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1.
Yonsei Medical Journal ; : 154-160, 2020.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-782196

RESUMO

PURPOSE: Recently, obstetric massive transfusion protocols have shifted toward early intervention. This study aimed to develop a prediction model for transfusion of ≥5 units of packed red blood cells (PRBCs) during cesarean section in women with placenta previa.MATERIALS AND METHODS: We conducted a cohort study including 287 women with placenta previa who delivered between September 2011 and April 2018. Univariate and multivariate logistic regression analyses were used to test the association between clinical factors, ultrasound factors, and massive transfusion. For the external validation set, we obtained data (n=50) from another hospital.RESULTS: We formulated a scoring model for predicting transfusion of ≥5 units of PRBCs, including maternal age, degree of previa, grade of lacunae, presence of a hypoechoic layer, and anterior placentation. For example, total score of 223/260 had a probability of 0.7 for massive transfusion. Hosmer-Lemeshow goodness-of-fit test indicated that the model was suitable (p>0.05). The area under the receiver operating characteristics curve (AUC) was 0.922 [95% confidence interval (CI) 0.89–0.95]. In external validation, the discrimination was good, with an AUC value of 0.833 (95% CI 0.70–0.92) for this model. Nomogram calibration plots indicated good agreement between the predicted and observed outcomes, exhibiting close approximation between the predicted and observed probability.CONCLUSION: We constructed a scoring model for predicting massive transfusion during cesarean section in women with placenta previa. This model may help in determining the need to prepare an appropriate amount of blood products and the optimal timing of blood transfusion.


Assuntos
Área Sob a Curva , Transfusão de Sangue , Calibragem , Cesárea , Estudos de Coortes , Discriminação Psicológica , Intervenção Educacional Precoce , Eritrócitos , Feminino , Humanos , Modelos Logísticos , Idade Materna , Nomogramas , Placenta Prévia , Placenta , Placentação , Hemorragia Pós-Parto , Gravidez , Curva ROC , Ultrassonografia
2.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wprim-781698

RESUMO

OBJECTIVE@#To study the association of related maternal factors with the susceptibility to congenital hypothyroidism (CH) in neonates.@*METHODS@#A case-control study was designed. The neonates who were diagnosed with CH in Neonatal Screening Center of Henan Province from January 1, 2016 to December 31, 2017 were enrolled as cases. Healthy neonates, matched for sex and age were enrolled as controls. A conditional logistic regression analysis and additive and multiplicative interaction analyses were used to identify the risk factors for susceptibility to CH.@*RESULTS@#A total of 2 771 661 neonates were screened during this period, among whom 1 494 neonates were diagnosed with CH, with a crude incidence rate of 53.9/100 000. A total of 843 pairs of the cases and the controls completed the telephone survey and provided qualified data. The conditional logistic regression analysis showed that an older maternal age at delivery, a low educational level in mothers, living in the rural area, a family history of thyroid diseases, histories of exposure to formaldehyde during pregnancy, exposure to radiation during pregnancy, and medication during pregnancy, were risk factors for CH (P<0.05), while low maternal age at delivery and progesterone intake during pregnancy were protective factors against CH (P<0.05).@*CONCLUSIONS@#An older maternal age at delivery, a low educational level in mothers, living in the rural area, a family history of thyroid diseases, and histories of exposure to formaldehyde during pregnancy, exposure to radiation during pregnancy and medication during pregnancy may increase the susceptibility to CH in neonates.


Assuntos
Estudos de Casos e Controles , Hipotireoidismo Congênito , Feminino , Humanos , Recém-Nascido , Idade Materna , Triagem Neonatal , Gravidez , Fatores de Risco
3.
Rev. Pesqui. (Univ. Fed. Estado Rio J., Online) ; 12: 281-287, jan.-dez. 2020. tab
Artigo em Inglês, Português | LILACS (Américas), BDENF | ID: biblio-1047844

RESUMO

Objetivo: investigar os fatores maternos e perinatais associados aos extremos da idade reprodutiva da mulher em São Luís, Maranhão. Método: trata-se de um estudo transversal, realizado em São Luís/MA, com população de 16.474 mães. Os dados foram coletados no Sinasc disponibilizado pela Secretaria Municipal. Utilizou-se o Teste Qui-quadrado de Pearson e calculou-se a Odds Ratio com nível de significância de α = 0.05. Resultados: verificou-se que as adolescentes apresentaram maior chance de nascimentos prematuros (OR=1,37; p< 0,001 mulheres com idade avançada apresentaram maior risco para baixo peso ao nascer (OR=1,22; p=0,022). Tanto as adolescentes (OR=2,09; p< 0,001) quanto as mães com idade avançada (OR=1,85; p<0,0011) possuem chances aumentadas para realizarem menos que seis consultas de pré-natal. Conclusão: os resultados perinatais, nascimento prematuro, baixo peso ao nascer e a realização de menos de seis consultas pré-natais são elevados nas gestações de adolescentes e mulheres em idade avançada


Objective: to investigate maternal and perinatal factors associated with extremes of women's reproductive age in São Luís, Maranhão. Method: this is a cross-sectional study conducted in São Luís/MA, with a population of 16,474 mothers. The data were collected in the Sinasc provided by the Municipal Health Secretariat. We used the Pearson Chi-square test and calculated the odds ratio with a significance level of α=0.05. Results: it was verified that the adolescents had a higher chance of preterm birth (OR=1.37; p<0,001); Women aged 35 years or older were at increased risk for low birth weight (OR=1.22; p=0.022). Both adolescents (OR=2.09; p<0,001) and older mothers (OR=1.85; p<0,001) have an increased chance to perform less than six prenatal visits. Conclusion: perinatal outcomes, preterm birth, low birth weight and fewer than six prenatal visits are frequent in the pregnancies of adolescents and women of advanced age


