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Genetic correlation between Prothrombin G20210A polymorphism and retinal vein occlusion risk
Zou, Yuanyuan; Zhang, Xi; Zhang, Jingyi; Ji, Xiangning; Liu, Yuqing; Zhao, Shaozhen.
  • Zou, Yuanyuan; Tianjin Medical University Eye Hospital, School of Optometry and Ophthalmology, Tianjin Medical University. Department of Refraction and Cornea. Tianjin. CN
  • Zhang, Xi; Cangzhou Central Hospital. The Second Department of Ophthalmology. Cangzhou. CN
  • Zhang, Jingyi; Cangzhou Central Hospital. The Second Department of Ophthalmology. Cangzhou. CN
  • Ji, Xiangning; Cangzhou Central Hospital. The Second Department of Ophthalmology. Cangzhou. CN
  • Liu, Yuqing; Cangzhou Central Hospital. The Second Department of Ophthalmology. Cangzhou. CN
  • Zhao, Shaozhen; Tianjin Medical University Eye Hospital, School of Optometry and Ophthalmology, Tianjin Medical University. Department of Refraction and Cornea. Tianjin. CN
Braz. j. med. biol. res ; 52(4): e8217, 2019. tab, graf
Article in English | LILACS | ID: biblio-1001511
ABSTRACT
The aim of this study was to perform an updated meta-analysis to quantitatively investigate the association between G20210A polymorphism of Prothrombin gene and the risk of retinal vein occlusion (RVO), based on the available publications with inconsistent results. We utilized the Stata software to perform the heterogeneity test, association test, Begg's and Egger's tests, and sensitivity analysis. We searched three on-line databases (PubMed, Embase, and WOS) and obtained a total of 422 articles. Based on our selection criteria, 24 case-control studies were finally enrolled in this overall meta-analysis; a subgroup analysis by the factors ethnicity, control source, and RVO type was done. Through the association test of overall meta-analysis, we did not observe a significant difference between RVO cases and controls under the A vs G (allele) (z=1.49, P=0.137), A vs G (carrier) (z=1.42, P =0.155), GA vs GG (z=1.50, P=0.135), and GA+AA vs GG (z=1.50, P=0.135). Furthermore, we observed similar negative results in the association test of subgroup analysis (all P>0.05). Heterogeneity, Begg's, and Egger's tests excluded the presence of high heterogeneity and publication bias. Statistically stable results were observed in the sensitivity analyses. Based on integrated analysis of the current evidence, Prothrombin gene G20210A polymorphism is likely unrelated to the risk of RVO.
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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Retinal Vein Occlusion / Prothrombin / Genetic Predisposition to Disease Type of study: Etiology study / Observational study / Risk factors / Systematic reviews Limits: Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Cangzhou Central Hospital/CN / Tianjin Medical University Eye Hospital, School of Optometry and Ophthalmology, Tianjin Medical University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Retinal Vein Occlusion / Prothrombin / Genetic Predisposition to Disease Type of study: Etiology study / Observational study / Risk factors / Systematic reviews Limits: Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Cangzhou Central Hospital/CN / Tianjin Medical University Eye Hospital, School of Optometry and Ophthalmology, Tianjin Medical University/CN