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1.
Int. arch. otorhinolaryngol. (Impr.) ; 24(1): 99-106, Jan.-Mar. 2020. tab
Artigo em Inglês | LILACS (Américas) | ID: biblio-1090548

RESUMO

Abstract Introduction Peripheral vestibular disorders can lead to cognitive deficits and are more common in elderly patients. Objective To evaluate and correlate cognitive, balance and gait aspects in elderly women with chronic peripheral vestibular dizziness, and to compare them with elderly women without vestibular disorders. Methods Twenty-two women presenting peripheral vestibular dizziness episodes for at least six months participated in the study. The individuals were categorized by dizziness severity level: moderate (n = 11) or severe (n = 11). The control group (n = 11) included women showing no vestibulopathy, light-headedness or dizziness. Cognitive assessments and semi-static and dynamic balance assessments were performed with the Balance Master (Neurocom International, Inc., Clackamas, OR), while the Dizziness Handicap Inventory provided a score for the severity of the symptoms. The groups were submitted to statistics of inference and correlation between cognitive, balance and stability variables. Results The group with severe dizziness showed higher sway speed of the center of pressure in the anteroposterior direction, smaller step length, and slower gait than the control group. Regarding the cognitive variables, the group with severe dizziness symptoms presented significant correlations with stability and gait variables. Conclusion The relationship between cognitive aspects, balance and gait was stronger in women with severe dizziness than in those with no vestibulopathy.


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Idoso , Doenças Vestibulares/complicações , Transtornos das Sensações/etiologia , Tontura/complicações , Equilíbrio Postural/fisiologia , Índice de Gravidade de Doença , Doenças Vestibulares/fisiopatologia , Doenças Vestibulares/reabilitação , Transtornos Cognitivos/etiologia , Tontura/fisiopatologia , Marcha/fisiologia
2.
Fisioter. Pesqui. (Online) ; 27(1): 41-47, jan.-mar. 2020. tab
Artigo em Português | LILACS (Américas) | ID: biblio-1090407

RESUMO

RESUMO As cardiopatias congênitas (CC) estão entre as principais causas de morbimortalidade na primeira infância e os lactentes com essa condição podem apresentar atrasos no desenvolvimento neuropsicomotor (DNPM). O objetivo deste estudo foi avaliar a influência da CC no DNPM de lactentes. Trata-se de um estudo observacional com avaliação do desenvolvimento neuropsicomotor realizada pela Bayley Scales of Infant and Toddler Development (BSID-III). As condições maternas e clínicas dos lactentes foram verificadas no relatório de alta médica e na caderneta de saúde da criança, e a condição socioeconômica das famílias pelo Critério da Classificação Econômica Brasil. Para associar as variáveis clínicas e o DNPM foram utilizados o coeficiente de correlação de Spearman e o teste de razão de verossimilhança. Foram avaliados 18 lactentes, com predomínio do sexo feminino (72,2%). A maioria das mães (47,1%) possuía ensino médio completo ou superior incompleto, com média da idade de 27,2±5,5 anos. Houve correlação das escalas do BSID-III com as variáveis quantitativas analisadas: escala motora com o peso (p=0,02 e r=0,54) e com uso de oxigenoterapia (p=0,009 e r=−0,591); já para as variáveis qualitativas as associações foram entre: escala motora e condição socioeconômica (p=0,015), escala motora e comunicação interatrial - (CIA) (p=0,023) e escala da linguagem e CIA (p=0,038). A CC influenciou o DNPM, principalmente no aspecto motor. Além disso peso, diagnóstico de CIA, uso de oxigenoterapia e condição socioeconômica foram considerados como principais fatores de risco para o atraso no DNPM.


RESUMEN Las cardiopatías congénitas (CC) se encuentran entre las principales causas de morbimortalidad en la primera infancia, y los lactantes con esta afección pueden tener retrasos en el desarrollo neuropsicomotor (DNPM). El presente estudio tuvo el objetivo de evaluar la influencia de las CC en el DNPM de los lactantes. Este es un estudio observacional en el cual se evaluó el desarrollo neuropsicomotor utilizando la Bayley scales of infant and toddler development (BSID-III). Las condiciones maternas y clínicas de los lactantes se obtuvieron en el informe de alta médica y en la libreta de salud del niño, y el estado socioeconómico de las familias en el Criterio de Clasificación Económica de Brasil. Para asociar las variables clínicas y el DNPM, se utilizaron el coeficiente de correlación de Spearman y la prueba de razón de probabilidad. Se evaluaron a 18 lactantes, con un predominio del sexo femenino (72,2%). La mayoría de las madres (47,1%) tenían la secundaria completa o la educación superior incompleta, con una edad promedio de 27,2±5,5 años. Hubo una correlación entre las escalas BSID-III y las variables cuantitativas analizadas: escala motora con el peso (p=0,02 y r=0,54) y con el uso de oxigenoterapia (p=0,009 y r=−0,591); para las variables cualitativas, las asociaciones fueron entre: escala motora y estado socioeconómico (p=0,015), escala motora y comunicación interauricular (CIA) (p=0,023) y escala de lenguaje y CIA (p=0,038). Las CC influyeron en el DNPM, principalmente en el aspecto motor. Además, el peso, el diagnóstico de CIA, el uso de oxigenoterapia y el estado socioeconómico fueron considerados los principales factores de riesgo para el retraso en el DNPM.


