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Desestruturação da polpa branca do baço na leishmaniose visceral canina: células e citocinas envolvidas / Disruption of the white pulp of the spleen in canine visceral leishmaniasis: cells and cytokines involved
Salvador; s.n; 2014. 183 p. ilus, tab.
Thesis in Portuguese | LILACS | ID: biblio-1000901
RESUMO
A leishmaniose visceral está associada às alterações arquiteturais esplênicas e redistribuição de populações celulares envolvidas na resposta imunológica. Os objetivos desta tese foram estudar a desestruturação da polpa branca do baço na leishmaniose visceral canina e quais as células e citocinas envolvidas nesse processo. Para isso, amostras de baços de cães de uma área endêmica para LV foram agrupadas em três categorias TIPO1-CONT ou TIPO1-SIA (cães não infectados ou sem infecção ativa e com polpa branca organizada), TIPO1-INF (cães infectados com polpa branca organizada) e TIPO3-INF (cães infectados com polpa branca desorganizada). No capítulo 2 e 3, as secções de baço foram marcadas através de imunoistoquímica com anticorpos anti-CD3 (linfócitos T), anti-CD79-α (linfócitos B), anti-S100 (célula dendrítica folicular), anti-Ki-67...
ABSTRACT
Visceral leishmaniasis is associated with splenic architectural changes and redistribution of cell populations involved in the immune response. The objectives of this thesis was to study the disruption of the white pulp of the spleen in canine visceral leishmaniasis and which cells and cytokines are involved in this process. For this, samples of spleens of dogs from an endemic area for VL were grouped into three categories TYPE1-CONT or TYPE1-NIF (non-infected dogs or without active infection with organized white pulp), TYPE1-INF (infected dogs with pulp organized white) and TYPE3-INF (infected animals with disorganized white pulp). In Chapter 2 and 3 the spleens sections were stained by immunohistochemistry with anti-CD3 (T lymphocytes), anti-CD79 (B lymphocytes), anti-S100 (follicular dendritic cells), anti-Ki-67...
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Spleen / Enzyme-Linked Immunosorbent Assay / Polymerase Chain Reaction / Leishmania Limits: Animals Language: Portuguese Year: 2014 Type: Thesis

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Full text: Available Index: LILACS (Americas) Main subject: Spleen / Enzyme-Linked Immunosorbent Assay / Polymerase Chain Reaction / Leishmania Limits: Animals Language: Portuguese Year: 2014 Type: Thesis