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1.
Med. lab ; 24(1): 13-35, 2020.
Artigo em Espanhol | LILACS (Américas), COLNAL | ID: biblio-1096999

RESUMO

Los procesos inflamatorios e infecciosos que se desencadenan en la próstata, primordial glándula reproductiva masculina, originan las tres principales enfermedades de este órgano: prostatitis, hiperplasia prostática benigna y cáncer. Para entender la relación que existe entre estas tres patologías y los procesos de infección e inflamación, se realizó una revisión de la literatura científica, a conveniencia, en la base de datos PubMed, empleando los términos próstata, prostatitis, hiperplasia prostática benigna y cáncer de próstata. La literatura revisada resalta la importancia del adecuado funcionamiento del sistema inmune en el tejido prostático para eliminar los microorganismos causantes de infecciones, proceso a través del cual se desencadena la inflamación del tejido. Además, infecciones urinarias ascendentes, que culminan en prostatitis crónica, favorecen el desarrollo de la hiperplasia prostática benigna, agrandamiento y fibrosis de la próstata en hombres adultos, e incluso su progresión a cáncer en individuos genéticamente susceptibles. Por otro lado, las limitaciones en el diagnóstico de las alteraciones prostáticas promueven la inflamación crónica, y el uso indiscriminado de antibióticos de amplio espectro para el tratamiento de la prostatitis, impulsa la diseminación sexual de microorganismos multirresistentes al tratamiento. Las alteraciones prostáticas, en especial la prostatitis, continúan siendo patologías enigmáticas de difícil diagnóstico y tratamiento. El estudio de la próstata, sus alteraciones y su relación con el sistema inmune contribuirán a limitar el uso indiscriminado de antibióticos y a reducir los costos en salud y los efectos sobre la calidad de vida de los individuos afectados


Inflammatory and infectious processes triggered in the prostate, the primary male reproductive gland, originate the three main diseases of this organ: prostatitis, benign prostatic hyperplasia and cancer. To understand the relationship between these three pathologies and inflammatory and infectious processes, a review of the scientific literature was carried out in PubMed database using the terms prostate, prostatitis, benign prostatic hyperplasia and prostate cancer. The revised articles highlight the importance of properly immune system functioning in the prostate tissue to remove the microorganisms that cause infections, a process which also triggers tissue inflammation. In addition, ascending urinary infections, which culminate in chronic prostatitis, favor the development of benign prostatic hyperplasia, enlargement and fibrosis of the prostate in adult men, and even its progression to cancer in genetically susceptible individuals. Furthermore, limitations in the diagnosis of prostatic disorders promote chronic inflammation, and the indiscriminate use of broad spectrum antibiotics for prostatitis treatment leads to sexual dissemination of multidrug-resistant microorganisms. Prostatic disorders, especially prostatitis, continue to be enigmatic pathologies of difficult diagnosis and treatment. The study of the prostate, its disorders and its relationship with the immune system will contribute to limit the indiscriminate use of antibiotics and to reduce health costs and the effects on the quality of life of affected individuals


Assuntos
Humanos , Pessoa de Meia-Idade , Idoso , Próstata , Hiperplasia Prostática , Neoplasias da Próstata , Prostatite , Infecções , Inflamação
2.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-742355

RESUMO

PURPOSE: To determine the role of metabolic syndrome (MetS) as a risk factor for acquired premature ejaculation (PE) after considering the various risk factors, such as lower urinary tract symptoms, erectile dysfunction, hypogonadism, and prostatitis. MATERIALS AND METHODS: From January 2012 to January 2017, records of 1,029 men were analyzed. We performed multivariate analysis to identify risk factors for PE, including the covariate of age, marital status, International Prostate Symptom Score, International Index of Erectile Function (IIEF) score, National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) score, serum testosterone levels, and all components of MetS. Acquired PE was defined as self-reported intravaginal ejaculation latency time ≤3 minutes, and MetS was diagnosed using the modified National Cholesterol Education Program Adult Treatment Panel III criteria. RESULTS: Of 1,029 men, 74 subjects (7.2%) had acquired PE and 111 (10.8%) had MetS. Multivariate analysis showed that the IIEF overall satisfaction score (odds ratio [OR]=0.67, p<0.001), NIH-CPSI pain score (OR=1.07, p=0.035), NIH-CPSI voiding score (OR=1.17, p=0.032), and presence of MetS (OR=2.20, p=0.022) were significantly correlated with the prevalence of acquired PE. In addition, the Male Sexual Health Questionnaire for Ejaculatory Dysfunction scores and ejaculation anxiety scores progressively decreased as the number of components of MetS increased. CONCLUSIONS: MetS may be an independent predisposing factor for the development of acquired PE. Effective prevention and treatment of MetS could also be important for the prevention and treatment of acquired PE.


