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The role of intraoperative narrow-band imaging in transoral laser microsurgery for early and moderately advanced glottic cancer / O papel da imagem de banda estreita intraoperatória na microcirurgia transoral a laser para câncer glótico inicial e moderadamente avançado
Klimza, Hanna; Jackowska, Joanna; Piazza, Cesare; Banaszewski, Jacek; Wierzbicka, Malgorzata.
  • Klimza, Hanna; Poznan University of Medical Sciences. Department of Otolaryngology, Head and Neck Surgery. Poznan. PL
  • Jackowska, Joanna; Poznan University of Medical Sciences. Department of Otolaryngology, Head and Neck Surgery. Poznan. PL
  • Piazza, Cesare; Fondazione IRCCS. National Cancer Institute of Milan. Milan. IT
  • Banaszewski, Jacek; Fondazione IRCCS. National Cancer Institute of Milan. Milan. IT
  • Wierzbicka, Malgorzata; Poznan University of Medical Sciences. Department of Otolaryngology, Head and Neck Surgery. Poznan. PL
Braz. j. otorhinolaryngol. (Impr.) ; 85(2): 228-236, Mar.-Apr. 2019. tab, graf
Article in English | LILACS | ID: biblio-1001551
ABSTRACT
Abstract

Introduction:

Trans-oral laser microsurgery is an established technique for the treatment of early and moderately advanced laryngeal cancer.

Objective:

The authors intend to test the usefulness of narrow-band imaging in the intraoperative assessment of the larynx mucosa in terms of specifying surgical margins.

Methods:

Forty-four consecutive T1-T2 glottic cancers treated with trans-oral laser microsurgery Type I-VI cordectomy were presented. Suspected areas (90 samples/44 patients) were biopsied under the guidance of narrow-band imaging and white light and sent for frozen section.

Results:

Our study revealed that 75 of 90 (83.3%) white light and narrow-band imaging-guided samples were histopathologically positive 30 (40%) were confirmed as carcinoma in situ or invasive carcinoma and 45 (60%) as moderate to severe dysplasia. In 6 patients mucosa was suspected only in narrow-band imaging, with no suspicion under white light. Thus, in these 6 patients 18/90 (20%) samples were taken. In 5/6 patients 16/18 (88.8%) samples were positive in frozen section in 6/18 (33.3%) carcinoma (2 patients), 10/18 (66.6%) severe dysplasia was confirmed (3 patients). In 1 patient 2/18 (11.1%) samples were negative in frozen section. Presented analysis showed, that sensitivity, specificity and accuracy of white light was 79.5%, 20% and 71.1% respectively, while narrow-band imaging was 100%, 0.0% and 85.7%, respectively.

Conclusion:

The intraoperative use of narrow-band imaging proved to be valuable in the visualization of suspect areas of the mucosa. Narrow-band imaging confirms the suspicions undertaken in white light and importantly, it showed microlesions beyond the scope of white light.
RESUMO
Resumo

Introdução:

A microcirurgia transoral a laser é uma técnica bem estabelecida para o tratamento de câncer de laringe inicial e moderadamente avançado.

Objetivo:

Verificar a utilidade da imagem de banda estreita na avaliação intraoperatória da mucosa laríngea na especificação das margens cirúrgicas.

Método:

Foram avaliados 44 cânceres glóticos T1-T2 consecutivos, tratados com cordectomia Tipo I-VI, por microcirurgia transoral a laser. As áreas suspeitas (90 amostras/44 pacientes) foram submetidas a biopsia e avaliadas através de imagens de banda estreita e luz branca e enviadas para cortes por congelação.

Resultados:

Nosso estudo revelou que 75 (83,3%) das 90 amostras apresentaram histopatologia positiva na análise com luz branca e imagens de banda estreita 30 (40%) foram confirmadas como carcinoma in situ ou carcinoma invasivo e 45 (60%) como displasia moderada a grave. Em seis pacientes, a mucosa apresentou-se suspeita apenas na imagem de banda estreita, sem suspeita sob luz branca. Assim, nesses seis pacientes 18/90 (20%) amostras foram colhidas. Em 5/6 pacientes, 16/18 (88,8%) amostras mostraram resultado positivo na análise de congelação em 6/18 (33,3%) amostras foi confirmado carcinoma (dois pacientes) e em 10/18 (66,6%) foi confirmada displasia grave (três pacientes). Em um paciente, 2/18 (11,1%) as amostras mostraram resultado negativo na congelação. A análise apresentada mostrou que a sensibilidade, a especificidade e a acurácia da luz branca foram de 79,5%, 20% e 71,1%, respectivamente, enquanto a imagem de banda estreita apresentou como resultados 100%, 0,0% e 85,7%, respectivamente.

Conclusão:

O uso intraoperatório de imagem de banda estreita provou ser valioso na identificação de áreas suspeitas da mucosa, confirmou as suspeitas verificadas na análise com luz branca e, o que é mais importante, identificou microlesões além do alcance da luz branca.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Carcinoma / Laryngeal Neoplasms / Laser Therapy / Narrow Band Imaging / Microsurgery Type of study: Evaluation studies / Practice guideline / Prognostic study Limits: Aged / Aged80 / Female / Humans / Male Language: English Journal: Braz. j. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2019 Type: Article Affiliation country: Italy / Poland Institution/Affiliation country: Fondazione IRCCS/IT / Poznan University of Medical Sciences/PL

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Full text: Available Index: LILACS (Americas) Main subject: Carcinoma / Laryngeal Neoplasms / Laser Therapy / Narrow Band Imaging / Microsurgery Type of study: Evaluation studies / Practice guideline / Prognostic study Limits: Aged / Aged80 / Female / Humans / Male Language: English Journal: Braz. j. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2019 Type: Article Affiliation country: Italy / Poland Institution/Affiliation country: Fondazione IRCCS/IT / Poznan University of Medical Sciences/PL