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1.
Blood Research ; : 1-9, 2020.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-820809

RESUMO

A bibliometric study is performed to analyze publication patterns in a specific research area and to establish a landscape model that can be used to quantitatively weigh publications. This study aimed to investigate AML research networks and to conduct a trend-related keyword analysis. We analyzed 48,202 studies about AML published from 1999 to 2019 in the Web of Science Core Collection. The network analysis was conducted using the R&R studio software. The journal Blood had the highest number of published articles with an h-index of 410. The USA had the highest number of total publications (18,719, 38.3%) and research funded by the government, institutions, and pharmaceutical companies (5,436, 10.8%). The institute with the largest number of publications was the MD Anderson Cancer Center. Kantarjian H, Garcia-Manero G, and Ravandi F were the leading authors of publications about AML. Keyword analysis revealed that FLT 3, micro-RNA, and NK cell topics were the hotspots in the cell and gene area in all publications. The overall AML research landscape is popular in the field of translational research as it can identify molecular, cell, and gene studies conducted by different funding agencies, countries, institutions, and author networks. With active funding and support from the Chinese government, the productivity of scientific research is increasing not only in the AML field but also in the medical/health-related science field.


Assuntos
Grupo com Ancestrais do Continente Asiático , Bibliometria , Eficiência , Administração Financeira , Humanos , Células Matadoras Naturais , Leucemia Mieloide Aguda , Publicações , Pesquisa Médica Translacional
2.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-762184

RESUMO

PURPOSE: Various immune cells, including eosinophils and neutrophils, are known to contribute to the development of chronic rhinosinusitis with nasal polyps (CRSwNP). However, the current understanding of the role of neutrophils in the development of CRSwNP still remains unclear. Therefore, we investigated risk factors for refractoriness of CRSwNP in an Asian population. METHODS: Protein levels of 17 neutrophil-related mediators in nasal polyps (NPs) were determined by multiplex immunoassay, and exploratory factor analysis using principal component analysis was performed. Immunofluorescence analysis was conducted to detect human neutrophil elastase (HNE) or myeloperoxidase (MPO)-positive cells. Tissue eosinophilic nasal polyp (ENP) and tissue neutrophilia (Neu(high)) were defined as greater than 70 eosinophils and 20 HNE-positive cells, otherwise was classified into non-eosinophilic nasal polyp (NENP) and absence of tissue neutrophilia (Neu(low)). RESULTS: In terms of disease control status, NENP-Neu(low) patients showed the higher rate of disease control than NENP-Neu(high) and ENP-Neu(high) patients. Linear by linear association demonstrated the trend in refractoriness from NENP-Neu(low) to NENP-Neu(high) or ENP-Neu(low) to ENP-Neu(high). When multiple logistic regression was performed, tissue neutrophilia (hazard ratio, 4.38; 95% confidence interval, 1.76-10.85) was found as the strongest risk factor for CRSwNP refractoriness. Additionally, exploratory factor analysis revealed that interleukin (IL)-18, interferon-γ, IL-1Ra, tumor necrosis factor-α, oncostatin M, and MPO were associated with good disease control status, whereas IL-36α and IL-1α were associated with refractory disease control status. In subgroup analysis, HNE-positive cells and IL-36α were significantly upregulated in the refractory group (P = 0.0132 and P = 0.0395, respectively), whereas MPO and IL-18 showed higher expression in the controlled group (P = 0.0002 and P = 0.0009, respectively). Moreover, immunofluorescence analysis revealed that IL-36R⁺HNE⁺-double positive cells were significantly increased in the refractory group compared to the control group. We also found that the ratio of HNE-positive cells to α1 anti-trypsin was increased in the refractory group. CONCLUSIONS: Tissue neutrophilia had an influence on treatment outcomes in the Asian CRSwNP patients. HNE-positive cells and IL-36α may be biomarkers for predicting refractoriness in Asians with CRSwNP. Additionally, imbalances in HNE and α1 anti-trypsin may be associated with pathophysiology of neutrophilic chronic rhinosinusitis.