Assuntos
Academias e Institutos , Adulto , Ansiedade , Causalidade , Colesterol , Educação , Ejaculação , Disfunção Erétil , Humanos , Hipogonadismo , Sintomas do Trato Urinário Inferior , Masculino , Estado Civil , Análise Multivariada , Obesidade , Ejaculação Precoce , Prevalência , Próstata , Prostatite , Saúde Reprodutiva , Fatores de Risco , Testosterona
3.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wprim-777245

RESUMO

The technical combination of acupuncture is a combination therapy based on the purpose of improving clinical efficacy. After years of clinical practice, the author has gradually summarized the dominant disease spectrum of combination therapy, especially for the treatment of difficult diseases such as male and dermatological. In the treatment of chronic prostatitis, the combination of acupuncture at "Zhibian (BL 54) through Shuidao (ST 28) therapy" is adopted. When urticaria is treated, the embedding, fire needle, needle knife and filiform needle can be combined to ensure better effect. Regarding the evidence-based acupuncture treatment research of chronic prostatitis and urticaria, it is believed that acupuncture treatment has been recommended as grade Ⅱ and Ⅰ, and there is no reliable treatment method in modern medicine. The author enumerates two cases of related diseases and explains the advantages of combination therapy.


Assuntos
Pontos de Acupuntura , Terapia por Acupuntura , Terapia Combinada , Humanos , Masculino , Moxibustão , Prostatite , Terapêutica , Resultado do Tratamento
4.
Rev. Soc. Argent. Diabetes ; 53(1): 41-44, Ene.-Abr. 2019.
Artigo em Espanhol | LILACS (Américas) | ID: biblio-1021906

RESUMO

La cistitis bacteriana aguda es un proceso infeccioso de la vejiga. La prescencia de disuria, polaquiuria, tenesmo, dolor hipogástrico y/o hematuria, aumenta la probabilidad diagnóstica. Ante la sospecha clínica debe solicitarse sedimento urinario y evaluar presencia de leucocituria, piuria o microhematuria, y requerir urocultivo previo al inicio del tratamiento. La prostatitis bacteriana aguda es una entidad poco frecuente pero que requiere diagnóstico y tratamiento precoz, con aislamiento del gérmen. La uretritis puede ser de etiología infecciosa o no. En estas patologías, el tratamiento no difiere de los pacientes sin diabetes, pero deben tenerse presente factores como la neuropatía autonómica que puede encubrir la sintomatología y aumentar el riesgo de descompensación metabólica y cetoacidosis


Acute bacterial cystitis is an infectious process of the bladder. The presence of dysuria, pollakiuria, tenesmus, hypogastric pain and/or hematuria increases the diagnostic probability. In view of clinical suspicion, urinary sediment should be requested to evaluate the presence of leukocyturia, pyuria or microhematuria, and urine culture requested before starting treatment. Acute bacterial prostatitis is a less frequent entity but requires early diagnosis and treatment, with germ isolation. Urethritis can be of infectious etiology or not. In these pathologies, treatment does not differ from patients without diabetes, but factors such as autonomic neuropathy that can conceal the symptoms and increase the risk of metabolic decompensation and ketoacidosis should be considered


Assuntos
Prostatite , Uretrite , Cistite
5.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-764104

RESUMO

Prostate cancer (CaP) is the most common cancer diagnosed among men in the United States and the fifth most common cancer among men in Korea. Unfortunately, the early stages of CaP may have no symptoms. Thus, early detection is very important and physicians managing voiding dysfunction must have awareness about CaP. The traditional tests used for early detection of CaP are the prostate-specific antigen (PSA) blood test and digital rectal examination. However, a high PSA level is not specific for CaP. Benign prostatic hyperplasia, prostatitis, urinary tract infection, and urinary retention can all cause a high PSA level. Thus, no test shows sufficient accuracy to truly be useful for screening men for CaP. A prostate biopsy is the only method that yields a definitive diagnosis of CaP; however, this test is invasive and uncomfortable. Recently, new biomarkers for CaP detection have been proposed to improve the accuracy of the PSA test. In this review, we summarize our knowledge of various new biomarkers, including PSA-associated biomarkers (the prostate health index and 4Kscore), molecular biomarkers (PCA3, TMPRSS2: ERG fusion gene, and various miRNAs), and proteomics-associated biomarkers, and the ways in which they may improve the detection rate of CaP. Accordingly, this review can raise awareness about CaP to physicians managing voiding dysfunction and be a good reference for them.


