, not only for meningococcal disease, but also for development of other vaccines and adjuvants(AU)


Assuntos
Vacinas Meningocócicas , Medicamentos de Referência , Infecções Meningocócicas/epidemiologia , Estudos Prospectivos , Vacinação , Cuba
2.
Rev. cient. odontol ; 8(1): e005-e005, ene.-abr. 2020. tab.
Artigo em Espanhol | LILACS (Américas), LIPECS | ID: biblio-1095495

RESUMO

Objetivo: Identificar los factores asociados a la presencia de los defectos de desarrollo del esmalte (DDE) de la dentición decidua. Material y métodos: El diseño de investigación fue, observacional, prospectivo y transversal; la muestra fue de 135 niños, 37 cumplieron los criterios de inclusión para el estudio, todos fueron evaluados en un consultorio dental. Resultados: Se realizó el análisis estadístico de los datos de manera descriptiva, con (chi-cuadrado, coeficiente de contingencia y gamma) para encontrar y evaluar las relaciones, respecto al DDE. El 59% de los niños evaluados fueron de sexo masculino, mientras que el 41% fueron niñas; en todos se encontró opacidad difusa. El nacimiento pretérmino se presentó en un 30% de los casos estudiados, mientras que el 70% cumplió el ciclo normal. La opacidad difusa fue la más prevalente. El 27% que nació con bajo peso presentan DDE. Se reportaron 4 niños con hipoplasia, de los cuales todos nacieron con un peso normal (>2500 gramos), solo 10 niños del total tuvieron un bajo peso, de entre 1500 y 2500 gramos y la mayoría fueron afectados por una opacidad difusa. El 78% de los niños presentó DDE en la zona anterior de la dentición. Conclusión: Los factores asociados en la aparición de DDE en el presente estudio no sería ninguno de los factores citados; sin embargo, el análisis descriptivo desarrollado establece que el sexo del bebé, el peso al nacer, el tipo de parto, las infecciones maternas durante la gestación y las infecciones durante el primer año de vida del bebé, podrían influenciar. (AU)


Objective: To identify the factors associated with the presence of enamel development defects (DDE) of deciduous teeth. Material and methods: This was a descriptive, prospective, transversal, observational study. The sample included 135 children, 37 of whom met the inclusion and exclusion criteria of the study and all were evaluated in a dental office. Results: Descriptive statistical analysis of the data was performed with the chi-square test, contingency coefficients and gamma statistics to determine and evaluate the relationships with respect to DDE. 59% of the children evaluated were male while 41% were females, with all showing diffuse opacity. Preterm birth occurred in 30% of the cases studied, while 70% had been delivered at term. Of the children with DDE, 27% were underweight at birth. Four children with hypoplasia had had a normal weight at birth (>2500 grams), while only 10 children had a low weight (1500-2500 g), and most presented diffuse opacity. 78% of children had DDE in the previous teething area. Conclusion: The factors associated with the occurrence of DDE in this study were not related to any of the factors cited; however sex, birth weight, type of delivery, maternal infections during pregnancy and infections during the first year of the baby's life may influence the presence of DDE. (AU)


Assuntos
Humanos , Dente Decíduo , Esmalte Dentário , Estudos Transversais , Estudos Prospectivos , Estudos Observacionais como Assunto
3.
Int. arch. otorhinolaryngol. (Impr.) ; 24(1): 62-67, Jan.-Mar. 2020. tab, graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-1090549

RESUMO

Abstract Introduction Posttonsillectomy pain results in significant morbidity to the patients. There is a disagreement in the literature regarding the use of local anesthetics during tonsillectomy. The aim of this placebo-controlled, double-blind study is to evaluate the effect of peritonsillar administration of local anesthetics. Objective To evaluate the role of intraoperative use of analgesics in tonsillar fossa and postoperative evaluation with visual analogue scale (VAS) scores in achieving pain relief after tonsillectomy procedure Methods In this study, 180 patients were randomized to 1 of the 6 groups: bupivacaine infiltration, lidocaine infiltration, normal saline infiltration, bupivacaine packing, lidocaine packing, and normal saline packing. Pain caused by speaking, swallowing, and on rest was assessed using VAS at 4, 8, 12, 16 hours, and at discharge. Results Significant analgesia was obtained in patients who received bupivacaine infiltration and packing compared with placebo (p < 0.05). The majority of the study subjects had no postoperative complications, and patients receiving bupivacaine infiltration required less additional analgesics in the first 24 hours after surgery. Conclusion We advocate the use of bupivacaine infiltration or packing immediately following the procedure to achieve adequate postoperative analgesia.


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Dor Pós-Operatória/tratamento farmacológico , Tonsilectomia , Analgesia , Analgésicos/administração & dosagem , Analgésicos/uso terapêutico , Cuidados Intraoperatórios , Dor Pós-Operatória/diagnóstico , Dor Pós-Operatória/prevenção & controle , Paquistão , Placebos/administração & dosagem , Complicações Pós-Operatórias , Medição da Dor/métodos , Bupivacaína/administração & dosagem , Bupivacaína/uso terapêutico , Método Duplo-Cego , Estudos Prospectivos , Injeções Intravenosas , Lidocaína/administração & dosagem , Lidocaína/uso terapêutico
4.
Int. arch. otorhinolaryngol. (Impr.) ; 24(1): 24-30, Jan.-Mar. 2020. tab, graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-1090560