Assuntos
Grupo com Ancestrais do Continente Asiático , Biomarcadores , Eosinófilos , Imunofluorescência , Humanos , Imunoensaio , Proteína Antagonista do Receptor de Interleucina 1 , Interleucina-18 , Interleucinas , Elastase de Leucócito , Modelos Logísticos , Pólipos Nasais , Necrose , Neutrófilos , Oncostatina M , Peroxidase , Análise de Componente Principal , Rinite , Fatores de Risco , Sinusite
3.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-762182

RESUMO

PURPOSE: Data are lacking on the association between the allergic rhinitis (AR) phenotype and sensitization to specific allergens or bronchial hyperresponsiveness (BHR) in children. We here investigated risk factors and comorbidities, including sensitization to specific allergens and BHR, for the AR phenotype by AR and its Impact on Asthma (ARIA) classification in a general population-based birth cohort study. METHODS: We enrolled 606 children aged 7 years from the Panel Study of Korean Children. The AR phenotype was assigned in accordance with the ARIA classification in children. Skin prick tests and Provocholine provocation test were performed. Risk factors and comorbidities for AR phenotypes were then analyzed. RESULTS: The prevalence of mild and moderate to severe AR in our study cohort was 37.2% and 8.8%, respectively. Recent use of analgesics or antipyretics and current cat ownership were associated with the risk of mild persistent AR. Sensitizations to Dermatophagoides Pteronyssinus (Der p), Japanese hop and cat were associated with moderate to severe persistent AR. Children with moderate to severe AR had a higher risk of current asthma and BHR compared to mild AR cases (adjusted odds ratio [aOR], 5.26; 95% confidence interval [CI], 1.77–15.62). Moderate to severe AR with allergic sensitization was associated with the highest risk of BHR (aOR, 11.77; 95% CI, 3.40–40.74). CONCLUSIONS: Moderate to severe-persistent AR is more closely related to respiratory comorbidities and sensitizations than mild AR. Stratifying the AR phenotype by ARIA classification may assist in disease management.


Assuntos
Alérgenos , Analgésicos , Animais , Antipiréticos , Grupo com Ancestrais do Continente Asiático , Asma , Hiper-Reatividade Brônquica , Gatos , Criança , Classificação , Estudos de Coortes , Comorbidade , Dermatophagoides pteronyssinus , Gerenciamento Clínico , Humanos , Cloreto de Metacolina , Razão de Chances , Propriedade , Parto , Fenótipo , Prevalência , Rinite Alérgica , Fatores de Risco , Pele
4.
Artigo em Coreano | WPRIM (Pacífico Ocidental) | ID: wprim-782304

RESUMO

PURPOSE: The purpose of this study was to identify the current issues concerning a mutual recognition agreement (MRA) for nursing professionals, and to suggest policy alternatives in South Korea.METHODS: The study was conducted through a literature review.RESULTS: The nursing MRA was signed by the European Union, the Association of Southeast Asian Nations, Australia-New Zealand, India-Singapore, and the Caribbean Community. The United States and Japan have not concluded a nursing MRA with other countries, but they have lowered the entry barriers for foreign nurses from certain countries. In order to prepare for a nursing MRA with developed countries such as the United States, Canada and Australia, it is necessary to establish international standards for nursing and to build a verification system for the qualifications of foreign nurses. In addition, there is a need to establish an independent professional licensing authority that assumes responsibility for all the tasks regarding a nursing license.CONCLUSION: The findings of this study can be used as basic data for the preparation of a nursing MRA, and can contribute to the establishment of policies for foreign nurses.


Assuntos
Grupo com Ancestrais do Continente Asiático , Austrália , Canadá , Região do Caribe , Países Desenvolvidos , Emigração e Imigração , União Europeia , Humanos , Japão , Coreia (Geográfico) , Licenciamento , Enfermeiras Internacionais , Enfermagem , Estados Unidos
5.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-782259