Assuntos
Humanos , Feminino , Gravidez , Adulto , Pessoa de Meia-Idade , Complicações na Gravidez/epidemiologia , Cuidado Pré-Natal , Idade Materna , Saúde Materno-Infantil , Fatores de Risco , Gravidez de Alto Risco , Assistência Perinatal
4.
Acta méd. costarric ; 61(4): 177-182, oct.-dic. 2019. tab, graf
Artigo em Espanhol | LILACS (Américas) | ID: biblio-1054728

RESUMO

Resumen Justificación: El síndrome de Down es la cromosomopatía más frecuente en Costa Rica y el mundo, así como la principal causa de discapacidad intelectual. La edad materna avanzada es el mayor factor de riesgo conocido para este padecimiento. El objetivo fue conocer la tendencia de síndrome de Down en nacidos vivos, según edad materna en Costa Rica. Métodos: Se realizó un estudio observacional de prevalencias de todos los casos de síndrome de Down nacidos vivos en Costa Rica entre 1996-2016, reportados al Centro Nacional de Registro de Enfermedades Congénitas, programa nacional de vigilancia de los defectos congénitos. Se determinó la tendencia y prevalencia en nacidos vivos según edad materna: < 20, 20-34 y 35 años o más, y según período: 1996-2007 y 2008-2016. Se realizó una regresión de Poisson, tomando como referencias el grupo 20-34 años y 1996-2002, y se compararon estimados mediante chi cuadrado de Wald. Se calculó la razón de prevalencias en madres ≥35 años y la fracción atribuible poblacional para este estrato. Por último, se comparó la tendencia del síndrome de Down con la tendencia de la tasa de fecundidad específica en madres ≥35 años en el país, para el período en estudio. Resultados: Para 1996-2016, la prevalencia de síndrome de Down en nacidos vivos fue de 1,02 x 1000 (IC95 %: 0,97-1,07). Hubo un aumento significativo de 0,91 (1996-2007) a 1,16 x 1000 (2008-2016), a expensas de la prevalencia en madres ≥35 años, la cual aumentó de 4,27 a 5,44 x 1000; mientras que la tasa de fecundidad en estas madres cayó significativamente de 20,15 x 1000 (IC95 %: 20,02-20,28) en 1996-2007, a 15,58 x 1000 (IC95 % 15,46-15,70) para o 2008-2016. La edad materna media en SD fue de 32,2 años, contra 25,5 años para la población general (p≤0,001). La razón de prevalencia ajustada por período, en madres de ≥35 años, contra madres de 20-34 años fue de 8,05 (IC95 % 7,25-8,95) y la fracción atribuible poblacional del 41,22 %. Conclusiones: La prevalencia al nacimiento de síndrome de Down en Costa Rica aumentó a expensas de la prevalencia en madres ≥35 años, pese a que la tasa de fecundidad específica en esas mujeres cayó significativamente. La inclusión del Hospital Nacional de Niños como institución de referencia nacional para este síndrome, dentro de la red de vigilancia de los defectos congénitos, pudo ser un factor determinante en el aumento de la prevalencia.


Abstract Justification: Down syndrome is the most frequent chromosomopathy in Costa Rica and the world, as well as the main cause of intellectual disability. Advanced maternal age is the main known risk factor for this condition. The objective was to know the trend of Down syndrome in live births according to maternal age in Costa Rica. Methods: A prevalence study was made of all Down syndrome cases, born alive in Costa Rica from 1996 to 2016 and reported to the Costa Rican Births Defects Register Center, a national program for the monitoring of congenital defects. The trend and prevalence in live births was determined, according to maternal age: <20, 20-34 and 35 years or more, and according to period: 1996-2007 and 2008-2016. A Poisson regression was carried out, taking as references the group 20-34 years and the period 1996-2002 and the results were compared Wald's chi-square. The prevalence ratio in mothers ≥35 years and the population attributable fraction was calculated for this stratum. Finally, the trend of Down syndrome was compared with the trend of the specific fertility rate in mothers ≥35 years. Results: For 1996-2016 the prevalence of Down syndrome in live births was 1.02 x 1000 (95% CI: 0.97-1.07). There was a significant increase from 0.91 (1996-2007) to 1.16 x 1000 (2008-2016), at the expense of the prevalence in mothers ≥35 years, which increased from 4.27 to 5.44 x 1000; while the fertility rate in these mothers fell significantly from 20.15 x 1000 (95% CI: 20.02-20.28) in 1996-2007, to 15.58 x 1000 (95% CI 15.46-15.70) in 2008-2016. Maternal age mean MS in SD was 32.2 years, versus 25.5 years in the general population (p≤0.001). The prevalence ratio adjusted by period, in mothers of ≥35 years, against mothers of 20-34 years was of 8.05 (95% CI 7.25-8.95) and the population attributable fraction was 41.22%. Conclusions: The livebirth`s prevalence of Down syndrome in Costa Rica increased for the study period, at the expense of prevalence in mothers ≥35 years, although the specific fertility rate in these women fell significantly. The inclusion of the National Children's Hospital - as a national reference institution for this syndrome - within the surveillance network of congenital defects, could be a determining factor in in prevalence rise.