RESUMO

Abstract Introduction Facial nerve palsy results in both functional disability and psychological morbidity. There are several well-established grading scales to quantify the quality of life of these patients. Objective Translate and validate the Facial Clinimetric Evaluation (FaCE) scale and Synkinesis Assessment Questionnaire (SAQ) to Brazilian Portuguese. Methods This study adopted a forward-backward translation method and performed cross-cultural adaptation. A pilot study was conducted to correct any confusing language and to evaluate content validity. A validation study was then performed. Internal consistency of the Brazilian Portuguese version of the FaCE and SAQ items was evaluated by Cronbach's alpha coefficient. Construct validity was assessed by Spear- man's Rank Correlation Coefficient between FaCE and SAQ scores to eFACE, House- Brackmann, Short Form 12 (SF-12) and Facial Disability Index (FDI) (sub)scores. Results A total of 90 patients were included. Cronbach's alpha for total domain scored 0.881 for FaCE and 0.809 for SAQ. FaCE total score correlation to eFACE total and House- Brackmann showed Spearman's r value of 0.537 and -0.538, respectively (p < 0.001). SAQ correlation to eFACE synkinesis subdomain was -0.449 (p < 0.001). No correlation was found between SAQ and HB score. FaCE total score correlations were of 0.301 and 0.547 for SF-12 PCS and MCS, respectively (p < 0.001). Correlation between FaCE total and FDI Physical and Social/well-being functions were 0.498 and 0.567 (p < 0.001). Conclusion Brazilian Portuguese FaCE scale and SAQ versions achieved high validity and reliability in the present study. These translated instruments demonstrated good psychometric properties, being proper to use in clinical practice in Brazil and with Brazilian Portuguese speakers.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Tradução , Inquéritos e Questionários , Sincinesia , Paralisia Facial , Qualidade de Vida , Índice de Gravidade de Doença , Brasil , Projetos Piloto , Estudos Prospectivos , Reprodutibilidade dos Testes , Avaliação da Deficiência
5.
Rev. Hosp. Ital. B. Aires (2004) ; 40(1): 4-10, mar. 2020. ilus, tab
Artigo em Espanhol | LILACS (Américas) | ID: biblio-1100756

RESUMO

Se realizó un estudio prospectivo y descriptivo, incluyendo 103 pacientes que fueron tratados por cáncer de laringe en etapa inicial (T1-T2) con cirugía transoral. De ellos, 55 se diagnosticaron en estadio T1, 16 en estadio T1-b y 32 en estadio T2. El control local inicial (CLI) en pacientes con tumores malignos de laringe estadificados T1 fue 91%, el control local con rescate (CLR) 96%, la preservación de la función de la laringe (PFL) 93% y la sobrevida específica 96%. En T1-b, el CLI fue 81%, el CLR 94%, la PFL 94% y la sobrevida específica 94%. En T2, el CLI fue 63%, el CLR 94%, la PFL 72% y la sobrevida específica 78%. La cirugía transoral en cáncer de laringe con T inicial tiene resultados oncológicos similares a otros tratamientos (cirugía externa o radioterapia), pero consideramos que es la mejor opción por su baja morbilidad, menor duración del tratamiento, y porque deja abiertas todas las posibilidades para tratar posibles recurrencias. (AU)


A prospective and descriptive study was conducted, including 103 patients who were treated for early stage laryngeal cancer (T1-T2) with transoral surgery. Of these, 55 were diagnosed in stage T1, 16 in stage T1-b and 32 in stage T2. The initial local control (CLI) in patients with malignant T1 laryngeal tumors was: 91%, local control with rescue (CLR) 96%, preservation of larynx function (PFL) 93% and specific survival 96%. In T1-b the CLI was 81%, the CLR 94%, the PFL 94% and the specific survival 94%. In T2 the CLI was 63%, the CLR 94%, the PFL 72% and the specific survival 78%. Transoral surgery in laryngeal cancer with initial T has oncological results similar to other treatments (external surgery or radiotherapy), but we consider that it is the best option because of its low morbidity, shorter duration of treatment, and because it leaves open all the possibilities to treat possible recurrences. (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias Laríngeas/cirurgia , Recidiva Local de Neoplasia/prevenção & controle , Complicações Pós-Operatórias/prevenção & controle , Procedimentos Cirúrgicos Operatórios/métodos , Prega Vocal/patologia , Qualidade da Voz , Traqueostomia/estatística & dados numéricos , Neoplasias Laríngeas/classificação , Neoplasias Laríngeas/diagnóstico , Neoplasias Laríngeas/fisiopatologia , Neoplasias Laríngeas/mortalidade , Neoplasias Laríngeas/radioterapia , Estudos Prospectivos , Epiglote/patologia , Duração da Terapia , Intubação Gastrointestinal/estatística & dados numéricos
6.
Rev. inf. cient ; 99(1): 3-11, ene.-feb. 2020. tab
Artigo em Espanhol | LILACS (Américas) | ID: biblio-1093924

RESUMO

RESUMEN Introducción: En el Hospital General Docente "Dr. Agostinho Neto" de Guantánamo no se han caracterizado las adolescentes maternas ingresadas en la Unidad de Cuidados Intensivos (UCI). Objetivo: Caracterizar la morbilidad materna en adolescentes ingresadas en la UCI del Hospital General Docente "Dr. Agostinho Neto" de Guantánamo durante el año 2019. Método: Se realizó un estudio observacional, prospectivo y transversal, con todas las maternas adolescentes ingresadas en dicha unidad durante el 2019. En cada una se analizó la edad, antecedentes patológicos, estado al egreso, modo de terminar el embarazo, realización de tratamiento quirúrgico, enfermedades relacionadas o no con el embarazo, complicaciones y si se trataron con ventilación mecánica. Resultados: El 18,2 % de las maternas ingresadas fueron adolescentes (3,2 del total de ingresos en la unidad). El 9,7 % recibió ventilación artificial. El 64,7 % tenía entre 18 y 19 años de edad y todas egresaron vivas. El 23,5 % era asmática, el 70,7 % era puérpera e ingresó por enfermedad obstétrica, al 41,2 % se les realizó tratamiento quirúrgico, el más común fue la histerectomía (41,2 %). La preclampsia grave - eclampsia (23,4 %) y la atonía uterina (25,9 %) fueron las enfermedades más comunes. El choque hipovolémico por atonía uterina (23,4 %) determinó el criterio de morbilidad materna severa. El 52,9 % de las pacientes presentó complicaciones. Conclusiones: La morbilidad materna en adolescentes ingresadas en esta UCI reveló que en esta etapa de la vida fue elevada la morbilidad por complicaciones del embarazo, el parto y el puerperio, lo que es un problema de salud no resuelto en la provincia de Guantánamo.


