Preoperative detection of TERT promoter and BRAFV600E mutations in papillary thyroid carcinoma in high-risk thyroid nodules
Arch. endocrinol. metab. (Online)
;
63(2): 107-112, Mar.-Apr. 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1001216
ABSTRACT
ABSTRACT Objectives:
This observational study analyzed telomerase reverse transcriptase (pTERT) mutations in 45 fine-needle aspiration (FNA) specimens obtained from thyroid nodules followed by postoperatively confirmation of papillary thyroid cancer (PTC) diagnosis, examining their relationship with clinicopathologic aspects and the BRAFV600E mutation. Subjects andmethods:
Clinical information was collected from patients who presented to Ribeirao Preto University Hospital for surgical consultation regarding a thyroid nodule and who underwent molecular testing between January 2010 to October 2012. Tests included a DNA-based somatic detection of BRAFV600E and pTERT mutations.Results:
We found coexistence of pTERTC228T and BRAFV600E mutations in 8.9% (4/45) of thyroid nodules. All nodules positive for pTERT mutations were BRAFV600E positives. There was a significant association between pTERTC228T/BRAFV600E with older age and advanced stage compared with the group negative for either mutation.Conclusions:
This series provides evidence that FNA is a reliable method for preoperative diagnosis of high-risk thyroid nodules. pTERTC228T/BRAFV600E mutations could be a marker of poor prognosis. Its use as a personalized molecular medicine tool to individualize treatment decisions and follow-up design needs to be further studied.
Full text:
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Index:
LILACS (Americas)
Main subject:
Thyroid Neoplasms
/
Thyroid Nodule
/
Telomerase
/
Proto-Oncogene Proteins B-raf
/
Thyroid Cancer, Papillary
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Arch. endocrinol. metab. (Online)
Journal subject:
Endocrinology
/
Metabolism
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Liga Bahiana Contra o Câncer/BR
/
Universidade Estadual do Sudoeste da Bahia/BR
/
Universidade Federal da Bahia/BR
/
Universidade de São Paulo/BR
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