ABSTRACT Congenital heart defects (CHD) are among the main causes of morbidity and mortality in infants who has this impairment may present delays in neuropsychomotor development (NPMD). This study assesses the influence of CHD on NPMD of infants. This is an observational study assessing neuropsychomotor development performed by Bayley Scales of Infant and Toddler Development - BSID-III. The Brazilian Economic Classification Criteria was used to verify the socioeconomic status of the families and also the maternal and infants' clinical conditions were verified in the medical discharge report and in the child's health handbook. For the association between the quantitative and qualitative variables with the NPMD, the Spearman's correlation coefficient and the likelihood ratio test were used. A total of 18 infants were assessed, with a predominance of females (72.2%). Most mothers (47.1%) had complete high school or incomplete higher education, with a mean age of 27.2±5.5 years. There was a correlation between the BSID-III scales and the quantitative variables analyzed: motor scale with weight (p=0.02 and r=0.54) and oxygen therapy (p=0.009 and r=−0.591); besides that, the qualitative variables correlation were: motor scale and socioeconomic condition (p=0.015), motor scale and Interatrial Communication - IAC (p=0.023) and language with IAC scales (p=0.038). CHD influences the delay of NPMD, mainly for motor aspect. Furthermore, weight, diagnosis of IAC, use of oxygen therapy and socioeconomic status were considered the main risk factors for the delay in NPMD.


Assuntos
Humanos , Lactente , Transtornos Psicomotores/etiologia , Transtornos das Habilidades Motoras/etiologia , Transtornos do Neurodesenvolvimento/etiologia , Cardiopatias Congênitas/complicações , Oxigenoterapia/efeitos adversos , Transtornos Psicomotores/diagnóstico , Fatores Socioeconômicos , Desenvolvimento Infantil/fisiologia , Estudos Transversais , Transtornos Cognitivos/diagnóstico , Transtornos Cognitivos/etiologia , Transtornos das Habilidades Motoras/diagnóstico , Transtornos do Neurodesenvolvimento/diagnóstico , Hospitalização , Transtornos da Linguagem/diagnóstico , Transtornos da Linguagem/etiologia , Tempo de Internação , Testes Neuropsicológicos
3.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-782081

RESUMO

BACKGROUND AND PURPOSE: Previous studies have explored the association between retinal vascular changes and cognitive impairment. The retinal vasculature shares some characteristics with the cerebral vasculature, and quantitative changes in it could indicate cognitive impairment. Hence, a comprehensive meta-analysis was performed to clarify the potential relationship between retinal vascular geometric changes and cognitive impairment.METHODS: Relevant databases were scrupulously and systematically searched for retinal vascular geometric changes including caliber, tortuosity, and fractal dimension (FD), and for cognitive impairment. The Newcastle-Ottawa Scale was used to evaluate the methodological quality of included studies. RevMan was used to perform the meta-analysis and detect publication bias. Sensitivity analyses were also performed.RESULTS: Five studies that involved 2,343 subjects were finally included in the meta-analysis. The results showed that there was no significant association between central retinal artery equivalents (Z=1.17) or central retinal venular equivalents (Z=1.74) and cognitive impairment (both p>0.05). Similarly, no significant difference was detected in retinal arteriolar tortuosity (Z=0.91) and venular tortuosity (Z=1.31) (both p>0.05). However, the retinal arteriolar FD (mean difference: −0.03, 95% CI: −0.05, −0.01) and venular FD (mean difference: −0.03, 95% CI: −0.05, −0.02) were associated with cognitive impairment.CONCLUSIONS: A smaller retinal microvascular FD might be associated with cognitive impairment. Further large-sample and well-controlled original studies are required to confirm the present findings.


Assuntos
Transtornos Cognitivos , Fractais , Viés de Publicação , Retina , Artéria Retiniana , Vasos Retinianos , Retinaldeído
4.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-787140

RESUMO

Alzheimer's disease (AD) is the most common neurodegenerative disorder causing dementia worldwide, and is mainly characterized by aggregated β-amyloid (Aβ). Increasing evidence has shown that plant extracts have the potential to delay AD development. The plant sterol β-Sitosterol has a potential role in inhibiting the production of platelet Aβ, suggesting that it may be useful for AD prevention. In the present study, we aimed to investigate the effect and mechanism of β-Sitosterol on deficits in learning and memory in amyloid protein precursor/presenilin 1 (APP/PS1) double transgenic mice. APP/PS1 mice were treated with β-Sitosterol for four weeks, from the age of seven months. Brain Aβ metabolism was evaluated using ELISA and Western blotting. We found that β-Sitosterol treatment can improve spatial learning and recognition memory ability, and reduce plaque load in APP/PS1 mice. β-Sitosterol treatment helped reverse dendritic spine loss in APP/PS1 mice and reversed the decreased hippocampal neuron miniature excitatory postsynaptic current frequency. Our research helps to explain and support the neuroprotective effect of β-Sitosterol, which may offer a novel pharmaceutical agent for the treatment of AD. Taken together, these findings suggest that β-Sitosterol ameliorates memory and learning impairment in APP/PS1 mice and possibly decreases Aβ deposition.