RESUMO

BACKGROUND/OBJECTIVES: We have previously designed the anti-cancer food scoring model (ACFS) 1.0, an evidence-based quantitative tool analyzing the anti-cancer or carcinogenic potential of diets. Analysis was performed using simple quantitative indexes divided into 6 categories (S, A, B, C, D, and E). In this study, we applied this scoring model to wider recipes and evaluated its nutritional relevance.MATERIALS/METHODS: National or known regional databases were searched for recipes from 6 categories: Korean out-dining, Korean home-dining, Western, Chinese, Mediterranean, and vegetarian. These recipes were scored using the ACFS formula and the nutrition profiles were analyzed.RESULTS: Eighty-eight international recipes were analyzed. All S-graded recipes were from vegetarian or Mediterranean categories. The median code values of each category were B (Korean home-dining), C (Korean out-dining), B (Chinese), A (Mediterranean), S (vegetarian), and D (Western). The following profiles were correlated (P < 0.05) with ACFS grades in the univariate trend analysis: total calories, total fat, animal fat, animal protein, total protein, vitamin D, riboflavin, niacin, vitamin B₁₂, pantothenic acid, sodium, animal iron, zinc, selenium, and cholesterol (negative trends), and carbohydrate rate, fiber, water-soluble fiber, vitamin K, vitamin C, and plant calcium (positive trends). Multivariate analysis revealed that animal fat, animal iron, and niacin (negative trends) and animal protein, fiber, and vitamin C (positive trends) were statistically significant. Pantothenic acid and sodium showed non-significant negative trends (P < 0.1), and vitamin B₁₂ showed a non-significant positive trend.CONCLUSION: This study provided a nutritional basis and extended the utility of ACFS, which is a bridgehead for future cancer-preventive clinical trials using ACFS.


Assuntos
Animais , Ácido Ascórbico , Grupo com Ancestrais do Continente Asiático , Cálcio , Colesterol , Dieta , Humanos , Ferro , Análise Multivariada , Niacina , Ácido Pantotênico , Plantas , Riboflavina , Selênio , Sódio , Vegetarianos , Vitamina D , Vitamina K , Vitaminas , Zinco
6.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-782174

RESUMO

The history and administrative system of the Asian Society of Abdominal Radiology (ASAR) are described briefly with a focus on its academic activity, including congresses and education. ASAR is one of the three regional societies in the field of abdominal radiology, comprising approximately 2500 members from seven countries in Asia. A further increase in the numbers of members and affiliated societies is expected with the advancement of imaging technology and the distribution of radiologic equipment and knowledge. ASAR is responsible in Asia for matters of interdisciplinary collaboration in the field of abdominal radiology and has successfully represented Asia in the field of radiology.


Assuntos
Abdome , Ásia , Grupo com Ancestrais do Continente Asiático , Comportamento Cooperativo , Educação , Humanos
7.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-782154

RESUMO

PURPOSE: We evaluated the associations of metabolic syndrome (MetS) and its components with testosterone levels in the Korean population.MATERIALS AND METHODS: This cross-sectional study was performed among 6,967 adult (age≥20 years) men who attended health screening during 2006 to 2015. MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. Associations were evaluated using unconditional logistic regression.RESULTS: The estimated age-adjusted prevalence of MetS in adult and middle-aged (≥40 years) Korean men was 27.5% and 30.6%, respectively. Quartile analysis showed that high serum testosterone levels were significantly associated with a low risk of MetS (highest vs. lowest quartile, odds ratio=0.528; p(trend)<0.001), with an approximately 13% reduction in MetS risk per 1 ng/mL increment of serum testosterone levels. After considering covariates such as age and body mass index (BMI), the reduction in MetS risk was attenuated but remained significant (7% reduced risk per 1 ng/mL). Testosterone levels were inversely correlated with all MetS components, including hyperglycemia (r=−0.041), increased body size (r=−0.093), increased triglyceride levels (r=−0.090), decreased high-density lipoprotein cholesterol levels (r=−0.030), and elevated blood pressure (r=−0.071, all p<0.05). Among them, elevated triglyceride levels and blood pressure were independently associated with low serum testosterone levels, even after adjustment for age and BMI.CONCLUSIONS: Serum testosterone levels were inversely associated with MetS in Korean men. This association was attenuated after adjustment for age and BMI but remained significant. Among MetS components, increased triglyceride levels and elevated blood pressure were independently associated with testosterone levels, regardless of obesity.


Assuntos
Adulto , Grupo com Ancestrais do Continente Asiático , Pressão Sanguínea , Índice de Massa Corporal , Tamanho Corporal , Colesterol , Estudos Transversais , Educação , Humanos , Hiperglicemia , Hipogonadismo , Lipoproteínas , Modelos Logísticos , Masculino , Programas de Rastreamento , Obesidade , Prevalência , Testosterona , Triglicerídeos
8.
Annals of Dermatology ; : 14-20, 2020.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-782145