ABSTRACT Introduction: In the General Teaching Hospital "Dr. Agostinho Neto" of Guantanamo have not characterized the maternal adolescents admitted to the Intensive Care Unit (ICU). Objective: To characterize maternal morbidity in adolescents admitted to the ICU of the General Teaching Hospital "Dr. Agostinho Neto"of Guantanamo during the year 2019. Method: An observational, prospective and cross-sectional study was carried out, with all adolescent mothers admitted to said unit during 2019. In each one, age, pathological history, state at discharge, were analyzed. way of terminating pregnancy, performing surgical treatment, diseases related or not to pregnancy, complications and whether they were treated with mechanical ventilation. Results: 18.2% of the mothers admitted were adolescents (3.2 of the total income in the unit). 9.7% received artificial ventilation. 64.7% were between 18 and 19 years old and all graduated alive. 23.5% were asthmatic, 70.7% were poor and admitted for obstetric disease, 41.2% underwent surgical treatment, the most common was hysterectomy (41.2%). Severe preclampsia-eclampsia (23.4%) and uterine atony (25.9%) were the most common diseases. Hypovolemic shock due to uterine atony (23.4%) determined the criterion of severe maternal morbidity. 52.9% of the patients presented complications. Conclusions: Maternal morbidity in adolescents admitted to this ICU revealed that morbidity due to complications of pregnancy, childbirth and the puerperium was elevated at this stage of life, which is an unresolved health problem in the province of Guantanamo.


RESUMO Introdução: No Hospital Geral de Ensino "Dr. Agostinho Neto" de Guantánamo não foram caracterizadas as adolescentes maternas internadas na Unidade de Terapia Intensiva (UTI). Objetivo: Caracterizar a morbidade materna em adolescentes internadas na UTI do Hospital Geral de Ensino "Dr. Agostinho Neto" de Guantánamo durante o ano de 2019. Método: Foi realizado um estudo observacional, prospectivo e transversal, com todas as mães adolescentes internadas nessa unidade durante o ano de 2019. Em cada uma, foram analisadas a idade, história patológica, estado de alta, maneira de interromper a gravidez, realizar tratamento cirúrgico, doenças relacionadas ou não à gravidez, complicações e se foram tratadas com ventilação mecânica. Resultados: 18,2% das mães admitidas eram adolescentes (3,2 da renda total da unidade). 9,7% receberam ventilação artificial. 64,7% tinham entre 18 e 19 anos e todos se formaram vivos. 23,5% eram asmáticos, 70,7% eram pobres e admitidos por doença obstétrica; 41,2% foram submetidos a tratamento cirúrgico; o mais comum foi a histerectomia (41,2%). Pré-eclâmpsia-eclâmpsia grave (23,4%) e atonia uterina (25,9%) foram as doenças mais comuns. O choque hipovolêmico por atonia uterina (23,4%) determinou o critério de morbidade materna grave. 52,9% dos pacientes apresentaram complicações. Conclusões: A morbidade materna em adolescentes internadas nesta UTI revelou que a morbidade por complicações na gravidez, parto e puerpério estava elevada nesta fase da vida, que é um problema de saúde não resolvido na província de Guantánamo.


Assuntos
Humanos , Gravidez , Adolescente , Complicações na Gravidez , Gravidez na Adolescência , Mortalidade Materna , Estudos Transversais , Estudos Prospectivos , Estudo Observacional
7.
Arch. argent. pediatr ; 118(1): 4-10, 2020-02-00. tab
Artigo em Inglês, Espanhol | LILACS (Américas), BINACIS | ID: biblio-1095269

RESUMO

Introducción. El maltrato infantil es causa frecuente de hospitalización en países en desarrollo. Los niños que sufren algún tipo de abuso físico o psicológico pueden desarrollar problemas de adaptación social. Este estudio analiza los factores de riesgo asociados con el síndrome de maltrato infantil en niños hospitalizados en el Servicio de Urgencias. Población y métodos. Estudio de casos y controles de niños con y sin maltrato infantil en una proporción 1:1, desde enero de 2015 a diciembre de 2016. Se analizaron los factores de riesgo más relevantes; se consideró estadísticamente significativo si la P ≤ 0,05. Resultados. Se incluyeron 148 niños con maltrato y 148 sin maltrato. El maltrato fetal fue el más frecuente, seguido del abandono. El agresor, en la mayoría de los casos, fue un familiar o algún conocido del niño. Ser madre adolescente (oddsratio ajustado [ORa] 3,19; intervalo de confianza [IC] 95 %: 1,49-6,80), baja educación (ORa 4,70; IC 95 %: 2,33-9,45), ingresos económicos bajos (ORa 2,02; IC 95 %: 1,16-3,5), uso de drogas ilegales (ORa 15,32; IC 95 %: 6,22-37,7), niño con discapacidad (ORa 8,58; IC 95 %: 2,76-26,6) y menores de 2 años (ORa 2,08; IC 95 %: 1,20- 3,63) fueron los factores de mayor riesgo para maltrato infantil. Conclusión. Madres adolescentes con bajo nivel socioeconómico tienen mayor riesgo por parte del cuidador. La discapacidad es un factor de riesgo que se incrementa al doble en el análisis multivariado cuando se asocia madre adolescente y consumo de drogas ilegales