Assuntos
Doença de Alzheimer , Amiloide , Animais , Plaquetas , Western Blotting , Encéfalo , Transtornos Cognitivos , Demência , Espinhas Dendríticas , Ensaio de Imunoadsorção Enzimática , Potenciais Pós-Sinápticos Excitadores , Aprendizagem , Memória , Metabolismo , Camundongos , Camundongos Transgênicos , Doenças Neurodegenerativas , Neurônios , Fármacos Neuroprotetores , Extratos Vegetais , Plantas , Placa Amiloide , Aprendizagem Espacial
5.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-810959

RESUMO

BACKGROUND: The 48/6 Model of Care is an integrative care initiative for improving the health outcomes of hospitalized older patients; however, its applicability in community-dwelling older adults as a health screening tool has not been investigated. The present study aimed to examine the applicability of this model, prevalence of dysfunction in 6 care areas, and its relationship with self-reported mobility in community-dwelling older adults.METHODS: This was a cross-sectional survey study of community-dwelling adults aged 65 or older. Participants were screened for problems using 9 items corresponding to the 6 care areas of the 48/6 Model of Care (cognitive functioning, functional mobility, pain management, nutrition and hydration, bladder and bowel management, and medication management). Mobility was assessed via the Life-Space Assessment (LSA). We examined the correlation between each screening item and the LSA.RESULTS: A total of 444 older adults (260 women, 58.6%) participated. The mean number of health problems was 2.3 ± 2.1, with the most common being pain, cognitive impairment, and urinary incontinence. These problems and LSA scores were significantly different by age groups. A multiple regression analysis showed that polypharmacy (β = −10.567, P < 0.001), dysphagia (β = −9.610, P = 0.021), and pain (β = −7.369, P = 0.004) were significantly associated with life-space mobility after controlling for age.CONCLUSION: The 48/6 Model of Care is applicable to community-dwelling older adults, who show high prevalence of dysfunction in the 6 care areas. This study supports the role of the model in screening for the health status of older adults living in the community, and in estimating mobility.


Assuntos
Adulto , Transtornos Cognitivos , Estudos Transversais , Transtornos de Deglutição , Feminino , Humanos , Programas de Rastreamento , Manejo da Dor , Polimedicação , Prevalência , Bexiga Urinária , Incontinência Urinária
6.
Rev. cuba. inform. méd ; 11(2)jul.-dic. 2019. graf
Artigo em Espanhol | LILACS (Américas), CUMED | ID: biblio-1093326

RESUMO

El uso de programas de entrenamiento y rehabilitación cognitiva asistido por computadora facilita abordar dificultades del funcionamiento cognitivo con precisión y consistencia. Este tipo de asistencia ha estado basado en los últimos años en juegos serios de tecnologías web, Realidad Virtual y Realidad Aumentada. En el presente trabajo se realizó una revisión bibliográfica de los juegos serios con estas tecnologías para el entrenamiento y la rehabilitación cognitiva, valorándose su incidencia en la motivación y las implicaciones de sus métodos y dispositivos de interacción en personas tratadas con estos juegos. Se exponen evidencias de individuos que han sido atendidos bajo este tipo de tratamiento no farmacológico(AU)


The use of computer-assisted cognitive training and rehabilitation programs facilitates addressing cognitive functioning difficulties with greater precision and consistency. This type of assistance has been based in recent years on serious games of web, Virtual Reality and Augmented Reality technologies. In the present paper, a bibliographic review of serious games with these technologies was carried out for training and cognitive rehabilitation, evaluating their incidence in the motivation and the implications of their methods and interaction devices in people treated with these games. Evidence is presented of individuals who have been treated under this type of non-pharmacological treatment(AU).


Assuntos
Transtornos Cognitivos/terapia , Jogos de Vídeo , Realidade Virtual , Realidade Aumentada
7.
Prensa méd. argent ; 105(10): 727-735, oct 2019. tab
Artigo em Inglês | LILACS (Américas), BINACIS | ID: biblio-1026057

RESUMO

The Amyotrophic Lateral Sclerosis (ALS) is a multisystemic disorder. It is considered a neuromuscular disease but also involves cognitive (executive functions, social cognition, attention, memory and language), emotional or behavior changes in over 50% of the reported cases and to of frontotemporal diagnosis lobar degeneration of behavioral variant in up to 15% of the cases. For this reason, the presence of cognitive and motivational problems was analysed in a Spanish sample of ALS patients through the prefrontal symptoms inventory (PSI) to determine applicability in this disease STI. A sample of 31 patients with a potential ALS or definitive diagnostic criteria according to El Escorial was used. Obtained results ISP were compared with a sample of 31 healthy people in the same proportions of gender, age and education level. Obtained results showed a not significant difference between the two populations in the motivational factor problems, related to the depression symptomatology frequently associated with ALS. A significant positive correlation between age at diagnosis and the scale of the motivational problems was observed, with a not significant trend related to problems in the executive control and in social the behavior control and with the age at diagnosis, in the same sense with age at diagnosis. Therefore, it can be concluded that, despite the results obtained, emotional and behavioral deficits in ALS patients and symptoms related to frontotemporal dementia (among others, anosognosia or lack of consciousness symptoms) could have interfered in patient perception about their symptomatology


Assuntos
Humanos , Masculino , Feminino , Estudos de Casos e Controles , Transtornos Cognitivos , Sintomas Afetivos/diagnóstico , Demência Frontotemporal/diagnóstico , Disfunção Cognitiva/diagnóstico , Esclerose Amiotrófica Lateral , Transtornos Mentais/diagnóstico
9.
Arq. bras. psicol. (Rio J. 2003) ; 71(2): 130-149, mai.-ago 2019.
Artigo em Português | LILACS (Américas), INDEXPSI | ID: biblio-1015012