RESUMO

BACKGROUND: Mycosis fungoides (MF) is the most common types of cutaneous T cell lymphoma. It typically presents with erythematous patches and plaques in the early stage and tumors and extracutaneous involvement with possibly fatal outcomes in the late stage. To facilitate early and accurate diagnosis of MF, it is essential to be knowledgeable of classic and variants of this disease. However, there is limited published data in the Chinese population.OBJECTIVE: To characterize our patient group and to provide additional insight into these malignancies.METHODS: Patients diagnosed with mycosis fungoides and its variants from October 2012 to January 2018 were retrospectively analyzed. Disease-specific survival (DSS) rate and curve according to early and advanced stages were also calculated.RESULTS: The mean age at diagnosis of ninety-three MF patients was 38.9±1.73 years (range: 6~77). Forty-five males (48.4%) and 48 females (51.6 %) were included in this study. The DSS rate of early-stage MF was 98.6%, while that of advanced stage MF was 88.9%. There was a significant difference in DSS rate between early stage and advanced stage MF (p=00.042, log-rank test). The median age of 10 patients with hypopigmented MF (hMF) was 10.5 years (range: 6~28). The age of hMF was younger than that of classical MF patients (p < 0.05).CONCLUSION: Early-stage MF has a better prognosis than advanced stage and hMF affects younger people than classic MF among Chinese. This study provides an insight into mycosis fungoides and its variants in a Chinese population.


Assuntos
Grupo com Ancestrais do Continente Asiático , Diagnóstico , Evolução Fatal , Feminino , Humanos , Linfoma , Linfoma Cutâneo de Células T , Masculino , Micose Fungoide , Prognóstico , Estudos Retrospectivos , Linfócitos T
9.
Yonsei Medical Journal ; : 48-55, 2020.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-782124

RESUMO

PURPOSE: Data on the comparative effectiveness of infliximab (IFX) or adalimumab (ADA) in patients with ulcerative colitis (UC) are extremely limited, especially in the Asian population. We compared clinically important outcomes [colectomy, UC-related emergency room (ER) visits, UC-related hospitalizations, and need for corticosteroids] for these two biologics in biologic-naïve Korean patients with UC.MATERIALS AND METHODS: Using National Health Insurance claims, we collected data on patients who were diagnosed with UC and exposed to IFX or ADA between 2010 and 2016.RESULTS: A total of 862 new users of biologics were included, of whom 630 were treated with IFX and 232 were treated with ADA. Over a median follow-up of 1.8 years after starting biologic therapy, there were no significant differences in the risk of colectomy [adjusted hazard ratio (aHR), 1.87; 95% confidence interval (CI), 0.30–11.63], ER visits (aHR, 1.58; 95% CI, 0.79–3.16), hospitalizations (aHR, 0.83; 95% CI, 0.59–1.17), and corticosteroid use (aHR, 1.16; 95% CI, 0.76–1.78) between IFX and ADA users. These results were stable even when only patients who used biologics for ≥6 months were analyzed. Additionally, these results were unchanged in patients treated with biologic monotherapy or combination therapy with immunomodulators.CONCLUSION: In this nationwide population-based study, there was no significant difference in the risk of colectomy, ER visits, hospitalizations, and corticosteroid use between IFX and ADA users. Our findings indicate that IFX and ADA have comparable effectiveness in biologic-naïve Korean patients with UC.


Assuntos
Adalimumab , Grupo com Ancestrais do Continente Asiático , Produtos Biológicos , Terapia Biológica , Colectomia , Colite Ulcerativa , Serviço Hospitalar de Emergência , Seguimentos , Hospitalização , Humanos , Fatores Imunológicos , Infliximab , Programas Nacionais de Saúde , Úlcera
10.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-782115

RESUMO

According to reports presented at the Asian Radiology Forum 2017 in Taipei, the landscape of screening in Asia is growing, and the role of radiologists is also evolving. The Asian Radiology Forum was first held by the Korean Society of Radiology and the national delegates of Asian radiological partner societies, who attended this meeting with the aim of discussing selected subjects of global relevance in radiology. In 2017, current trends and policies concerning various cancer screening programs from each delegate country were discussed. Various screening programs were discussed, including liver screening in Thailand, thyroid cancer screening in Korea, and lung cancer screening data from the ongoing projects in Taiwan and Japan. The Asian Oceanian Society of Radiology could serve as a platform for international collaboration, and educational exchange between member societies was also highlighted in the forum. Most Asian radiology societies are looking forward to an expansion in the scale of international collaboration and for the provision of additional exchange programs in the future.