Assuntos
Biomarcadores , Biópsia , Diagnóstico , Exame Retal Digital , Discriminação Psicológica , Detecção Precoce de Câncer , Testes Hematológicos , Humanos , Coreia (Geográfico) , Masculino , Programas de Rastreamento , Métodos , Próstata , Antígeno Prostático Específico , Hiperplasia Prostática , Neoplasias da Próstata , Prostatite , Estados Unidos , Retenção Urinária , Infecções Urinárias
6.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-763188

RESUMO

PURPOSE: The purpose of this study was to determine whether histologic inflammation (HI) in initial and repeat prostate biopsy specimens was significantly associated with the detection of prostate cancer. MATERIALS AND METHODS: Between 2005 and 2017, the clinicopathological records of patients with high prostate-specific antigen (PSA) levels who underwent initial and repeat prostate biopsies were retrospectively reviewed. The presence of HI and its degree in each biopsied specimen were interpreted by one uropathologist with 20 years of experience. The association between HI and cancer diagnosis was statistically assessed, with p 0%) on biopsied specimens, respectively. Comparison of the cancer and noncancer groups revealed that a greater rate of HI specimens in the initial biopsy was associated with fewer prostate cancer diagnoses following repeat biopsy (p < 0.001). Other comparisons between the cancer and non-cancer groups showed that the cancer group had a significantly higher rate of hypertension, whereas those non-cancer group had a significantly higher rate of benign prostatic hyperplasia and prostatitis (p < 0.05). CONCLUSION: A finding of a lesser degree of HI in the initial and a greater degree of HI in the repeat biopsied specimens was associated with the higher probability of cancer diagnosis in patients with high PSA levels.


Assuntos
Biópsia , Diagnóstico , Humanos , Hipertensão , Inflamação , Próstata , Antígeno Prostático Específico , Hiperplasia Prostática , Neoplasias da Próstata , Prostatite , Estudos Retrospectivos
7.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-776637

RESUMO

OBJECTIVE@#To evaluate the efficacy and safety of essential oil treatment for type III chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).@*METHODS@#A randomized controlled trial was conducted from December 2014 to October 2015. Seventy type III CP/CPPS patients were assigned to the essential oil group (35 cases) or almond placebo oil control group (35 cases) by a random number table. The oil was smeared by self-massage on the suprapubic and sacral region once a day for 4 weeks. The National Institutes of Health Chronic Prostatitis Syndrome Index (NIH-CPSI) and expressed prostatic secretions (EPS) were examined. The primary outcome was NIH-CPSI pain domain. The secondary outcomes included other NIH-CPSI domains and laboratory examinations of EPS. Adverse events were also observed.@*RESULTS@#Sixty-six subjects completed the full 4-week treatment. There was no significant difference between almond oil control and essential oil groups in terms of the total score of NIH-CPSI, pain, quality of life and urination domain scores of NIH-CPSI and EPS examinations (P>0.05). In the essential oil group, pain between rectum and testicles (perineum) in the domain of pain or discomfort was significantly reduced at week 2 and week 4 compared with almond oil control group (P<0.01). No serious adverse events occurred.@*CONCLUSION@#The essential oil may reduce the pain or discomfort in the perineum region in patients with CP/CPPS. (Registration No. ChiCTR-IPR-14005448).


Assuntos
Adulto , Dor Crônica , Tratamento Farmacológico , Humanos , Masculino , Óleos Voláteis , Dor Pélvica , Tratamento Farmacológico , Projetos Piloto , Prostatite , Tratamento Farmacológico , Síndrome , Resultado do Tratamento
8.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-761881

RESUMO

PURPOSE: Because of the inconsistent symptoms associated with Ureaplasma infections, their clinical significances in genitourinary tracts are under debate. Therefore, we evaluated the presence of Ureaplasma urealyticum (UU) and Ureaplasma parvum (UP) in urine samples and examined their associations with chronic prostatitis (CP) through a case and control study. MATERIALS AND METHODS: We included 696 nonchlamydial nongonococcal (NCNG) urine samples from men; 350 were categorized into non-inflammatory CP, 88 in inflammatory CP, and 258 in non-CP group. We amplified a region in the Ureaplasma urease areas from these samples and determined their biovars using the Sanger method. RESULTS: Among the NCNG population, the rates of UU, UP, and non-UU/UP were 3.88%, 6.46%, and 89.66%, respectively. The overall infection rates of non-CP, inflammatory CP, and non-inflammatory CP groups were 4.15%, 6.10%, and 3.65% in UU (p=0.612) and 6.85%, 7.22%, and 6.50% in UP (p=0.968), respectively. UU infection increased the risk of white blood cell (WBC) counts (≥5) in urine (p=0.005). In contrast, UP infections did not increase the risks of urethritis. Re-analysis from the 633 men who were excluded from urethritis effects did not reveal the associations between UU infection and the clinical characteristics of CP. Furthermore, the profiles from the National Institutes of Health-Chronic Prostatitis Symptom Index questionnaire and WBC counts in expressed prostatic secretion were similar among the non-CP and the two CP groups in each Ureaplasma infection. CONCLUSIONS: We found that UU may induce male urethritis. However, Ureapalsma species in urine were not definitively associated with the occurrence of CP.