RESUMO

As distorções cognitivas são erros lógicos de pensamentos que podem alterar a realidade do sujeito, causando possíveis sintomas depressivos. O objetivo do estudo foi construir um instrumento intitulado de Escala de Distorções Cognitivas Depressivas (EDICOD) e buscar evidências de validade baseada no conteúdo e estrutura interna, utilizando análise fatorial exploratória e o modelo da Teoria de Resposta ao Item (TRI). Na etapa de construção do estudo, participaram oito juízes e 27 estudantes de graduação para uma aplicação piloto para adequação dos itens. Posteriormente, 459 indivíduos, divididos entre sujeitos não clínicos e clínicos com diagnóstico de depressão, de ambos os sexos, com faixa etária entre 18 e 60 anos. Após as análises psicométricas, a escala ficou reduzida com 36 itens, divididos em três fatores interpretáveis, sendo esses, Abstração seletiva/personalização (F1), Inferência arbitrária/maximização e minimização (F2) e por último, Pensamento dicotômico/hipergeneralização (F3). Assim, a EDICOD apresentou ser um instrumento adequado de rastreio das principais distorções cognitivas, principalmente para possível uso em ambiente clínico


Cognitive distortions are logical errors of thoughts that can alter the subject's reality, causing possible depressive symptoms. The purpose of the study was to construct an instrument titled Depression Cognitive Distortion Scale (EDICOD) and to seek evidence of validity based on content and internal structure using exploratory factorial analysis and the Item Response Theory (TRI) model. In the construction phase of the study, eight judges and 27 undergraduate students participated in a pilot application to adjust the items. Subsequently, 459 individuals, divided between non-clinical and clinical subjects with a diagnosis of depression, of both sexes, aged between 18 and 60 years, participated. After the psychometric analysis, the scale was reduced to 36 items, divided into three interpretable factors: Selective abstraction/personalization (F1), arbitrary inference/maximization and minimization (F2), and finally, dichotomous thinking/hypergeneralization (F3). Thus, EDICOD presented an adequate tool for screening the main cognitive distortions, mainly for possible use in clinical settings


Las distorsiones cognitivas son errores lógicos de pensamientos que pueden alterar la realidad del sujeto, causando posibles síntomas depresivos. El objetivo del estudio fue construir un instrumento titulado de Escala de Distorsiones Cognitivas Depresivas (EDICOD) y buscar evidencias de validez basada en el contenido y la estructura interna, utilizando análisis factorial exploratorio y el modelo de la Teoría de Respuesta al Ítem (TRI). En la etapa de construcción del estudio, participaron ocho jueces y 27 estudiantes de graduación para una aplicación piloto para adecuación de los ítems. Posteriormente, 459 individuos, divididos entre sujetos no clínicos y clínicos con diagnóstico de depresión, de ambos sexos, con rango de edad entre 18 y 60 años. Después de los análisis psicométricos, la escala se redujo con 36 ítems, divididos en tres factores interpretables, siendo éstos, Abstracción selectiva/personalización (F1), Inferencia arbitraria/maximización y minimización (F2) y por último, Pensamiento dicotómico/hipergeneralización (F3). Así, la EDICOD presentó ser un instrumento adecuado de rastreo de las principales distorsiones cognitivas, principalmente para posible uso en ambiente clínico


Assuntos
Humanos , Testes Psicológicos , Psicometria , Transtornos Cognitivos , Transtorno Depressivo
10.
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 41(4): 289-296, July-Aug. 2019. tab, graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-1011508

RESUMO

Objective: To evaluate whether exposing rats to individual or combined environmental stressors triggers endophenotypes related to mood and anxiety disorders, and whether this effect depends on the nature of the behavior (i.e., innate or learned). Methods: We conducted a three-phase experimental protocol. In phase I (baseline), animals subjected to mixed schedule of reinforcement were trained to press a lever with a fixed interval of 1 minute and a limited hold of 3 seconds. On the last day of phase I, an open-field test was performed and the animals were divided into four experimental groups (n=8/group). In phase II (repeated stress), each group was exposed to either hot air blast (HAB), paradoxical sleep deprivation (PSD) or both (HAB+PSD group) on alternate days over a 10-day period. Control group animals were not exposed to stressors. In phase III (post-stress evaluation), behavior was analyzed on the first (short-term effects), third (mid-term effects), and fifth (long-term effects) days after repeated stress. Results: The PSD group presented operant hyperactivity, the HAB group presented spontaneous hypoactivity and anxiety, and the HAB+PSD group presented spontaneous hyperactivity, operant hypoactivity, impulsivity, loss of interest, and cognitive impairment. Conclusion: A combination of environmental stressors (HAB and PSD) may induce endophenotypes related to bipolar disorder.


