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1.
Rev. cuba. pediatr ; 91(1): e441, ene.-mar. 2019. tab, graf
Artigo em Espanhol | LILACS (Américas) | ID: biblio-985592

RESUMO

Introducción: Existen pocas investigaciones sobre factores de riesgo de tumores renales pediátricos. Objetivo: Caracterizar en detalle regiones geográficas de alta incidencia de tumores renales pediátricos en el centro de Argentina y su posible vinculación con factores de riesgo genéticos. Métodos: El área de estudio comprendió la provincia de Córdoba (Argentina). Se generó una base de datos de incidencia del cáncer renal infantil con información del Registro Provincial de Tumores. Se realizaron análisis de conglomerados espaciotemporales. En localidades dentro de los conglomerados, se llevaron a cabo entrevistas en profundidad a informantes claves. Resultados: Se registraron 56 casos de tumores renales pediátricos en el Registro en el periodo 2004-2013. Se detectó un conglomerado espacial significativo que abarca siete departamentos de la provincia. En esa región se concretaron seis entrevistas en profundidad a informantes claves. Los entrevistados resaltaron la mayor frecuencia de enfermedad genética de Sandhoff y las prácticas de endogamia (corroboradas en numerosos resultados científicos). A partir de estos datos se determinaron zonas de superposición de tumores renales y de la enfermedad de Sandhoff. Conclusiones: Se detectó una región particular de la provincia con alta frecuencia de tumores renales pediátricos y de la enfermedad de Sandhoff. Numerosos estudios científicos determinan que la endogamia es el factor de riesgo que aumenta la frecuencia de esta enfermedad en esta región. En futuras investigaciones se deberá corroborar si la endogamia también actúa aumentando la incidencia de tumores renales infantiles(AU)


Introduction: There is little research on risk factors of pediatric renal tumors. Objective: To characterize in detail the geographic regions of greatest incidence of pediatric renal tumors in central Argentina and exploring their possible link to genetic risk factors. Methods: The study area comprised the province of Córdoba (Argentina), and a database of pediatric renal tumors incidence was generated with information from the Provincial Tumor Registry. Analyses of spatio-temporal clusters were performed. In-depth interviews with key informants were carried out at localities within the conglomerates. Results: 56 cases of pediatric renal tumors were registered in the Provincial Registry of Tumors between 2004 and 2013. A significant spatial conglomerate was detected, covering seven districts of the province. In that region, six in-depth interviews were conducted with key informants. Interviewees highlighted the increased frequency of Sandhoff genetic disease and endogamous practices (corroborated in numerous scientific results). From these data, zones of overlap of renal tumors and of Sandhoff disease were determined. Conclusions: A particular region of the province was detected with high frequency of pediatric renal tumors and Sandhoff disease. Numerous scientific studies have determined that endogamy is the risk factor that increases the frequency of Sandhoff disease in this region. In future research, it should be confirmed whether it also acts by increasing the incidence of renal tumors in children(AU)


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Consanguinidade , Predisposição Genética para Doença/etiologia , Neoplasias Renais/complicações , Neoplasias Renais/epidemiologia , Argentina , Conglomerados Espaço-Temporais , Neoplasias Renais/genética
2.
Rev. cuba. med. mil ; 47(1): 33-4, ene.-mar. 2018. tab
Artigo em Espanhol | LILACS (Américas) | ID: biblio-960592

RESUMO

Introducción: el adenocarcinoma renal representa hasta el 80 por ciento de los tumores sólidos de este órgano, además de ser el de peor pronóstico. Objetivo: analizar la influencia del estadio tumoral inicial en la sobrevida de pacientes con adenocarcinoma renal. Métodos: se realizó un estudio descriptivo en una muestra de 69 pacientes con diagnóstico de adenocarcinoma renal, atendidos en el Hospital Militar Central Dr. Luis Díaz Soto de enero de 2005 a diciembre de 2014. Las variables estudiadas fueron: edad, sexo, signos y síntomas, exámenes imaginológicos utilizados, estadio tumoral, modalidades terapéuticas empleadas, complicaciones presentadas y la sobrevida posterior al tratamiento. Resultados: prevaleció el grupo de edades de 60-69 años con 46 pacientes (66,7 por ciento) y del sexo masculino con 42 para un 61 por ciento. Predominó el diagnóstico incidental en 52 pacientes (75,4 por ciento). El ultrasonido se empleó en la totalidad de los casos y fue positivo en el 98,6 por ciento. Preponderaron las lesiones en el estadio I en 32 pacientes (46,3 por ciento). La modalidad terapéutica más empleada fue el tratamiento quirúrgico en 65 pacientes (94,2 por ciento), al ser la nefrectomía total por vía lumbar la más practicada con 44 pacientes (63,8 por ciento). La sobrevida a los 5 años fue del 93,7 por ciento. Conclusiones: El diagnóstico del adenocarcinoma renal en estadios iniciales, posibilitó mejor pronóstico y mayor sobrevida de los pacientes. Existió relación directa entre los factores pronósticos, clínicos y tumorales, con la evolución y la mortalidad por adenocarcinoma renal(AU)


Introduction: the renal adenocarcinoma represents until 80 percent of the solid tumors of this organ, besides being that of worse prognosis. Objective: to analyze the influence of the initial tumoral stage in the survival of patient with renal adenocarcinoma. Methods: A descriptive was carried in to sample of 69 patients with diagnosis of renal adenocarcinoma, assisted in the Central Military Hospital Dr. Luis Díaz Soto from January of 2005 to December of 2014. The studied variables were: age, sex, signs and symptoms, imaginologic exams used, tumoral stage, therapeutic modalities employed, complications and the survival later to the treatment. Results: the group of 60-69 year-old ages prevailed with 46 patients (66.7 percent) and of the masculine sex with 42 for 61 percent. The incidental diagnosis prevailed in 52 patients (75.4 percent). The ultrasound was used in the entirety of the cases and it was positive in 98.6 percent. Prevailed the lesions in the I stage in 32 patients (4.3 percent). The therapeutic modality more employed was the surgical treatment in 65 patients (94.2 percent), being the total nephrectomy for lumbar via were practiced in 44 patients (63.8 percent). The survival to the 5 years was of the one 93.7 percent. Conclusions: The diagnosis of the renal adenocarcinoma, in initial stages, facilitates a better prognosis and a bigger survival of the patients. Direct relationship exists among the prognostic factors, clinical and tumoral, with the evolution and the mortality for renal(AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Idoso , Análise de Sobrevida , Neoplasias Renais/epidemiologia , Nefrectomia/efeitos adversos , Carcinoma de Células Renais/diagnóstico por imagem , Epidemiologia Descritiva
4.
Rev. habanera cienc. méd ; 16(5): 751-760, set.-oct. 2017. ilus
Artigo em Espanhol | LILACS (Américas), CUMED | ID: biblio-901767