Assuntos
Ásia , Grupo com Ancestrais do Continente Asiático , Comportamento Cooperativo , Detecção Precoce de Câncer , Humanos , Cooperação Internacional , Japão , Coreia (Geográfico) , Fígado , Neoplasias Pulmonares , Programas de Rastreamento , Oceania , Taiwan , Tailândia , Neoplasias da Glândula Tireoide
11.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-782114

RESUMO

According to the reports presented at the Fourth Asian Oceanian Radiology Forum (AORF) 2018, organized by the Korean Society of Radiology during the Korean Congress of Radiology in September 2018 in Seoul, there is an increasing demand for the Asian Oceanian Society of Radiology and its member societies for international education in radiology in the Asian Oceanian region. In AORF 2018, the national delegates of the Asian Oceanian radiological partner societies primarily discussed their societies' activities and current status of international education in radiology.


Assuntos
Ásia , Grupo com Ancestrais do Continente Asiático , Educação , Humanos , Cooperação Internacional , Oceania , Seul
12.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-782097

RESUMO

OBJECTIVES: An Asian Gynecologic Oncology Group phase III randomized trial was conducted to determine whether maintenance chemotherapy could improve progression-free survival (PFS) in stages III/IV ovarian cancer.METHODS: Between 2007 and 2014, 45 newly-diagnosed ovarian cancer patients were enrolled after complete remission and randomized (1:1) to arm A (4-weekly carboplatin area under the curve 4 and pegylated liposomal doxorubicin [PLD] 30 mg/m2, n=24) for 6 cycles or arm B (observation, n=21). The primary end-point was PFS. A post hoc translational study was conducted to deep sequence BRCA/homologous recombination deficiency (HRD) genes, because BRCA/HRD mutations (BRCA/HRDm) are known to be associated with better prognosis.RESULTS: Enrollment was slow, accrual was closed when 7+ years had passed. With a median follow-up of 88.9 months, the median PFS was significantly better in arm A (55.5 months) than arm B (9.2 months) (hazard ratio [HR]=0.40; 95% confidence interval [CI]=0.19–0.87; p=0.020), yet the median overall survival was not significantly different in arm A (not reached) than arm B (95.1 months) (p=0.148). Overall grade 3/4 adverse events were more frequent in arm A than arm B (60.9% vs 0.0%) (p<0.001). Quality of life was generally not significantly different. Distribution of BRCA1/2m or BRCA/HRDm was not significantly biased between the two arms. Wild-type BRCA/non-HRD subgroup seemed to fare better with maintenance therapy (HR=0.35; 95% CI=0.11–1.18; p=0.091).CONCLUSIONS: Despite limitations in small sample size, it suggests that maintenance carboplatin-PLD chemotherapy could improve PFS in advanced ovarian cancer.


Assuntos
Braço , Grupo com Ancestrais do Continente Asiático , Viés , Carboplatina , Intervalo Livre de Doença , Doxorrubicina , Tratamento Farmacológico , Seguimentos , Humanos , Quimioterapia de Manutenção , Neoplasias Ovarianas , Prognóstico , Qualidade de Vida , Recombinação Genética , Tamanho da Amostra
14.
Chonnam Medical Journal ; : 62-67, 2020.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-787272

RESUMO

We evaluated the association between body mass index (BMI) and the prevalence of asthma. Using data from the 2015 Korean Community Health Survey, 214,971 participants aged between 19 and 106 years were included in this study. Asthma was defined based on the self-report of physician diagnosis. BMI was classified as underweight (<18.5 kg/m²), normal weight (18.5 kg/m²≤BMI<23.0 kg/m²), overweight (23.0 kg/m²≤ BMI<27.4 kg/m²), and obese (≥27.5 kg/m²) based on the BMI categories for Asians by the World Health Organization. Multiple logistic regression analysis was performed with sampling weights to evaluate the association between BMI and asthma after adjusting for age, educational level, income, type of residential area, smoking status, alcohol consumption, physical activity, hypertension, and diabetes. In men, BMI had an inverted J-shaped association with the prevalence of asthma, with an odds ratio of 1.88 (95% confidence interval [CI]: 1.89–2.24) for underweight and 1.12 (95% CIs: 0.97–1.29) for obesity. In women, BMI had a J-shaped association with the prevalence of asthma, with an odds ratio of 1.05 (95% CIs: 0.91–1.22) for underweight and 2.29 (95% CIs: 2.06–2.56) for obesity. In conclusion, in a nationally representative sample of Korean adults, the association between BMI and the prevalence of asthma varied between the sexes. This suggests that malnutrition and obesity are involved in the pathophysiology of asthma.


