Swimming training potentiates the recovery of femoral neck strength in young diabetic rats under insulin therapy
Clinics
;
74: e829, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1001830
ABSTRACT
OBJECTIVE:
To test whether swimming training benefits femoral neck strength in young diabetic rats under insulin therapy.METHODS:
A total of 60 male Wistar rats (age 40 days) were divided equally into the following six groups control sedentary, control exercise, diabetic sedentary, diabetic exercise, diabetic sedentary plus insulin and diabetic exercise plus insulin. Diabetes was induced with a unique intraperitoneal injection (60 mg/kg body weight) of streptozotocin. Seven days after the injection and after 12 hours of fasting, the animals with blood glucose levels ≥300 mg/dL were considered diabetic. Seven days after the induction of diabetes, the animals in the exercise groups were subjected to progressive swimming training (final week 90 min/day; 5 days/week; 5% load) for eight weeks. The animals in the insulin groups received a daily dose of insulin (2-4 U/day) for the same period.RESULTS:
Severe streptozotocin-induced diabetes reduced the structural properties of the femoral neck (trabecular bone volume, trabecular thickness and collagen fiber content). The femoral neck mechanical properties (maximum load and tenacity) were also impaired in the diabetic rats. Insulin therapy partially reversed the damage induced by diabetes on the structural properties of the bone and mitigated the reductions in the mechanical properties of the bone. The combination of therapies further increased the femoral neck trabecular bone volume (∼30%), trabecular thickness (∼24%), collagen type I (∼19%) and type III (∼13%) fiber contents, maximum load (∼25%) and tenacity (∼14%).CONCLUSIONS:
Eight weeks of swimming training potentiates the recovery of femoral neck strength in young rats with severe streptozotocin-induced diabetes under insulin therapy.
Full text:
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Index:
LILACS (Americas)
Main subject:
Swimming
/
Diabetes Mellitus, Experimental
/
Exercise Therapy
/
Femur Neck
/
Hypoglycemic Agents
/
Insulin
Type of study:
Evaluation studies
Limits:
Animals
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2019
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Sao Joao Evangelista/BR
/
Universidade Federal de Vicosa/BR
/
Universidade Federal dos Vales do Jequitinhonha e Mucuri/BR
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