RESUMO

Introducción: El Síndrome de Von Hippel Lindau es una afección neoplásica multisistémica, heredada de manera autosómica dominante y con alta penetrancia. Su expresividad clínica es muy diversa,oscilando la incidencia entre 1/35000 y 1/36000 nacidos vivos. Esta enfermedad usualmente se diagnostica entre los 20 y 30 años, pero los síntomas pueden aparecer en la infancia. La lesión clínica inicial más común y precoz es el hemangioblastoma de la retina y/o del sistema nervioso central. Objetivo: Presentar un caso de un paciente con carcinomas renales múltiples como manifestación inicial de un Síndrome de Von Hippel Lindau. Presentación del Caso: Paciente masculino de 59 años, con antecedentes de salud, quien acude a urgencias por cuadro febril de 3 días de evolución, que fue interpretado como Dengue; se le realizó, dentro de los complementarios, ultrasonido abdominal, donde se descubrió masa sólida a nivel del polo superior del riñón derecho, asociado a existencia de otra en polo inferior de este mismo riñón, así como de 2 más en el contralateral. Además, se encontraron varios quistes pancreáticos y 2 renales izquierdos corticales. El paciente fue intervenido quirúrgicamente; se corroboró el diagnóstico de carcinomas renales de células claras. El examen oftalmológico reveló la presencia de un hemangioblastoma retiniano derecho; en tanto la tomografía computarizada simple de cráneo y la resonancia magnética espinal no mostraron alteraciones. Conclusiones: Este síndrome es una rara, pero grave afección genética, caracterizada por un alto riesgo de desarrollar enfermedades neoplásicas, lo que hace que sea aún más importante conocerlo, para poder identificar y tratar a tiempo sus temidas complicaciones(AU)


Introduction: Von Hippel Lindau Syndrome is a multisystem neoplastic affection, which is inherited as an autosomal dominant trait, with high penetrance. Its clinical expressivity is very diverse, ranging its incidence between 1/35000 and 1/36000 born alive. This disease is usually diagnosed between the 20 and 30 years of age, but its symptoms can appear in childhood. The most common and early initial clinical lesion is the hemangioblastoma of the retina and/or central nervous system. Objective:To present a case of a patient with multiple renal carcinoma as initial manifestation of Von Hippel Lindau Syndrome. Case presentation: 59 years old male patient with a history of good health who comes to the Emergency Room because of febrile clinical state of 3 days´ evolution, that was interpreted as dengue. Abdominal ultrasound was included in the complementary studies, in which a solid mass at level of upper pole of right kidney was observed, associated with the existence of another one in lower pole of the same kidney, as well as two others in contralateral. Also, multiple pancreatic cysts and two left cortical renal ones were found. The patient underwent surgery, and the diagnosis of clear cells renal carcinoma was corroborated. The ophthalmological exam revealed the presence of a right retinal hemangioblastoma whereas the plain skull CT-scan, and the magnetic resonance imaging of the lumbar spine did not show any alterations. Conclusions:This syndrome is a rare, but a serious genetic affection, characterized by a high risk to develop neoplastic diseases; that´s one reason why it is very important to know about it in order to identify, and treat its feared complications in time(AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Carcinoma de Células Renais/diagnóstico , Doença de von Hippel-Lindau/complicações , Neoplasias Renais/epidemiologia , Relatos de Casos
5.
Einstein (Säo Paulo) ; 13(4): 492-499, Oct.-Dec. 2015. tab
Artigo em Português | LILACS (Américas) | ID: lil-770485

RESUMO

Abstract Objective To analyze and compare the health-related quality of life of adult survivors of acute lymphocytic leukemia and Wilms’ tumor amongst themselves and in relation to healthy participants. Methods Ninety participants aged above 18 years were selected and divided into three groups, each comprising 30 individuals. The Control Group was composed of physically healthy subjects, with no cancer history; and there were two experimental groups: those diagnosed as acute lymphocytic leukemia, and those as Wilms’ Tumor. Quality of life was assessed over the telephone, using the Medical Outcomes Study 36-Item Short Form Health Survey. Results Male survivors presented with better results as compared to female survivors and controls in the Vitality domain, for acute lymphocytic leukemia (p=0.042) and Wilms’ tumor (p=0.013). For acute lymphocytic leukemia survivors, in Social aspects (p=0.031), Mental health (p=0.041), and Emotional aspects (p=0.040), the latter also for survivors of Wilms’ tumor (p=0.040). The best results related to the Functional capacity domain were recorded for the experimental group that had a late diagnosis of acute lymphocytic leukemia. There were significant differences between groups except for the Social and Emotional domains for self-perceived health, with positive responses that characterized their health as good, very good, and excellent. Conclusion Survivors of acute lymphocytic leukemia showed no evidence of relevant impairment of health-related quality of life. The Medical Outcomes Study 36-Item Short Form Health Survey (via telephone) can be a resource to access and evaluate survivors.


