Your browser doesn't support javascript.
loading
Psoriasis in obesity: comparison of serum levels of leptin and adiponectin in obese subjects - cases and controls
Bavoso, Nádia Couto; Pinto, Jackson Machado; Soares, Maria Marta Sarquis; Diniz, Michelle dos Santos; Teixeira Júnior, Antônio Lúcio.
  • Bavoso, Nádia Couto; Santa Casa de Misericórdia de Belo Horizonte. Dermatology Service. Belo Horizonte. BR
  • Pinto, Jackson Machado; Santa Casa de Misericórdia de Belo Horizonte. Dermatology Service. Belo Horizonte. BR
  • Soares, Maria Marta Sarquis; Universidade Federal de Minas Gerais. Department of Clinical Medicine. Belo Horizonte. BR
  • Diniz, Michelle dos Santos; Santa Casa de Misericórdia de Belo Horizonte. Dermatology Service. Belo Horizonte. BR
  • Teixeira Júnior, Antônio Lúcio; Universidade Federal de Minas Gerais. Faculdade de Medicina. Discipline of Neurology. Belo Horizonte. BR
An. bras. dermatol ; 94(2): 192-197, Mar.-Apr. 2019. tab
Article in English | LILACS | ID: biblio-1001127
ABSTRACT
Abstract

BACKGROUND:

Psoriasis and obesity are somewhat related to a low-grade systemic inflammatory response.

OBJECTIVES:

To determine leptin and adiponectin levels in psoriasis patients compared to control patients matched for weight.

METHODS:

A case-control study was performed, evaluating 113 psoriasis patients and 41 controls with other dermatologic diseases.

RESULTS:

The prevalence of obesity was 33% in cases and 21.9% in controls. All evaluated comorbidities were more prevalent among cases. When stratified by weight, the comorbidities were more frequent in overweight patients. We found no correlation between being overweight (p=0.25), leptin (p=0.18) or adiponectin (p=0.762) levels and psoriasis severity. When overweight cases and controls were compared, we found differences in the adiponectin values (p= 0.04). The overweight cases had lower adiponectin levels than the overweight controls. We found no differences in the leptin dosage between cases and controls. The overweight cases had higher leptin values than the normal weight cases (p<0.001). STUDY

LIMITATIONS:

Several patients used systemic anti-inflammatory medication.

CONCLUSIONS:

The prevalence of obesity among psoriasis cases (33%) was higher than in the general population (17.4%). We did not find any correlation between severity of psoriasis and inflammatory cytokines and the condition of being overweight. The overweight cases had lower values of adiponectin than the overweight controls. It seems, therefore, that there is a relationship between adiponectin and psoriasis, but this relationship depends on the presence of obesity.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Psoriasis / Leptin / Adiponectin / Hypertension / Obesity Type of study: Observational study / Prevalence study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Santa Casa de Misericórdia de Belo Horizonte/BR / Universidade Federal de Minas Gerais/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Psoriasis / Leptin / Adiponectin / Hypertension / Obesity Type of study: Observational study / Prevalence study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Santa Casa de Misericórdia de Belo Horizonte/BR / Universidade Federal de Minas Gerais/BR