Introduction. Child maltreatment is a common cause of hospitalization in developing countries. Children who suffer some type of physical or psychological abuse may develop social adaptation problems. This study analyzed the risk factors associated with child maltreatment syndrome in children admitted to the Emergency Department. Population and methods. This was a case-control study of children who suffered maltreatment and controls at a 1:1 ratio conducted between January 2015 and December 2016. The most relevant risk factors were analyzed; a p value ≤ 0.05 was considered statistically significant. Results. In total, 148 children who suffered maltreatment and 148 controls were included. Fetal abuse was the most common problem, followed by neglect. In most cases, the abuser was a relative or acquaintance of the child. Being a teenage mother (adjusted odds ratio [aOR]: 3.19; 95 % confidence interval [CI]: 1.49-6.80), a low level of education (aOR: 4.70; 95 % CI: 2.33-9.45), a low income (aOR: 2.02; 95 % CI: 1.16-3.5), illegal drug use (aOR: 15.32; 95 % CI: 6.22-37.7), a child with disability (aOR: 8.58; 95 % CI: 2.76-26.6), and age younger than 2 years (aOR: 2.08; 95% CI: 1.20-3.63) were the highest risk factors for child maltreatment. Conclusion. Teenage mothers with a low socioeconomic level have the higher risk for abuse from a caregiver. Disability is a risk factor that doubles in the multivariate analysis when associated with teenage mothers.


Assuntos
Humanos , Masculino , Feminino , Gravidez , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Maus-Tratos Infantis/etnologia , Maus-Tratos Infantis/estatística & dados numéricos , Fatores de Risco , Classe Social , Estudos de Casos e Controles , Estudos Prospectivos , Transtornos Relacionados ao Uso de Substâncias , Serviços Médicos de Emergência , México
8.
Arch. argent. pediatr ; 118(1): e8-e15, 2020-02-00. tab, ilus
Artigo em Inglês, Espanhol | LILACS (Américas), BINACIS | ID: biblio-1095409

RESUMO

Introducción. Los probióticos y prebióticos presentan beneficios potenciales en la inflamacióncrónica de las mucosas, incluida la prevención de la enterocolitis necrosante. No obstante, los mecanismos y resultados de estos efectos inmunomoduladores son confusos. El objetivo fue investigar la respuesta de las citocinas a Lactobacillus y Bifidobacterium asociados con fructo- y galactooligosacáridos (simbióticos) y lactoferrina en recién nacidos de muy bajo peso al nacer.Población y métodos. Se asignó aleatoriamente a lactantes con ≤32 semanas de gestación y ≤1500 g de peso para recibir simbióticos o 1 ml de agua destilada como placebo desde la primera alimentación hasta el alta. Se obtuvieron muestras de sangre los días posnatales 0 ± 2, 14 ± 2 y 28 ± 2, y se midieron interferón-γ, interleucina (IL)-5, IL-10 e IL-17A.Resultados. En el grupo del estudio (n = 25), la concentración de IL-10 disminuyó a lo largo del estudio (p = 0,011), pero no cambió en el grupo de referencia. La concentración de IL-5 se mantuvo constante los primeros 14 días y luego disminuyó significativamente (p= 0,042) en el grupo del estudio, mientras que aumentó en los primeros 14 días (p = 0,019) y luego disminuyó en 28 días (p = 0,011) en el grupo de referencia (n = 25).La concentración de otras citocinas no cambió a lo largo del estudio.Conclusión. El uso combinado de probióticos con oligosacáridos y lactoferrina estuvo asociado con una disminución en la concentración de IL-10, pero no se observó un cambio en las otras citocinas.


Introduction. Probiotics and prebiotics, which are multifunctional agents, have potential benefits in chronic mucosal inflammation, including the prevention of necrotizing enterocolitis. However, the mechanisms and the results of these immunomodulatory effects are not clear. This study aimed to investigate the cytokine response to the combination of Lactobacillus and Bifidobacterium together with fructo- and galacto-oligosaccharides (symbiotic) and lactoferrin in very low birth weight neonates.Population and Methods. Infants ≤ 32 GWs and ≤ 1,500 g were randomly assigned to receive a symbiotic combination or 1 ml distilled water as placebo starting with the first feed until discharge. Blood samples were obtained at postnatal 0 ± 2, 14 ± 2, and 28 ± 2 days, and the serum levels of interferon-γ, interleukin (IL)-5, IL-10, and IL-17A were measured.Results. In the study group (n = 25), the IL-10 levels decreased throughout the study period (p = 0.011) but did not change in the control group. The IL-5 levels remained steady in the first 14 days and decreased significantly thereafter (p = 0.042) in the study group, whereas they increased in the first 14 days (p = 0.019), and then decreased in 28 days (p = 0.011) in the control group (n = 25). The levels of the other cytokines did not change throughout the study period.Conclusion.The combined use of probiotics with oligosaccharides and lactoferrin was associated with a decrease in IL-10 levels, but no change was observed in the other cytokines.


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Citocinas/análise , Probióticos/uso terapêutico , Prebióticos , Simbióticos/administração & dosagem , Lactoferrina/administração & dosagem , Oligossacarídeos/uso terapêutico , Turquia , Estudos Prospectivos , Citocinas/sangue , Recém-Nascido de muito Baixo Peso , Enterocolite Necrosante/prevenção & controle , Leite Humano
9.
Rev. habanera cienc. méd ; 19(1): 76-91, ene.-feb. 2020. tab
Artigo em Espanhol | LILACS (Américas), CUMED | ID: biblio-1099147