Resumo Objetivo Analisar e comparar a qualidade de vida relacionada à saúde de sobreviventes adultos de leucemia linfocítica aguda e tumor de Wilms entre si, e em relação a participantes sadios. Métodos Foram selecionados noventa participantes, acima de 18 anos, os quais foram divididos em três grupos, sendo cada um com 30 sujeitos: Grupo Controle, que contou com indivíduos fisicamente saudáveis, sem histórico oncológico; grupo experimental formado por pacientes que tiveram diagnóstico de leucemia linfocítica aguda; e grupo experimental formado por pacientes que tiveram diagnóstico de Tumor de Wilms. A avaliação da qualidade de vida foi realizada por telefone e utilizou o Medical Outcomes Study 36-Item Short Form Health Survey. Resultados Os sobreviventes do sexo masculino apresentaram melhores resultados em relação aos do sexo feminino e controles no Aspecto vitalidade, para leucemia linfocítica aguda (p=0,042) e tumor de Wilms (p=0,013). Para os sobreviventes de leucemia linfocítica aguda nos Aspectos sociais (p=0,031), Saúde mental (p=0,041) e Aspectos emocionais (p=0,040), neste último também para as sobreviventes de Tumor de Wilms (p=0,040). Os melhores resultados relacionados ao domínio Capacidade funcional foram registrados para o grupo experimental de pacientes que tiveram diagnóstico tardio de leucemia linfocítica aguda. Observaram-se diferenças significativas entre os grupos, exceto para os domínios Aspectos sociais e emocionais para a percepção da própria saúde, que teve respostas de cunho positivo, que qualificavam a própria saúde como boa, muito boa e excelente. Conclusão O grupo experimental de pacientes que tiveram diagnóstico de leucemia linfocítica aguda não apresentou evidências de comprometimento relevante da qualidade de vida relacionada à saúde. O Medical Outcomes Study 36-Item Short Form Health Survey (via telefone) pode ser um recurso de acesso e avaliação de sobreviventes.


Assuntos
Adolescente , Adulto , Feminino , Humanos , Masculino , Adulto Jovem , Neoplasias Renais/epidemiologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/epidemiologia , Qualidade de Vida , Autorrelato , Sobreviventes/psicologia , Tumor de Wilms/epidemiologia , Idade de Início , Análise de Variância , Estudos de Casos e Controles , Seguimentos , Indicadores Básicos de Saúde , Neoplasias Renais/psicologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/psicologia , Fatores Sexuais , Fatores Socioeconômicos , Taxa de Sobrevida , Telefone , Tumor de Wilms/psicologia
6.
Medicina (B.Aires) ; 75(3): 159-162, June 2015. tab
Artigo em Espanhol | LILACS (Américas) | ID: lil-757097

RESUMO

El objetivo del trabajo es describir las características epidemiológicas de la población con tumores renales en nuestra institución, la estrategia de diagnóstico y tratamiento y los hallazgos anatomo-patológicos. Se realizó una recolección prospectiva de datos epidemiológicos, de diagnóstico y tratamiento, así como también de los resultados patológicos en un período de 4.5 años, desde enero de 2010 a junio de 2014. En ese lapso 819 casos (796 pacientes) fueron tratados por masa renal. La edad media: 60.7 años (DE 13.1), 553 (69.5%) fueron hombres. El 29% (230) presentó obesidad (IMC ≥ 30). El diagnóstico fue incidental en 653 casos (79.7%). Un 48.8% (388 pacientes) presentó uno o más factores de riesgo, siendo el tabaquismo el más frecuente (34%). En 238 pacientes (29.9%) se presentó más de una comorbilidad. El 18% presentó creatinina preoperatoria ≥ a 1.3 mg/dl. El 45% de las lesiones fueron ≤ a 4 cm (cT1a). El 10.8% (86) de los pacientes presentaron metástasis al diagnóstico. El 93.5% de las lesiones fueron resecadas y el 6.5% fueron vigiladas activamente (no resecadas). Se utilizó la nefrectomía radical en el 51.5% y cirugía renal conservadora en el 48.5% de los pacientes operados. El abordaje laparoscópico fue utilizado en el 56.2%. El tumor renal se caracteriza en la actualidad por un diagnóstico incidental en estadios patológicos iniciales. La cirugía renal conservadora es la primera opción en casi la mitad de los pacientes. La vigilancia activa ha sido utilizada en un porcentaje mayor a lo comunicado en la literatura.


The aim of this paper is to describe the epidemiological characteristics, clinical management and pathologic patterns in a population with renal tumors in our institution. Prospective data collection was performed over a period of 4.5 years, from January 2010 to June 2014. A total of 819 cases (796 patients) were treated for renal mass during this period. The mean age was 60.7 years (SD 13.1). There were 553 (69.5%) males (male to female ratio: 2.2: 1). Twenty nine per cent (230 patients) were obese (BMI ≥ 30). The diagnosis was incidental in 653 cases (79.7%), 48.8% presented one or more risk factors, being smoking the most frequent (34%). In 238 patients (29.9%) there was more than one comorbidity; 18% had preoperative creatinine ≥ 1.3 mg/dl. Lesions were ≤ 4 cm (cT1a) in 45% of the patients, and 10.8% (86) had metastases at diagnosis. The lesions were resected in 93.5% and actively monitored in 6.5% (not resected). In surgery treated patients, radical nephrectomy was performed in 51.5% of cases, and nephron sparing surgery in 48.5% of them. The laparoscopic approach was used in 56.2%. The pattern of presentation of renal masses is characterized by incidental diagnosis in early disease stages. Nephron sparing surgery is the first choice in nearly half of patients. Active surveillance has been used in a greater percentage than previously reported.


Assuntos
Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Renais/epidemiologia , Argentina/epidemiologia , Estudos Prospectivos , Fatores de Risco
7.
Korean Journal of Urology ; : 422-428, 2015.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-95912

RESUMO

The incidence of cancer is sharply increasing. Cancer is a leading cause of death as well as a significant burden on society. The incidence of urological cancer has shown a higher than average increase and will become an important concern in the future. Therefore, an overall and accurate understanding of the incidence of urological cancer is essential. In this study, which was based on the Korea National Cancer Incidence Database, annual incident cases, age-standardized incidence rates, annual percentage change (APC), and distribution by age group were examined in kidney, bladder, and prostate cancers, respectively. From 1999 to 2011, the total number of each type of urological cancer was as follows: kidney cancer (32,600 cases, 25.5%), bladder cancer (37,950 cases, 29.7%), and prostate cancer (57,332 cases, 44.8%). The age-standardized incidence rates of prostate cancer showed a significant increase with an APC of 12.3% in males. Kidney cancer gradually increased with an APC of 6.0% for both sexes and became the second most frequent urological cancer after 2008. Bladder cancer showed no significant change with an APC of -0.2% for both sexes and has decreased slightly since 2007. The distribution of kidney cancer according to age showed two peaks in the 50- to 54-year-old and 65- to 69-year-old age groups. Bladder and prostate cancers occurred mostly in the 70- to 74-year-old age group. The proportions of male to female were 2.5:1 in kidney cancer and 5.6:1 in bladder cancer. We have summarized the incidence trends of kidney, bladder, and prostate cancers and have provided useful information for screening and management of these cancers in the future.


