Pharmacokinetics of oleracimine in rats by ultra-high-performance liquid chromatography
Braz. J. Pharm. Sci. (Online)
;
54(4): e17242, 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-1001571
ABSTRACT
The novel alkaloid, oleracimine, presented remarkable anti-inflammatory bioactivity, and therefore, its pharmacokinetics was investigated in rat plasma after intravenous and oral administration by using a rapid ultra-high-performance liquid chromatography (UHPLC) method with UV detection at 270 nm. The analysis was performed on a shim-pack ODS column (75 mm×2 mm, 1.6 µm particle size, Shimadzu, Japan) column using isocratic elution with a mobile phase consisting of methanol-water (6238, v/v) within 3 min. The results indicated that oleracimine was rapidly distributed with Tmax for 11.7 min after oral administration, which presented the double-peak phenomenon in the pharmacokinetic profile with a higher oral absolute bioavailability of 55.1% ± 7.83%.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pharmacokinetics
/
Chromatography, Liquid
/
Portulaca
Limits:
Animals
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2018
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Liaoning University of Traditional Chinese Medicine/CN
/
National Institute for Radiological Protection/CN
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