7. 0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson's disease patients
Clinics
;
74: e573, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1001827
ABSTRACT
OBJECTIVES:
The pedunculopontine nucleus (PPN) is considered a promising new target for neurostimulation in Parkinson's disease (PD) patients with postural instability and gait disturbance that is refractory to other treatment modalities. However, the PPN is typically difficult to visualize with magnetic resonance imaging (MRI) at clinical field strengths, which greatly limits the PPN as a viable surgical target for deep brain stimulation (DBS). Thus, the aim of this study is to directly visualize the PPN based on 7.0T ultrahigh-field MRI.METHODS:
Five PD patients were enrolled and scanned using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI scanner. Then, the MP2RAGE sequences were imported into a commercially available navigation system. The coordinates of the directly localized PPN poles were recorded in the navigation system relative to the anterior commissure-posterior commissure plane.RESULTS:
Our results indicated that the PPN presented intermediate signal intensity in the 7.0T ultrahigh-field MR images in comparison with the surrounding structure, such as the hypo-intensity of the periaqueductal gray and the hyperintensity of the neighboring white matter tracts, in PD patients. The mean coordinates for the rostral and caudal poles of PPN were 6.50 mm and 7.20 mm lateral, 1.58 mm and 2.21 mm posterior, and 8.89 mm and 13.83 mm relative to the posterior commissure.CONCLUSION:
Our findings provide, for the first time, direct visualization of the PPN using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI, which may improve the accuracy of stereotactic targeting of the PPN and improve the outcomes in patients undergoing DBS.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Parkinson Disease
/
Magnetic Resonance Imaging
/
Image Enhancement
/
Pedunculopontine Tegmental Nucleus
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2019
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Capital Medical University/CN
/
Chinese Academy of Medical Sciences and Peking Union Medical College/CN
/
Institute of Biophysics Chinese Academy of Sciences/CN
/
Institute of Biophysics, Chinese Academy of Sciences/CN
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