Assuntos
Feminino , Humanos , Incidência , Neoplasias Renais/epidemiologia , Masculino , Neoplasias da Próstata/epidemiologia , República da Coreia/epidemiologia , Neoplasias da Bexiga Urinária/epidemiologia , Neoplasias Urogenitais/epidemiologia
8.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-155785

RESUMO

BACKGROUND/AIMS: We investigated the incidence and clinical characteristics of renal cell carcinoma (RCC) in the native kidney of renal transplant recipients. METHODS: Between 1991 and 2010, 1,425 patients underwent kidney transplantation at our institution. We retrospectively evaluated the clinical features and outcomes in renal transplant patients with RCC in the native kidney after renal transplantation. RESULTS: The patients included three males and two females with a mean age of 63 years (range, 52 to 74). The incidence of RCC was 0.35%. The median interval between renal transplantation and RCC occurrence was 16.2 years (range, 9 to 20). All of our patients with RCC had developed renal cysts either before (n = 3) or after (n = 2) renal transplantation. The mean duration of dialysis was 12 months (range, 2 to 39). Of the five patients, four underwent dialysis treatment for less than 8 months. All the RCCs were low grade at the time of diagnosis. Four patients underwent radical nephrectomy, and one patient refused the operation. The four patients who underwent radical nephrectomy showed no evidence of local recurrence or distant metastasis during the median follow-up of 2.9 years. However, the patient who did not undergo surgery developed spinal metastasis from the RCC 6 years later. CONCLUSIONS: This study suggests that the follow-up period is an important factor for the development of RCC in renal transplant recipients, and more vigorous screening with a longer follow-up period is required in renal transplant recipients.


Assuntos
Idoso , Carcinoma de Células Renais/epidemiologia , Feminino , Humanos , Incidência , Neoplasias Renais/epidemiologia , Transplante de Rim , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , República da Coreia/epidemiologia , Estudos Retrospectivos
9.
Indian J Pathol Microbiol ; 2012 Oct-Dec 55(4): 439-442
Artigo em Inglês | IMSEAR (Sudeste Asiático), GHL | ID: sea-145633

RESUMO

Background: Mucinous tubular and spindle carcinoma (MTSCC) of kidney is a rare, low-grade polymorphic tumor. Recent studies have described a wide morphology spectrum of this tumor. Aim: To report the clinico-pathologic features of six cases of MTSCC of kidney. Materials and Methods: Six cases of MTSCC of kidney were studied and literature was reviewed. Immunohistochemistry was done by Envision method. Results: The age of the patients ranged from 44 to 84 years (mean 58.5 years). Four patients were males and two were females. The tumor was located in the left kidney in four cases and in the right kidney in two cases. The tumor size ranged from 4.5 to 15 cm (mean 6.4 cm). All tumors exhibited an admixture of tubules, spindle cells, and mucinous stroma in variable proportions. Tubules were predominant in five cases and spindle cells in one case. Psammomatous calcifications, papillations, and necrosis were seen in two cases. Collections of foamy histiocytes were noted in four cases. Cytoplasmic vacuoles and osseous metaplasia were seen in one case each. All cases were Fuhrman's nuclear grade II. Five cases were of stage pT1, and one was pT3. All cases stained positive for alcian blue at pH 2.5. Immunohistochemical stain CK7 was positive in all cases and CD10 was positive in 1/1 case. All patients were alive and well at follow-up of 12-59 months (mean 33.5 months). No metastases were detected. Conclusions: We report six cases of MTSCC of kidney, a rare distinct variant of RCC, with a favorable prognosis. A male predominance was seen in our cases. MTSCC shares histologic and immunohistochemical overlap with papillary renal cell carcinoma (PRCC) and cytogenetic analysis should be performed in difficult cases to avoid a misdiagnosis.


Assuntos
Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma/diagnóstico , Carcinoma/epidemiologia , Carcinoma/imunologia , Carcinoma/patologia , Carcinoma/cirurgia , Carcinoma de Células Renais/diagnóstico , Carcinoma de Células Renais/epidemiologia , Carcinoma de Células Renais/patologia , Carcinoma de Células Renais/cirurgia , Feminino , Humanos , Queratina-7/diagnóstico , Neoplasias Renais/diagnóstico , Neoplasias Renais/epidemiologia , Neoplasias Renais/imunologia , Neoplasias Renais/patologia , Neoplasias Renais/cirurgia , Masculino , Nefrectomia/métodos , Prognóstico
11.
Rev. chil. urol ; 76(4): 257-260, 2011. tab, graf
Artigo em Espanhol | LILACS (Américas) | ID: lil-658275

RESUMO

El objetivo del presente trabajo fue actualizar el análisis de los egresos hospitalarios (EH) de cáncer genitourinario (CGU), específicamente cáncer de próstata, testículo, vejiga y riñón, en nuestro país. Para estos efectos se obtuvieron los datos del boletín de egresos hospitalarios del Ministerio de Salud (MINSAL) del año 2005, utilizándose los códigos de la clasificación internacional de enfermedades de la OMS (CIE-10). Los distintos diagnósticos fueron caracterizados según su composición geográfica y demográfica, comparándose con la información publicada en los reportes anteriores. La proporción de patología oncológica genitourinaria dentro de los egresos hospitalarios por patología genitourinaria ha experimentado un alza sostenida, correspondiendo 10,9 por ciento a cáncer de próstata, 4,28 por ciento a cáncer de testículo, 3,92 por ciento a cáncer de vejiga, y 2,2 por ciento a cáncer renal. El presente reporte constituye una aproximación a nuestro quehacer como urólogos en nuestro país, y al mismo tiempo grafica la necesidad de crear herramientas de registro epidemiológico más efectivas.


The aim of the study was to update the analysis of hospital discharges because of genitourinary cancer in our country. For these purposes, data were obtained from the registers of the Chilean Ministry of Health. Diseases were codified according to the WHO ICD-10 classification. Hospital discharges because of genitourinary cancer has shown a steady increase since 1993.According to the last register (2005), 10.9 percent corresponds to prostate cancer, 4.28 percent to testicular cancer,3.92 percent to bladder cancer and 2.2 percent to renal cell cancer. The present analysis is a rough estimation of our activity in urological oncology. However, more accurate epidemiological tools are needed.


