The effect of graft application and simvastatin treatment on tibial bone defect in rats. A histological and immunohistochemical study
Acta cir. bras
;
34(4): e201900408, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1001086
ABSTRACT
Abstract Purpose:
To evaluate histologically and immunohistochemically the bone regeneration after application of simvastatin on tibial bone defects in rats.Methods:
Sixty Wistar albino rats were divided into 3 groups as control (6 mm tibial bone defect), defect + graft (allograft treatment), and defect + graft + simvastatin (10 mg/kg/day) for 28 days.Results:
Histopathological examination revealed inflammation in control group (defect group), congestion in blood vessels, and an increase in osteoclast cells. In defect + graft group, osteoclastic activity was observed and osteocyte cells were continued to develop. In defect + graft + simvastatin group, osteocytes and matrix formation were increased in the new bone trabeculae. Osteopontin and osteonectin expression were positive in the osteclast cells in the control group. Osteoblasts and some osteocytes showed a positive reaction of osteopontin and osteopontin. In defect + graft + simvastatin group, osteonectin and osteopontin expression were positive in osteoblast and osteocyte cells, and a positive expression in osteon formation was also seen in new bone trabeculae.Conclusion:
The simvastatin application was thought to increase bone turnover by increasing the osteoinductive effect with graft and significantly affect the formation of new bone.
Full text:
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Index:
LILACS (Americas)
Main subject:
Tibia
/
Bone Regeneration
/
Simvastatin
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2019
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Dicle University/TR
/
University of Bingöl/TR
/
University of Dicle/TR
/
University of Katip Çelebi/TR
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