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Remineralizing effect of commercial fluoride varnishes on artificial enamel lesions
Godoi, Fernanda Alvarez de; Carlos, Natália Russo; Bridi, Enrico Coser; Amaral, Flávia Lucisano Botelho do; França, Fabiana Mantovani Gomes; Turssi, Cecilia Pedroso; Kantovitz, Kamila Rosamilia; Basting, Roberta Tarkany.
  • Godoi, Fernanda Alvarez de; São Leopoldo Mandic Research Institute. Campinas. BR
  • Carlos, Natália Russo; São Leopoldo Mandic Research Institute. Campinas. BR
  • Bridi, Enrico Coser; São Leopoldo Mandic Research Institute. Campinas. BR
  • Amaral, Flávia Lucisano Botelho do; São Leopoldo Mandic Research Institute. Campinas. BR
  • França, Fabiana Mantovani Gomes; São Leopoldo Mandic Research Institute. Campinas. BR
  • Turssi, Cecilia Pedroso; São Leopoldo Mandic Research Institute. Campinas. BR
  • Kantovitz, Kamila Rosamilia; São Leopoldo Mandic Research Institute. Campinas. BR
  • Basting, Roberta Tarkany; São Leopoldo Mandic Research Institute. Campinas. BR
Braz. oral res. (Online) ; 33: e044, 2019. tab, graf
Article in English | LILACS | ID: biblio-1001614
ABSTRACT
Abstract The aim of this study was to evaluate soluble and insoluble fluoride concentrations in commercial varnishes, and their remineralization effect on artificial caries enamel lesions using surface and cross-sectional microhardness evaluations. Forty bovine enamel blocks were separated into four groups (n=10) control (no treatment), Enamelast (Ultradent Products), Duraphat (Colgate-Palmolive) and Clinpro White Varnish (3M ESPE). Surface enamel microhardness evaluations were obtained, artificial enamel caries lesions were developed by dynamic pH-cycling, and the varnishes were then applied every 6 days, after which the enamel blocks were submitted to dynamic remineralization by pH cycles. After removal of the varnishes, the enamel surfaces were reassessed for microhardness. The blocks were sectioned longitudinally, and cross-sectional microhardness measurements were performed at different surface depths (up to 300 μm depth). Polarized light microscopy images (PLMI) were made to analyze subsurface caries lesions. The fluoride concentration in whole (soluble and insoluble fluoride) and centrifuged (soluble fluoride) varnishes was determined using an extraction method with acetone. The data were analyzed to evaluate the surface microhardness, making adjustments for generalized linear models. There was a significant decrease in enamel surface microhardness after performing all the treatments (p<0.0001). Enamelast and Duraphat showed significantly higher enamel microhardness values than the control and the Clinpro groups (p = 0.0002). Microhardness loss percentage was significantly lower for Enamelast (p = 0.071; One-way ANOVA). PLMI showed that subsurface caries lesions were not remineralized with the varnish treatments. No significant differences in the in-depth microhardness levels (p = 0.7536; ANOVA) were observed among the treatments. Enamelast presented higher soluble and insoluble fluoride concentrations than the other varnishes (p < 0.0001; Kruskal-Wallis and Dunn tests). Enamelast and Duraphat varnishes promoted enamel surface remineralization, but no varnish remineralized the subsurface lesion body. Although insoluble and soluble fluoride concentration values did not correspond to those declared by the manufacturer, Enamelast presented higher fluoride concentration than the others.
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Full text: Available Index: LILACS (Americas) Main subject: Tooth Remineralization / Cariostatic Agents / Fluorides, Topical / Dental Caries / Dental Enamel Type of study: Evaluation studies / Prognostic study Limits: Animals Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: São Leopoldo Mandic Research Institute/BR

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Full text: Available Index: LILACS (Americas) Main subject: Tooth Remineralization / Cariostatic Agents / Fluorides, Topical / Dental Caries / Dental Enamel Type of study: Evaluation studies / Prognostic study Limits: Animals Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: São Leopoldo Mandic Research Institute/BR