Assuntos
Humanos , Masculino , Alta do Paciente/estatística & dados numéricos , Neoplasias Urogenitais/epidemiologia , Chile/epidemiologia , Demografia , Neoplasias Renais/epidemiologia , Neoplasias Testiculares/epidemiologia , Neoplasias da Próstata/epidemiologia , Neoplasias da Bexiga Urinária/epidemiologia
12.
Rev. chil. urol ; 76(4): 275-280, 2011. graf, tab
Artigo em Espanhol | LILACS (Américas) | ID: lil-658279

RESUMO

Introducción: El cáncer renal ocupa el tercer lugar dentro de los tumores genitourinarios y el 3 por ciento de los tumores malignos primarios, siendo el cáncer urológico con mayor mortalidad y cuya incidencia ha aumentado a nivel mundial. Material y método: Revisión retrospectiva de las fichas de todos los pacientes con diagnóstico de cáncer renal que fueron nefrectomizados o tumorectomizados entre los años 1999 y 2009 en el Hospital Naval Almirante Nef de Viña del Mar, con un total de 135 pacientes. Resultados: Observamos un aumento importante en el número de casos el año 2009, siendo más frecuente en hombres durante los diez años revisados. La media de la edad fue de 61,81 años y la mayoría no presentaba factores de riesgo. Cuarenta y ocho por ciento de los casos diagnosticados fueron hallazgos y 60 por ciento de éstos se encontraban en etapa I. El síntoma más frecuente fue el dolor abdominal. Setenta por ciento de los casos fueron diagnosticados por ecotomografía abdominal y 12 por ciento por pielotac. El 11 por ciento de los pacientes presentaron metástasis posquirúrgicas, siendo la mayoría a pulmón seguido de hígado. De éstos, 20 por ciento habían presentado tumores primarios menores de 7 cm. Conclusión: La incidencia del cáncer renal va en aumento y el diagnóstico precoz de lesiones asintomáticas y de bajo volumen que presentan un porcentaje no despreciable de infiltración tumoral, sugieren un manejo quirúrgico agresivo.


Introduction: Renal cancer represents the third most common cancer within genitourinary tumors and3 percent of all primary malignant tumors. It is the urological cancer with the most mortality rate and it´s incidence has increased worldwide. Methods: Restrospective review of the medical records of every patient diagnosed with renal cancer who where nephrectomized or tumorectomized between the years 1999 and 2009 at Hospital Naval Almirante Nef, Viña del Mar, with a total of 135 patients. Results: There was an important increase in the number of cases in 2009. The higher frequency in men was maintained during the years studied. The mean age was 61.81 years and most of the patients didn’t have any risk factors. 40 percent of the diagnosed cases were asymptomatic findings and 60 percent of them where on stage I. The most frequent symptom was abdominal pain. 70 percent of all cases where diagnosed by abdominal ecotomography and 12 percent CT without contrast. 11 percent of the patients presented post-surgical metastasis, most of them to lung followed by liver. 20 percent of them had primary tumors smaller than 7 cm. Conclusion: The incidence of renal cancer is increasing and the early diagnosis of asymptomatic and small lesions which in an important percentage have tumoral infiltration suggest an aggressive surgical treatment.


Assuntos
Humanos , Masculino , Adolescente , Adulto , Feminino , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Nefrectomia , Neoplasias Renais/cirurgia , Neoplasias Renais/epidemiologia , Chile , Invasividade Neoplásica , Estadiamento de Neoplasias , Neoplasias Renais/patologia , Complicações Pós-Operatórias , Estudos Retrospectivos
13.
Indian J Cancer ; 2010 Jul-Sept; 47(3): 287-291
Artigo em Inglês | IMSEAR (Sudeste Asiático), GHL | ID: sea-144352

RESUMO

Purpose: We have analyzed the changing trends in surgical treatment of renal tumors over the last 2 decades with regard to age incidence, presentation, incidental detection, and histopathology. Materials and Methods: Records of renal tumors were analyzed from January 1, 1988 to December 31, 2007. Data were split into 4 parts based on a 5-year time period, 1 for each cohort of patients: cohort 1 (1988-1992)-103 patients, cohort 2 (1993-1997)-161 patients, cohort 3 (1998-2002)-243 patients, and cohort 4 (2003-2007)-304 patients. A comparative study was performed with regard to age incidence, presentation, incidentallomas, histopathology, and management with statistical analysis. Results: Out of 811 renal tumors, 17.63% cases were benign and 82.37% were malignant. In the first cohort, 34.95% cases were detected in the seventh decade as compared with cohort 4 in which these were detected in the sixth (34.86%) and fifth decades (21.38%). Incidentallomas increased from 11 (10.67%) in cohort 1 to 84 (27.63%) in cohort 4 (P = 0.001). The cases of surgically treated tumors increased in number from 103 to 304 in cohort 4. Among the presenting features, incidence of weight loss, flank pain, and lump decreased while other clinical syndromes were constant. Only open radical nephrectomy was performed in the first 2 consecutive timeperiods. Laparoscopic radical nephrectomy was increasingly used in cohort 4 as compared with cohort 3 (121 vs 32, respectively). Similarly, open nephron sparing surgery (NSS) was increasingly used in cohort 4 as compared with cohort 3. Among the histopathologies, clear cell carcinoma was most common (73.35 %), but Fuhrman grading showed a trend toward more cases detected with grade 1 and 2 in cohort 4; 23.73% and 61.86%, respectively, as compared with 15.85% and 45.12% in cohort 1 (P = 0.001); more T1 tumors were detected (63.42% in cohort 4 as compared with 41.46% in cohort 1). Conclusions: A majority of renal tumors presented as symptomatic tumors. Recently, tumors are being detected at an early stage and grade; in the younger patients, with an increasing trend of laparoscopic and open NSS.