Assuntos
Animais , Masculino , Ratos , Estresse Psicológico/fisiopatologia , Comportamento Animal , Transtorno Bipolar/fisiopatologia , Transtornos Cognitivos/fisiopatologia , Ansiedade , Privação do Sono , Ratos Wistar , Cognição , Modelos Animais de Doenças
11.
J. pediatr. (Rio J.) ; 95(4): 451-457, July-Aug. 2019. tab, graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-1040345

RESUMO

Abstract Objective: To evaluate the cognitive abilities of children and adolescents with sickle cell anemia diagnosed through neonatal screening and to compare them with healthy controls, adjusting the results to their socioeconomic status. Methods: Cognitive assessment was performed with the Wechsler WISC-III scale in 64 children and adolescents with sickle cell anemia and in 64 controls matched by gender and age, without the disease and without neurological impairment; socioeconomic status was measured by the Criterion Brasil. Results: All cognitive scores were lower in the group of patients. The mean overall IQ, Verbal IQ, and Performance IQ were, respectively, 90.95 for the group of patients and 113.97 for the controls (p < 0.001); 91.41 for the group of patients and 112.31 for the controls (p < 0.001); 92.34 for the group of patients and 113.38 for the controls (p < 0.001). Scores for processing speed, distraction resistance, and perceptual organization were also significantly lower in patients. A direct and significant correlation was detected between socioeconomic status and cognitive scores. In the multivariate analysis, for the same socioeconomic status, a child with sickle cell anemia had an average IQ of 21.2 points lower than the mean IQ observed for the controls (p < 0.001), indicating that the disease, adjusted for the socioeconomic effect, is a strong predictor of the overall IQ. Conclusion: The cognitive impairment of children with sickle cell anemia is severe and manifests even when the disease effect is adjusted to the socioeconomic status. In the authors' view, such impairment requires an early preventive approach in order to avoid this cognitive damage.


Resumo Objetivo: Avaliar os sistemas cognitivos de crianças e adolescentes com anemia falciforme provenientes de triagem neonatal e compará-las com controles sadios, ajustando-se os resultados para o nível socioeconômico. Método: A avaliação cognitiva foi feita com a escala de Wechsler WISC-III em 64 crianças e adolescentes com anemia falciforme e em 64 controles pareados por sexo e idade, sem a doença e sem comprometimento neurológico; o nível socioeconômico foi aferido pelo Critério Brasil. Resultados: Todos os escores cognitivos foram inferiores no grupo de pacientes. As médias de QI Total, QI Verbal e QI de Execução foram respectivamente 90,95 para o grupo de pacientes e 113,97 para os controles (p < 0,001); 91,41 para o grupo de pacientes e 112,31 para os controles (p < 0,001); 92,34 para o grupo de pacientes e 113,38 para os controles (p < 0,001). Os escores de velocidade de processamento, de resistência à distração e de organização perceptual foram, também, significativamente mais baixos nos pacientes. Detectou-se correlação direta e significativa entre o nível socioeconômico e os escores cognitivos. Em análise multivariada, para um mesmo nível socioeconômico, uma criança com anemia falciforme teve QI total, em média, 21,2 pontos mais baixo do que a média dos controles (p < 0,001), indicou que a doença, ajustada para o efeito socioeconômico, é forte fator preditivo do QI total. Conclusão: Os prejuízos cognitivos das crianças com anemia falciforme são intensos e se manifestam mesmo quando o efeito da doença é ajustado para o nível socioeconômico, o que, a nosso ver, requer abordagem preventiva precoce para tentar evitar tais prejuízos.


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Transtornos Cognitivos/etiologia , Anemia Falciforme/complicações , Fatores Socioeconômicos , Escalas de Wechsler , Brasil , Estudos de Casos e Controles , Estudos Transversais , Transtornos Cognitivos/prevenção & controle , Testes de Inteligência , Testes Neuropsicológicos
12.
Dement. neuropsychol ; 13(2): 203-209, Apr.-June 2019. tab, graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-1011953

RESUMO

ABSTRACT. Semantic verbal fluency (SVF) is one of the most widely used tests for cognitive assessment due to its diagnostic utility (DU). Objective: our objective is to evaluate the DU to detect cognitive impairment (CI) of a short version of the SVF applied in 30 seconds (SVF1-30). Methods: a prospective sample of consecutive patients evaluated in a Neurology Unit between December 2016 and December 2017 were assessed with the Global Deterioration Scale (GDS), 30-second and 60-second SVF tests (animals), and the Fototest, which includes a fluency task of people's names. The DU for CI was evaluated by the area under the ROC curve and effect size ("d" Cohen). Results: the study included 1012 patients (256 with CI, 395 with dementia). SVF1-30 shows a good correlation with GDS stage. The DU of SVF1-30 is identical to that of the classical version, applied in 60 seconds, (SVFtotal) for CI (0.89 ± 0.01; p > 0.50), and shows no significant difference for dementia (0.85 ± 0.01 vs. 0.86 ± 0.01, p > 0.15). Discussion: the DU of SVF1-30 is similar to that of the SVFtotal, allowing a reduction in examination time with no loss of discriminative capacity.


RESUMO. A fluência verbal semântica (SVF) é um dos testes mais utilizados na avaliação cognitiva devido à sua utilidade diagnóstica (UD). Objetivo: Nosso objetivo foi o de avaliar o DU de uma versão abreviada do SVF aplicado em 30 segundos (SVF1-30) para a detecção do comprometimento cognitivo (CC). Métodos: Amostra prospectiva de pacientes avaliados em uma Unidade de Neurologia entre dezembro de 2016 e dezembro de 2017. Global Deterioration Scale (GDS), um teste de SVF (animais), registrando os resultados em 30 e 60 segundos e Fototest, que inclui uma tarefa de fluência de nomes de pessoas foram aplicadas. A UD para CC foi avaliada pela área sob a curva ROC e o tamanho do efeito ("d" Cohen). Resultados: foram incluídos 1012 sujeitos (256 CC e 395 demência). O SVF1-30 mostrou uma boa correlação com o estágio GDS. A UD de SVF1-30 é idêntico ao da versão clássica (SVFtotal) para CC (0,89 ± 0,01; p > 0,50) e sem diferença significativa para demência (0,85 ± 0,01 vs. 0,86 ± 0,01; p > 0,15). Discussão: a UD do SVF1-30 é similar ao SVFtotal, o que permite diminuir o tempo de exploração sem perder a capacidade discriminativa.