Assuntos
Academias e Institutos , Estudos de Casos e Controles , Humanos , Leucócitos , Masculino , Métodos , Próstata , Prostatite , Infecções por Ureaplasma , Ureaplasma urealyticum , Ureaplasma , Urease , Uretrite
9.
Porto Alegre; Universidade Federal do Rio Grande do Sul. Telessaúde; 2018. ilus.
Não convencional em Português | LILACS (Américas) | ID: biblio-995587

RESUMO

Sintomas de prostatite são muito comuns na população, ocorrendo com uma prevalência média de 8,2%. Estima-se que 35% a 50% dos homens apresentarão esses sintomas em algum momento de sua vida. Entre as formas de prostatite, a apresentação mais comum é a Prostatite Crônica/ Síndrome da Dor Pélvica Crônica (PC/SDPC). PC/SDPC é uma síndrome clínica definida essencialmente pela presença de dor pélvica crônica não causada por patologias identificáveis. Apesar do termo "prostatite", parcela significativa dos casos não tem sinal de inflamação ("-ite") da próstata. Infecções causadas por Clamídia, Micoplasma ou Ureaplasma geralmente não são responsáveis pela PC/SDPC. Tampouco se sabe em que extensão a próstata é responsável pelos sintomas. Além de prevalente, a PC/SDPC prejudica a qualidade de vida dos homens e tem importante impacto econômico. Está frequentemente associada a dor genital, dor ejaculatória, dor abdominal, sintomas do trato urinário inferior e disfunção erétil. Ansiedade e medo de doenças graves são achados comuns em pacientes com PC/SDPC e podem contribuir com os sintomas. Múltiplas consultas, investigações e procedimentos também são riscos aos quais esses pacientes estão sujeitos. Pouca atenção tem sido dada à essa condição, o que resulta em literatura relativamente escassa sobre o assunto. Considerando a diversidade e severidade dos sintomas, assim como as comorbidades sistêmicas que frequentemente estão associadas (como síndrome do intestino irritável e fibromialgia), abordagens terapêuticas uniformes e monoterápicas raramente funcionam. Não surpreende que a PC/SDPC seja uma condição associada a significativa frustração, tanto nos pacientes quanto nos médicos. É necessário, portanto, que o diagnóstico e tratamento adequado seja feito na Atenção Primária à Saúde (APS), em vistas a melhorar a qualidade de vida do paciente e evitar encaminhamentos desnecessários ao urologista. Esta guia apresenta informação que orienta a conduta para casos de prostatite crônica/síndrome da dor pélvica crônica no contexto da Atenção Primária à Saúde, incluindo: Classificação, Sinais e Sintomas, Diagnóstico, Tratamento, Encaminhamento para serviço especializado, Referências, Anexo.


Assuntos
Humanos , Prostatite , Prostatite/diagnóstico , Dor Pélvica/diagnóstico , Dor Pélvica/terapia , Atenção Primária à Saúde , Encaminhamento e Consulta , Combinação Trimetoprima e Sulfametoxazol/uso terapêutico , Doxazossina/uso terapêutico
10.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-742349

RESUMO

Prostatic calculi often occur in middle-aged and old men. Prostatic calculi are usually classified as primary/endogenous stones or secondary/extrinsic stones. Endogenous stones are commonly caused by obstruction of the prostatic ducts around the enlarged prostate by benign prostatic hyperplasia (BPH) or by chronic inflammation. Extrinsic stones occur mainly around the urethra, because they are caused by urine reflux. The exact prevalence of prostatic calculi is not known, and it has been reported to vary widely, from 7% to 70%. Most cases of prostatic calculi are not accompanied by symptoms. Therefore, most cases are found incidentally during the diagnosis of BPH using transrectal ultrasonography (TRUS). However, prostatic calculi associated with chronic prostatitis may be accompanied by chronic pelvic pain. Rare cases have been reported in which extrinsic prostatic calculi caused by urine reflux have led to voiding difficulty due to their size. More than 80% of prostatic calculi are composed of calcium phosphate. Prostatic calculi can be easily diagnosed using TRUS or computed tomography. Treatment is often unnecessary, but if an individual experiences difficulty in urination or chronic pain, prostatic calculi can be easily removed using a transurethral electroresection loop or holmium laser.