Assuntos
Humanos , Prevalência , Idade Materna , Síndrome de Down , Síndrome de Down/epidemiologia , Costa Rica , Doenças Genéticas Inatas
5.
Rev. Bras. Saúde Mater. Infant. (Online) ; 19(4): 947-956, Sept.-Dec. 2019. tab, graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-1057128

RESUMO

Abstract Objectives: to analyze the trend and the associated factors with the presence of cleft lip and/or cleft palate in Brazilian newborns, in order to verify possible associations with maternal care and newborn factors. Methods: a cross-sectional and ecological study, involving all live births in Brazil, recorded in the Information System on Live Births from 2005 to 2016. Maternal and infant information were evaluated using trend analysis and odds ratio, with a 95% confidence interval. The analyses were performed using SPSS software. Results: we analyzed 17,800 live births with presence of cleft lip and/or cleft palate. The Brazilian prevalence rate was 0.51 / 1000 live births, with South and Southeast Regions registering higher rates than the national rate. There was an association with maternal age above 35 years old, with no partner, less than seven prenatal consultations, premature birth and cesarean section. About the factors of the newborn, being male, Apgar less than seven in the 1st and 5th minutes of life, low birth weight and white color were associated. Conclusions: Brazil has an increasing tendency for cleft lip and/or cleft palate (p=0.019), reinforcing the need to strengthen health care networks, providing adequate support for newborn with cleft lip and/or cleft palate and their families.


Resumo Objetivos: analisar a tendência e os fatores associados à presença de fissura labial e/ou fenda palatina em recém-nascidos brasileiros, a fim de verificar possíveis associações da mesma com fatores maternos, assistenciais e do recém-nascido. Métodos: estudo transversal, ecológico, envolvendo todos os nascimentos vivos do Brasil, registrados no Sistema de Informação sobre Nascidos Vivos de 2005 a 2016. Foram avaliadas informações maternas e infantis, utilizando-se análise de tendência e razão de chances, com intervalo de confiança de 95%. As análises foram realizadas através do software SPSS. Resultados: foram analisados 17.800 nascidos vivos com presença de fissura labial e/ou fenda palatina. A taxa de prevalência brasileira foi de 0,51/1000 nascidos vivos, sendo que as Regiões Sul e Sudeste registraram taxas maiores do que a nacional. Houve associação com idade materna superior a 35 anos, sem companheiro, menos de sete consultas de pré-natal, nascimento prematuro e cesariana. Sobre os fatores do recém-nascido, o sexo masculino, Apgar menor que sete no 1º e 5º minutos de vida, baixo peso ao nascer e raça/cor branca apresentaram associação. Conclusões: o Brasil apresenta tendência crescente das taxas de fissura labial e/ou fenda palatina (p=0,019), reforçando a necessidade de fortalecimento das redes de atenção à saúde, prevendo o amparo adequado aos bebês com fissura labial e/ou fenda palatina e suas famílias.


Assuntos
Humanos , Recém-Nascido , Brasil/epidemiologia , Fenda Labial/epidemiologia , Fissura Palatina/epidemiologia , Nascimento Vivo/epidemiologia , Sistemas de Informação em Saúde/estatística & dados numéricos , Anormalidades Congênitas , Recém-Nascido de Baixo Peso , Cesárea , Estudos Transversais , Idade Materna , Nascimento Prematuro
6.
Rev. Bras. Saúde Mater. Infant. (Online) ; 19(3): 601-609, Jul.-Sept. 2019. tab
Artigo em Inglês | LILACS (Américas) | ID: biblio-1041085

RESUMO

Abstract Objectives: to compare the adverse perinatal outcomes in pregnancies of adolescents and elderly women of public health network. Methods: a cross-sectional study carried out with pregnant women at the extremes of reproductive age according to the classification of the Brazilian Ministry of Health (adolescents those aged ≤19 years and those who were older than 35 years) and their newborns. Socioeconomic data (income, schooling, occupation and marital status), as well as clinical (diseases), anthropometric (maternal BMI) and perinatal (gender, weight, length, Apgar and gestational age) data were collected, and Poisson regression in hierarchical model was performed, with the results in Ratio of Prevalence (PR) and its respective Confidence Interval at 95% (95% CI). Results: when comparing adolescent and elderly women, 38.7% vs 54.6% (PR=0.71, CI=0.54-0.94, p=0.002) were observed, respectively, cesarean deliveries; 37.8% vs 25.2% (PR=0.83, CI=0.58-1.19, p=0.332) preterm births; 16.6% vs 20.5% (RP=1.07, CI=0.78-1.46, p=0.666) births of small infants for gestational age (SGA); 18.0% vs 15.3% (RP=1.01, CI=0.69-1.47, p=0.948) births of large-for-gestational-age newborns (LGA); 32.2% vs 34.7% (RP=1.08, CI=0.82-1.42, p=0.578), low birth weight infants and 28.5% vs 42.9% (RP=1.18, CI=0.91-1.54, p=0.201) with high birth length. Conclusions: When compared with adolescent women, pregnant women of advanced age presented a higher frequency of cesarean deliveries.