Assuntos
Adulto , Consumo de Bebidas Alcoólicas , Grupo com Ancestrais do Continente Asiático , Asma , Índice de Massa Corporal , Diagnóstico , Feminino , Inquéritos Epidemiológicos , Humanos , Hipertensão , Modelos Logísticos , Masculino , Desnutrição , Atividade Motora , Obesidade , Razão de Chances , Sobrepeso , Prevalência , Fumaça , Fumar , Magreza , Pesos e Medidas , Organização Mundial da Saúde
15.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-811199

RESUMO

PURPOSE: C-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor that is overexpressed in many cancers. CtBP1 transcriptionally represses a broad array of tumor suppressors, which promotes cancer cell proliferation, migration, invasion, and resistance to apoptosis. Recent studies have demonstrated that CtBP1 is a potential target for cancer therapy. This study was designed to screen for compounds that potentially target CtBP1.METHODS: Using a structure-based virtual screening for CtBP1 inhibitors, we found protocatechuic aldehyde (PA), a natural compound found in the root of a traditional Chinese herb, Salvia miltiorrhiza, that directly binds to CtBP1. Microscale thermophoresis assay was performed to determine whether PA and CtBP1 directly bind to each other. Further, clustered regularly interspaced short palindromic repeats associated Cas9 nuclease-mediated CtBP1 knockout in breast cancer cells was used to validate the CtBP1 targeting specificity of PA.RESULTS: Functional studies showed that PA repressed the proliferation and migration of breast cancer cells. Furthermore, PA elevated the expression of the downstream targets of CtBP1, p21 and E-cadherin, and decreased CtBP1 binding affinity for the promoter regions of p21 and E-cadherin in breast cancer cells. However, PA did not affect the expression of p21 and E-cadherin in the CtBP1 knockout breast cancer cells. In addition, the CtBP1 knockout breast cancer cells showed resistance to PA-induced repression of proliferation and migration.CONCLUSION: Our findings demonstrated that PA directly bound to CtBP1 and inhibited the growth and migration of breast cancer cells through CtBP1 inhibition. Structural modifications of PA are further required to enhance its binding affinity and selectivity for CtBP1.


Assuntos
Apoptose , Grupo com Ancestrais do Continente Asiático , Neoplasias da Mama , Mama , Caderinas , Proteínas de Transporte , Proliferação de Células , Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas , Humanos , Programas de Rastreamento , Regiões Promotoras Genéticas , Repressão Psicológica , Salvia miltiorrhiza , Sensibilidade e Especificidade
16.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-811151

RESUMO

The prevalence of obesity in Asia is of epidemic proportions, with an estimated 1 billion overweight/obese individuals in the region. The majority of patients with type 2 diabetes mellitus (T2DM) are overweight/obese, which increases the risk of cardiorenal outcomes in these patients; hence, sustained reductions in body weight and visceral adiposity are important management goals. However, most of the glucose-lowering therapies such as insulin, sulfonylureas, glinides, and thiazolidinediones induce weight gain, which makes the management of overweight/obese T2DM patients challenging. Sodium-glucose cotransporter-2 (SGLT-2) inhibitors are the only oral glucose-lowering agents that have been shown to reduce body weight and visceral adiposity. In addition, SGLT-2 inhibitors therapy reduces ectopic fat deposition and improves adipose tissue function and weight-related quality of life. In this article, we aim to consolidate the existing literature on the effects of SGLT-2 inhibitors in Asian patients with T2DM and to produce clinical recommendations on their use in overweight or obese patients with T2DM. Recommendations from international and regional guidelines, as well as published data from clinical trials in Asian populations and cardiovascular outcomes trials are reviewed. Based on the available data, SGLT-2 inhibitors represent an evidence-based therapeutic option for the management of overweight/obese patients with T2DM.