Assuntos
Cálcio , Cálculos , Dor Crônica , Diagnóstico , Humanos , Inflamação , Lasers de Estado Sólido , Masculino , Dor Pélvica , Prevalência , Próstata , Hiperplasia Prostática , Prostatite , Ultrassonografia , Uretra , Micção
12.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-691406

RESUMO

<p><b>OBJECTIVE</b>To investigated the anti-inflammatory and antimicrobial effects of anthocyanins extracted from black soybean on the chronic bacterial prostatitis (CBP) rat model.</p><p><b>METHODS</b>The Sprague-Dawley rats were divided into 4 groups, including control, ciprofloxacin, anthocyanins and anthocyanins with ciprofloxacin groups (n=8 in each group). Then, drip infusion of bacterial suspension (Escherichia coli Z17 O:K:H) into Sprague-Dawley rats was conducted to induce CBP. In 4 weeks, results of prostate tissue, urine culture, and histological analysis on the prostate were analyzed for each group.</p><p><b>RESULTS</b>The use of ciprofloxacin, anthocyanins, and anthocyanins with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in the reduction of prostatic inflammation compared with the control group (P<0.05). The anthocyanins with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group (P<0.05).</p><p><b>CONCLUSIONS</b>These results suggest that anthocyanins may have anti-inflammatory and antimicrobial effects, as well as a synergistic effect with ciprofloxacin. Therefore, we suggest that the combination of anthocyanins and ciprofloxacin may be effective in treating CBP to obtain a higher rate of treatment success.</p>


Assuntos
Células Acinares , Patologia , Animais , Antocianinas , Farmacologia , Anti-Infecciosos , Farmacologia , Anti-Inflamatórios , Farmacologia , Doença Crônica , Modelos Animais de Doenças , Infecções por Escherichia coli , Tratamento Farmacológico , Urina , Fibrose , Inflamação , Patologia , Masculino , Extratos Vegetais , Farmacologia , Próstata , Microbiologia , Patologia , Prostatite , Tratamento Farmacológico , Microbiologia , Urina , Ratos Sprague-Dawley , Índice de Gravidade de Doença , Soja , Química , Urina , Microbiologia
13.
National Journal of Andrology ; (12): 640-644, 2018.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wprim-689706

RESUMO

<p><b>Objective</b>To evaluate the efficiency and safety of № I Empirical Prescription for Chronic Prostatitis (№ I EPCP) in the treatment of type Ⅲ refractory chronic prostatitis.</p><p><b>METHODS</b>We randomly assigned 53 cases of type Ⅲ refractory chronic prostatitis with damp-heat and blood stasis to an experimental and a control group to receive № I EPCP at 1 dose per day and saw palmetto extract at 160 mg bid), respectively, all for 8 weeks. Before and after 4 and 8 weeks of treatment, we obtained The National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores, Traditional Chinese Medicine Syndrome Scores (TCMSS), maximum urinary flow rate (Qmax), average urinary flow rate (Qavg), Hamilton Depression Rating Scale (HAMD) scores and Hamilton Anxiety Rating Scale (HAMA) scores, and compared them between the two groups of patients.</p><p><b>RESULTS</b>Totally 48 of the patients completed the medication and follow-up, 25 in the experimental and 23 in the control group. Compared with the baseline, the NIH-CPSI scores after 8 weeks of treatment were significantly decreased in the experimental (27.82 ± 7.25 vs 15.46 ± 4.77, P <0.05) and the control group (25.98 ± 6.47 vs 21.06 ± 5.74, P <0.05), and so were the TCMSSs (24.64 ± 9.82 vs 16.42 ± 6.33 and 9.15 ± 3.74, P <0.05, and 23.67 ± 8.73 vs 18.55 ± 5.92 and 13.48 ± 4.45, P <0.05); the Qmax at 8 weeks were dramatically increased in the experimental group ([18.45 ± 7.81] vs [23.44 ± 8.73] ml/s, P <0.05) and the control ([17.58 ± 6.92] vs [21.26 ± 8.32] ml/s, P <0.05), and so was the Qavg ([11.27 ± 5.33] vs [16.51 ± 7.36] ml/s, P <0.05 and [10.66 ± 5.82] vs [13.44 ± 6.16] ml/s, P <0.05); the HAMD scores were remarkably reduced in the experimental group (22.74 ± 6.37 vs 17.62 ± 5.71 and 12.54 ± 5.22, P <0.05) and the control (23.55 ± 7.14 vs 22.34 ± 6.88 and 21.62 ± 5.63, P <0.05), and so were the HAMA scores (21.37 ± 7.15 vs 18.42 ± 6.35 and 14.63 ± 7.11, P <0.05 and 20.54 ± 6.77 vs 19.87 ± 6.24 and 19.42 ± 7.04, P <0.05). No obvious adverse reactions were observed in either of the two groups during the medication.</p><p><b>CONCLUSIONS</b>№ I EPCP deserves promotion and clinical application for its definite effectiveness and safety in the treatment of type Ⅲ refractory chronic prostatitis with damp-heat and blood stasis.</p>