Assuntos
Idade de Início , Idoso , Criança , Feminino , Dor no Flanco , Hematúria , Humanos , Incidência , Neoplasias Renais/epidemiologia , Neoplasias Renais/patologia , Neoplasias Renais/fisiopatologia , Neoplasias Renais/cirurgia , Laparoscopia , Masculino , Pessoa de Meia-Idade , Nefrectomia , Sarcoma de Células Claras/epidemiologia , Sarcoma de Células Claras/patologia , Sarcoma de Células Claras/fisiopatologia , Sarcoma de Células Claras/cirurgia , Perda de Peso
14.
Int. braz. j. urol ; 36(2): 141-150, Mar.-Apr. 2010. ilus, tab
Artigo em Inglês | LILACS (Américas) | ID: lil-548373

RESUMO

PURPOSE: The aim of this study was to discover if elderly patients exhibit comparable outcomes and survival benefits to those achieved in younger patients. MATERIALS AND METHODS: We assessed 35 patients over 80 years old treated by radical nephrectomy or nephroureterectomy for malignant and inflammatory conditions within the previous 4 years. A multivariate analysis regarding survival and recovery was conducted and included various preoperative parameters. The subjective opinion of patients or patient's relatives (in cases where the patient had past away) was estimated by answering the following questions: (a) are you satisfied with your decision to undergo the operation? (b) would you undergo it once more if needed? (c) would you advise it to a patient your age? RESULTS: The median age was 83.5 years. Radical nephrectomy with a flank approach was performed in 65.7 percent of cases and nephroureterectomy with a transabdominal approach in 34.3 percent of cases. The median recovery was 13 weeks. During a median follow-up of 31 months (range 12 to 53), 80 percent of patients were disease free. The remaining 20 percent passed away demonstrating a median survival of 25 months (range 13-38). Eighty-eight percent of patients were satisfied with their decision to undergo the operation, 91.4 percent would undergo it once more if needed and 91.4 percent would advise it to a patient their age. CONCLUSIONS: Radical nephrectomy and nephroureterectomy are safe and effective in well-selected patients over 80 years old. Elderly patients exhibit comparable preoperative outcomes and survival benefits to those achieved in younger patients. Various preoperative clinical variables that effect the survival of patients but not their recovery could be identified.


Assuntos
Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Neoplasias Renais/cirurgia , Laparoscopia/métodos , Nefrectomia/métodos , Ureter/cirurgia , Neoplasias Ureterais/cirurgia , Fatores Etários , Brasil/epidemiologia , Carcinoma de Células de Transição/patologia , Carcinoma de Células de Transição/cirurgia , Neoplasias Renais/epidemiologia , Neoplasias Renais/patologia , Laparoscopia/mortalidade , Nefrectomia/mortalidade , Complicações Pós-Operatórias , Estudos Retrospectivos , Análise de Sobrevida , Neoplasias Ureterais/epidemiologia , Neoplasias Ureterais/patologia
15.
Int. braz. j. urol ; 36(2): 151-158, Mar.-Apr. 2010. graf, tab
Artigo em Inglês | LILACS (Américas) | ID: lil-548374

RESUMO

PURPOSE: In Brazil, National data regarding the epidemiology of renal cell carcinoma (RCC) are scarce. The aim of this study was to describe the demographic, clinical, and pathologic characteristics of RCC diagnosed and treated by members of the SBU - Brazilian Society of Urology. MATERIALS AND METHODS: For this cross-sectional study, data were collected through an on line questionnaire available to the members of the Brazilian Society of Urology (SBU). Between May 2007 and May 2008, voluntary participant urologists collected data on demographic, clinical and pathological characteristics from patients diagnosed with RCC in their practice. RESULTS: Fifty SBU affiliated institutions contributed with patient information to the study. Of the 508 patients, 58.9 percent were male, 78.9 percent were white, and the mean age was 59.8 years. Smoking history, high blood pressure and a body mass index above 30 kg/m2 were present in 14.8 percent, 46.1 percent and 17.9 percent of the patients, respectively. Abdominal ultrasound and computed tomography were the main diagnostic methods. The majority of the cases were localized tumors and metastasis were presented in 9.5 percent of the patients; 98.4 percent underwent nephrectomy. Clear cell carcinoma was the most common histological type. In comparison with private institutions, stage IV disease was less frequent among patients treated at public health services (P = 0.033). CONCLUSIONS: RCC in Brazil is more common in white men in their sixth decade of life. Ultrasound is the main diagnostic tool for the diagnosis of clear cell carcinoma and we found that localized disease was predominant. A national registry of RCC is feasible and may provide valuable information.


Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Carcinoma de Células Renais/epidemiologia , Neoplasias Renais/epidemiologia , Distribuição por Idade , Brasil/epidemiologia , Estudos Transversais , Demografia , Fatores de Risco , Distribuição por Sexo
16.
Int. braz. j. urol ; 35(4): 427-431, July-Aug. 2009. tab
Artigo em Inglês | LILACS (Américas) | ID: lil-527200

RESUMO

Objective: The incidence of solid renal masses has increased sharply in recent years due to widespread use of abdominal imaging studies. The aim of the present study was to evaluate the incidence of benign lesions in solid renal masses according to tumor size. Materials and Methods: The authors retrospectively reviewed the records of 305 patients with 328 renal solid masses treated by surgery. Based on a report by one pathologist, the specimen tumor size and the histology of each lesion were tabulated. The frequency of renal cell carcinoma and benign renal lesions was evaluated and a correlation between tumor size and pathological features of the masses was observed. Results: The frequency of malignant lesions in the 328 renal masses was 83.2 percent. When lesions were stratified into groups with diameters ¡Ü 3 cm or > 3 cm, the incidence of benign histology was 22.9 percent and 13.3 percent, respectively (p = 0.026). The odds ratios for finding a benign lesion in masses ¡Ü 3 cm was 1.93 (IC 95 percent, 1.07 - 3.46) compared to masses > 3 cm. Conclusion: The incidence of benign lesions is significantly higher in renal masses smaller than 3 cm in diameter, which should be taken in account when the treatment of renal solid masses is planned.