Resumo Objetivos: comparar os resultados perinatais adversos em gestações de adolescentes e mulheres em idade avançada de rede pública de saúde. Métodos: estudo transversal realizado com gestantes nos extremos de idade reprodutiva segundo classificação do Ministério da Saúde do Brasil (adolescentes aquelas com idade ≤19 anos e em idade avançada aquelas com idade ≥35 anos) e seus recém-nascidos. Foram coletados dados socioeconômicos (renda, escolaridade, ocupação e situação conjugal), clínicos (presença de doenças), antropométricos (IMC materno) e perinatais (sexo, peso, comprimento, Apgar e idade gestacional), e realizada regressão de Poisson em modelo hie-rarquizado, com resultados em Razão de Prevalência (RP) e respectivo Intervalo de Confiança a 95% (IC95%). Resultados: quando comparadas gestantes adolescentes e aquelas em idade avançada, foram observados, respectivamente: 38,7% vs 54,6% (RP=0,71; IC=0,54-0,94; p=0,002) partos cesarianos; 37,8% vs 25,2% (RP=0,83; IC=0,58-1,19; p=0,332) nascimentos de pré-termos; 16,6% vs 20,5% (RP=1,07; IC=0,78-1,46; p=0,666) nascimentos de recém-nascidos pequenos para idade gestacional; 18,0% vs 15,3% (RP=1,01; IC=0,69-1,47; p=0,948) nascimentos de recém-nascidos grandes para a idade gestacional; 32,2% vs 34,7% (RP=1,08; IC=0,82-1,42; p=0,578)recém-nascidos com baixo peso ao nascer e28,5% vs 42,9% (RP=1,18; IC=0,91-1,54; p=0,201) com comprimento elevado ao nascer. Conclusões: as gestantes em idade avançada quando comparadas com as adolescentes apresentaram maior frequência de partos cesarianos.


Assuntos
Humanos , Feminino , Gravidez , Recém-Nascido , Adolescente , Adulto , Complicações na Gravidez , Gravidez na Adolescência , Idade Materna , Índice de Apgar , Fatores Socioeconômicos , Brasil , Cesárea , Antropometria , Estudos Transversais , Idade Gestacional , Gravidez de Alto Risco , Sistemas Públicos de Saúde
7.
Rev. Bras. Saúde Mater. Infant. (Online) ; 19(2): 335-341, Apr.-June 2019. tab
Artigo em Inglês | LILACS (Américas) | ID: biblio-1013140

RESUMO

Abstract Objectives: ididentify the scores on the pregnant women's knowledge on the signs of alert and labor and correlate the scores with the maternal age, number of children and the guidance they received during pregnancy. Methods: this is a descriptive, cross-sectional study with a quantitative approach on pregnant women's previous knowledge of the signs of alert and labor performed with 100 pregnant women on their 30th week of gestation at the Hospital de Clínicas da UFTM (Clinical Hospital). The data collection was carried out from April to June 2016, using a semi-structured instrument tested as a pilot study. Results: only 21% of the pregnant women reported taking part in the pregnant women's group; 61% of them referred to not receiving any information on the signs of alert and labor. A statistically significant association was verified between the number of correct answers and the guidance they received during prenatal consultations. However, there was no correlation between the correct scores on maternal age and the number of children. Conclusions: the pregnant women who did not receive any kind of guidance, they had lower scores on the correct answers, which shows the importance of guiding them about Health Education during their prenatal consultations.


Resumo Objetivos: identificar escores de conhecimento de gestantes sobre os sinais de alerta e de trabalho de parto e correlacionar escores de acerto com a idade materna, o número de filhos e o recebimento de orientações durante a gestação. Métodos: trata-se de um estudo de abordagem quantitativa, transversal, sobre o conhecimento prévio acerca dos sinais de alerta e de trabalho de parto realizado com 100 gestantes, a partir da 30ª semana gestacional, no Hospital de Clínicas da UFTM. A coleta de dados foi realizada no período de abril a junho de 2016 por meio de instrumento semiestruturado, testado mediante estudo piloto. Resultados: apenas 21% das gestantes relataram a participação em grupo de gestantes e 61% referiram não ter recebido nenhum tipo de informação sobre os sinais de alerta e de trabalho de parto. Verificou-se uma associação estatisticamente significante entre o número de acertos e as orientações recebidas durante o pré-natal. Entretanto, não houve correlação entre escores de acerto e a idade materna e o número de filhos. Conclusões: gestantes que não receberam orientações tiveram escores de acertos mais baixos o que demonstra a importância da Educação em Saúde durante o pré-natal.


Assuntos
Humanos , Feminino , Gravidez , Cuidado Pré-Natal , Trabalho de Parto , Serviços de Saúde Materno-Infantil , Tocologia/educação , Gravidez , Educação em Saúde , Idade Materna , Dor do Parto
8.
Rev. Bras. Saúde Mater. Infant. (Online) ; 19(2): 351-361, Apr.-June 2019. tab
Artigo em Inglês | LILACS (Américas) | ID: biblio-1013144

RESUMO

Abstract Objectives: to relate pregestational nutritional status, maternal age and number of pregnancies to the distribution of macronutrients and micronutrients according to the type of processing offoods consumed by high-risk pregnant women. Methods: a retrospective cross-sectional study was carried out with data from medical records of 200 pregnant women served by a public outpatient clinic in Rio Grande do Sul from 2014 to 2016. Results: the mean percentages of lipids, monounsaturated fatty acids, polyunsaturated fatty acids and sodium intake were higher among ultra-processed foods. There was a significant inverse correlation between maternal age and total calorie intake (p=0.003) and percentage of carbohydrates (p=0.005) and proteins (p=0.037) from ultra-processed foods. There was also a significant association between pregestational nutritional status and total calorie intake (p=0.018) and percentage of carbohydrates (p=0.048) from ultra-processed foods. Conclusions: the mean percentages of lipids, monounsaturated fatty acids, polyunsaturated fatty acids and sodium intake were higher among ultra-processed foods. It was observed that the older the maternal age of high-risk pregnant women, the lower the intake of total calories and percentages of carbohydrates and proteins from ultra-processed foods. It was also observed that pregestational nutritional status was significantly associated with the intake of total calories and percentage of carbohydrates from ultra-processed foods.