Assuntos
Humanos , Transtornos Cognitivos , Doença de Alzheimer , Testes de Estado Mental e Demência
13.
Prensa méd. argent ; 105(4): 205-213, jun 2019.
Artigo em Inglês | LILACS (Américas), BINACIS | ID: biblio-1045980

RESUMO

The study was aimed at investigating the features of gnostic functions in the elderly people suffering from dementia. To implement the objectives of the study and to solve the set tasks, the following methods were used: visual gnosis tests (recognition of images, the selection of three subject pictures, selecting parts of a whole, etc.), the acoustic gnosis tests (score and perception of rhythms, recognition of nonspeech sounds), and tactile gnosis tests (tactile identification, Teuber test, Foerster test). When running the visual gnosis tests, the elderly people with the dementia diseases slowly initiated the tasks, made numerous errors, and sometimes could not cope with the tasks at all. Also, the perception integrity disorders, the presence of fragmentation, lack of accuracy, differentiation, preservation of specific objective images-objects, and the violation in the understanding of the spatial arrangement of things were revealed. When performing the auditory-motor coordination tests, the elderly people suffering from dementia needed more time to listen to, they asked for the repeated sound representation, and there were often errors in the rhythmic structure reproduction. When performing the tactile gnosis tests, the elderly people suffering from dementia had difficulties in identifying the subject by touch, in understanding the right and left-sided spatial relationships, and also made errors in recognizing one of the touches when the experimenter touched their hands. Based on the study results, the recommendations have been developed for the preservation and improvement of the existing gnostic functions' disorders in the elderly people suffering from dementia. The recommendations are complex, and they can also be useful for the medical staff whose professional activity is directly related to the elderly people suffering from dementia, their relatives and the persons closest to them.


Assuntos
Humanos , Idoso , Idoso de 80 Anos ou mais , Reconhecimento Visual de Modelos , Teste de Sequência Alfanumérica , Acústica , Cognição , Transtornos Cognitivos/terapia , Demência/patologia , Agnosia/patologia
14.
Fisioter. Pesqui. (Online) ; 26(1): 37-43, Jan.-Mar. 2019. tab, graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-1002007

RESUMO

ABSTRACT The mini-mental state examination (MMSE) is a screening test used worldwide for identifying changes in the scope of cognition. Studies have shown the influence of education, age and sex in the MMSE score. However, in Brazil, the studies consider only one factor to score it. The aim of this study was to establish a prediction equation for the MMSE. An exploratory cross-sectional study was developed and trained researchers examined participants at the community. The volunteers were evaluated by the MMSE and also by the Geriatric Depression Scale (GDS). The MMSE score was the dependent variable. Age, educational level, sex, and GDS score were the independent variables. Multivariate regression analysis was used to determine the model of best prediction value for MMSE scores. A total of 250 participants aged 20-99 years, without cognitive impairment, were assessed. The educational level, age, and sex explained 38% of the total variance of the MMSE score (p<0.0001) and resulted in the following equation: MMSE=23.350+0.265(years of schooling)-0.042(age)+1.323(sex), in which female=1 and male=2. The MMSE scores can be better explained and predicted when educational level, age, and sex are considered. These results enhance the knowledge regarding the variables that influence the MMSE score, as well as provide a way to consider all of them in the test score, providing a better screening of these patients.


RESUMO O mini-exame do estado mental (MEEM) é um teste de rastreio mundialmente utilizado para identificar alterações no âmbito da cognição. Estudos têm demonstrado a influência da educação, idade e gênero na pontuação do MEEM. No entanto, no Brasil, os estudos consideram apenas um fator para a pontuação no teste. O objetivo do estudo foi estabelecer uma equação preditiva para o MEEM. Um estudo transversal exploratório foi desenvolvido e examinadores treinados avaliaram participantes da comunidade. Os voluntários foram avaliados pelo MEEM e pela Escala de Depressão Geriátrica (EDG). A pontuação do MEEM foi a variável dependente. A idade, nível educacional, gênero e pontuação na EDG foram as variáveis independentes. A análise de regressão multivariada foi utilizada para determinar o modelo de melhor valor preditivo para os escores do MEEM. Foram avaliados 250 indivíduos entre 20 e 99 anos, sem comprometimento cognitivo. O nível educacional, a idade e o sexo explicaram 38% da variância total da pontuação do MEEM (p<0,0001) e resultaram na equação: MEEM=23,350+0,265(anos de escolaridade)-0,042(idade)+1,323(gênero), em que mulher=1 e homem=2. A pontuação do MEEM pode ser melhor explicada e predita quando o nível educacional, idade e gênero são considerados. Os resultados contribuem para o conhecimento sobre as variáveis que influenciam o escore do MEEM, bem como fornece uma maneira de considerá-las na pontuação do teste, proporcionando uma melhor triagem desses pacientes.