Assuntos
Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Nefropatias/patologia , Incidência , Nefropatias/epidemiologia , Neoplasias Renais/epidemiologia , Neoplasias Renais/patologia , Estudos Retrospectivos , Carga Tumoral , Adulto Jovem
17.
Rev. chil. urol ; 74(1): 43-47, 2009. tab
Artigo em Espanhol | LILACS (Américas) | ID: lil-562708

RESUMO

Introducción: El carcinoma renal muticéntrico es decir aquellos carcinomas que cuentan con un tumor principal y uno o más secundarios, ocurre en el 10 por ciento de los casos. Su ocurrencia se asocian entre otro, a factores tales como el tamaño tumoral y el tipo histológico. El riesgo de multicentricidad permite evaluar la mejor opción de tratamiento quirúrgico oncológico. Objetivos: Evaluar la frecuencia de multicentricidad en el carcinoma renal y factores morfológicos asociados. Material y método: Análisis de 165 nefrectomías radicales por tumor renal desde 1990 hasta el año 2005 por un protocolo preestablecido. Resultados: La multicentricidad se presentó en 18 casos (10,9 por ciento). El número promedio de tumores secundarios fue de 4,9 por caso, la concordancia con el grado nuclear de Furhman y el tipo histológico con el tumor principal fue de 100 por ciento y 66 por ciento respectivamente. 8 de los 18 casos (44 por ciento) correspondían a un estadio T1a de la OMS, de estos 5 eran carcinomas papilares. Del total de la muestra 6 de 6 (100 por ciento ) carcinomas papilares fueron multicéntricos y 12 de 148 (8,1por ciento) carcinomas de células claras fueron multicéntricos. Trece de 18 tumores principales median menos de 7 cm y el 93 por ciento de los tumores secundarios median menos de 2,5 cm. Conclusiones: La frecuencia de multicentricidad en el carcinoma renal fue cercana al 10 por ciento, casi la mitad de los casos se presentaron en el estadio T1a, de los cuales la mayoría correspondieron a Carcinomas papilares. El conocimiento del tipo histológico es importante a la hora de seleccionar el tipo de cirugía a practicar, en este caso por sobre el tamaño tumoral.


Introduction: Multicentric renal carcinoma (ie those that have a primary tumor and one or more secondary), occurs in 10 percent of cases. Its occurrence is associated to tumor size and histologic type. The multicentricity risk allows to assess the best surgical treatment. Objectives: To evaluate the frequency of multicentricity in renal cell carcinoma and his morphological factors.Material and methods: An analysis of 165 radical nephrectomies for renal tumors from 1990 until 2005 was conducted. Results: Multicentricity was found in 17 cases (10.9 percent). The average number of secondary tumors was 4.9; the correlation with histologic type and Furhman nuclear grade with the main tumor was 100 percent and 66 percent respectively. Eight cases (44 percent ) were stage T1a (5 were papillary carcinomas). 6 / 15 (40 percent) of papillary carcinomas were multicentric and 12/179 (6.7 percent) of clear cell carcinoma were multicentric tumors.13/18 of the primary tumor measured less than 7 cm and 93 percentof secondary tumors measured less than 2.5 cm. Conclusions: The frequency of multicentricity in renal cell carcinoma was 10 percent, most of the cases were in stage T1a, most of which were papillary carcinomas. Knowledge of the histologic type is more important than the tumor size for the selection of the best surgical approach.


Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Carcinoma de Células Renais/cirurgia , Carcinoma de Células Renais/patologia , Invasividade Neoplásica , Neoplasias Renais/cirurgia , Neoplasias Renais/patologia , Distribuição por Idade , Carcinoma de Células Renais/epidemiologia , Estadiamento de Neoplasias , Nefrectomia , Neoplasias Renais/epidemiologia
18.
Rev. chil. urol ; 74(4): 317-322, 2009.
Artigo em Espanhol | LILACS (Américas) | ID: lil-572103

RESUMO

El adenocarcinoma de células renales constituye el 3 por ciento del total de los tumores malignos, aproximadamente el 90 por ciento de los tumores primarios de origen renal y tercero en prevalencia en el área urológica luego de los de próstata y vesical. El objetivo de este estudio es caracterizar y analizar una muestra de 100 pacientes portadores de adenocarcinoma renal de nuestro servicio y fundamentalmente evaluar su pronóstico según etapificación. Estudio descriptivo, retrospectivo de 100 pacientes encontrados en las historias revisadas de los años 1999 y 2005, en el Hospital Nacional Guillermo Almenara Irigoyen en Lima - Perú. Se analizan datos clínicos, diagnóstico anátomo-patológico, etapificación y quirúrgico. Análisis estadístico mediante base de datos. El promedio de edad fue de 63,8 años. Los pacientes hombres fueron el 60 por ciento. De la presentación destacan el dolor y la hematuria. Hubo más tumores del lado derecho (57 por ciento) que del lado izquierdo. Etapificación: EC I: 30 por ciento, EC II: 20 por ciento, EC III: 20 por ciento, EC IV: 30 por ciento. El adenocarcinoma renal afecta principalmente durante la séptima década de la vida y es tres veces más frecuente en hombres que en mujeres. La presentación clínica más común es el dolor, cobrando relevancia la utilización de métodos radiológicos para su diagnóstico. La incidencia encontrada tanto según estadio patológico como pronóstico no difiere de lo analizado en la literatura nacional e internacional.


Renal cell carcinoma accounts for 3 percent of all cancers, 90 percent of primary renal tumors and is third in the list of urologic tumors after prostate and bladder. The purpose of this study is to analyze a sample of 100 patients from our institution and evaluate their prognosis and staging. This is a retrospective study of100 cases founded in hospital records reviewed from 1999 to 2005 in the Hospital Nacional Guillermo Almenara Irigoyen in Lima - Perú. Clinical data, pathology diagnosis, staging, prognosis and surgical management are analyzed. Mean age was 63,8 years and 60 percent of the patients were male. The main symptom was pain. Staging: EC I: 30 percent, EC II: 20 percent, EC III: 20 percent, EC IV: 30 percent. Renal cell carcinoma affects mainly men in the seventh decade of life. Radiologic studies are fundamental for its diagnosis. Incidence and staging do not differ with other reported series.