RESUMO

Introducción: La adaptación del corazón humano al acondicionamiento físico ha sido un tema de interés médico-científico, pues el remodelado cardíaco que comprende variación en el tamaño, forma, grosor de las paredes, y masa ventricular responde al tipo de actividad física. Objetivo: Determinar las modificaciones anatómicas del ventrículo izquierdo en kayacistas y canoístas femeninos y masculinos de alto rendimiento. Material y Métodos: Se realizó un estudio prospectivo, descriptivo de corte transversal en deportistas de canotaje de alto rendimiento que acudieron al Instituto de Medicina del Deporte durante la preparación especial con vistas a participar en los Juegos Olímpicos de Rio de Janeiro 2016. La muestra se conformó con 20 deportistas que cumplieron los criterios de inclusión establecidos, se recogieron los resultados de los diferentes parámetros ecocardiográficos que fueron estudiados para comprobar si existía modificación anatómica del ventrículo izquierdo (MAVI). Se empleó la estadística descriptiva e inferencial. Resultados: Edad promedio 20,9 ± 1,18 años, predominio del sexo masculino (65 por ciento); kayak (60 por ciento) y velocidad (55 por ciento) fueron las disciplinas deportivas y modalidades competitivas predominantes , fue frecuente la hipertrofia concéntrica en ambos sexos (65 por ciento), la edad deportiva de igual o menos de 10 años (60 por ciento), espesor relativo de la pared aumentado (65 por ciento), el índice AKS mayor se encontró en la hipertrofia excéntrica (1,3 por ciento) y el porciento de grasa predominante fue en la hipertrofia concéntrica para un (7,9 por ciento). Conclusiones: El espesor relativo de la pared ventricular tuvo una relación significativa con la modalidad competitiva(AU)


Introduction: The adaptation of the human heart to physical conditioning has been a medical and scientific topic of interest where cardiac remodeling involving changes in size, form, thickness of the walls and ventricular mass responds to the type of physical activity. Objective: To determine the anatomical modifications of the left ventricle in high performance male and female canoeing and kayaking athletes. Material and methods: A prospective, descriptive, cross-sectional study was conducted in high performance canoeing athletes that attended the Instituto de Medicina del Deporte during the special training in view of the preparation for the Olympic Games in Rio de Janeiro, 2016. The sample was composed of 20 athletes that fulfilled the established inclusion criteria. The results of the different echocardiographic parameters were collected and analyzed in order to check whether there were anatomical modifications of the left ventricle (AMLV). Differential and descriptive statistics were used. Results: The average age was 20, 9 ± 1, 18 years, the male sex predominated in the study (65 percent), kayak (60 percent) and velocity (55 percent) were the predominant sports disciplines and competitive modalities, respectively. Concentric hypertrophy in both sexes (65 percent), sporting age of 10 years or less (60 percent), and increase in relative wall thickness (65 percent) were frequent; the highest AKS index was found in eccentric hypertrophy (1,3 percent) and predominant fat percentage was observed in concentric hypertrophy (7,9 percent). Conclusions: The relative thickness of the ventricular wall had a significant relationship with the competitive modalities(AU)


Assuntos
Masculino , Feminino , Adolescente , Adulto , Esportes Aquáticos/lesões , Ventrículos do Coração/fisiopatologia , Ventrículos do Coração/diagnóstico por imagem , Ecocardiografia/métodos , Epidemiologia Descritiva , Estudos Transversais , Estudos Prospectivos
10.
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 42(1): 68-71, Jan.-Feb. 2020. tab, graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-1055368

RESUMO

Objective: Circadian dysregulation plays an important role in the etiology of mood disorders. Evening chronotype is frequent in these patients. However, prospective studies about the influence of chronotype on mood symptoms have reached unclear conclusions in patients with bipolar disorder (BD). The objective of this study was to investigate relationship between chronotype and prognostic factors for BD. Methods: At the baseline, 80 euthymic BD patients answered a demographic questionnaire and clinical scales to evaluate anxiety, functioning and chronotype. Circadian preference was measured using the Morningness-Eveningness Questionnaire, in which lower scores indicate eveningness. Mood episodes and hospitalizations were evaluated monthly for 18 months. Results: Among the BD patients, 14 (17.5%) were definitely morning type, 35 (43.8%), moderately morning, 27 (33.7%) intermediate (neither) and 4 (5%) moderately evening. Eveningness was associated with obesity or overweight (p = 0.03), greater anxiety (p = 0.002) and better functioning (p = 0.01), as well as with mood episodes (p = 0.04), but not with psychiatric hospitalizations (p = 0.82). This group tended toward depressive episodes (p = 0.06), but not (hypo)mania (p = 0.56). Conclusion: This study indicated that evening chronotype predicts a poor prognostic for BD. It reinforces the relevance of treating rhythm disruptions even during euthymia to improve patient quality of life and prevent mood episodes.


Assuntos
Humanos , Masculino , Feminino , Adulto , Idoso , Adulto Jovem , Ansiedade/fisiopatologia , Transtorno Bipolar/fisiopatologia , Ritmo Circadiano/fisiologia , Prognóstico , Escalas de Graduação Psiquiátrica , Qualidade de Vida , Fatores de Tempo , Modelos Logísticos , Estudos Prospectivos , Inquéritos e Questionários , Estatísticas não Paramétricas , Transtornos Cronobiológicos/fisiopatologia , Hospitalização/estatística & dados numéricos , Pessoa de Meia-Idade
11.
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 42(1): 72-76, Jan.-Feb. 2020. tab, graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-1055367

RESUMO

Objective: Depression has been associated with hepatitis C, as well as with its treatment with proinflammatory cytokines (i.e., interferon). The new direct-acting antiviral agents (DAAs) have minimal adverse effects and high potency, with a direct inhibitory effect on non-structural viral proteins. We studied the incidence and associated factors of depression in a real-life prospective cohort of chronic hepatitis C patients treated with the new DAAs. Methods: The sample was recruited from a cohort of 91 patients with hepatitis C, of both sexes, with advanced level of fibrosis and no HIV coinfection, consecutively enrolled during a 6-month period for DAA treatment; those euthymic at baseline (n=54) were selected. All were evaluated through the depression module of the Patient Health Questionnaire (PHQ-9-DSM-IV), at three time points: baseline, 4 weeks, and end-of-treatment. Results: The cumulative incidence (95%CI) of major depression and any depressive disorder during DAA treatment was 13% (6.4-24.4) and 46.3% (33.7-59.4), respectively. No differences were observed between those patients with and without cirrhosis or ribavirin treatment (p > 0.05). Risk factors for incident major depression during DAA treatment included family depression (relative risk 9.1 [1.62-51.1]), substance use disorder (11.0 [1.7-73.5]), and baseline PHQ-9 score (2.1 [1.1-3.1]). Conclusions: The findings of this study highlight the importance of screening for new depression among patients receiving new DAAs, and identify potential associated risk factors.


