Tissue healing efficacy in burn patients treated with 1% silver sulfadiazine versus other treatments: a systematic review and meta-analysis of randomized controlled trials
An. bras. dermatol
;
94(2): 204-210, Mar.-Apr. 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1001128
ABSTRACT
Abstract This study aims to evaluate tissue healing efficacy in burn patients treated with 1% silver sulfadiazine versus other treatments. This is a systematic literature review and meta-analysis of randomized clinical trials performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) and PICO strategy, registered in the International Prospective Register of Systematic Reviews (PROSPERO) under the number CRD42017081057. The review found 71 studies in MEDLINE/Pubmed, 1 in Clinical Trials, 19 in the Cochrane Library, and 4 in LILACS in five manual searches. Of these, 81 studies were pre-selected. After independent analysis by two reviewers, only 11 studies met the inclusion criteria for the review. All studies (n = 11) using alternative treatments to silver sulfadiazine were shown to be superior in the mean time for complete wound healing, with statistically significant differences between experimental and control groups (p <0.00001); mean difference (- 4.26), 95% CI [- 5.96, - 2.56].
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Silver Sulfadiazine
/
Wound Healing
/
Burns
/
Anti-Infective Agents, Local
Type of study:
Controlled clinical trial
/
Practice guideline
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade Metropolitana de Manaus/BR
/
Universidade Federal do Amazonas/BR
/
Universidade do Estado do Amazonas/BR
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