Development and evaluation of multiparticulate biphasic system for the treatment of circadian diseases
Braz. J. Pharm. Sci. (Online)
;
54(4): e17167, 2018. tab, graf, ilus
Article
in English
| LILACS
| ID: biblio-1001565
ABSTRACT
Multiparticulate systems have biopharmaceutical advantages when compared to the monolithic systems, once they allow different patterns of drug release and can be used in different treatments. The aim of the present work was to develop a biphasic controlled release delivery system, using propranolol hydrochloride (PROP) that can be used for the treatment of circadian diseases. This system was obtained by the combination of cellulosic polymers hydroxypropyl methylcellulose (HPMC) and ethylcellulose (EC) in a 2² factorial experimental design, which allowed the optimization of the development stage. The pellets produced and used in biphasic formulations were evaluated for physical and chemical characteristics and presented acceptable results. The immediate fraction obtained showed the complete release in 30 min while the others kept the release of the drug for 24 h. This study showed that the combination of beads with different releasing characteristics allowed to obtain different release profiles, which can be modulated according to the pathological needs, especially with regard to circadian diseases that suffer alterations throughout the day.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Research Design
/
Chronotherapy
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Parana/BR
/
Prati-Donaduzzi and Cia Ltda/BR
/
State University of the West of Paraná/BR
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