Assuntos
Terapia por Acupuntura , Doença Crônica , Medicamentos de Ervas Chinesas , Temperatura Alta , Humanos , Masculino , Medicina Tradicional Chinesa , Métodos , Extratos Vegetais , Prostatite , Tratamento Farmacológico , Síndrome
14.
National Journal of Andrology ; (12): 491-498, 2018.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wprim-689703

RESUMO

<p><b>Objective</b>To investigate the effects of fosfomycin tromethamine (FT) on the expressions of tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), and interleukin-6 (IL-6) in the prostate tissue of the rats with chronic bacterial prostatitis (CBP).</p><p><b>METHODS</b>We randomly divided 70 male SD rats into 7 groups of equal number: blank control, CBP model control, positive control, 14 d low-dose FT, 7 d low-dose FT, 14 d high-dose FT, and 7 d high-dose FT. The CBP model rats in the latter five groups were treated intragastrically with levofloxacin at 100 mg/kg/d for 30 days and FT at 200 mg/kg/d for 14 and 7 days and at 300 mg/kg/d for 14 and 7 days, respectively. Then we collected the prostate tissue from the animals for determination of the levels of TNF-α, IL-8 and IL-6 by ELISA.</p><p><b>RESULTS</b>Compared with the blank controls, the CBP model rats showed significantly increased levels of TNF-α ([19.83 ± 6.1] vs [32.93 ± 6.21] ng/g prot, P <0.01), IL-8 ([8.26 ± 0.52] vs [16.2 ± 2.84] ng/g prot, P <0.01) and IL-6 ([1.55 ± 0.11] vs [2.51 ± 1.06] ng/g prot, P <0.05) in the prostate tissue. In comparison with the CBP model controls, the levels of TNF-α and IL-8 were remarkably decreased in the groups of positive control ([20.54 ± 5.78] ng/g prot, P <0.01; [12.43 ± 4.02] ng/g prot, P <0.05), 14 d low-dose FT ([21.95 ± 6.48] ng/g prot, P <0.01; [11.11 ± 2.86] ng/g prot, P <0.01), 7 d low-dose FT ([23.8 ± 6.93] ng/g prot, P <0.05; [12.43 ± 4.02] ng/g prot, P <0.05), 14 d high-dose FT ([19.97 ± 2.58] ng/g prot, P <0.01; [8.83 ± 1.32] ng/g prot, P <0.01), and 7 d high-dose FT ([21.97 ± 3.38] ng/g prot, P <0.01; [12.68±1.97] ng/g prot, P <0.05). No statistically significant differences were observed between the positive control and FT groups in the contents of TNF-α, IL-8 or IL-6 (P >0.05). The expression of IL-6 was markedly reduced in the 14 d high-dose FT group as compared with the model controls ([1.76 ± 0.46] vs [2.51 ± 1.06] ng/g prot, P<0.05) but exhibited no significant difference between the CBP model control and the other groups (P >0.05).</p><p><b>CONCLUSIONS</b>Fosfomycin tromethamine inhibits the expressions of TNF-α, IL-8 and IL-6 in the prostate tissue, suppresses its inflammatory reaction, promotes the repair of damaged prostatic structure, and thus contributes to the treatment of chronic bacterial prostatitis in rats.</p>


Assuntos
Animais , Antibacterianos , Farmacologia , Infecções Bacterianas , Tratamento Farmacológico , Microbiologia , Fosfomicina , Farmacologia , Interleucina-6 , Metabolismo , Interleucina-8 , Metabolismo , Levofloxacino , Farmacologia , Masculino , Próstata , Metabolismo , Prostatite , Tratamento Farmacológico , Metabolismo , Distribuição Aleatória , Ratos , Ratos Sprague-Dawley , Fator de Necrose Tumoral alfa , Metabolismo
15.
National Journal of Andrology ; (12): 553-557, 2018.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wprim-689692

RESUMO

<p><b>Objective</b>To know the basic status of researches on the mental health of prostatitis patients in China by statistical analysis of the literature published in the past two decades and provide some reference for such studies.</p><p><b>METHODS</b>Using the bibliometrics method, we performed statistical analyses on the publication years, journals, and authors of the articles published in the core journals concerning the mental health of prostatitis patients in China as well as on the topics of the identified studies using their titles, key words and abstracts.</p><p><b>RESULTS</b>Totally, 226 related studies were identified, of which 31 (by 29 authors) were published in the Chinese core journals. As for the topics of the included studies, 102 (45.13%) focused on the role and significance of psychotherapy in the treatment of prostatitis, 52 (23.01%) on the correlation of psychological factors with prostatitis, and 23 (10.18%) on the correlation of psychopathic factors with prostatitis complicated by sexual dysfunction. Most of the articles on the mental health of prostatitis patients were published in National Journal of Andrology.</p><p><b>CONCLUSIONS</b>Studies on the mental health of prostatitis patients in China are carried out in varied institutions and different directions but, however, need to be furthered and deepened. For this condition, a comprehensive therapeutic mode of "prevention-communication-treatment" is coming into being, and the methodology for related researches is gradually turning from linear to stereoscopic.</p>


