Swertiamarin attenuates carbon tetrachloride (CCl4)-induced liver injury and inï¬ammation in rats by regulating the TLR4 signaling pathway
Braz. J. Pharm. Sci. (Online)
;
54(4): e17449, 2018. graf
Article
in English
| LILACS
| ID: biblio-1001568
ABSTRACT
The aim of the present study is to illustrate the effects of swertiamarin (STM), a natural iridoid from herbal medicines, on hepatic inï¬ammation induced by carbon tetrachloride (CCl4) in rats. Male Sprague Dawley rats were exposed to CCl4 with or without STM co-administration for 8 weeks. Our results revealed that STM administration (100 and 200 mg/kg b.w.) signiï¬cantly attenuated inflammation in livers of CCl4-treated rats. STM remarkably reduced the production of interleukin-1ß (IL-1ß), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), macrophage inflammatory protein-1a (MIP-1α), and monocyte chemotactic protein-1 (MCP-1) in liver tissue of CCl4-treated rats. In addition, STM treatment downregulated connective tissue growth factor (CTGF) and ser307pIRS-1 expression, which was induced by CCl4 exposure. In the process of exploring the anti-inflammatory mechanisms of STM action, we demonstrated that STM signiï¬cantly inhibited Toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) p65 expression in the liver. In conclusion, these results suggested that the inhibition of CCl4-induced inï¬ammation by STM was, at least in part, due to its regulation of the TLR4 /NF-κB signaling pathway
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Carbon Tetrachloride
/
Toll-Like Receptor 4
/
Chemical and Drug Induced Liver Injury
Limits:
Animals
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2018
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
General Hospital of the Yangtze River Shipping/CN
/
Huazhong University of Science and Technology/CN
Similar
MEDLINE
...
LILACS
LIS