Assuntos
Humanos , Masculino , Feminino , Adulto , Idoso , Antivirais/uso terapêutico , Hepatite C/psicologia , Hepatite C/tratamento farmacológico , Transtorno Depressivo/epidemiologia , Escalas de Graduação Psiquiátrica , Ribavirina/uso terapêutico , Espanha/epidemiologia , Fatores de Tempo , Modelos Logísticos , Incidência , Estudos Prospectivos , Fatores de Risco , Resultado do Tratamento , Hepatite C/epidemiologia , Pessoa de Meia-Idade
12.
Int. j. morphol ; 38(1): 30-34, Feb. 2020. graf
Artigo em Espanhol | LILACS (Américas) | ID: biblio-1056392

RESUMO

Realizar un estudio anatómico in vivo con la especial y pequeña disección quirúrgica durante una colecistectomía laparoscópica sobre las variaciones de la arteria cística. Estudio prospectivo de 38 meses, en 2000 pacientes consecutivos sometidos a colecistectomía laparoscópica programada, sin signos de inflamación aguda, ni alteración que impida disección y correcta evaluación del triángulo hepatocístico. Se disecó quirúrgicamente identificándose la arteria cística y posible duplicación, eran clínicamente importantes aquellas con diámetro mayor a 1,5 mm, requerían maniobra hemostática. Se anotaron los hallazgos en planilla especial a los fines del presente estudio. En 1831 casos había arteria única en medio del triángulo hepatocístico. Hubo 169 variaciones (8,45 %). En 97 casos: doble vascularización, con una arteria en situación normal y otra ubicada lateralmente al triangulo hepatocístico. En 44 pacientes había una arteria única lateralmente al conducto cístico que no lo cruzaba nunca. En 22 casos existía una arteria cruzando el colédoco y el cístico entrando en el triángulo. En 6 oportunidades una doble arteria, una en el triángulo hepatocístico y otra lateralmente que no cruzaba el cístico ni colédoco. En una oportunidad se observó una sola arteria importante que salía directamente de la placa cística entre segmento 4 y 5, y en otro caso solo pequeñas arterias proveniente de la placa cística. Podemos dividirlas en arterias únicas o dobles, en base exclusiva a la necesidad de maniobra hemostática. Podemos decir que las variaciones estarán presentes en aproximadamente 1/12 casos y necesitará una maniobra hemostática especial en 1/20 casos.


This is an anatomical study with the special and small dissection of a laparoscopic cholecystectomy on the surgically important variations of the cystic artery. A prospective, 19-month study was conducted in 2000, including consecutive patients undergoing programmed laparoscopic cholecystectomy, without signs of acute inflammation, or alteration, that would prevent dissection and correct evaluation of the cystohepatic triangle. It was surgically dissected, identifying the main cystic artery and its possible collateral arteries. Those with a diameter greater than 1.5 mm being considered as clinically important, requiring haemostatic maneuver (clipping and / or electrocoagulation). The findings were recorded on a special form for the purposes of this study. The classic, single-artery arrangement in the middle of the cystohepatic triangle was found in 1831 cases. The variations found were 169 (8.45 %). In 97 cases there was double vascularization, with one artery in normal position and another outside the cystic duct. In 44 patients, a single artery that did not cross the cystic was observed. In 22 cases an artery outside the cystic but crossing it before the duct. In 6 cases a double artery, one in the cystohepatic triangle and another outside the triangle, did not cross the cystic or the bile duct. In one instance, a single major artery was seen emerging directly from the cystic plaque between segments four and five. These can be divided into single or double arteries, based exclusively on the need for hemostatic maneuver. Knowledge of anatomical variations of the cystic artery is important for the surgeon. The variation presents in 1 of 12 cases, and requires a special hemostatic maneuver in 1 of 20 cases.


Assuntos
Humanos , Ducto Cístico/irrigação sanguínea , Variação Anatômica , Vesícula Biliar/irrigação sanguínea , Doenças da Vesícula Biliar/cirurgia , Artéria Hepática/anatomia & histologia , Estudos Prospectivos , Colecistectomia Laparoscópica
13.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-762470

RESUMO

Active surveillance culture (ASC) can help detect hidden reservoirs, but the routine use of ASC for extended spectrum β-lactamase-producing Enterobacteriaceae is controversial in an endemic situation. We aimed to determine the prevalence and risk factors of extended spectrum β-lactamase-producing Klebsiella pneumoniae (EBSL-Kpn) colonization among intensive care unit (ICU)-admitted patients. Prospective screening of ESBL-Kpn colonization was performed for ICU-admitted patients within 48 hours for two months. A perirectal swab sample was inoculated on MacConkey agar supplemented with 2 µg/mL ceftazidime. ESBL genotype was determined by PCR-sequencing, and clonal relatedness was evaluated by pulsed-field gel electrophoresis (PFGE). The risk factors of ESBL-Kpn colonization were evaluated. The ESBL-Kpn colonization rate among the 281 patients at ICU admission was 6.4% (18/281), and bla(CTX-M-15) was detected in all isolates. ESBL producers also showed resistance to fluoroquinolone (38.9%, 7/18). All isolates had the same ESBL genotype (bla(CTX-M-15)) and a highly clustered PFGE pattern, suggesting cross-transmission without a documented outbreak. In univariate analysis, the risk factor for ESBL-Kpn colonization over the control was the length of hospital stay (odds ratio=1.062; P=0.019). Routine use of ASC could help control endemic ESBL–Kpn for ICU patients.