Assuntos
Humanos , Masculino , Feminino , Carcinoma de Células Renais/patologia , Hospitais/estatística & dados numéricos , Neoplasias Renais/epidemiologia , Distribuição por Sexo
19.
Rev. chil. urol ; 74(3): 217-222, 2009. tab
Artigo em Espanhol | LILACS (Américas) | ID: lil-551917

RESUMO

El cáncer de vía urinaria alta (pelvis renal y/o uréter) es una neoplasia rara. Generalmente es del tipo células de transición. El objetivo de este trabajo es conocer los aspectos epidemiológicos, clínicos y de manejo de los pacientes institucionales con esta patología que han consultado en el Hospital Nacional “Guillermo Almenara Irigoyen”en Lima - Perú. Se revisaron retrospectivamente los ingresos al Servicio de Urología entre los años 1999 al 2005. Se recuperaron 26 ingresos con este diagnóstico. Se analizan sexo, edad, antecedentes clínicos, síntomas, exámenes de laboratorio, tipo histológico, tratamientos, complicaciones y seguimiento. Las edades fluctuaron entre los 47 y 82 años (promedio de 64,8 años). El 53,8 por ciento fueron mujeres. El tabaquismo lamentablemente no se consigna en los ingresos. La hematuria fue el principal síntoma. El 100 por ciento presentaba hematuria en el examen de orina. El 19,2 por ciento estaban con metástasis al momento del diagnóstico. Casi todos los pacientes tuvieron manejo quirúrgico clásico de forma convencional o laparoscópica. El 100 por ciento tenían carcinoma de células transicionales. Las complicaciones perioperatorias fueron mínimas. No se registra mortalidad operatoria. Esta patología es un cáncer poco frecuente, que debe sospecharse ante toda hematuria, que es el principal motivo de consulta. Idealmente el diagnóstico debe ser precoz. Su manejo debe ser esencialmente quirúrgico.


Introduction: Upper urinary tract tumors are infrequent. However when present, they are usually related to transitional cell carcinoma. The purpose of this study was to analyze epidemiologic, clinic and therapeutic aspects of this disease in the Hospital Nacional “Guillermo Almenara Irigoyen” in Lima - Perú. Material and Methods: A Retrospective review of all our admissions between 1999 and 2005 was performed. A total of 26 patients were admitted with this diagnosis. Gender, age, clinical findings, pathology, treatment and follow-up are analyzed.Results: Mean age was 64,8 years (47-82 years), 53,8 percent were women. Tobacco consumption did not appear in the admission data. The chief complaint was hematuria and 100 percent had microscopic hematuria in the lab tests. Almost all the patients underwent surgery (mainly nephroureterectomy with partial cistectomy). All cases had transitional cell cancer. There were minimal complications and no surgical mortality. Conclusions: Carcinoma of the upper urinary tract is infrequent, must be suspected in the event of hematuria. Ideally diagnosis should be preoperative with histological confirmation. Most of the cases are transitional cell cancer, and management must be essentially surgical.


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Carcinoma de Células de Transição/epidemiologia , Neoplasias Renais/epidemiologia , Neoplasias Ureterais/epidemiologia , Carcinoma de Células de Transição/cirurgia , Carcinoma de Células de Transição/patologia , Seguimentos , Estadiamento de Neoplasias , Neoplasias Renais/cirurgia , Neoplasias Renais/patologia , Neoplasias Ureterais/cirurgia , Neoplasias Ureterais/patologia , Complicações Pós-Operatórias , Prognóstico , Peru/epidemiologia , Recidiva , Estudos Retrospectivos
20.
Cuad. méd.-soc. (Santiago de Chile) ; 47(3): 162-175, sept. 2007. tab, graf
Artigo em Espanhol | LILACS (Américas) | ID: lil-589268

RESUMO

Se presenta el perfil oncológico de la Región de Antofagasta. Mediante la comparación de la mortalidad regional por las distintas localizaciones de cáncer con la mortalidad nacional y de otras áreas se deduce que persiste un exceso de mortalidad por cáncer vesical (2002-2004) y broncopulmonar (2001-2004), en hombres y en mujeres; y que hay un exceso de cáncer renal y hepático en varones y un exceso de cáncer pancreático en mujeres. Se descarta el papel del envejecimiento poblacional en lo que respecta a los cánceres de vejiga y de pulmón. Se discuten las características de estos cánceres en Chile y en otros países: mortalidad, incidencia, tendencias, relación con el sexo y con otros factores posibles. Se citan las investigaciones nacionales relativas a la presencia y papel del arsénico en el aire, agua, alimentos y procesos laborales en la región. Las diferencias por sexo sugieren que: el cáncer vesical se relaciona con el ambiente general más que con el ambiente laboral (los excesos son similares en ambos sexos); el cáncer pulmonar, con el ambiente general y con el ambiente laboral (proceso metalúrgico); el cáncer renal y el del hígado, con circunstancias atingentes al género masculino pero probablemente no con el arsénico en el caso del cáncer hepático; y el cáncer de páncreas, posiblemente con el ambiente general. En Antofagasta y regiones vecinas hay menos mortalidad por cánceres digestivos y de próstata y ovario. Esta extensión en el espacio contrasta con la especificidad regional de los excesos. Se recomienda continuar e intensificar la investigación, monitoreo y control multisectorial de aquellos cánceres cuyo exceso persiste desde hace varias décadas en la Región de Antofagasta.


We present the oncological profile of Antofagasta Region, within a general regional approach to the state of health of the population. Through the comparison of regional mortality for the different cancer localizations with mortality in the country and in other regions, we show a persistent excess of bladder and lung cancer in men and women; an excess in kidney and liver cancer in men, and an excess of pancreatic cancer in women. The role of age structure is discarded, at least as far as bladder and lung cancer are concerned. The characteristics of these cancers in Chile and other countries are discussed: mortality, incidence, trends, relationships with gender, and to other possible factors. The previous national investigations related to the presence and the role of arsenic in the air, in drinking water, in food and in occupational processes in the region are cited. Gender associations suggest that: bladder cancer is related to the general environment more than to occupation (the excess is similar for both sexes); lung cancer is related both with the general and the occupational (copper smelting) environment; kidney and liver cancer, with men-related circumstances but probably not with arsenic, in the case of hepatic cancer; and pancreatic cancer, possibly with the general environment. In both Antofagasta and neigh boring regions there is less mortality than in the country as a whole from cancers of the digestive tract and of prostate and ovary. This spatial extension does not apply to the cancers found to be in excess in Antofagasta. We conclude that research, monitoring and multisector control must continue and be intensified regarding the types of cancer for which a regional excess has persisted over several decades.


Assuntos
Humanos , Neoplasias Pulmonares/epidemiologia , Neoplasias da Vesícula Biliar/epidemiologia , Distribuição por Idade e Sexo , Arsênico/efeitos adversos , Chile/epidemiologia , Poluição Ambiental/efeitos adversos , Mortalidade , Neoplasias Hepáticas/epidemiologia , Neoplasias Pancreáticas/epidemiologia , Neoplasias Renais/epidemiologia , Câncer Ocupacional
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