Predictors of time to sputum culture conversion in multi-drug-resistant tuberculosis and extensively drug-resistant tuberculosis in patients at Tshepong-Klerksdorp Hospital
S. Afr. j. infect. dis. (Online)
;
34(1): 1-8, 2019. ilus
Article
in English
| AIM
| ID: biblio-1270731
ABSTRACT
Setting:
Klerksdorp-Tshepong Hospital Complex MDR-TB Unit, North-West Province, South Africa.Background:
To determine the time to sputum culture conversion (TTSCC) and factors predictive of TTSCC in patients with multi-drug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in the North-West Province.Methods:
A retrospective cohort study, abstracting patient demographic and clinical data, laboratory results, dates of sputum testing and sputum culture conversion results, from medical records of 526 MDR-TB and 47 XDR-TB patients started on TB treatment between 01 January 2012 and 31 December 2014. Predictors of TTSCC were determined by Cox proportional hazards regression.Results:
The median age was 38 years (interquartile range 3147) with 64% being male. Overall, 79% (449) were Human Immunodeficiency Virus (HIV)-infected. The median TTSCC was 56.5 days and 162.5 days for MDR-TB and XDR-TB patients, respectively. In the multivariate analysis, age [hazard ratio (HR) 0.89, 95% confidence interval (CI) 0.960.99], being underweight (HR 0.631.61, 95% CI 0.451.030.882.51), Acid Fast Bacilli (AFB) positivity (HR 0.72, 95% CI 0.511.01) and having XDR-TB (HR 0.36. 95% CI 0.190.69) were predictive of longer TTSCC.Conclusion:
Predictors of TTSC allow for MDR-TB- and XDR-TB-diagnosed patients to be identified early for effective management. Those with risk factors for delayed sputum culture conversion which are being underweight and having XDR-TB should be monitored carefully during treatment so that they can achieve sputum culture conversion early
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Index:
AIM (Africa)
Main subject:
South Africa
/
Sputum
/
Tuberculosis, Multidrug-Resistant
/
Early Diagnosis
/
Nutritional Sciences
/
Extensively Drug-Resistant Tuberculosis
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
/
Screening study
Country/Region as subject:
Africa
Language:
English
Journal:
S. Afr. j. infect. dis. (Online)
Year:
2019
Type:
Article
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