Resumo Objetivos: relacionar o estado nutricional pré-gestacional, a idade materna e o número de gestações com a distribuição de macronutrientes e micronutrientes conforme o tipo de processamento dos alimentos consumidos por gestantes de alto risco. Métodos: estudo retrospectivo transversal, realizado a partir de dados de prontuários de 200 gestantes atendidas em um ambulatório público do Rio Grande do Sul, no período de 2014 a 2016. Resultados: a média de consumo em percentuais de lipídios, ácidos graxos monoinsaturados, poli-insaturados e sódio foi maior entre os alimentos ultraprocessados. Observou-se correlação significativamente inversa entre a idade materna e o consumo de calorias totais (p=0,003), percentuais de carboidratos (p=0,005) e proteínas (p=0,037) provenientes de alimentos ultraprocessados. Verificou-se também associação significativa entre o estado nutricional pré-gestacional e o consumo de calorias totais (p=0,018) e percentual de carboidrato (p=0,048) provenientes de alimentos ultraprocessados. Conclusões: a média de consumo em percentuais de lipídios, ácidos graxos monoinsaturados, poli-insaturados e sódio foi maior entre os alimentos ultraprocessados, verificou-se que quanto maior a idade materna da gestante de alto risco, menor é o consumo de calorias totais, percentuais de carboidratos e proteínas, oriundos dos alimentos ultraprocessados e identificou-se também que o estado nutricional pré-gestacional possui associação significativa com o consumo de calorias totais e percentual de carboidrato provenientes de alimentos ultraprocessados.


Assuntos
Humanos , Feminino , Gravidez , Estado Nutricional , Gravidez de Alto Risco , Nutrição Pré-Natal , Comportamento Alimentar , Brasil , Alimentos , Registros Médicos , Estudos Transversais , Estudos Retrospectivos , Idade Materna , Micronutrientes , Saúde Materna
9.
Prensa méd. argent ; 105(5): 293-295, jun 2019. tab
Artigo em Inglês | LILACS (Américas), BINACIS | ID: biblio-1024573

RESUMO

Introduction: Mole hydatiforme is the most common type of gestational trophoblast disease (GTI) and the aim of this study, is evaluation the frequency of changes in thyroid function test in mole hydatidiform patients. Materials and Methods: In this retrospective study, 63 patients with mole hydatidiform who reffering to gynecolgy ward of Ali ibn Abitaleb Hospital in Zahedan from April 2016 to March 2017, were studied. Information such as age, gravidity and laboratory findings inclluding thyroid function test (TFT) and the presence or absence of clinical sympltoms were recorded in the information forms and analyzed by SPSS software. Results: In this study, 63 patients with mole hydatidiform were studied. The mean age of the patients was 26.6 ± 7.7 years. The most common clinical manifestations of hyperthyroidism in patients with mole hydatidorme was tachycardia (39.7%). There was no relationschip between age and gravidity with the hyperthyroid simptoms and thyroid function test. Conclusion: Overall, the results of this study showed ttat 67% of patients with mole hydatidiform hay reduced TSH and more than 50% of cases hay increased free T3 and T4. There was no relationship between maternal age and gravidity with changes in thyroid functional test (AU)


Assuntos
Humanos , Feminino , Gravidez , Adulto , Testes de Função Tireóidea/tendências , Mola Hidatiforme/diagnóstico , Estudos Transversais , Estudos Retrospectivos , Idade Materna , Doença Trofoblástica Gestacional/diagnóstico
10.
Demetra (Rio J.) ; 14: e36842, mar. 2019. ilus, tab
Artigo em Inglês, Português | LILACS (Américas) | ID: biblio-1097609

RESUMO

Objetivo: Estimar a prevalência de excesso de peso na gestação e identificar sua associação com variáveis socioeconômicas, demográficas, antecedentes obstétricos e excesso de peso pré-gestacional em gestantes usuárias de unidades de saúde de Colombo, Paraná. Metodologia: A coleta de dados aconteceu por meio da aplicação de questionário, entre abril e novembro de 2016. Participaram do estudo 316 gestantes com idade entre 18 e 46 anos. Resultados: A prevalência de excesso de peso gestacional foi de 46,2%. Na análise ajustada, a prevalência do desfecho foi maior nas gestantes entre 20 e 34 anos (RP 1,72;IC95%1,04-2,83) e acima de 35 anos (RP 2,08;IC95%1,18-3,66), maior paridade (três ou mais gestações - RP 1,47;IC95%1,04-2,09) e com excesso de peso pré-gestacional (RP 5,09;IC95%3,63-7,14). Entre as fumantes, a prevalência foi menor (RP 0,45;IC95%0,23-0,89). Conclusão: Acompanhar o peso pré-gestacional e o ganho de peso gestacional é de grande importância para a atenção primária e é recomendável que as mulheres estejam com o peso adequado antes da gestação. (AU)


Objective: To estimate the prevalence of overweight in pregnant women and associate it with socio-economic and demographic variables, obstetric history and pregestational overweight in pregnant women attending health centers in the city of Colombo, in Brazil. Methods: We used a questionnaire to collect the data between April and November 2016. Three hundred and sixteen pregnant women between 18 and 46 years old were included in our study. Results: The prevalence of gestational overweight was 46.2%. In the djusted analysis, that prevalence was higher in pregnant women between 20 and 34 years old (PR 1.72; CI 95% 1.04-2.83) and over 35 years old (PR 2.08; CI 95% 1.18-3.66), in women with higher parity (three or more pregnancies - PR 1.47; CI 95% 1.04-2.09) and those who presented pregestational overweight (PR 5.09; CI 95% 3.63-7.14). Among the smokers, there was a lower prevalence of overweight (PR 0.45; CI 95% 0.23-0.89). Conclusion: Monitoring pregestational weight and weight gain during pregnancy is extremely important for primary care and it is recommended that women have an adequate weight before their pregnancy. (AU)