Assuntos
Ágar , Ceftazidima , Colo , Cuidados Críticos , Eletroforese em Gel de Campo Pulsado , Enterobacteriaceae , Genótipo , Humanos , Unidades de Terapia Intensiva , Klebsiella pneumoniae , Klebsiella , Tempo de Internação , Programas de Rastreamento , Prevalência , Estudos Prospectivos , Fatores de Risco
14.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-762461

RESUMO

BACKGROUND: Rapid and accurate diagnosis of acute myocardial infarction (AMI) is critical for initiating effective treatment and achieving better prognosis. We investigated the performance of copeptin for early diagnosis of AMI, in comparison with creatine kinase myocardial band (CK-MB) and troponin I (TnI). METHODS: We prospectively enrolled 271 patients presenting with chest pain (within six hours of onset), suggestive of acute coronary syndrome, at an emergency department (ED). Serum CK-MB, TnI, and copeptin levels were measured. The diagnostic performance of CK-MB, TnI, and copeptin, alone and in combination, for AMI was assessed by ROC curve analysis by comparing the area under the curve (AUC). Sensitivity, specificity, negative predictive value, and positive predictive value of each marker were obtained, and the characteristics of each marker were analyzed. RESULTS: The patients were diagnosed as having ST elevation myocardial infarction (STEMI; N=43), non-ST elevation myocardial infarction (NSTEMI; N=25), unstable angina (N=78), or other diseases (N=125). AUC comparisons showed copeptin had significantly better diagnostic performance than TnI in patients with chest pain within two hours of onset (AMI: P=0.022, ≤1 hour; STEMI: P=0.017, ≤1 hour and P=0.010, ≤2 hours). In addition, TnI and copeptin in combination exhibited significantly better diagnostic performance than CK-MB plus TnI in AMI and STEMI patients. CONCLUSIONS: The combination of TnI and copeptin improves AMI diagnostic performance in patients with early-onset chest pain in an ED setting.


Assuntos
Síndrome Coronariana Aguda , Angina Instável , Área Sob a Curva , Dor no Peito , Creatina Quinase , Diagnóstico , Diagnóstico Precoce , Emergências , Serviço Hospitalar de Emergência , Humanos , Infarto do Miocárdio , Prognóstico , Estudos Prospectivos , Curva ROC , Sensibilidade e Especificidade , Troponina I
15.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-786145

RESUMO

OBJECTIVE: Axial spondyloarthritis (axSpA) is often accompanied by cardiac manifestations, such as valvular heart disease. In this prospective cohort study, we evaluated the incidence of cardiac abnormalities in Korean axSpA patients by echocardiography.METHODS: AxSpA patients were prospectively recruited from a single tertiary hospital. Baseline demographic, clinical, radiographic, and echocardiographic data were collected at the time of enrollment. Echocardiography evaluations were performed with a focus on valvular heart disease and systolic and diastolic function. Logistic regression analyses were used to identify factors associated with diastolic dysfunction in axSpA.RESULTS: A total of 357 axSpA patients were included in the analyses, of whom 78 (21.8%) exhibited diastolic dysfunction, with no reports of systolic dysfunction. Thirteen patients (3.6%) had valvular heart disease, and aortic valve regurgitation (n=5) and mitral valve regurgitation (n=6) were most common. Multivariable logistic regression analyses indicated that older age and higher body mass index (BMI) were positively associated with diastolic dysfunction, whereas human leukocyte antigen (HLA)-B27 positivity was negatively associated with diastolic dysfunction.CONCLUSION: Valvular heart disease is infrequent in Korean axSpA patients. However, diastolic dysfunction is common in axSpA patients, and is significantly associated with older age, higher BMI, and HLA-B27.


Assuntos
Valva Aórtica , Índice de Massa Corporal , Estudos de Coortes , Ecocardiografia , Insuficiência Cardíaca Diastólica , Doenças das Valvas Cardíacas , Antígeno HLA-B27 , Humanos , Incidência , Coreia (Geográfico) , Leucócitos , Modelos Logísticos , Insuficiência da Valva Mitral , Estudos Prospectivos , Espondiloartropatias , Centros de Atenção Terciária
16.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-786074

RESUMO

OBJECTIVE: Postmenopausal women show a more atherogenic lipid profile and elevated cardiovascular risk compared to premenopausal women. The aim of this study was to investigate the efficacy and safety of high-dose atorvastatin on the improvement of the blood lipid profile of postmenopausal women in Korea.METHODS: This study is a prospective, open-label, single-arm clinical trial that was conducted in 3 teaching hospitals. Postmenopausal women with a moderate-to-high cardiovascular risk, according to guidelines from the Korean Society of Lipid & Atherosclerosis, were enrolled. Participants were administered 20 mg of atorvastatin daily for the first 8 weeks, and if the targeted low-density lipoprotein cholesterol (LDL-C) level was not achieved, the dose was increased to 40 mg for the second 8 weeks. The primary endpoint was percentage change of LDL-C from baseline after 16 weeks of drug administration.RESULTS: Forty-four women were enrolled, 28 of whom (75.6%) had diabetes mellitus. By the end of treatment period (16 weeks) all patients had achieved LDL-C target levels, with 33 (94.2%) of the participants achieving it after only 8 weeks of administration. After 16 weeks, LDL-C decreased by 45.8±16.7% (p<0.001) from the baseline, and total cholesterol (33.2±10.9%; p<0.001), triglyceride (24.2±37.5%; p=0.001), and apolipoprotein B (34.9±15.6%; p<0.001) also significantly decreased. Blood glucose and liver enzyme levels slightly increased, but none of the participants developed serious adverse events that would cause them to prematurely withdraw from the clinical trial.CONCLUSION: 20 and 40 mg atorvastatin was effective and safe for treating dyslipidemia in postmenopausal Korean women with moderate-to-high cardiovascular risk.


