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Short-term oral administration of risperidone induces pancreatic damage and hyperamylasemia in Sprague-dawley rats
Shah, Rehmat; Subhan, Fazal; Sultan, Syed Muhammad; Ali, Gowhar.
  • Shah, Rehmat; University of Peshawar. Department of Pharmacy. Pharmacology Research Laboratory. PK
  • Subhan, Fazal; University of Peshawar. Department of Pharmacy. Pharmacology Research Laboratory. PK
  • Sultan, Syed Muhammad; Peshawar/Khyber Teaching Hospital. Khyber Medical College. Department of Psychiatry. Peshawar. PK
  • Ali, Gowhar; University of Peshawar. Department of Pharmacy. Pharmacology Research Laboratory. PK
Braz. J. Pharm. Sci. (Online) ; 54(4): e17841, 2018. graf
Article in English | LILACS | ID: biblio-1001588
ABSTRACT
Risperidone is an atypical antipsychotic acting mainly as a dopamine D2 and serotonin 5-HT2 receptors antagonist prescribed in the treatment of schizophrenia and various affective disorders. Risperidone has been reported to be associated with weight gain, panreatitis and type 2 diabetes mellitus. Various mechanisms of risperidone-induced toxicities have been reported but the histology of tissues especially pancreas has never been studied. Therefore, the current study was designed to elucidate the toxic effects of chronic administration of risperidone on pancreas, liver and kidneys. Animals (rats) of either gender were divided into two groups, the risperidone and control groups. Risperidone was administered in a dose of 2.5 mg/kg/d for three weeks. The controls received acidified saline only. Both the groups received restricted diet (20 g/12 h). The body weight and level of random blood sugar (RBS) were measured on a weekly basis. The levels of lipase and amylase were determined at the conclusion of the experiment. At the end of the experiment, the tissues were dissected out for histopathological evaluation. Risperidone showed no weight gain, hyperglycemia or rise in the level of lipase (P> 0.05); however, the level of amylase was raised (***P<0.05). Histological examination under light microscope showed no hepatotoxicity, nephrotoxicity but did show damage to the pancreas. The findings of this study indicated that the incidence of adverse effects associated with risperidone could be prevented/alleviated/delayed by allowing restricted diet.
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Full text: Available Index: LILACS (Americas) Main subject: Pancreas / Administration, Oral / Risperidone Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2018 Type: Article Affiliation country: Pakistan Institution/Affiliation country: Khyber Teaching Hospital+PK / University of Peshawar/PK

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Full text: Available Index: LILACS (Americas) Main subject: Pancreas / Administration, Oral / Risperidone Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2018 Type: Article Affiliation country: Pakistan Institution/Affiliation country: Khyber Teaching Hospital+PK / University of Peshawar/PK