Assuntos
Andrologia , Bibliometria , China , Humanos , Masculino , Saúde Mental , Prostatite , Psicologia , Terapêutica , Psicoterapia
16.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-715332

RESUMO

PURPOSE: The neurological molecular mechanisms underlying the voiding dysfunction associated with nonbacterial chronic prostatitis/chronic pelvic pain syndrome remain poorly understood. In this study, we assessed whether prostate inflammation activated bladder afferent neurons, leading to bladder dysfunction, and sought to elucidate the underlying mechanisms. METHODS: Thirty male Sprague-Dawley rats were divided into 3 groups: sham-saline, formalin-injected, and capsaicin-pretreated and formalin-injected. Chemical prostatitis was induced by 0.1 mL of 10% buffered formalin injected into the ventral prostate. Capsaicin was injected subcutaneously to desensitize capsaicin-sensitive nerves. In each group, conscious cystometry was performed, and c-fos expression within the spinal cord was determined immunocytochemically. Double immunofluorescent staining with c-fos and choline acetyltransferase (ChAT) was performed. On the third day after pseudorabies virus (PRV) infection, c-fos and PRV double-staining was performed. RESULTS: Intraprostatic formalin significantly increased the maximal voiding pressure and decreased the intercontraction interval, compared with controls. Pretreatment with capsaicin significantly reversed these effects. More c-fos-positive cells were observed in the sacral parasympathetic nucleus (SPN) and dorsal gray commissure (DCM) in the prostatitis group than in the sham group. c-fos-positive cells decreased in the capsaicin-pretreated group. Preganglionic neurons labeled by c-fos and ChAT were observed in the SPN in rats with prostatitis. Interneurons labeled by c-fos and PRV were identified in the DCM after PRV infection. CONCLUSIONS: Our results suggest that prostate inflammation activates afferent nerve fibers projecting to the lumbosacral spinal cord, producing reflex activation of spinal neurons innervating the bladder and bladder hyperreflexia. This is mediated by capsaicin-sensitive prostate afferent neurons.


Assuntos
Animais , Capsaicina , Colina O-Acetiltransferase , Formaldeído , Herpesvirus Suídeo 1 , Humanos , Inflamação , Interneurônios , Masculino , Modelos Animais , Fibras Nervosas , Neurônios , Neurônios Aferentes , Dor Pélvica , Próstata , Prostatite , Ratos , Ratos Sprague-Dawley , Reflexo , Reflexo Anormal , Medula Espinal , Bexiga Urinária
17.
Artigo em Coreano | WPRIM (Pacífico Ocidental) | ID: wprim-715026

RESUMO

BACKGROUND: Prostatitis, one of the most common diseases of the prostate, is a complex disease with various clinical features. This study aims to analyze the utilization and prescribing patterns of antibiotics in Korean patients with prostatitis between 2008 and 2015. METHODS: We used the National Health Insurance Database complied from the Health Insurance Review and Assessment Service (HIRA). The outcomes included the number of claims, number of patients, medical cost, and length of stay for each year. In addition, the prescribing patterns of antibiotics, including fluoroquinolone, and low-dose use of ciprofloxacin and levofloxacin were investigated. RESULTS: The total number of patients and medical cost increased by 9.5% and 51.7% from 2008 to 2015, respectively. Most prostatitis patients were classified as chronic prostatitis patients. The prescribing proportion of antibiotics for chronic prostatitis outpatients decreased from 71.0% to 66.9% from 2008 to 2015, and fluoroquinolone accounted for more than half of the total antibiotics. Over 80% of prescription of levofloxacin and ciprofloxacin was identified to be for low-dose use. CONCLUSION: Most of the patients with prostatitis experienced pain relief and condition improvement after antibiotic treatment; however, chronic prostatitis and chronic pelvic pain syndrome recur easily. Therefore, active disease management and further studies are needed to enhance our understanding of effective treatment for prostatitis.