Assuntos
Tecido Adiposo , Adiposidade , Ásia , Grupo com Ancestrais do Continente Asiático , Peso Corporal , Diabetes Mellitus Tipo 2 , Humanos , Insulina , Obesidade , Obesidade Abdominal , Sobrepeso , Prevalência , Qualidade de Vida , Tiazolidinedionas , Ganho de Peso
17.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-811140

RESUMO

BACKGROUND: Soybean food consumption has been considered as a possible way to lower incidence of cardiometabolic syndrome (CMS) among Asians. However, results from studies investigating its efficacy on CMS in Asians have been inconsistent.METHODS: We analyzed the association between soybean intake frequency and prevalence of CMS based on data from the Korea National Health and Nutrition Examination Survey 2007 to 2011. Data of 9,287 women aged 20 to 64 years were analyzed. Food frequency questionnaire was used to assess soybean food consumption frequency. General linear model and multivariable logistic regression model were used to examine the association of soybean intake quintile with CMS and its risk factors. Least square means of metabolic factors mostly showed no significant relevance except liver indexes.RESULTS: Compared to participants in the 1st quintile (<2 times/week of soybean food), odds ratios (OR) for CMS and abdominal obesity (AO) in the 4th quintile (8.5 times/week<soybean food≤17 times/week) were 0.73 (95% confidence interval [CI], 0.57 to 0.95) and 0.72 (95% CI, 0.58 to 0.90), respectively. After excluding Tofu products, ORs of CMS, AO, high blood pressure, and hypertriglyceridemia were lower than those without excluding Tofu products. However, results still did not show significant inverse linear trend across frequency quintiles.CONCLUSION: Our findings suggest that soybean intake of 8.5 to 17 times/week was inversely associated with CMS in Korean women. The relation between soybean intake >17 times/week and CMS varied depending on soybean food items.


Assuntos
Grupo com Ancestrais do Continente Asiático , Diabetes Mellitus , Ingestão de Alimentos , Feminino , Humanos , Hipertensão , Hipertrigliceridemia , Incidência , Coreia (Geográfico) , Modelos Lineares , Fígado , Modelos Logísticos , Inquéritos Nutricionais , Obesidade Abdominal , Razão de Chances , Prevalência , Fatores de Risco , Alimentos de Soja , Soja
18.
Annals of Dermatology ; : 130-140, 2020.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-811085

RESUMO

BACKGROUND: Atopic dermatitis (AD) is recognized as a common inflammatory skin disease and frequently occurred in Asian and Black individuals.OBJECTIVE: Since the limitation of dataset associated with human severe AD, this study aimed to screen potential novel biomarkers involved in mild AD.METHODS: Expression profile data (GSE75890) were obtained from the database of Gene Expression Omnibus. Using limma package, the differentially expressed genes (DEGs) between samples from AD and healthy control were selected. Furthermore, function analysis was conducted. Meanwhile, the protein-protein interaction (PPI) network and transcription factor (TF)-miRNA-target regulatory network were constructed. And quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the expressions patterns of key genes.RESULTS: In total, 285 DEGs including 214 upregulated and 71 downregulated genes were identified between samples from two groups. The upregulated DEGs were mainly involved in nine pathways, such as hematopoietic cell lineage, pertussis, p53 signaling pathway, staphylococcus aureus infection, and cell cycle, while tight junction was the only pathway enriched by the downregulated DEGs. Cyclin B (CCNB)1, CCNB2, cyclin A (CCNA)2, C-X-C motif chemokine ligand (CXCL)10, and CXCL9 were key nodes in PPI network. The TF-miRNA-target gene regulatory network focused on miRNAs such as miR-106b, miR-106a, and miR-17, TFs such as nuclear factor kappa B subunit 1, RELA proto-oncogene, Sp1 transcription factor, and genes such as matrix metallopeptidase 9, peroxisome proliferator activated receptor gamma , and serpin family E member 1. Moreover, the upregulation of these genes, including CCNB1, CCNB2, CCNA2, CXCL10, and CXCL9 were confirmed by qRT-PCR.CONCLUSION: CCNB1, CCNB2, CCNA2, and CXCL9 might be novel markers of mild AD. miR-106b and miR-17 may involve in regulation of immune response in AD patients.