Assuntos
Humanos , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Peso Corporal , Gestantes , Idade Materna , Sobrepeso , Nutrição Pré-Natal
11.
Korean Circulation Journal ; : 545-554, 2019.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-759433

RESUMO

OBJECTIVES: To report our experiences in pregnant patients with pulmonary arterial hypertension (PAH) who were treated with targeted therapy. METHODS: From 2011 to 2017, women who decided to maintain pregnancies in our PAH clinic were included. Clinical data, management, and outcomes of the mothers and fetuses were reviewed. RESULTS: Nine women with PAH and 10 deliveries were reviewed. The median maternal age was 28 (26–32) years old. The functional status of each patient was New York Heart Association functional class II or III at first visit. Sildenafil was prescribed in advance in 9 cases of delivery. Multidiscipline team approach management and intensive care were performed during the peripartum period. There was no maternal or fetal mortality. Severe cardiac events occurred in 2 patients with Eisenmenger syndrome: cardiac arrest and uncontrolled arrhythmia. Non-cardiac events occurred in 3 cases: postpartum bleeding, urinary tract infection, and pneumonia. The median gestational period at delivery was about 34 (32–38) weeks. Three cases were emergent delivery because of unexpected preterm labor. Intrauterine growth restriction developed in 4 fetuses. CONCLUSIONS: Pregnancy could be maintained by the introduction of targeted therapy rather more safely than the previous era in the case of maintenance of pregnancy. Intensive care and a multidisciplinary team approach can possibly improve the outcomes of the pregnant women with PAH and their babies. However, pregnancy in patients with PAH is still strongly prohibited and it can be tried in expert center where there has sufficient multidisciplinary team approach in case of inevitability.


Assuntos
Arritmias Cardíacas , Cuidados Críticos , Complexo de Eisenmenger , Feminino , Mortalidade Fetal , Feto , Coração , Parada Cardíaca , Hemorragia , Humanos , Hipertensão , Hipertensão Pulmonar , Idade Materna , Mães , Trabalho de Parto Prematuro , Período Periparto , Pneumonia , Período Pós-Parto , Gravidez , Gestantes , Citrato de Sildenafila , Infecções Urinárias
12.
Artigo em Coreano | WPRIM (Pacífico Ocidental) | ID: wprim-758571

RESUMO

PURPOSE: This study aims to investigate the effects of smoking on the development of placenta-associated syndromes, including preeclampsia, abruptio placentae, and placenta previa, which share the common pathophysiology of vascular compromise of the placenta. METHODS: A total of 966,629 pregnancies identified from the Korean National Insurance Claims Database and the National Health Information Database were analyzed from 2010 to 2014. The adjusted odds ratio and attributable risk of smoking for the development of placenta-associated syndromes, such as preeclampsia, placenta previa, and abruptio placentae, were analyzed. Maternal age, alcohol consumption, exercise habit, and economic status were controlled as confounding variables. A binary logistic regression model was used, and simple and multiple logistic regression analyses were performed. RESULTS: Among 966,629 pregnancies, 11.86% of women were ever smokers. Ever smokers had a higher risk of developing placenta previa (adjusted odds ratio, 1.23; 95% confidence interval [CI], 1.18–1.29; adjusted attributable risk, 18.70%). The adjusted odds ratio of developing placenta-associated syndromes in ever smokers compared to nonsmokers over the age of 35 years with a low economic status was 1.32 (95% CI, 1.18–1.47), with an adjusted attributable risk of 23.95%. CONCLUSION: The risk of developing placenta-associated syndromes, such as preeclampsia, placenta previa, and abruptio placentae, is high in ever smokers. Pregnant ever smokers who are >35 years and belong to the lower one-third of the economic division require special care to prevent the development of placenta-associated syndromes.


Assuntos
Descolamento Prematuro da Placenta , Consumo de Bebidas Alcoólicas , Fatores de Confusão Epidemiológicos , Feminino , Humanos , Seguro , Coreia (Geográfico) , Modelos Logísticos , Idade Materna , Razão de Chances , Placenta , Placenta Prévia , Pré-Eclâmpsia , Gravidez , Fumaça , Fumar
13.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-763685

RESUMO

BACKGROUND: Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. METHODS: To identify clinical and metabolic predictors for GDM in women with OAV, we conducted a retrospective study and identified women with OAV in the OGTT done at 24 to 30 weeks gestational age (GA) and repeated the second OGTT between 32 and 34 weeks of GA. RESULTS: Among 137 women with OAV in the initial OGTT, 58 (42.3%) had normal, 40 (29.2%) had OAV and 39 (28.5%) had GDM in the second OGTT. Maternal age, prepregnancy body mass index, weight gain from prepregnancy to the second OGTT, GA at the time of the OGTT, and parity were similar among normal, OAV, and GDM groups. Plasma glucose levels in screening tests were different (151.8±15.7, 155.8±14.6, 162.5±20.3 mg/dL, P<0.05), but fasting, 1-, 2-, and 3-hour glucose levels in the initial OGTT were not. Compared to women with screen negative, women with untreated OAV had a higher frequency of macrosomia. CONCLUSION: We demonstrated that women with OAV in the initial OGTT significantly progressed to GDM in the second OGTT. Clinical parameters predicting progression to GDM were not found. Repeating the OGTT in women with OAV in the initial test may be helpful to detect GDM progression.