Assuntos
Apolipoproteínas , Grupo com Ancestrais do Continente Asiático , Aterosclerose , Atorvastatina , Glicemia , Colesterol , Diabetes Mellitus , Dislipidemias , Feminino , Hospitais de Ensino , Humanos , Coreia (Geográfico) , Lipoproteínas , Fígado , Pós-Menopausa , Estudos Prospectivos , Triglicerídeos
17.
Asia Pacific Allergy ; (4): 3-2020.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-785462

RESUMO

BACKGROUND: A reliable objective tool using as a predictor of asthma control status could assist asthma management.OBJECTIVE: To find the parameters of forced oscillation technique (FOT) as predictors for the future loss of asthma symptom control.METHODS: Children with well-controlled asthma symptom, aged 6–12 years, were recruited for a 12-week prospective study. FOT and spirometer measures and their bronchodilator response were evaluated at baseline. The level of asthma symptom control was evaluated according to Global Initiative for Asthma.RESULTS: Among 68 recruited children, 41 children (60.3%) maintain their asthma control between 2 visits (group C-C), and 27 children (39.7%) lost their asthma control on the follow-up visit (group C-LC). Baseline FOT parameters, including the values of respiratory resistance at 5 Hz (R5), respiratory resistance at 20 Hz (R20), respiratory reactance at 5 Hz, area of reactance, %predicted of R5 and percentage of bronchodilator response (%∆) of R5 and R20 were significantly different between C-C and C-LC groups. In contrast, only %∆ of forced vital capacity, forced expiratory volume in 1 second (FEV₁), and FEF25%–75% (forced expiratory flow 25%–75%) were significantly different between groups. Multiple logistic regression analysis revealed that %predicted of R5, %∆R5, %predicted of FEV₁ and %∆FEV₁ were the predictive factors for predicting the future loss of asthma control. The following cutoff values demonstrated the best sensitivity and specificity for predicting loss of asthma control: %predicted of R5=91.28, %∆R5=21.2, %predicted of FEV₁=89.5, and %∆FEV₁=7.8. The combination of these parameters predicted the risk of loss of asthma control with area under the curve of 0.924, accuracy of 83.8%.CONCLUSION: Resistance FOT measures have an additive role to spirometric parameter in predicting future loss of asthma control.


Assuntos
Asma , Criança , Seguimentos , Volume Expiratório Forçado , Humanos , Modelos Logísticos , Estudos Prospectivos , Sensibilidade e Especificidade , Espirometria , Capacidade Vital
18.
Asia Pacific Allergy ; (4): 6-2020.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-785459

RESUMO

BACKGROUND: The prevalence of peanut allergy (PA) among children has increased significantly over the past decade. Even though the prevalence of PA in Singapore is considered low, peanut is the top trigger for food-induced anaphylaxis in Singaporean children.OBJECTIVE: To describe the demographic characteristics and clinical features of children with PA.METHODS: This is a 5-year retrospective review of children diagnosed with PA based on clinical history coupled with a positive skin prick test to peanut or positive oral food challenge results.RESULTS: There were 269 patients (53.9% males) with a clinical diagnosis of PA. The median age at first allergic presentation for the PA group was 24 months old, with interquartile range of 13–39 months. The most common form of peanut introduced was roasted peanut. The rate of peanut anaphylaxis was 7.1%. Concomitant tree nut sensitization was found in 32.3% of this cohort, predominantly to cashew nut. Majority of them have a personal history of atopy – 75.8% with eczema, 63.6% with allergic rhinitis, and 19.7% with asthma.CONCLUSION: This is the first large review of peanut-allergic children in Singapore. Prospective population-based studies are needed to establish the true prevalence and risk factors associated with the development of this potentially life-threatening condition.


Assuntos
Anacardium , Anafilaxia , Arachis , Ásia , Asma , Criança , Estudos de Coortes , Diagnóstico , Eczema , Humanos , Nozes , Hipersensibilidade a Amendoim , Prevalência , Estudos Prospectivos , Estudos Retrospectivos , Rinite Alérgica , Fatores de Risco , Singapura , Pele , Árvores
20.
Yonsei Medical Journal ; : 218-228, 2020.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-811474

RESUMO

PURPOSE: Metabolic syndrome (MetS) is a major public health problem related to increased risks of cardiovascular disease and type 2 diabetes. We investigated whether recommended levels of leisure time physical activity (LTPA) decrease the risk of MetS in a community-based prospective cohort study (Ansung and Ansan cohort).MATERIALS AND METHODS: A total of 3910 adults (1890 men, 2020 women) without MetS examined in 2001–2002 (baseline) were included in this study and followed up from 2013 to 2014. We measured LTPA energy expenditure using the standard metabolic equivalent value [metabolic equivalent of task (MET)-h/wk]. Individuals were categorized into five groups (physically inactive, 0.1 to <7.5, 7.5 to <15.0, 15.0 to <22.5, 22.5 to <40.0, and ≥40.0 MET-h/wk).RESULTS: The mean follow-up period was 11.8 years. Among the cohort, 482 men (25.5%) and 541 women (26.8%) were diagnosed with newly developed MetS. Multivariate logistic analysis revealed a 4.4% lower MetS risk among those performing two to three times the recommended minimum of 7.5 MET-h/wk [multivariate relative risk (RR), 0.956; 95% confidence interval (CI), 0.654–1.398] and a 21.9% lower risk among those performing three to four times the physical activity minimum (multivariate RR, 0.781; 95% CI, 0.574–1.063). This association was only significant in females performing three to four times the minimum (crude RR, 0.655; 95% CI, 0.432–0.994).CONCLUSION: We noted that physical activity at more than 2 times the recommended minimum prevents MetS. Healthcare professionals should encourage inactive adults to be physically active during their leisure time to take advantage of its health benefits.


Assuntos
Adulto , Doenças Cardiovasculares , Estudos de Coortes , Assistência à Saúde , Metabolismo Energético , Feminino , Seguimentos , Humanos , Benefícios do Seguro , Coreia (Geográfico) , Atividades de Lazer , Masculino , Equivalente Metabólico , Atividade Motora , Estudos Prospectivos , Saúde Pública
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