Assuntos
Grupo com Ancestrais do Continente Asiático , Biomarcadores , Ciclo Celular , Linhagem da Célula , Biologia Computacional , Ciclina A , Ciclina B , Conjunto de Dados , Dermatite , Dermatite Atópica , Expressão Gênica , Redes Reguladoras de Genes , Humanos , MicroRNAs , NF-kappa B , PPAR gama , Proto-Oncogenes , Reação em Cadeia da Polimerase em Tempo Real , Dermatopatias , Fator de Transcrição Sp1 , Staphylococcus aureus , Junções Íntimas , Fatores de Transcrição , Regulação para Cima , Coqueluche
19.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-810973

RESUMO

BACKGROUND: Elevated blood pressure is a major preventable cause of cardiovascular diseases. Alcohol consumption is a well-known risk factor of elevated blood pressure. The aldehyde dehydrogenase 2 (ALDH2) polymorphism is common in Eastern Asians, and inactive ALDH2 genotypes are associated with both avoiding alcohol consumption and aldehyde accumulation. Therefore, this study assessed the associations between alcohol consumption and hypertension and blood pressure according to the ALDH2 genotypes.METHODS: This study consists of 8,526 participants in the Dong-gu Study. Multivariate logistic regression was used to calculate the odds ratio (OR) according to alcohol consumption after stratifying by gender and ALDH2 genotypes. Multivariate linear regression was performed to estimate the systolic blood pressure (SBP) and diastolic blood pressure (DBP) according to the amount of alcohol consumed.RESULTS: In men, alcohol consumption was positively associated with both SBP and DBP in active ALDH2 carriers, but not in inactive ALDH2 carriers. In active ALDH2 carriers, compared to non-drinkers, the OR of hypertension was 1.16 (95% confidence interval [CI], 0.91–1.49) for < 1 drink/day, and 1.44 (95% CI, 1.15–1.80) for ≥ 1 drink/day in men. With each 1 drink/day increase, SBP and DBP increased by 3 and 1 mmHg in men, respectively. There was no significant association between ALDH2 genotypes and hypertension and blood pressure in women.CONCLUSION: ALDH2 genotype modified the association between alcohol consumption and blood pressure in men. There was a positive relationship between alcohol consumption and blood pressure in active ALDH2 carriers, but no significant relationship in inactive ALDH2 carriers.


Assuntos
Acetaldeído , Consumo de Bebidas Alcoólicas , Aldeído Desidrogenase , Grupo com Ancestrais do Continente Asiático , Pressão Sanguínea , Doenças Cardiovasculares , Estudos de Coortes , Feminino , Genótipo , Humanos , Hipertensão , Modelos Lineares , Modelos Logísticos , Masculino , Razão de Chances , Oxirredutases , Fatores de Risco
20.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-810971

RESUMO

BACKGROUND: Studies on the efficacy of implantable cardioverter-defibrillator (ICD) therapy for primary prevention in Asian patients are relatively lacking compared to those for secondary prevention. Also, it is important to stratify which patients will benefit from ICD therapy for primary prevention.METHODS: Of 483 consecutive patients who received new implantation of ICD in 9 centers in Korea, 305 patients with reduced left ventricular systolic function and/or documented ventricular fibrillation/tachycardia were enrolled and divided into primary (n = 167) and secondary prevention groups (n = 138).RESULTS: During mean follow-up duration of 2.6 ± 1.6 years, appropriate ICD therapy occurred in 78 patients (25.6%), and appropriate ICD shock and anti-tachycardia pacing occurred in 15.1% and 15.1% of patients, respectively. Appropriate ICD shock rate was not different between the two groups (primary 12% vs. secondary 18.8%, P = 0.118). However, appropriate ICD therapy rate including shock and anti-tachycardia pacing was significantly higher (primary 18% vs. secondary 34.8%, P = 0.001) in the secondary prevention group. Type of prevention and etiology, appropriate and inappropriate ICD shock did not affect all-cause death. High levels of N-terminal pro-B-type natriuretic peptide, New York Heart Association functional class, low levels of estimated glomerular filtration ratio, and body mass index were associated with death before appropriate ICD shock in the primary prevention group. When patients were categorized in 5 risk score groups according to the sum of values defined by each cut-off level, significant differences in death rate before appropriate ICD shock were observed among risk 0 (0%), 1 (3.6%), 2 (3%), 3 (26.5%), and 4 (40%) (P < 0.001).CONCLUSION: In this multicenter regional registry, the frequency of appropriate ICD therapy is not low in the primary prevention group. In addition, combination of poor prognostic factors of heart failure is useful in risk stratification of patients who are not benefiting from ICD therapy for primary prevention.


Assuntos
Grupo com Ancestrais do Continente Asiático , Índice de Massa Corporal , Desfibriladores Implantáveis , Filtração , Seguimentos , Coração , Insuficiência Cardíaca , Humanos , Coreia (Geográfico) , Mortalidade , Prevenção Primária , Medição de Risco , Prevenção Secundária , Choque
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