RESUMEN El mini-examen del estado mental (MEEM) es una prueba de rastreo mundialmente utilizada para identificar alteraciones en el ámbito de la cognición. Los estudios han demostrado la influencia de la educación, la edad y el sexo en la puntuación del MEEM. Sin embargo, en Brasil, los estudios consideran sólo un factor para la puntuación en la prueba. El objetivo del estudio fue establecer una ecuación predictiva para el MEEM. Un estudio transversal exploratorio fue desarrollado y examinadores entrenados evaluaron a participantes de la comunidad. Los participantes fueron evaluados por el MEEM y la Escala de Depresión Geriátrica (EDG). La puntuación del MEEM fue la variable dependiente. La edad, nivel educativo, sexo y puntuación en la EDG fueron las variables independientes. El análisis de regresión multivariada fue utilizado para determinar el modelo de mejor valor predictivo para los escores del MEEM. Se evaluaron 250 individuos entre 20 y 99 años, sin comprometimiento cognitivo. El nivel educativo, la edad y el sexo explicaron el 38% de la varianza total de la puntuación del MEEM (p <0,0001) y resultaron en la ecuación: MEEM=23,350+0,265(años de escolaridad)-0,042 (edad)+1,323 (sexo), en que mujer = 1 y hombre = 2. La puntuación del MEEM puede ser mejor explicada y predecible cuando se considera el nivel educativo, la edad y el sexo. Los resultados contribuyen para el conocimiento sobre las variables que influencian el score del MEEM, así como proporciona una manera de considerar las variables en la puntuación de la prueba, proporcionando una mejor forma de triar a estos pacientes.


Assuntos
Humanos , Masculino , Feminino , Idoso , Idoso de 80 Anos ou mais , Transtornos Cognitivos/diagnóstico , Testes de Estado Mental e Demência , Fatores Sexuais , Estudos Transversais , Fatores Etários , Escolaridade , Questionário de Saúde do Paciente
15.
Estud. Psicol. (Campinas, Online) ; 36: e180016, 2019. tab, graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-1001991

RESUMO

The present study analyzes the relationship between maladaptive beliefs, personality traits, and Borderline Personality Disorder symptoms by focusing in the mediating role of beliefs in the prediction between personality and psychiatric disorders. The sample consisted of 823 adults aged between 18 and 39 years (M = 24.09, SD = 4.71), who answered a questionnaire of symptoms and beliefs for Borderline Personality Disorder and Big Five Personality Inventory. The predictive model that fit better to the data indicates Neuroticism and Conscientiousness as predictors of Borderline Personality Disorder symptoms, mediated by maladaptive belief patterns. In this sense, it is possible to conclude that both personality traits and maladaptive beliefs are important for the understanding of Borderline Personality Disorder. The theoretical implications of this result and the limitations of the study are discussed.


O presente estudo analisou as relações existentes entre crenças desadaptativas, traços de personalidade e sintomas do Transtorno da Personalidade Borderline, com foco no papel mediador das crenças na relação entre personalidade e transtornos de personalidade. Participaram 823 adultos, idades entre 18 e 39 anos (M = 24,09; DP = 4,71), que responderam a um questionário de sintomas e de crenças para o Transtorno da Personalidade Borderline e ao inventário dos cinco grandes fatores de personalidade. O modelo preditivo que melhor se ajustou aos dados indica Neuroticismo e Conscienciosidade como preditores dos sintomas de Transtorno da Personalidade Borderline, sendo seus efeitos mediados por padrões de crença desadaptativos. Assim, foi possível concluir que tanto os traços de personalidade quanto as crenças desadaptativas são importantes para a compreensão do Transtorno da Personalidade Borderline. As implicações teóricas desse resultado e as limitações do estudo são discutidas.


Assuntos
Humanos , Masculino , Feminino , Transtorno da Personalidade Borderline , Transtornos Cognitivos
16.
Artigo em Coreano | WPRIM (Pacífico Ocidental) | ID: wprim-762194

RESUMO

Obstructive sleep apnea syndrome (OSAS) is the most severe form of obstructive sleep-disordered breathing. It can produce cardiovascular problems, growth retardation, cognitive deficits, and behavioral problems such as attention deficit/hyperactivity symptoms in children. The diagnostic gold standard for OSAS is overnight polysomnography, but it is expensive, time-consuming, and labor intensive, and is conducted by specialized centers which have trained personnel. Therefore, sleep questionnaires as screening tools for OSAS was developed. The benefits of sleep questionnaires are easy/quick application and low cost. The objective of this review is to describe several available pediatric sleep questionnaires which are helpful in screening OSAS.


Assuntos
Criança , Transtornos Cognitivos , Humanos , Programas de Rastreamento , Polissonografia , Comportamento Problema , Síndromes da Apneia do Sono , Apneia Obstrutiva do Sono
17.
Yonsei Medical Journal ; : 774-781, 2019.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-762107

RESUMO

PURPOSE: Cerebral small vessel disease (SVD) is known to be associated with ischemic stroke, intracerebral hemorrhage (ICH), and cognitive impairment. In this retrospective observational study, we explored SVD markers on MRI relevant to spontaneous ICH. MATERIALS AND METHODS: The ICH group consisted of 150 consecutive patients with a first primary parenchymal ICH, and the control group consisted of 271 age- and sex-matched individuals who underwent brain MRI in a health care center. We compared cerebral microbleeds (CMBs), white matter hyperintensities (WMHs), enlarged perivascular space (EPVS), and lacunae in the ICH and control groups. RESULTS: A total of 1278 CMB lesions were identified in 121 of the 150 patients in the ICH group (80.6%), while 77 CMB lesions were found in 32 of the 271 individuals in the control group (11.8%). WMH and EPVS were more severe and lacunae were more frequent in the ICH patients than in the control group. When receiver operating characteristic (ROC) curves were plotted, number of CMBs most significantly predicted ICH. All imaging markers were significantly associated with ICH in every age group. The location of CMBs coincided with the location of ICH, and ICH volume correlated with CMB count. CONCLUSION: All MRI markers for SVD were worse in ICH patients than in healthy controls, and these markers were prominent even in young ICH patients. Lacunae, WMH, EPVS, and CMB should be considered as factors related with spontaneous ICH.


