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Concentrações plasmáticas de citocinas e quimiocinas na infecção pelo HTLV-1 / Plasma concentrations of cytokines and chemokines in HTLV-1
Salvador; s.n; 2015. 83 p. ilus, tab.
Thesis in Portuguese | LILACS | ID: biblio-1000982
RESUMO

INTRODUÇÃO:

O vírus linfotrópico das células T humano tipo 1 (HTLV-1) é endêmico na Bahia e está associado com doenças graves, como a Paraparesia Espástica Tropical/Mielopatia associada ao HTLV-1 (HAM/TSP) e a Dermatite Infecciosa associada ao HTLV-1 (DIH). Escassos trabalhos tem sido reportados com a avaliação de citocinas e quimiocinas em indivíduos jovens infectados pelo HTLV-1 e não existem dados sobre a manifestação simultânea DIH e HAM/TSP na faixa infanto-juvenil.

OBJETIVO:

Avaliar as concentrações plasmáticas de citocinas e quimiocinas na infecção pelo HTLV-1 em indivíduos infanto-juvenis.

MÉTODO:

Foram incluídos 61 indivíduos portadores do HTLV-1 distribuídos nos grupos Portadores assintomáticos, pacientes com a DIH, pacientes com DIH/HAM/TSP, pacientes com a HAM/TSP e 20 indivíduos saudáveis sem a infecção pelo HTLV-1, todos na faixa infanto-juvenil. As concentrações plasmáticas foram comparadas através do método de Elisa e de Cytometric Bead Array (CBA)...
ABSTRACT

INTRODUCTION:

The lymphotropic virus of cells T human type 1 (HTLV ) is endemic in Bahia and it is associated with serious diseases such as Tropical Spastic Paraparesis/associated myelopathy with HTLV-1 and Infectious Dermatitis associated with HTLV -1 (IDH). Very little work has been reported with the evaluation of cytokines and chemokines in the IDH and there has been no data on the manifestation simultaneous IDH and HAM/TSP in children and youth range.

OBJECTIVE:

To evaluate the plasma concentrations of cytokines and chemokines in HTLV-1 infection in children and young individuals.

METHOD:

We included 61 individuals HTLV-1 spread in groups Asymptomatic Carriers, patients with IDH, patients with IDH/HAM/TSP, patients with HAM/TSP and 20 healthy individuals without HTLV-1, all in children's range. Plasma concentrations were compared using the ELISA method and Cytometric Bead Array (CBA)...
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Lymphocytes / Human T-lymphotropic virus 1 / Cytokines Limits: Humans Language: Portuguese Year: 2015 Type: Thesis

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Full text: Available Index: LILACS (Americas) Main subject: Lymphocytes / Human T-lymphotropic virus 1 / Cytokines Limits: Humans Language: Portuguese Year: 2015 Type: Thesis