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Pharmacokinetics of oleracimine in rats by ultra-high-performance liquid chromatography
Qu, Gonglin; Xu, Liang; Zhang, Wenjie; Ying, Xixiang.
  • Qu, Gonglin; National Institute for Radiological Protection. Beijing. CN
  • Xu, Liang; Liaoning University of Traditional Chinese Medicine. School of Pharmacy. Dalian. CN
  • Zhang, Wenjie; Liaoning University of Traditional Chinese Medicine. School of Pharmacy. Dalian. CN
  • Ying, Xixiang; s.af
Braz. J. Pharm. Sci. (Online) ; 54(4): e17242, 2018. tab, graf
Article in English | LILACS | ID: biblio-1001571
ABSTRACT
The novel alkaloid, oleracimine, presented remarkable anti-inflammatory bioactivity, and therefore, its pharmacokinetics was investigated in rat plasma after intravenous and oral administration by using a rapid ultra-high-performance liquid chromatography (UHPLC) method with UV detection at 270 nm. The analysis was performed on a shim-pack ODS column (75 mm×2 mm, 1.6 µm particle size, Shimadzu, Japan) column using isocratic elution with a mobile phase consisting of methanol-water (6238, v/v) within 3 min. The results indicated that oleracimine was rapidly distributed with Tmax for 11.7 min after oral administration, which presented the double-peak phenomenon in the pharmacokinetic profile with a higher oral absolute bioavailability of 55.1% ± 7.83%.
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Full text: Available Index: LILACS (Americas) Main subject: Pharmacokinetics / Chromatography, Liquid / Portulaca Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Liaoning University of Traditional Chinese Medicine/CN / National Institute for Radiological Protection/CN

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Full text: Available Index: LILACS (Americas) Main subject: Pharmacokinetics / Chromatography, Liquid / Portulaca Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Liaoning University of Traditional Chinese Medicine/CN / National Institute for Radiological Protection/CN