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Biomass smoke COPD has less tomographic abnormalities but worse hypoxemia compared with tobacco COPD
Meneghini, A C; Koenigkam-Santos, M; Pereira, M; Tonidandel, P R; Terra-Filho, J; Cunha, F Q; Menezes, M B de; Vianna, E O.
  • Meneghini, A C; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto. BR
  • Koenigkam-Santos, M; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto. BR
  • Pereira, M; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Campinas. BR
  • Tonidandel, P R; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Campinas. BR
  • Terra-Filho, J; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto. BR
  • Cunha, F Q; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Farmacologia. Ribeirão Preto. BR
  • Menezes, M B de; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto. BR
  • Vianna, E O; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto. BR
Braz. j. med. biol. res ; 52(5): e8233, 2019. tab
Article in English | LILACS | ID: biblio-1001522
ABSTRACT
Special attention has emerged towards biomass smoke-induced chronic obstructive pulmonary disease (COPD), providing new knowledge for prevention and therapeutic approach of non-smoker COPD patients. However, the understanding of biomass smoke COPD is still limited and somewhat controversial. The aim of the present study was to compare COPD exclusively caused by tobacco smoking with COPD exclusively caused by environmental or occupational exposures. For this cross-sectional study, COPD patients were recruited from outpatient clinics and formed two groups non-smoker COPD group (n=16) with exposure to biomass smoke who did not smoke cigarette and tobacco smoker COPD group (n=15) with people who did not report biomass smoke exposure. Subjects underwent pulmonary function tests, thoracic high-resolution computed tomography, 6-min walk test, and sputum induction. The non-smoker COPD group had biomass smoke exposure of 133.3±86 hour-years. The tobacco COPD group smoked 48.5±27.4 pack-years. Women were 62.5 and 66.7%, respectively, of non-smokers and smokers. The non-smoker COPD group showed higher prevalence of dyspnea, lower arterial oxygen tension (PaO2), and lower arterial oxygen saturation (SaO2%) with similar spirometry results, lung volumes, and diffusion capacity. Regarding inflammatory biomarkers, differences were detected in sputum number of lymphomononuclear cells and in sputum concentrations of interleukin (IL)-6 and IL-8 with higher values in the smoker group. Emphysema was more prevalent in the tobacco smoker group, which also showed higher relative bronchial wall thickness and lower lung density by quantitative analysis. Biomass smoke induced more hypoxemia compared to tobacco in COPD patients with similar severity.
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Full text: Available Index: LILACS (Americas) Main subject: Smoke / Nicotiana / Biomass / Pulmonary Disease, Chronic Obstructive / Hypoxia Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Aged / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Smoke / Nicotiana / Biomass / Pulmonary Disease, Chronic Obstructive / Hypoxia Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Aged / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR / Universidade de São Paulo/BR