Assuntos
Glicemia , Índice de Massa Corporal , Diabetes Gestacional , Jejum , Feminino , Idade Gestacional , Glucose , Teste de Tolerância a Glucose , Humanos , Programas de Rastreamento , Idade Materna , Paridade , Gravidez , Resultado da Gravidez , Gestantes , Estudos Retrospectivos , Ganho de Peso
14.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-763362

RESUMO

OBJECTIVE: It is widely accepted that aging decreases women’s fertility capacity. The aim of this study was to assess correlations between maternal age and the morphokinetic parameters and cleavage pattern of embryos. METHODS: The morphokinetics of embryos derived from women 40 years of age were compared retrospectively in terms of time of second polar body extrusion, time of pronuclei appearance, time of pronuclei fading, and time of two to eight discrete cells (t2–t8). Furthermore, abnormal cleavage patterns such as uneven blastomeres at the two-cell stage, cell fusion (Fu), and trichotomous mitoses (TM) were assessed. RESULTS: Only t5 occurred later in women aged 36–40 and >40 years when compared with those aged 0.05). However, Fu and TM were more common in women aged >40 years than in younger women (p<0.001). CONCLUSION: Maternal age was correlated with the cleavage pattern of embryos. Therefore, evaluating embryo morphokinetics may contribute to optimal embryo selection, thereby increasing fertility in patients with advanced maternal age.


Assuntos
Envelhecimento , Blastômeros , Fusão Celular , Estruturas Embrionárias , Feminino , Fertilidade , Humanos , Idade Materna , Mitose , Corpos Polares , Estudos Retrospectivos , Injeções de Esperma Intracitoplásmicas
15.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-763348

RESUMO

OBJECTIVE: As paternal age increases, the quality of sperm decreases due to increased DNA fragmentation and aneuploidy. Higher levels of structural chromosomal aberrations in the gametes ultimately decrease both the morphologic quality of embryos and the pregnancy rate. In this study, we investigated whether paternal age affected the euploidy rate. METHODS: This study was performed using the medical records of patients who underwent in vitro fertilization (IVF) procedures with preimplantation genetic screening (PGS) from January 2016 to August 2017 at a single center. Based on their morphological grade, embryos were categorized as good- or poor-quality blastocysts. The effects of paternal age were elucidated by adjusting for maternal age. RESULTS: Among the 571 total blastocysts, 219 euploid blastocysts were analyzed by PGS (38.4%). When the study population was divided into four groups according to both maternal and paternal age, significant differences were only noted between groups that differed by maternal age (group 1 vs. 3, p=0.031; group 2 vs. 4, p=0.027). Further analysis revealed no significant differences in the euploidy rate among the groups according to the morphological grade of the embryos. CONCLUSION: Paternal age did not have a significant impact on euploidy rates when PGS was performed. An additional study with a larger sample size is needed to clarify the effects of advanced paternal age on IVF outcomes.


Assuntos
Aneuploidia , Blastocisto , Aberrações Cromossômicas , Fragmentação do DNA , Desenvolvimento Embrionário , Estruturas Embrionárias , Feminino , Fertilização In Vitro , Testes Genéticos , Células Germinativas , Humanos , Técnicas In Vitro , Idade Materna , Registros Médicos , Idade Paterna , Gravidez , Taxa de Gravidez , Tamanho da Amostra , Espermatozoides
16.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wprim-776786

RESUMO

OBJECTIVE@#To explore the correlation between fetal nuchal fold (NF) thickening and fetal chromosomal abnormality.@*METHODS@#In total 919 pregnant women undergoing ultrasound examination were selected for interventional prenatal diagnosis in order to detect fetal chromosomal abnormality.@*RESULTS@#The detection rate of chromosomal abnormality has significantly increased with NF thickness, advanced maternal age, presence of other ultrasound abnormalities (P<0.05). Trisomy 21 was the most common abnormality, and there was a prepondance for male fetuses.@*CONCLUSION@#Increased NF thickness is strongly associated with the risk of fetal chromosomal abnormalities, advanced maternal age and presence of additional ultrasound abnormalities.


Assuntos
Aberrações Cromossômicas , Feminino , Feto , Humanos , Idade Materna , Medição da Translucência Nucal , Gravidez , Ultrassonografia Pré-Natal
17.
Psychiatry Investigation ; : 679-685, 2019.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-760980

RESUMO

OBJECTIVE: No reports have investigated the influence of age at first or last childbirth on maternal mental health. The aim of this study was to determine whether there is an association between age at first or last childbirth and the mental health of premenopausal women. METHODS: The data used in this study were collected from the 2010 to 2012 Korea National Health and Nutrition Examination Surveys. A total of 3,370 premenopausal women were considered. The association between childbirth age and maternal mental health factors, including stress, depressed mood, and suicidal ideations were analyzed using multiple logistic regression analyses adjusted for confounding factors. RESULTS: After adjusting confounding factors, younger maternal age at first childbirth was found to be associated with an increase in the prevalence of maternal depressed mood and suicidal ideations. Also, older maternal age at last childbirth was related to an increase in maternal stress, depressed mood and suicidal ideations. CONCLUSION: Both younger first childbirth and older last childbirth maternal age may be risk factors for poor outcomes of premenopausal women’s mental health. These data support the need for comprehensive mental health assessment for premenopausal women who either gave birth at an age too young or too old.