Assuntos
Encéfalo , Angiopatia Amiloide Cerebral , Hemorragia Cerebral , Doenças de Pequenos Vasos Cerebrais , Transtornos Cognitivos , Assistência à Saúde , Humanos , Hipertensão , Hemorragias Intracranianas , Imagem por Ressonância Magnética , Estudo Observacional , Estudos Retrospectivos , Curva ROC , Acidente Vascular Cerebral , Substância Branca
18.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-739821

RESUMO

Traumatic brain injury is a main cause of long-term neurological disability, and many patients suffer from cognitive impairment for a lengthy period. Cognitive impairment is a fatal malady to that limits active rehabilitation, and functional recovery in patients with traumatic brain injury. In severe cases, it is impossible to assess cognitive function precisely, and severe cognitive impairment makes it difficult to establish a rehabilitation plan, as well as evaluate the course of rehabilitation. Evaluation of cognitive function is essential for establishing a rehabilitation plan, as well as evaluating the course of rehabilitation. We report a case of the analysis of electroencephalography with global synchronization index and low-resolution brain electromagnetic tomography applied, for evaluation of cognitive function that was difficult with conventional tests, due to severe cognitive impairment in a 77-year-old male patient that experienced traumatic brain injury.


Assuntos
Idoso , Encéfalo , Lesões Encefálicas , Transtornos Cognitivos , Cognição , Eletroencefalografia , Humanos , Imãs , Masculino , Reabilitação
19.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-739662

RESUMO

Depression is a major mood disorder. Abnormal expression of glial glutamate transporter-1 (GLT-1) is associated with depression. Schisantherin B (STB) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine for thousands of years. This paper was designed to investigate the effects of STB on depressive mice induced by forced swimming test (FST). Additionally, we also assessed the impairment of FST on cognitive function in mice with different ages. FST and open field test (OFT) were used for assessing depressive symptoms, and Y-maze was used for evaluating cognition processes. Our study showed that STB acting as an antidepressant, which increased GLT-1 levels by promoting PI3K/AKT/mTOR pathway. Although the damage is reversible, short-term learning and memory impairment caused by FST test is more serious in the aged mice, and STB also exerts cognition improvement ability in the meanwhile. Our findings suggested that STB might be a promising therapeutic agent of depression by regulating the GLT-1 restoration as well as activating PI3K/AKT/mTOR pathway.


Assuntos
Animais , Cognição , Transtornos Cognitivos , Depressão , Ácido Glutâmico , Medicina Herbária , Aprendizagem , Lignanas , Memória , Camundongos , Transtornos do Humor , Esforço Físico , Schisandra
20.
Experimental Neurobiology ; : 119-129, 2019.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wprim-739526

RESUMO

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a progressive degenerative white matter disorder caused by mutations in the tyrosine kinase domain of the CSF1R gene. ALSP is often misdiagnosed as other diseases due to its rarity and various clinical presentations such as Parkinsonism, pyramidal signs, cognitive impairment and/or psychiatric symptoms. We describe an autopsy case of ALSP with a CSF1R mutation. A 61-year-old woman presented insidious-onset gait difficulty for 12 years since her age of 49, and premature ovarian failure since her age of 35. At initial hospital visit, brain magnetic resonance imaging revealed hydrocephalus. Initially, Parkinson's syndrome was diagnosed, and she was prescribed L-dopa/carbidopa because of spasticity and rigidity of extremities, which had worsened. Subsequently, severe neuropsychiatric symptoms and cognitive impairment developed and radiologically, features of leukoencephalopathy or leukodystrophy were detected. She showed a down-hill course and died, 12 years after initial diagnosis. At autopsy, the brain showed severe symmetric atrophy of bilateral white matter, paper-thin corpus callosum, thin internal capsule, and marked hydrocephalus. Microscopically, diffuse loss of white matter, relatively preserved subcortical U-fibers, and many eosinophilic bulbous neuroaxonal spheroids were noted, but there was no calcification. Pigmented glia with brown cytoplasmic pigmentation were readily found in the white matter, which were positive for Periodic acid-Schiff, p62, and CD163 stains, but almost negative for CD68. Whole-exome and Sanger sequencing revealed a CSF1R mutation (c.2539G>A, p.Glu847Lys) which was reported in prior one ALSP case. This example demonstrates that ALSP could be associated with premature ovarian failure.


Assuntos
Atrofia , Autopsia , Axônios , Encéfalo , Transtornos Cognitivos , Corantes , Corpo Caloso , Citoplasma , Diagnóstico , Eosinófilos , Extremidades , Feminino , Marcha , Humanos , Hidrocefalia , Cápsula Interna , Leucoencefalopatias , Imagem por Ressonância Magnética , Pessoa de Meia-Idade , Espasticidade Muscular , Neuroglia , Transtornos Parkinsonianos , Pigmentação , Insuficiência Ovariana Primária , Proteínas Tirosina Quinases , Substância Branca
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