Assuntos
Antibacterianos , Ciprofloxacino , Gerenciamento Clínico , Humanos , Seguro Saúde , Coreia (Geográfico) , Tempo de Internação , Levofloxacino , Programas Nacionais de Saúde , Pacientes Ambulatoriais , Dor Pélvica , Prescrições , Próstata , Prostatite
18.
Urol. colomb ; 27(3): 233-242, 2018. tab
Artigo em Espanhol | LILACS (Américas), COLNAL | ID: biblio-981252

RESUMO

La prostatitis, considerada una patología enigmática por su complejidad en el diagnóstico, involucra el uso indiscriminado de antibióticos sin tener evidencia de la infección. Siendo la eyaculación una cascada sincronizada de eventos que permiten que los espermatozoides interactúen con el oocito,1 todos los componentes del semen deben estar en óptimas condiciones para hacer más eficiente el proceso, sin embargo, el semen contiene células espermáticas y plasma seminal, en el que pueden alojarse una amplia diversidad de microorganismos e interferir durante la fecundación. Los microorganismos presentes en el semen provienen de diferentes localizaciones anatómicas e inclusive pueden ser microbiota del tracto genitourinario o microorganismos patógenos que desencadenan procesos infecciosos con secuelas sobre la fertilidad masculina como es el caso de la prostatitis bacteriana. El objetivo de esta revisión es describir una patología de mal diagnóstico y de gran magnitud sobre la fertilidad masculina, como es la prostatitis.


Prostatitis, considered an enigmatic pathology because of its complexity in diagnosis, involves the use of indiscriminate use of antibiotics without having evidence of the infection. Ejaculation being a synchronized cascade of events that allow spermatozoa interact with the oocito,1 all components of the must be in optimal condition to do more. efficient process, however, the semen contains cells spermatozoa and seminal plasma, in which they can be housed a wide diversity of microorganisms and interfere with during fertilization. The microorganisms present in the semen comes from different anatomical locations and may even be microbiota of the genitourinary tract or pathogenic microorganisms that trigger processes infectious with sequels on male fertility such as is the case with bacterial prostatitis. The aim of this review is to describe a pathology of misdiagnosis and of on male fertility, as is the case with the prostatitis.


Assuntos
Humanos , Prostatite , Próstata , Ejaculação , Fertilidade
19.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-714120

RESUMO

BACKGROUND: The prostate is prone to infections. Hypothetically, bacteria can be inoculated into the prostate during a transrectal prostate biopsy (TRPB) and progress into chronic bacterial prostatitis. Therefore, we examined new bacterial infections in biopsied prostates after TRPB and whether they affect clinical characteristics in the biopsied patients. METHODS: Of men whose prostate cultures have been taken prior to TRPB, 105 men with bacteria-free benign prostate pathology underwent an additional repeated prostate culture within a year after TRPB. RESULTS: Twenty out of 105 men (19.05%) acquired new bacteria in their naïve prostates after TRPB. Except for one single case of Escherichia coli infection, 19 men had acquired gram-positive bacteria species. Between the culture-positive and negative groups, there were no significant differences in age, serum prostate-specific antigen (PSA) level, white blood cell (WBC) counts in expressed prostatic secretion (EPS), prostate volume, symptom severities in Korean version of the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) questionnaire, and patient-specific risk factors for biopsy associated infectious complications. Additionally, the TRPB procedure increased the WBC counts in post-biopsy EPS (P = 0.031, McNemar test), but did not increase the serum PSA level and symptoms of NIH-CPSI in 20 men who acquired new bacteria after TRPB. CONCLUSION: The TRPB procedure was significantly associated with acquiring new bacterial infections in the biopsied prostate, but these localized bacteria did not affect patients' serum PSA level and symptoms after biopsy.


Assuntos
Academias e Institutos , Bactérias , Infecções Bacterianas , Biópsia , Infecções por Escherichia coli , Bactérias Gram-Positivas , Humanos , Leucócitos , Masculino , Patologia , Próstata , Antígeno Prostático Específico , Prostatite , Fatores de Risco
20.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-721496

RESUMO

Urinary tract infections (UTIs) are infectious diseases that commonly occur in communities. Although several international guidelines for the management of UTIs have been available, clinical characteristics, etiology and antimicrobial susceptibility patterns may differ from country to country. This work represents an update of the 2011 Korean guideline for UTIs. The current guideline was developed by the update and adaptation method. This clinical practice guideline provides recommendations for the diagnosis and management of UTIs, including asymptomatic bacteriuria, acute uncomplicated cystitis, acute uncomplicated pyelonephritis, complicated pyelonephritis related to urinary tract obstruction, and acute bacterial prostatitis. This guideline targets community-acquired UTIs occurring among adult patients. Healthcare-associated UTIs, catheter-associated UTIs, and infections in immunocompromised patients were not included in this guideline.


Assuntos
Adulto , Bacteriúria , Doenças Transmissíveis , Cistite , Diagnóstico , Humanos , Hospedeiro Imunocomprometido , Métodos , Prostatite , Pielonefrite , Infecções Urinárias , Sistema Urinário
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