Assuntos
Depressão , Feminino , Humanos , Coreia (Geográfico) , Modelos Logísticos , Idade Materna , Saúde Mental , Inquéritos Nutricionais , Parto , Prevalência , Fatores de Risco , Ideação Suicida , Suicídio
18.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-760708

RESUMO

OBJECTIVES: Nicotine narrows uterine blood vessels reducing the flow of oxygen and nutrients to the developing fetus. This study examined the effects of fetal exposure to secondhand smoke on neonatal anthropometry. METHODS: This cross sectional study recruited 128 pregnant women in the third trimester of single pregnancies who had no chronic illness, were not active or ex-smokers, and who were willing to participate in the study. Pregnant women who were exposed to secondhand smoke had umbilical cord blood nicotine concentrations of ≥ 1 ng/mL. Neonatal anthropometry was assessed according to the newborn birth weight and length. The independent t-test was used to determine the neonatal difference in mean birth weight and length between the women who were exposed to secondhand smoke, and those who were not exposed. A multiple linear regression analysis was employed to assess the effect of secondhand smoke exposure on birth weight and birth length, controlling for potential confounding variables (weight gain during pregnancy, body mass index, parity, maternal age, and maternal hemoglobin). RESULTS: There were 35 women exposed to secondhand smoke (nicotine ≥ 1 ng/mL). Neonate birth weight and birth length were lower among mothers who were exposed to secondhand smoke. However, only neonate birth weight was significantly reduced by exposure to secondhand smoke (p = 0.005). The mean birth weight of these neonates was 2,916.5 g ± 327.3 g which was 205.6 g less than in unexposed fetuses. CONCLUSION: Exposure of mothers to secondhand smoke during pregnancy reduces fetal development and neonatal weight.


Assuntos
Antropometria , Peso ao Nascer , Vasos Sanguíneos , Índice de Massa Corporal , Doença Crônica , Fatores de Confusão Epidemiológicos , Feminino , Sangue Fetal , Desenvolvimento Fetal , Feto , Humanos , Recém-Nascido , Modelos Lineares , Idade Materna , Mães , Nicotina , Oxigênio , Paridade , Parto , Gravidez , Terceiro Trimestre da Gravidez , Gestantes , Poluição por Fumaça de Tabaco , Cordão Umbilical
19.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-760683

RESUMO

Currently, the rate of cesarean sections being performed in Korea is approximately 40%, with Korea ranking 4th among the Organization for Economic Co-operation and Development countries with respect to cesarean deliveries. Breech presentation at term is an important indication for cesarean section among other factors, including medicolegal concerns and pregnancies in women of advanced maternal age. Term breech presentation is associated with a higher fetal mortality rate than that associated with a cephalic presentation. Therefore, in Korea, most of these women deliver by cesarean section to avoid the complications of vaginal breech delivery. However, cesarean section is itself associated with considerable obstetric morbidity and sometimes, mortality. External cephalic version (ECV) is a useful method to reduce the cesarean section rate in women with breech presentation and therefore to reduce the incidence of breech presentation at delivery. Studies have shown that routine use of ECV reduces the cesarean section rate by approximately two-thirds in term pregnancies with breech presentation. ECV is accepted as a safe, efficacious, and cost-effective method and is recommended by both the American College of Obstetricians and Gynecologists and the Royal College of Obstetricians and Gynecologists in all pregnancies with term breech presentation, if not contraindicated. In Korea, although most clinicians are aware of the option of ECV, their relative lack of experience in performing the procedure and fear of complications render them hesitant to perform ECV. This review is aimed at guiding obstetricians by describing the efficacy, safety concerns, and technical aspects of this procedure.


Assuntos
Apresentação Pélvica , Cardiotocografia , Cesárea , Feminino , Mortalidade Fetal , Humanos , Incidência , Coreia (Geográfico) , Idade Materna , Métodos , Mortalidade , Gravidez , Versão Fetal
20.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-760680

RESUMO

OBJECTIVE: After globally acceptance of planned vaginal birth after cesarean section (VBAC), the mode of induction is still a matter of debate and requires further discussion. We aimed to study obstetric outcomes in post-cesarean patients undergoing induction of labor with prostaglandin gel compared with patients who developed spontaneous labor pains. METHODS: All patients at 34 weeks or more of gestation with previous one cesarean section eligible for trial of labor after cesarean section admitted in a labor room within one year were divided in 2 groups. Group one consisted of patients who experienced the spontaneous onset of labor pains and group 2 consisted of patients who underwent induction of labor with prostaglandin gel. They were analyzed for maternofetal outcomes. Descriptive statistics, independent sample t-test, and chi-square test were applied using SPSS 20 software for statistical analysis. RESULTS: Both groups were comparable in maternal age, parity, and fetal weight, but different in bishop score, mode of delivery, and neonatal outcome. Admisson bishop score was 6.61±2.51 in group 1 and 3.15±1.27 in group 2 (P<0.005). In the patients who experienced spontaneous labor, 86.82% had successful VBAC. In the patients with induced labor, 64.34% had successful VBAC with an average dose of gel of 1.65±0.75. Both groups had one case each of uterine rupture. The neonatal intensive care unit admission rate was 4.1% in group one and 10.4% in group 2. CONCLUSION: This study reflects that supervised labor induction with prostaglandin gel in previous one cesarean section patients is a safe and effective option.


Assuntos
Cesárea , Feminino , Peso Fetal , Humanos , Recém-Nascido , Terapia Intensiva Neonatal , Dor do Parto , Trabalho de Parto Induzido , Idade Materna , Paridade , Gravidez , Prostaglandinas , Prova de Trabalho de Parto , Ruptura Uterina , Nascimento Vaginal Após Cesárea
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